DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep3 and C4b

DIOPT Version :9

Sequence 1:	NP_523507.2	Gene:	Tep3 / 34045	FlyBaseID:	FBgn0041181	Length:	1469	Species:	Drosophila melanogaster
Sequence 2:	XP_006523594.1	Gene:	C4b / 12268	MGIID:	88228	Length:	1758	Species:	Mus musculus

Alignment Length:	1698	Identity:	396/1698 - (23%)
Similarity:	642/1698 - (37%)	Gaps:	419/1698 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 CQTSAQG----LYSIIAPNTLRPNSQFHVAVSLHNAPESATFKVGIL-----GSSYT---DFKTV 75
            |.:|.|.    |:|   |:.:...:...|.|.|.:||.....|..:.     |.|.:   |||..
Mouse    14 CASSLQKPRLLLFS---PSVVNLGTPLSVGVQLLDAPPGQEVKGSVFLRNPKGGSCSPKKDFKLS 75

  Fly    76 ELRPFSTQLLHFEIP-----------ALRTDRYRLTAEG--LGGVQF-TNETQ---LHFESKQHT 123
            ....|  .||..|:|           ..|....:|.|:.  |....| ..|||   |.|.|::..
Mouse    76 SGDDF--VLLSLEVPLEDVRSCGLFDLRRAPHIQLVAQSPWLRNTAFKATETQGVNLLFSSRRGH 138

  Fly   124 VLVQTDKSIYKPGDLVHYRVLILDANLKPARGYGRVHVDIKDSGDNIIRSYKDIRLTNSIYSNEL 188
            :.||||:.||.||..|.|||..||..::|:..:..:.|: ...|..:::  |:|..:.||:.:..
Mouse   139 IFVQTDQPIYNPGQRVRYRVFALDQKMRPSTDFLTITVE-NSHGLRVLK--KEIFTSTSIFQDAF 200

  Fly   189 RLSDSPRFGTWSIVVDVSD---QEHTQTFEILDHILPKFVVDIDTPKHAIY----KDGKIAATVR 246
            .:.|....|||.|....||   ...:..||:..::||.|.|.|...|..|.    ...:|...::
Mouse   201 TIPDISEPGTWKISARFSDGLESNRSTHFEVKKYVLPNFEVKITPWKPYILMVPSNSDEIQLDIQ 265

  Fly   247 AHYAFGQPIVGEATLSIYPTFF----GSLQPFVNDLITRKVVPIDGNAYFEFDIE------NELH 301
            |.|.:|:|:.|.|    |..|.    ...:.|:..|.|:..: ::|..:.....:      ::::
Mouse   266 ARYIYGKPVQGVA----YTRFALMDEQGKRTFLRGLETQAKL-VEGRTHISISKDQFQAALDKIN 325

  Fly   302 L-KQDYE--RQYLLDALV-------EEKSTGSVQNYSTVLTLHLNHYRVEAVKVPSYYIPGVPFE 356
            : .:|.|  |.|...|::       ||....|.:..|:..:|.|:       :...:.:||..|.
Mouse   326 IGVRDLEGLRLYAATAVIESPGGEMEEAELTSWRFVSSAFSLDLS-------RTKRHLVPGAHFL 383

  Fly   357 ATARIARNDGGQLRDFNPQITAYLTNVYGSSEMYNRTAYSLDASGEIKMKFTVPIGDRDEFHSII 421
            ..|.:....|.:..:...:::|  |.|.||.........|.:..|::.:.|.:|        ..:
Mouse   384 LQALVQEMSGSEASNVPVKVSA--TLVSGSDSQVLDIQQSTNGIGQVSISFPIP--------PTV 438

  Fly   422 VDYQGVISEVGKI------------PSKHLHSKNYITAKVLNDR-PTVN-------QEISVVVRS 466
            .:.:.::| .|.:            ||:   ...:::.:.|:.| |:|.       |.:.:...:
Mouse   439 TELRLLVS-AGSLYPAIARLTVQAPPSR---GTGFLSIEPLDPRSPSVGDTFILNLQPVGIPAPT 499

  Fly   467 FAPIKYFMYQVVGRGDIILSRNVDVAPG-----TFHTIKFLASFAMMPRANLLVYTVIDGEFVYD 526
            |:   ::.|.::.||.|       :|.|     |..::..|....:.|....:.|....|..|.:
Mouse   500 FS---HYYYMIISRGQI-------MAMGREPRKTVTSVSVLVDHQLAPSFYFVAYFYHQGHPVAN 554

