Protein Alignment Tep3 and Pzp

DIOPT Version :10

• Sequence 1: NP_523507.2
• Gene: Tep3 / 34045
• FlyBaseID: FBgn0041181
• Length: 1469
• Species: Drosophila melanogaster
• Sequence 2: NP_031402.3
• Gene: Pzp / 11287
• MGIID: 87854
• Length: 1495
• Species: Mus musculus
• Alignment Length: 1605
• Identity: 380/1605 - (23%)
• Similarity: 652/1605 - (40%)
• Gaps: 364/1605 - (22%)

  Fly    26 SAQGLYSIIAPNTLRPNSQFHVAVSLHNAPESATFKVGILGSSYTDFKTVELRPFSTQLLHFEIP 90
            :|:..|.::.|:.:.........|||::..|:....:           |:|.....|:||..:
Mouse    26 TAKPQYVVLVPSEVYSGVPEKACVSLNHVNETVMLSL-----------TLEYAMQQTKLLTDQ-- 77

  Fly    91 ALRTDRYRLTAEGLGG---------VQFTNETQLHFESK-------QHTVLVQTDKSIYKPGDLV 139
            |:..|.:..:...:.|         |:....||...:.|       :..|.|||||.|||||.:|
Mouse    78 AVDKDSFYCSPFTISGSPLPYTFITVEIKGPTQRFIKKKSIQIIKAESPVFVQTDKPIYKPGQIV 142

  Fly   140 HYRVLILDANLKPARGYGRVHVDIKDSGDNIIRSYKDIRLTNSIYSNELRLSDSPRFGTWSIVVD 204
            .:||:.:|.:.:|......| |.|:....|.|..:::|.|...::.....||..|..|.:.:||.
Mouse   143 KFRVVSVDISFRPLNETFPV-VYIETPKRNRIFQWQNIHLAGGLHQLSFPLSVEPALGIYKVVVQ 206

  Fly   205 V-SDQEHTQTFEILDHILPKFVVDIDTPKHAIYKDGKIAATVRAHYAFGQPIVGEATLSI---YP 265
            . |.::...:||:.:::||||.|.|...|...:.:.::..|....|.:|:|:.|..||.:   |.
Mouse   207 KDSGKKIEHSFEVKEYVLPKFEVIIKMQKTMAFLEEELPITACGVYTYGKPVPGLVTLRVCRKYS 271

  Fly   266 TFFGSLQPFVNDLITRKV-VPIDGNAYFEFDIENEL-HLKQ-DYERQYLLDALVEEKSTG----- 322
            .:..:.....:..|..:. ...|....|...::.:: .|:| .::.:..::|.::|:.||
Mouse   272 RYRSTCHNQNSMSICEEFSQQADDKGCFRQVVKTKVFQLRQKGHDMKIEVEAKIKEEGTGIELTG 336

  Fly   323 ----SVQNYSTVLTLHLNHYRVEAVKVPSYYIPGVPFEATARIARNDGGQLRDFNPQITAYLT-- 381
                .:.|..:         :::..||.:.|.||:||.....:....|..:.  |..||:.::
Mouse   337 IGSCEIANALS---------KLKFTKVNTNYRPGLPFSGQVLLVDEKGKPIP--NKNITSVVSPL 390

  Fly   382 ---NVYGSSEMYNRTAYSLDASGEIKMKFTVPI-------------GDR---DEFHSIIVDYQG- 426
               :::.:.| :.....|:|.|     .||.|.             .|.   ||||: ..|:..
Mouse   391 GYLSIFTTDE-HGLANISIDTS-----NFTAPFLRVVVTYKQNHVCYDNWWLDEFHT-QADHSAT 448

  Fly   427 -VISEVGKIPSKHLHSKNYITAKVLNDRPTV--NQEISV-------VVRSFAPIKYFMYQVVGRG 481
             |.|.          |::||..:::......  .|||.:       ::::...:.:: |.:..||
Mouse   449 LVFSP----------SQSYIQLELVFGTLACGQTQEIRIHYLLNEDIMKNEKDLTFY-YLIKARG 502

