Protein Alignment Tep3 and C4B_2

DIOPT Version :10

• Sequence 1: NP_523507.2
• Gene: Tep3 / 34045
• FlyBaseID: FBgn0041181
• Length: 1469
• Species: Drosophila melanogaster
• Sequence 2: NP_001229752.1
• Gene: C4B_2 / 100293534
• HGNCID: 42398
• Length: 1744
• Species: Homo sapiens
• Alignment Length: 1705
• Identity: 401/1705 - (23%)
• Similarity: 648/1705 - (38%)
• Gaps: 448/1705 - (26%)

  Fly    33 IIAPNTLRPNSQFHVAVSLHNAPESATFKVGIL----------GSSYTDFKTVELRPFSTQLLHF 87
            :.:|:.:.......|.|.|.:.|.....|..:.          .|...||.....|.|:  ||..
Human    25 LFSPSVVHLGVPLSVGVQLQDVPRGQVVKGSVFLRNPSRNNVPCSPKVDFTLSSERDFA--LLSL 87

  Fly    88 EIP-----------ALRTDRYRLTA------EGLGGVQFTNETQLHFESKQHTVLVQTDKSIYKP 135
            ::|           .||....:|.|      :.|..........|.|.|::..:.:|||:.||.|
Human    88 QVPLKDAKSCGLHQLLRGPEVQLVAHSPWLKDSLSRTTNIQGINLLFSSRRGHLFLQTDQPIYNP 152

  Fly   136 GDLVHYRVLILDANLKPARGYGRVHVDIKDSGDNIIRSYKDIRLTNSIYSNELRLSDSPRFGTWS 200
            |..|.|||..||..::|:.  ..:.|.:::|....:|. |::.:.:||:.::..:.|....|||.
Human   153 GQRVRYRVFALDQKMRPST--DTITVMVENSHGLRVRK-KEVYMPSSIFQDDFVIPDISEPGTWK 214

  Fly   201 IVVDVSD--QEHTQT-FEILDHILPKFVVDI--------DTPKHAIYKDGKIAATVRAHYAFGQP 254
            |....||  :.::.| ||:..::||.|.|.|        ..|.|.    .::...::|.|.:|:|
Human   215 ISARFSDGLESNSSTQFEVKKYVLPNFEVKITPGKPYILTVPGHL----DEMQLDIQARYIYGKP 275

  Fly   255 IVGEATLSIYPTFFGSLQPFVNDLITRKVVPIDGNAYFEFDIENELHL----------KQDYE-- 307
            :.|.|.:.     ||.|..             ||...|...:|::..|          |.:::
Human   276 VQGVAYVR-----FGLLDE-------------DGKKTFFRGLESQTKLVNGQSHISLSKAEFQDA 322

  Fly   308 --------------RQYLLDALV-------EEKSTGSVQNYSTVLTLHLNHYRVEAVKVPSYYIP 351
                          |.|:..|::       ||....|....|:..:|.|:       |...:.:|
Human   323 LEKLNMGITDLQGLRLYVAAAIIEYPGGEMEEAELTSWYFVSSPFSLDLS-------KTKRHLVP 380

  Fly   352 GVPFEATARIARNDGGQLRDFNPQITAYLTNVYGSSEMYNRTAYSLDASGEIKMKFTVPIGDRDE 416
            |.||...|.:....|........:::|.:::. ||.........:.|.||::.:...:|
Human   381 GAPFLLQALVREMSGSPASGIPVKVSATVSSP-GSVPEVQDIQQNTDGSGQVSIPIIIP------ 438

  Fly   417 FHSIIVDYQGVIS-----------EVGKIPSKHLHSKNYITAKVLNDRP-----TVNQEISVVVR 465
              ..|.:.|..:|           .|...||   ....:::.:..:.||     |:|..:. .|.
Human   439 --QTISELQLSVSAGSPHPAIARLTVAAPPS---GGPGFLSIERPDSRPPRVGDTLNLNLR-AVG 497

  Fly   466 SFAPIKYFMYQVVGRGDII------------LSRNVD--VAPGTFHTIKFLASFAMMPRANLLVY 516
            |.|...::.|.::.||.|:            :|..||  :|| :|:.:.|. .....|.||.|
Human   498 SGATFSHYYYMILSRGQIVFMNREPKRTLTSVSVFVDHHLAP-SFYFVAFY-YHGDHPVANSL-- 558

  Fly   517 TVIDGEFVYDEQVIQLEENLLNAVQVDAPIRAPPGQDIDIGISTKPYSYVGLMLVDQNANDLRSG 581
                   ..|.|....|..|  .:.||...:...|:.:.:.:.|...:.|.|..:|   ..|.:.
Human   559 -------RVDVQAGACEGKL--ELSVDGAKQYRNGESVKLHLETDSLALVALGALD---TALYAA 611

