DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep3 and CD109

DIOPT Version :9

Sequence 1:	NP_523507.2	Gene:	Tep3 / 34045	FlyBaseID:	FBgn0041181	Length:	1469	Species:	Drosophila melanogaster
Sequence 2:	NP_598000.2	Gene:	CD109 / 135228	HGNCID:	21685	Length:	1445	Species:	Homo sapiens

Alignment Length:	1567	Identity:	427/1567 - (27%)
Similarity:	713/1567 - (45%)	Gaps:	252/1567 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 ILVTACLLCQ-TSAQGL-----YSIIAPNTLRPNSQFHVAVS-LHNAPESATFKVGIL--GSSYT 70
            :|..|.|||. |:|..:     :.:.||..:||.....:.|. |.:.|...|.|..:|  .|:.|
Human     6 LLTAAHLLCVCTAALAVAPGPRFLVTAPGIIRPGGNVTIGVELLEHCPSQVTVKAELLKTASNLT 70

  Fly    71 -------------DFKTVELRPFSTQLLHFEIPALRTD---RYRLTAEGLGGVQFTNETQLHFES 119
                         .|||:.|.         .:|....|   ..|:|......:.|:|.|:|.||:
Human    71 VSVLEAEGVFEKGSFKTLTLP---------SLPLNSADEIYELRVTGRTQDEILFSNSTRLSFET 126

  Fly   120 KQHTVLVQTDKSIYKPGDLVHYRVLILDANLKPARGYGRVHVDIKDSGDNIIRSYKDIRLTNSIY 184
            |:.:|.:||||::|||...|.:|::.|.::.||.:  ..:::.|||...|:|:.:...:....:.
Human   127 KRISVFIQTDKALYKPKQEVKFRIVTLFSDFKPYK--TSLNILIKDPKSNLIQQWLSQQSDLGVI 189

  Fly   185 SNELRLSDSPRFGTWSIVVDVSDQEHTQTFEILDHILPKFVVDIDTPKHAIYKDGKIAATVRAHY 249
            |...:||..|..|.|||.|.|:||.:.|:|::.:::||||.|.:.||.:.......:..|:.|.|
Human   190 SKTFQLSSHPILGDWSIQVQVNDQTYYQSFQVSEYVLPKFEVTLQTPLYCSMNSKHLNGTITAKY 254

  Fly   250 AFGQPIVGEATLSIYP-TFFGSLQPFVNDLITRKVVPIDGNAYFEFDIENELHLKQDYERQYLLD 313
            .:|:|:.|:.||:..| :|:|..:...      |...|:|:|.|.|:         |.|.:.::|
Human   255 TYGKPVKGDVTLTFLPLSFWGKKKNIT------KTFKINGSANFSFN---------DEEMKNVMD 304

  Fly   314 A--------------------LVEEKSTGSVQNYSTVLTLHLNHYRVEAVKVPSYYIPGVPFEAT 358
            :                    .|.|..||..:|.||.:....:.|.:|.....:...|.:.|.||
Human   305 SSNGLSEYLDLSSPGPVEILTTVTESVTGISRNVSTNVFFKQHDYIIEFFDYTTVLKPSLNFTAT 369

  Fly   359 ARIARNDGGQL----RDFNPQITA----YLTNVYGSS------EMYNRTAYSLDASGEIKMKFTV 409
            .::.|.||.||    |..|..||.    |.....||:      |...:..|::..||..|::|.:
Human   370 VKVTRADGNQLTLEERRNNVVITVTQRNYTEYWSGSNSGNQKMEAVQKINYTVPQSGTFKIEFPI 434

  Fly   410 PIGDRDEFHSIIVDYQGVISEVGKIPSKHLH------SKNYITAKVLNDRPTVNQEISVVVRSFA 468
             :.|..|.       |.....:|...|..:|      ||.||..|..::...|.....:||....
Human   435 -LEDSSEL-------QLKAYFLGSKSSMAVHSLFKSPSKTYIQLKTRDENIKVGSPFELVVSGNK 491

  Fly   469 PIKYFMYQVVGRGDIILSRNVDVAPGTFHTIKF--LASFAMMPRANLLVYTV-IDGEFVYDEQVI 530
            .:|...|.||.||.:       ||.|..::..|  ....:..|:|.::||.: .|||.:.|...|
Human   492 RLKELSYMVVSRGQL-------VAVGKQNSTMFSLTPENSWTPKACVIVYYIEDDGEIISDVLKI 549

