Protein Alignment Tep3 and c3a.4

DIOPT Version :9

• Sequence 1: NP_523507.2
• Gene: Tep3 / 34045
• FlyBaseID: FBgn0041181
• Length: 1469
• Species: Drosophila melanogaster
• Sequence 2: XP_002660623.3
• Gene: c3a.4 / 100331428
• ZFINID: ZDB-GENE-140822-3
• Length: 1642
• Species: Danio rerio
• Alignment Length: 1647
• Identity: 405/1647 - (24%)
• Similarity: 667/1647 - (40%)
• Gaps: 372/1647 - (22%)

  Fly    20 CLLCQTS----------AQGLYSIIAPNTLRPNSQFHVAVSLHNAPESATFKVGILGSSYTDFKT 74
            ||:|..:          .|.||.:.|||.|:..|...|.|...:. ..|:..|.|   |...||.
Zfish     4 CLVCVAAVILSLPLLSFCQPLYILSAPNKLKLGSAERVFVEAQDY-AGASLNVRI---SVRRFKD 64

  Fly    75 VELRPFST-----------QLLHFEIPA------LRTDRYRLTAEGLGGVQFTN---ETQLHFES 119
            .:....||           :|:..|:|:      ....:|.:..     .||.|   :.|:....
Zfish    65 DQREVASTSVTLTAGKNFQELVEIEVPSNSFTFDKSAQQYAVLQ-----AQFPNKLLQKQILVTF 124

  Fly   120 KQHTVLVQTDKSIYKPGDLVHYRVLILDANL-KPARGYGRVHVDIKDSGDNIIRSYKDIRLTNSI 183
            :...:::||||:||.|...|||||..|...: :|.:...||.:   .:.|.|....|.:.....:
Zfish   125 QSGHIVLQTDKTIYTPDSTVHYRVFSLSPGMTRPFQSGVRVEI---LTPDGISLESKSVFPDGGV 186

  Fly   184 YSNELRLSDSPRFGTWSIVV---DVSDQEHTQTFEILDHILPKFVVDIDTPKHAIY-KDGKIAAT 244
            .|....::|....|.|.:|.   :...:..|..||:.:::||.|.|.:...|...| .|..:...
Zfish   187 VSGTFGITDPASPGLWKLVAWHKNSPQKNFTSEFEVKEYVLPSFEVSLSPHKAFFYVNDDSLLVD 251

  Fly   245 VRAHYAFGQPIVG------------EATLSIYPTFFGSLQPFVNDLITRKVVPIDGNAYFEFDIE 297
            :.|.|.||:.:.|            :..:|| |   ||||         :|...||:...:.
Zfish   252 IHAKYLFGETVNGHGFVVFGVVTEDKGKISI-P---GSLQ---------RVQIWDGSGTAQL--- 300

  Fly   298 NELHLKQDYE--RQ------YLLDALVEEKSTGSVQNYSTVLTLHLNHYRVEAVKVPSYYIPGVP 354
            .:..:.|.:.  ||      |:..:|:.|..:..|:.:...:.:..:.|.:...:.|.::.||:|
Zfish   301 TKRQILQTFPEIRQLVGKSLYISVSLLTESGSEMVEAHKKGIHIVTSPYTIYFKRTPQFFKPGMP 365

  Fly   355 FEATARIARNDGGQLR----DFNP----------QITAYLTNVYGSSEMYNRTAYSLD----ASG 401
            |:.:..:...|....:    :.||          .|.....|..|.|.....||.:.|    :..
Zfish   366 FDVSVYVTNPDETPAKNVKVEVNPGGVSGQTKANGIAKVTINTPGGSSTLEITARTSDPQLTSRQ 430

  Fly   402 EIKMKFT----VPIGDRDEFHSIIVDYQGVISEVGKIPSKHLHSKNYITAKV------LNDRPTV 456
            :.:.|.|    ||.|.                           |:||:...:      :.|...|
Zfish   431 QAEKKMTAHAYVPKGG---------------------------SRNYLHIGIDAAELRIGDSMKV 468

  Fly   457 NQEI--SVVVRSFAPIKYFMYQVVGRGDIILSRNVDVAPGTFHTIKFLASFAMMPRANLLV-YTV 518
            |..:  |..||.    :.|.|.::.||.|:.:........|..::....:..|:|....:. |.|
Zfish   469 NLNLGQSPGVRD----QDFTYMILSRGQIVQANRFKRRGQTLVSLSLPVTKDMVPSFRFVAYYHV 529