  Fly   527 EQVIQLE----ENLLNAVQVDAPIRAPPGQDIDIGISTKPYSYVGLMLVDQ--NANDLRSGHDLT 585
            ..:|.::    |..|. ::||..........:.:.|.|...:.|.|..||.  .|...||...|.
Mouse   555 SLLINIQSRDCEGKLQ-LKVDGAKEYRNADMMKLRIQTDSKALVALGAVDMALYAVGGRSHKPLD 618

  Fly   586 HKRLMDALRSYELSDVNTPMGSPG--------KESGV-------ITMSNTDYFIEKEAES----N 631
            ..::.:.:.||     |...|..|        :::|:       :|.:..|....||.:|    |
Mouse   619 MSKVFEVINSY-----NVGCGPGGGDDALQVFQDAGLAFSDGDRLTQTREDLSCPKEKKSRQKRN 678

  Fly   632 PALDREVSTGPEEDKLTTVRKTDIGPAHKIEVNTLPPGK------GRYAFSYTPKPFWH------ 684
            ....:.||     :||......|.....:..:..||..:      .|.......:||..
Mouse   679 VNFQKAVS-----EKLGQYSSPDAKRCCQDGMTKLPMKRTCEQRAARVPQQACREPFLSCCKFAE 738

  Fly   685 -------NPRVHVMRDP---------------------ADTWLFLNISASSDGRNSIHRRIPSEM 721
                   ..:.|:.|:.                     .:.||:......|....::.  :|..|
Mouse   739 DLRRNQTRSQAHLARNNHNMLQEEDLIDEDDILVRTSFPENWLWRVEPVDSSKLLTVW--LPDSM 801

  Fly   722 TSWVVSAFALDPVNGLGLSPPNGKLEAYKEFYISTELPYSIKRDELIAIPFVVHN--NRDSDLNV 784
            |:|.:...:|....||.::.|. ::..:::|::...||.||:|.|...:..|::|  |.|..::|
Mouse   802 TTWEIHGVSLSKSKGLCVAKPT-RVRVFRKFHLHLRLPISIRRFEQFELRPVLYNYLNDDVAVSV 865

  Fly   785 EVTFYNSALDFDFPQLDPKATNQPKVEL------YRRRSLQVPGRSARSVSFIVTPKRVGPLLVK 843
            .||                    |...|      ...:.:.||..|||.|:|.|.|.....:.:|
Mouse   866 HVT--------------------PVEGLCLAGGGMMAQQVTVPAGSARPVAFSVVPTAAANVPLK 910

  Fly   844 AMAAS-SQAGDTVEQNLLVEHPGAMERINRGFLFELNSNAQNRRNVTIAVP----RNAIPES--- 900
            .:|.. ...||.|.:.|.:|..||:.|....:    |.:..|....|:.:|    .|.:|:.
Mouse   911 VVARGVFDLGDAVSKILQIEKEGAIHREELVY----NLDPLNNLGRTLEIPGSSDPNIVPDGDFS 971

  Fly   901 --TRIEVSAVGDLIGS----LVGNLDSLILLPTGCGEQTMVNFVPNLIVLRYLGRLRQ---LTPE 956
              .|:..|...:.:||    ..|.:.||:.||.||.||||:...|.|....||.|..|   |:||
Mouse   972 SLVRVTASEPLETMGSEGALSPGGVASLLRLPQGCAEQTMIYLAPTLTASNYLDRTEQWSKLSPE 1036

  Fly   957 VELRATNNLAIGYQRILYYRHENGAFSAFGLDIKR-SSTWLTAYVARSLRQAAPFTQVDSNVLQK 1020
            .:..|.:.:..||.||..:|..:|:|.|:   :.| |||||||:|.:.|..|..........||:
Mouse  1037 TKDHAVDLIQKGYMRIQQFRKNDGSFGAW---LHRDSSTWLTAFVLKILSLAQEQVGNSPEKLQE 1098