  Fly   482 DI-----------------ILSRNVDVAPGTFHTIKFLASFAMMPRANLLVYTVI-DGEFVYDEQ 528
            .|                 :.|..:.|.||            |.|.|.||:|.:: :.|.|.|.|
Mouse   503 SIFNLGSHVLSLEQGNMKGVFSLPIQVEPG------------MAPEAQLLIYAILPNEELVADAQ 555

  Fly   529 VIQLEENLLNAVQVDAP-IRAPPGQDIDIGISTKPYSYVGLMLVDQNANDLR------------- 579
            ..::|:...|.|.:..| .::.|..|..:.:...|.|...|..|||:...|:
Mouse   556 NFEIEKCFANKVNLSFPSAQSLPASDTHLKVKAAPLSLCALTAVDQSVLLLKPEAKLSPQSIYNL 620

  Fly   580 -----------------------SGHDLTHKRLMDALRSYELSDVNTPMGSPG--------KESG 613
                                   ||.|:||..:           |.||..|.|        :..|
Mouse   621 LPGKTVQGAFFGVPVYKDHENCISGEDITHNGI-----------VYTPKHSLGDNDAHSIFQSVG 674

  Fly   614 VITMSNTDYFIEK-----EAESNPALD-------REVSTGP------------------EEDKLT 648
            :...:|:.  |.|     |.:..||:.       ...::||                  |.:::.
Mouse   675 INIFTNSK--IHKPRFCQEFQHYPAMGGVAPQALAVAASGPGSSFRAMGVPMMGLDYSDEINQVV 737

  Fly   649 TVRKTDIGPAHKIEVNTLPPGKGRYAFSYTPKPFWHNPRVHVMRDPADTWLF--LNISASSDGRN 711
            .||:|                    ...|.|                :||::  :.:..|.||..
Mouse   738 EVRET--------------------VRKYFP----------------ETWIWDLVPLDVSGDGEL 766

  Fly   712 SIHRRIPSEMTSWVVSAFALDPVNGLGLSPPNGKLEAYKEFYISTELPYSIKRDELIAIPFVVHN 776
            ::  ::|..:|.|..|||.|....||||| ....|:|::.|::...||||:.|.|...:...|.|
Mouse   767 AV--KVPDTITEWKASAFCLSGTTGLGLS-STISLQAFQPFFLELTLPYSVVRGEAFTLKATVLN 828

  Fly   777 NRDSDLNVEVTFYNSALDFDFPQLDPKATNQPKVELYRRRSLQVP-----------GRSARSVSF 830
            .....:.:.|....|.   ||                    |.||           |...::||:
Mouse   829 YMSHCIQIRVDLEISP---DF--------------------LAVPVGGHENSHCICGNERKTVSW 870

  Fly   831 IVTPKRVGPLLVKAMAASSQA----------------GDTVEQNLLVEHPG-AMERINRGFLFEL 878
            .||||.:|.:...|.|.:.|:                .|||.::::||..| ..|:.....|...
Mouse   871 AVTPKSLGEVNFTATAEALQSPELCGNKLTEVPALVHKDTVVKSVIVEPEGIEKEQTYNTLLCPQ 935

  Fly   879 NSNAQNRRNVTIAVPRNAIPESTRIEVSAVGDLIGSLVGNLDSLILLPTGCGEQTMVNFVPNLIV 943
            ::..|:  |.::.:|.|.:..|.|...|.:||::||.:.||.:|:.:|.|||||.||.||||:.|
Mouse   936 DTELQD--NWSLELPPNVVEGSARATHSVLGDILGSAMQNLQNLLQMPYGCGEQNMVLFVPNIYV 998