  Fly   519 IDGEFVYDEQVIQLEENLLNAVQVDA--PIRA-PPGQDIDIGISTKPYSYVGLMLVDQNANDLRS 580
            ...|.|.|...:.:::..:.:::|:.  |:.. .||::.::.|:..|.:.|||:.||:....|.:
Zfish   530 GSSEVVSDSVWVDVKDTCMGSLKVEVHDPVEVYEPGEEFELRITGDPGAKVGLVAVDKGVYVLNN 594

  Fly   581 GHDLTHKRLMDALRSYELSDVNTPMGSPGKESGVITMSNTDYFIEKEAESNPALDREVSTGPE-- 643
            .|.:|..::.|.:.|:   |.....|| ||.|..:.......|     ||:.|....|.|..|
Zfish   595 KHRITQSKIWDVVESH---DTGCTAGS-GKNSMQVFSDAGLLF-----ESSSAGGTSVRTNSECP 650

  Fly   644 --------EDKLTTVRKTDI----GPAHKIEVNTLP-----------------PGKG-RYAFSYT 678
                    .:.|..:.||.:    |.|.:..|:.|.                 .||. |.||...
Zfish   651 SSSRRRKRRETLVNLHKTLLDKYSGLARECCVDGLKALDVLDFSCEYRSSFILDGKECRDAFLDC 715

  Fly   679 PKPFWHNPRVHVMRDPADTWLFLNISASSDGRNS---IHRRIPSE-------------------- 720
                 .|.......:||:..:||..|...:..||   :.|.:..|
Zfish   716 -----CNRLTSHREEPAEEEIFLGRSEDEEFVNSDDIVSRTLFPESWLWEEVMLPKCLGNRQCQT 775

  Fly   721 -------------MTSWVVSAFALDPVNGLGLSPPNGKLEAYKEFYISTELPYSIKRDELIAIPF 772
                         :|:|.::|.:|...:|:.::..:..:.| |.|:|..::|||..|:|.|.|..
Zfish   776 TTLPKDGLWLKDSITTWEITAISLSNTHGICVADVHEMIVA-KNFFIDLKIPYSAVRNEQIEIKA 839

  Fly   773 VVHNNRDSDLNVEVTFYNSALDFDFPQLDPKATNQPKVELYRRRSLQVPGRSARSVSFIVTPKRV 837
            ::||.....:.|.|.. ....|...|     |:|:.:..:    ::.|..:|:.||.|::.|..:
Zfish   840 IIHNLYSKAVKVRVEL-KETKDICSP-----ASNKGRYAV----TVTVASKSSYSVPFVIVPLAL 894

  Fly   838 G--PLLVKAMAASSQAGDTVEQNLLVEHPGAMERINRGFLFELNSNAQNRRNVTIAVPRNAI--- 897
            |  .:.||| |||.:..|.|:::|||...|.:.:|:....|    |...:.:..:.|.|:.|
Zfish   895 GRHAIEVKA-AASGRGNDGVKKDLLVVSEGVLTKISENLQF----NPFKKGDEDVQVIRSHILKD 954

  Fly   898 -----PESTRIEVSAVGDLI---------GSLVGNLDSLILLPTGCGEQTMVNFVPNLIVLRYLG 948
                 |.||.::  |:||.|         |:.:|   |||:.|.|||||.|:.....:|...||.
Zfish   955 QAPNTPSSTYVQ--AIGDTITITIEKAISGAAMG---SLIIQPGGCGEQNMMGLTMPVIATHYLD 1014

  Fly   949 RLRQL-TPEVELR--ATNNLAIGYQRILYYRHENGAFSAFGLDIKR-SSTWLTAYVARSLRQAAP 1009
            :..|. |....||  ||..:..||.:.|.||..:|:|:|:   |.| ||||||||||:....|:.
Zfish  1015 KTNQWHTVRAGLRQTATEYIRKGYNQELAYRKSDGSFAAW---INRPSSTWLTAYVAKVFAMASD 1076