  Fly   531 QLEENLLNAVQVD-APIRAPPGQDIDIGIS-TKPYSYVGLMLVDQNANDLRSGHDLTHKRLMDAL 593
            .::....|.:::. :.::|.|.:.:.:.|| |:|.|.||::.||::.|.:.:.:|:|.:.::..|
Human   550 PVQLVFKNKIKLYWSKVKAEPSEKVSLRISVTQPDSIVGIVAVDKSVNLMNASNDITMENVVHEL 614

  Fly   594 RSYELSDVNTPMGSPGKESGVITMSNTDYFIEKEAES-------------NPALDREVSTGPEED 645
            ..|                      ||.|::.....|             :..|.::...|..::
Human   615 ELY----------------------NTGYYLGMFMNSFAVFQECGLWVLTDANLTKDYIDGVYDN 657

  Fly   646 KLTTVRKTDIGPAHKIEVNTLPPGKGRYAFSYTPKPFWHNPRVHVMRDPADTWLFLNISASSDGR 710
            .....|..:....|.:::         :.||....|       ||.:...:||::|:.:......
Human   658 AEYAERFMEENEGHIVDI---------HDFSLGSSP-------HVRKHFPETWIWLDTNMGYRIY 706

  Fly   711 NSIHRRIPSEMTSWVVSAFALDPVNGLGLSPPNGKLEAYKEFYISTELPYSIKRDELIAIPFVVH 775
            ......:|..:||||.:.|.:....||||:....:|:|::.|:|...||||:.|.|..|:...:.
Human   707 QEFEVTVPDSITSWVATGFVISEDLGLGLTTTPVELQAFQPFFIFLNLPYSVIRGEEFALEITIF 771

  Fly   776 NNRDSDLNVEVTFYNS-ALDFDFPQLDPKATNQPKVELYRRRSLQVPGRSARSVSFIVTPKRVGP 839
            |.......|:|....| ..|......:..||.       .:::|.||.....:|.|.:.|..:|.
Human   772 NYLKDATEVKVIIEKSDKFDILMTSNEINATG-------HQQTLLVPSEDGATVLFPIRPTHLGE 829

  Fly   840 LLVKAMAASSQAGDTVEQNLLVEHPGAMERINRGFLFELNSN--AQNRRNVTIAVPRNAIPESTR 902
            :.:...|.|..|.|.|.|.:||:..|..:..::..|.:|..|  ....:.::.:.|.|.:..|.|
Human   830 IPITVTALSPTASDAVTQMILVKAEGIEKSYSQSILLDLTDNRLQSTLKTLSFSFPPNTVTGSER 894

  Fly   903 IEVSAVGDLIGSLVGNLDSLILLPTGCGEQTMVNFVPNLIVLRYLGRLRQLTPEVELRATNNLAI 967
            ::::|:||::|..:..|.|||.:|.|||||.|:||.||:.:|.||.:.:|||..::.:|.:.:..
Human   895 VQITAIGDVLGPSINGLASLIRMPYGCGEQNMINFAPNIYILDYLTKKKQLTDNLKEKALSFMRQ 959

  Fly   968 GYQRILYYRHENGAFSAFGLDIKRSSTWLTAYVARSLRQAAPFTQVDSNVLQKALTYLGSVQSAN 1032
            ||||.|.|:.|:|:|||||......||||:|:|.|...:|.|:..:|.|||.:..|:|...|.:|
Human   960 GYQRELLYQREDGSFSAFGNYDPSGSTWLSAFVLRCFLEADPYIDIDQNVLHRTYTWLKGHQKSN 1024

  Fly  1033 GGFEERGDVFERFGDDG----ISLTAFVTLALMENVDLYPEYRNNIN--KALDFI----TRGLDG 1087
            |.|.:.|.|.......|    ::|||::..:|:.    |.:|:.||:  :::.|:    :||:
Human  1025 GEFWDPGRVIHSELQGGNKSPVTLTAYIVTSLLG----YRKYQPNIDVQESIHFLESEFSRGI-- 1083