  Fly  1021 ALTYLGSVQSANGGFEERGDVFERF-------GDDGISLTAFVTLALMENVDLY-----PEYRN- 1072
            ..::|.:.|..:|.|.:...|..|.       .|:.::|||||.:||...:|::     .:.:|
Mouse  1099 TASWLLAQQLGDGSFHDPCPVIHRAMQGGLVGSDETVALTAFVVIALHHGLDVFQDDDAKQLKNR 1163

  Fly  1073 ---NINKALDFI----TRGLDGSSNLHAMAIGTY--VLSRANHNAKAAFLQRLDSMATNKDGLKW 1128
               :|.||..|:    :.||.|:   ||.||..|  .|::|:.:.:......|.:||.......:
Mouse  1164 VEASITKANSFLGQKASAGLLGA---HAAAITAYALTLTKASEDLRNVAHNSLMAMAEETGEHLY 1225

  Fly  1129 W------------------NKTAPAGEQQSPWYNATRSVNIEISAYAALALLENNLVGD-ALPVL 1174
            |                  :.|.|..:..:.|        ||.:|||.|.||.....|. |....
Mouse  1226 WGLVLGSQDKVVLRPTAPRSPTEPVPQAPALW--------IETTAYALLHLLLREGKGKMADKAA 1282

  Fly  1175 NWLMDQRNPKGGFVASQDTVVGLQALLMF-------AER-----FSSQGNN------LQIGFHYG 1221
            :||..|.:..|.|.::|||||.|.||..:       .|:     .||.|.|      |.:..|..
Mouse  1283 SWLTHQGSFHGAFRSTQDTVVTLDALSAYWIASHTTEEKALNVTLSSMGRNGLKTHGLHLNNHQV 1347

  Fly  1222 EGAETIINVNAENSLALQTVELPNNL-KNLSVSATGRGMALAQVSYTYNT----NVTS------- 1274
            :|.|.               ||..:| ..:||...|......::..|||.    |.|.
Mouse  1348 KGLEE---------------ELKFSLGSTISVKVEGNSKGTLKILRTYNVLDMKNTTCQDLQIEV 1397

  Fly  1275 --------AWPRFVLDPTVNRNSHADYLHLSAC------------------------ASFVSVVG 1307
                    ||..        ...:.||..:.|.                        .....||.
Mouse  1398 KVTGAVEYAWDA--------NEDYEDYYDMPAADDPSVPLQPVTPLQLFEGRRSRRRREAPKVVE 1454

  Fly  1308 ENEQR---------------SNMAVMEVHLPSGFVVDRDTLPTLES-SER-IKKVETQNRNTKVV 1355
            |.|.|               |.||:.::.|.|||...|..|..|.| |:| :...||...:  |:
Mouse  1455 EQESRVQYTVCIWRNGKLGLSGMAIADITLLSGFHALRADLEKLTSLSDRYVSHFETDGPH--VL 1517

  Fly  1356 IYFDYLDRREVCPTLHAYKTVKVTKHRPVAVVMYDYYDSARRARQFYRAPKSN--ICDICEHANC 1418
            :|||.:.....|....|.:.|.|...:|.:.|:||||....:...||.||..:  :..:|.
Mouse  1518 LYFDSVPTTRECVGFGASQEVVVGLVQPSSAVLYDYYSPDHKCSVFYAAPTKSQLLATLCS---- 1578

  Fly  1419 GDLCEKAE 1426
            ||:|:.||
Mouse  1579 GDVCQCAE 1586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep3	NP_523507.2	A2M_N	124..215	CDD:280081	28/93 (30%)
		A2M_N_2	448..573	CDD:285005	28/141 (20%)
		A2M	697..787	CDD:278630	23/91 (25%)
		A2M_2	918..1203	CDD:239227	101/329 (31%)
		A2M_comp	967..1200	CDD:284982	79/274 (29%)
		A2M_recep	1313..1402	CDD:284981	29/90 (32%)
C4b	XP_006523594.1	A2M_N	139..231	CDD:376626	29/94 (31%)
		MG3	233..318	CDD:375334	20/89 (22%)
		A2M_N_2	470..609	CDD:377903	29/149 (19%)
		ANATO	686..752	CDD:237984	10/70 (14%)
		A2M	780..867	CDD:365945	23/89 (26%)
		A2M_comp	978..1311	CDD:369461	105/346 (30%)
		A2M_recep	1475..1564	CDD:369460	29/90 (32%)
		NTR_like	1582..1736	CDD:382999	3/5 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840024
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.810