DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tep3 and LOC101730404

DIOPT Version :9

Sequence 1:	NP_523507.2	Gene:	Tep3 / 34045	FlyBaseID:	FBgn0041181	Length:	1469	Species:	Drosophila melanogaster
Sequence 2:	XP_031761602.1	Gene:	LOC101730404 / 101730404	-ID:	-	Length:	737	Species:	Xenopus tropicalis

Alignment Length:	793	Identity:	190/793 - (23%)
Similarity:	328/793 - (41%)	Gaps:	195/793 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   311 LLDALVEEKSTGSVQNYSTVLTLHLNHY----RVEAVKVPSYYIPGVPFEATARIARNDGGQLRD 371
            :|.:|.||| ||..:     |..|...:    .||.|.:.:||..|:||.          |.::.
Frog    32 VLASLTEEK-TGHKE-----LGFHFLQFIVLENVEFVNLDTYYQKGIPFT----------GMMKV 80

  Fly   372 FNPQITAYLTNVYGSSEMYNRTAYSLDASGEIKMKFTVPIGDRD---EFHSIIVDYQGVISEVGK 433
            ||.:          ...|.|...|.:....|:....|: :.|.:   .|.....|:..::|..|:
Frog    81 FNLK----------KDPMRNEKVYLVVNVDEVDTNITL-VTDENGMARFSLDTSDWNDMVSLTGR 134

  Fly   434 IPSKH-------------LHSKNYITAKVLNDRPTVNQEISVVVRSFAPIKY------------- 472
            |..:.             .:|::....||    .||.:::....:....::|
Frog   135 ISFEEGAGYFRALQWLFPFYSESNSFLKV----QTVAEDLLCSTKQSVSVEYTIDKNELDPESDH 195

  Fly   473 --FMYQVVGRGDIILSR--NVDV--------APGTFHTIKFLASFAMMPRANLLVYTVI-DGEFV 524
              |.|.::.:|.||.::  .|||        ..|:|: :.||.:..::|.|.||||.:. |||..
Frog   196 LSFFYILMSKGTIITAKEHKVDVKNLPSGPILQGSFN-VTFLVTMNLVPVATLLVYAIFPDGEVA 259

  Fly   525 YD----------EQVIQLE--ENLLNAVQVDAPIRAPPGQDIDIGISTKPYSYVGLMLVDQNAND 577
            .|          :..:|||  ||.::           ||.::::.:.....|...:..||:...
Frog   260 ADRVRYNVPICFDNKVQLEFRENNVH-----------PGGNVNLDVKADAGSLCSVRSVDKGLL- 312

  Fly   578 LRSGHDLTHKRLMDALRSYE---------------LSDVNTPMGSPGKESGVIT-----MSNTD- 621
            |...|. |:|...|.||.|.               |.||..|   |.:....:.     .|..|
Frog   313 LHQEHK-TNKMGSDILRFYGRGFPYTIEDFEPYPCLEDVPVP---PNRAKRSLKRAPWYQSEADV 373

  Fly   622 YFIEKEAE----SNPALDREVSTG-PEEDKLTTVRKTDIGPA-HKIE-VNTLPPGKGRYAFSYTP 679
            |.:.|.:.    :|..:.:.|:.. ||..:..:: |..:|.| .|:: ..|.|..|......:.|
Frog   374 YSLFKSSSLKVFTNTRIRKPVTCELPEYTRRFSI-KDGVGAADRKLDSPGTAPASKEHPVRKFFP 437

  Fly   680 KPFWHNPRVHVMRDPADTWLFLNISASSDGRNSIHRRIPSEMTSWVVSAFALDPVNGLGLSPPNG 744
                            :|||:..:|....|:.|::...|..:|.||..||.:.. :|.| ...:.
Frog   438 ----------------ETWLYDLVSVGPQGKKSLNLTAPHSITEWVTDAFCVGN-SGFG-EVHDI 484

  Fly   745 KLEAYKEFYISTELPYSIKRDELIAIPFVVHNNRDSDLNVEVTFYNSALDFDFPQLDPKATNQPK 809
            |::.::.::|...||||:.:.|...:..:|:|..:..:.|||     ||..      |....:|:
Frog   485 KMKTFQPYFIDLLLPYSVVQKEHFTLTALVYNYLNHCVLVEV-----ALTI------PPEFGEPR 538

  Fly   810 VELYRRRSLQVPGRSARSVSFIVTPKRVG--PLLVKAMAASSQAG--------------DTVEQN 858
            .::  .:|..:.|:...|.::.:|..::|  |..|.:.|...:..              |.|::.
Frog   539 TDI--EKSACICGQETASFTWNITASKLGTIPFKVTSRALHVEGDCSDVVLDPETKFKHDAVQKT 601

  Fly   859 LLVEHPGAMERINRGFLFELNSNA------QNRRNVTIAVPRNAIPESTRIEVSAVGDLIGSLVG 917
            :||: |..:|      :|:.:::.      ..|..|::.:|.|.:..|....::.:||::|:.:.
Frog   602 ILVK-PSGVE------VFKTHTSLLCPTGDSVRDEVSLVLPDNVVEGSGHAHITVLGDVLGNTIS 659

  Fly   918 NLDSLILLPTGCGEQTMVNFVPNLIVLRYLGRLRQLTPEVELRATNNLAIGYQRILYYRHENGAF 982
            ||..|:.||.|||||.|..|.||:.||.||...:.||||::.:..|.|..||||.|.::|:|||:
Frog   660 NLGDLLQLPYGCGEQNMAQFAPNVYVLEYLQSAKALTPEIKDKVLNYLTTGYQRQLMFKHDNGAY 724

  Fly   983 SAFGLDIKRSSTW 995
            ||||...:..:||
Frog   725 SAFGKKDEEGNTW 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep3	NP_523507.2	A2M_N	124..215	CDD:280081
		A2M_N_2	448..573	CDD:285005	36/162 (22%)
		A2M	697..787	CDD:278630	25/89 (28%)
		A2M_2	918..1203	CDD:239227	39/78 (50%)
		A2M_comp	967..1200	CDD:284982	15/29 (52%)
		A2M_recep	1313..1402	CDD:284981
LOC101730404	XP_031761602.1	MG4	61..>134	CDD:407661	18/93 (19%)
		A2M_N_2	161..313	CDD:400170	37/168 (22%)
		A2M	439..528	CDD:395153	26/95 (27%)
		SVA	<490..571	CDD:398804	21/93 (23%)
		ISOPREN_C2_like	657..>737	CDD:415487	37/79 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010