  Fly  1088 SSNLHAMAIGTYVLSRANHNAKAAFLQRLDSMATNKDGLKWWNKTAPAGEQQSPWYNATRSVNIE 1152
             |:.:.:|:.||.||..........|..|...|..:.|:::|  .:...:....|  ..||::||
Human  1084 -SDNYTLALITYALSSVGSPKAKEALNMLTWRAEQEGGMQFW--VSSESKLSDSW--QPRSLDIE 1143

  Fly  1153 ISAYAALALLENNLVGDALPVLNWLMDQRNPKGGFVASQDTVVGLQALLMFAERFSSQGNNLQIG 1217
            ::|||.|:........:.:|::.||..|||..|||.::|||.|.|:||..||...:::..|:|:.
Human  1144 VAAYALLSHFLQFQTSEGIPIMRWLSRQRNSLGGFASTQDTTVALKALSEFAALMNTERTNIQVT 1208

  Fly  1218 FHYGEGAETIIN--VNAENSLALQTVEL----PNNLKNLSVSATGRGMALAQVSYTYNTNVTSAW 1276
            . .|..:.:.:.  ::..|.|.|||.||    |.   .:::||.|.|.|:.|::..||...:.:.
Human  1209 V-TGPSSPSPVKFLIDTHNRLLLQTAELAVVQPT---AVNISANGFGFAICQLNVVYNVKASGSS 1269

  Fly  1277 PR---------FVLDPTVNRN----SHADYLHLSACASFVSVVGENEQRSNMAVMEVHLPSGFVV 1328
            .|         |.||..|..|    :|.|   |:.|.||     ....||.||:|||:|.|||:|
Human  1270 RRRRSIQNQEAFDLDVAVKENKDDLNHVD---LNVCTSF-----SGPGRSGMALMEVNLLSGFMV 1326

  Fly  1329 DRDTLPTLESSERIKKVETQNRNTKVVIYFDYLDRREVCPTLHAYKTVKVTKHRPVAVVMYDYYD 1393
            ..:   .:..||.:||||..  :.|:.:|.|.::..:.|..:.|.:..||:..:..:|.:.|||:
Human  1327 PSE---AISLSETVKKVEYD--HGKLNLYLDSVNETQFCVNIPAVRNFKVSNTQDASVSIVDYYE 1386

  Fly  1394 SARRARQFYRAP-KSNICDICEHANCGDLCEKAEKRESKRPDDYTAIAGHSSGSRHTAIPLASVV 1457
            ..|:|.:.|.:. |.:.||:|........||..                 :|||.|.    :||:
Human  1387 PRRQAVRSYNSEVKLSSCDLCSDVQGCRPCEDG-----------------ASGSHHH----SSVI 1430

  Fly  1458 MVLSMLL 1464
            .:....|
Human  1431 FIFCFKL 1437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep3	NP_523507.2	A2M_N	124..215	CDD:280081	31/90 (34%)
		A2M_N_2	448..573	CDD:285005	34/129 (26%)
		A2M	697..787	CDD:278630	26/89 (29%)
		A2M_2	918..1203	CDD:239227	104/294 (35%)
		A2M_comp	967..1200	CDD:284982	80/242 (33%)
		A2M_recep	1313..1402	CDD:284981	30/88 (34%)
CD109	NP_598000.2	YfaS	<66..>1000	CDD:225248	270/1019 (26%)
		A2M_N	130..221	CDD:280081	32/92 (35%)
		A2M_N_2	470..596	CDD:285005	35/132 (27%)
		Bait region (approximate). /evidence=ECO:0000250	593..702		22/146 (15%)
		A2M	693..782	CDD:278630	26/88 (30%)
		A2M_2	907..1194	CDD:239227	104/297 (35%)
		A2M_comp	959..1196	CDD:284982	83/247 (34%)
		A2M_recep	1311..1395	CDD:284981	30/88 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149963
Domainoid	1	1.000	60	1.000	Domainoid score	I10574
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H25183
Inparanoid	1	1.050	613	1.000	Inparanoid score	I912
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45959
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	1	1.000	-	-		FOG0002157
OrthoInspector	1	1.000	-	-		otm40305
orthoMCL	1	0.900	-	-		OOG6_100452
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2582
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.810