  Fly   944 LRYLGRLRQLTPEVELRATNNLAIGYQRILYYRHENGAFSAFGL---DIKRSSTWLTAYVARSLR 1005
            |.||...:|||..::.:|.|.|..||||.|.|:|.:|::|.||.   .....:|||||:|.::..
Mouse   999 LNYLNETQQLTEAIKSKAINYLISGYQRQLNYQHSDGSYSTFGNHGGGNTPGNTWLTAFVLKAFA 1063

  Fly  1006 QAAPFTQVDSNVLQKALTYLGSVQSANGGFEERG----DVFERFGDDGISLTAFVTLALMENVDL 1066
            ||.....::...:..|..:|...|..||.|::.|    :..:...||.::|:|::|:||:|..
Mouse  1064 QAQSHIFIEKTHITNAFNWLSMKQKENGCFQQSGYLLNNAMKGGVDDEVTLSAYITIALLEMP-- 1126

  Fly  1067 YPEYRNNINKAL-----DFITRGLDGSSNLHAMAIGTYVLSRANHNAKAAFLQRLDSMATNKDGL 1126
            .|...:.:..||     .:.:......|:::..|:..|..:.|.:.||.:.|  |:|:  |||.:
Mouse  1127 LPVTHSAVRNALFCLETAWASISQSQESHVYTKALLAYAFALAGNKAKRSEL--LESL--NKDAV 1187

  Fly  1127 K-----WWNKTAPAGEQQSPWYNATR--SVNIEISAYAALAL-----------LENNLVGDALPV 1173
            |     .|.:.....:.::..:...|  |..:|::||..||.           |.::.:..|..:
Mouse  1188 KEEDSLHWQRPGDVQKVKALSFYQPRAPSAEVEMTAYVLLAYLTSESSRPTRDLSSSDLSTASKI 1252

  Fly  1174 LNWLMDQRNPKGGFVASQDTVVGLQALLMF-AERFSSQGNNLQIGFHYGEGAETIINVNAENSLA 1237
            :.|:..|:|..|||.::|||||.||||..: |..|:.....:.:............:||:.|.|.
Mouse  1253 VKWISKQQNSHGGFSSTQDTVVALQALSKYGAATFTRSQKEVLVTIESSGTFSKTFHVNSGNRLL 1317

  Fly  1238 LQTVELPNNLKNLSVSATGRGMALAQVSYTYN-TNVTSAWPRFVLDPT---VNRNSHADYLHLSA 1298
            ||.|.||:...|.....:|.|....|.|..|| ..|......|.|...   :|.:...|:.....
Mouse  1318 LQEVRLPDLPGNYVTKGSGSGCVYLQTSLKYNILPVADGKAPFALQVNTLPLNFDKAGDHRTFQI 1382

  Fly  1299 CASFVSVVGENEQRSNMAVMEVHLPSGFVVDRDTLPTLESSERIKKVETQNRNTKVVIYFDYLDR 1363
            ..: ||..||... |||.:::|.:.|||:..:.::..|:....|::.|....:  |:||.:.|..
Mouse  1383 RIN-VSYTGERPS-SNMVIVDVKMVSGFIPMKPSVKKLQDQPNIQRTEVNTNH--VLIYIEKLTN 1443

  Fly  1364 REVCPTLHAYKTVKVTKHRPVAVVMYDYYDSARRARQFYRAPKSN 1408
            :.:..:....:.:.|...:|..:.:||||::.....:.|.||.|:
Mouse  1444 QTLGFSFAVEQDIPVKNLKPAPIKVYDYYETDEFTVEEYSAPFSD 1488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep3	NP_523507.2	YfaS	<128..1399	CDD:441940	354/1476 (24%)
		A2M_2	918..1203	CDD:239227	100/314 (32%)
Pzp	NP_031402.3	YfaS	<127..1401	CDD:441940	340/1400 (24%)
		Bait region	686..744		9/77 (12%)
		A2M	750..840	CDD:459711	29/92 (32%)
		A2M_2	970..1282	CDD:239227	100/317 (32%)
		A2M_recep	1393..1483	CDD:462226	20/92 (22%)