  Fly  1010 FTQVDSNVLQKALTYL-GSVQSANGGFEERGDVF--ERFG-----DDGISLTAFVTLALME---- 1062
            ...:|.||:..||.:| .:.|..||.|.|...|.  |..|     :...|:|||||:||.|
Zfish  1077 IIHIDQNVICSALRWLIMNRQLPNGVFRENAPVIHGEMTGNVQGSNSEASMTAFVTIALQEGRSR 1141

  Fly  1063 ------NVDLYPEYRNNINKALDFITRGLDGSSNLHAMAIGTYVLSRANHNAKAAFLQRLDSMAT 1121
                  ::|      ::|.||:.::...|.|..|.:|:|:.:|.|:.||...|...:.:
Zfish  1142 CNGQVSSLD------SSIYKAIAYLKSQLQGLINPYAVAMASYALANANSLNKQVLMSK------ 1194

  Fly  1122 NKDGLKWWNKTAPAGEQQSPW-YNATRSVNIEISAYAALALLENNLVGDALPVLNWLMDQRNPKG 1185
                         |...:|.| ...:.|..:|.|:||.|||::.:...:..|::|||.:||...|
Zfish  1195 -------------ASADKSHWPVPGSSSFTLEASSYALLALVKLHDYQNTAPIVNWLNNQRQYNG 1246

  Fly  1186 GFVASQDTVVGLQALLMFAERFSSQGNNLQIGFHYG---EGAE-TIINVNAENSLALQTVELPNN 1246
            |:..:|.|::..||:   ||......|..|:.....   ||.. |:...:..|....||.::|:|
Zfish  1247 GYGTTQATIMVFQAV---AEYRIHAKNIKQLDLELSIRVEGVRPTVFTFSKNNDHLSQTAKIPSN 1308

  Fly  1247 LKNLSVSATGRGMALAQV---SYTYNTNVTSAWPRFVLDPTVNRNSHADYLHLSACASFVSVVGE 1308
             |.:::||.|.|.|...|   .|......:|....|.|:.|..:::...|  ..|..|:...:..
Zfish  1309 -KGITISAKGFGEASVTVVTEYYAKPKESSSTCKNFELELTFEKDNEVRY--QGATESYKLTINT 1370

  Fly  1309 N----EQRSNMAVMEVHLPSGFVVDRDTLPTLES--SERIKKVETQNRNTK---VVIYFDYLDRR 1364
            .    ::.:.|::::|.|.:|||||.:.|..|.:  .:.|:|.|...:.::   ::||.|.:.
Zfish  1371 RYLSADRDATMSILDVSLLTGFVVDENDLKALSTGRDKLIQKFEMNKQLSERGSLIIYLDKIS-- 1433

  Fly  1365 EVCPTLHAYK-TVKVTKHR--------PVAVVMYDYYDSARRARQFYRAPK-----SNIC--DIC 1413
                  |..| .|....||        |..|.:|:||....|..:||...:     ..||  |:|
Zfish  1434 ------HTRKDRVAFRLHRIMNGGFLQPAGVTVYEYYSIENRCVKFYHPTRKEGGLQKICKNDVC 1492

  Fly  1414 EHA--NCGDLCEKAEK-RESKR 1432
            :.|  ||.  .:|.|| :|:.|
Zfish  1493 QCAEDNCS--LQKKEKIQEAHR 1512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep3	NP_523507.2	A2M_N	124..215	CDD:280081	25/94 (27%)
		A2M_N_2	448..573	CDD:285005	29/136 (21%)
		A2M	697..787	CDD:278630	26/125 (21%)
		A2M_2	918..1203	CDD:239227	100/307 (33%)
		A2M_comp	967..1200	CDD:284982	80/252 (32%)
		A2M_recep	1313..1402	CDD:284981	27/102 (26%)
c3a.4	XP_002660623.3	A2M_N	131..222	CDD:280081	26/93 (28%)
		A2M_N_2	453..591	CDD:285005	30/141 (21%)
		ANATO	668..734	CDD:237984	14/70 (20%)
		A2M	756..855	CDD:278630	20/99 (20%)
		complement_C3_C4_C5	981..1264	CDD:239226	103/316 (33%)
		A2M_comp	1036..1264	CDD:284982	82/258 (32%)
		A2M_recep	1379..1474	CDD:284981	27/102 (26%)
		NTR_like	1494..1641	CDD:295338	8/21 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584197
Domainoid	1	1.000	48	1.000	Domainoid score	I11904
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	7	6.800