  Fly   582 HDLTHK-----RLMDALRSYELSDVNTPMGSPGKESGV-------ITMSNTDYFIEKEAESNPAL 634
            ...:||     ::.:|:.||:|.     .|..|.:|.:       :..|:.|.:         .|
Human   612 GSKSHKPLNMGKVFEAMNSYDLG-----CGPGGGDSALQVFQAAGLAFSDGDQW---------TL 662

  Fly   635 DREVSTGPEEDKLTTVRKTDIGPAHKIEVNTLPPGKGRYAFSYTPKPFWHN--PRVHVMR----- 692
            .|:..:.|:|.  ||.:|.::.....|....     |:|| |.|.|....:  .|:.:||
Human   663 SRKRLSCPKEK--TTRKKRNVNFQKAINEKL-----GQYA-SPTAKRCCQDGVTRLPMMRSCEQR 719

  Fly   693 -------DPADTWL-------FLNISASSDGRNSIHRR--------------------------- 716
                   |..:.:|       .|...:...|:..:.|.
Human   720 AARVQQPDCREPFLSCCQFAESLRKKSRDKGQAGLQRALEILQEEDLIDEDDIPVRSFFPENWLW 784

  Fly   717 --------------IPSEMTSWVVSAFALDPVNGLGLSPPNGKLEAYKEFYISTELPYSIKRDEL 767
                          :|..:|:|.:...:|....||.::.| .:|..::||::...||.|::|.|.
Human   785 RVETVDRFQILTLWLPDSLTTWEIHGLSLSKTKGLCVATP-VQLRVFREFHLHLRLPMSVRRFEQ 848

  Fly   768 IAIPFVVHNNRDSDLNVEVTFYNSALDFDFPQLDPKATNQPKVELY-------RRRSLQVPGRSA 825
            :.:..|::|..|.:|.|.|            .:.|       ||..       ..:.:.||..||
Human   849 LELRPVLYNYLDKNLTVSV------------HVSP-------VEGLCLAGGGGLAQQVLVPAGSA 894

  Fly   826 RSVSFIVTPKRVGPLLVKAMAASS---QAGDTVEQNLLVEHPGAMERINRGFLFELNSNAQNRRN 887
            |.|:|.|.|.....:.:|.:|..|   ..||.|.:.|.:|..||:.|  ...::||  |..:.|.
Human   895 RPVAFSVVPTAAAAVSLKVVARGSFEFPVGDAVSKVLQIEKEGAIHR--EELVYEL--NPLDHRG 955

  Fly   888 VTIAVPRNA----IPES-----TRIEVSAVGDLIGS----LVGNLDSLILLPTGCGEQTMVNFVP 939
            .|:.:|.|:    ||:.     .|:..|...|.:||    ..|.:.||:.||.|||||||:...|
Human   956 RTLEIPGNSDPNMIPDGDFNSYVRVTASDPLDTLGSEGALSPGGVASLLRLPRGCGEQTMIYLAP 1020

  Fly   940 NLIVLRYLGRLRQ---LTPEVELRATNNLAIGYQRILYYRHENGAFSAFGLDIKR-SSTWLTAYV 1000
            .|...|||.:..|   |.||.:..|.:.:..||.||..:|..:|:::|:   :.| |||||||:|
Human  1021 TLAASRYLDKTEQWSTLPPETKDHAVDLIQKGYMRIQQFRKADGSYAAW---LSRGSSTWLTAFV 1082

  Fly  1001 ARSLRQAAPFTQVDSNVLQKALTYLGSVQSANGGFEERGDVFERF-------GDDGISLTAFVTL 1058
            .:.|..|..........||:...:|.|.|.|:|.|::...|..|.       .|:.::||||||:
Human  1083 LKVLSLAQEQVGGSPEKLQETSNWLLSQQQADGSFQDLSPVIHRSMQGGLVGNDETVALTAFVTI 1147

  Fly  1059 ALMENVDLYPE---------YRNNINKALDFI----TRGLDGSSNLHAMAIGTY--VLSRANHNA 1108
            ||...:.::.:         ...:|:||..|:    :.||.|:   ||.||..|  .|::|..:.
Human  1148 ALHHGLAVFQDEGAEPLKQRVEASISKASSFLGEKASAGLLGA---HAAAITAYALTLTKAPADL 1209

  Fly  1109 KAAFLQRLDSMATNK-DGLKWWNKTAPAGEQQSP-----------------WYNATRSVNIEISA 1155
            :......|.:||... |.|.|.:.|.......||                 |        ||.:|
Human  1210 RGVAHNNLMAMAQETGDNLYWGSVTGSQSNAVSPTPAPRNPSDPMPQAPALW--------IETTA 1266

  Fly  1156 YAAL-ALLENNLVGDALPVLNWLMDQRNPKGGFVASQDTVVGLQALLMF-------AER-----F 1207
            ||.| .||.......|.....||..|.:.:|||.::||||:.|.||..:       .||     .
Human  1267 YALLHLLLHEGKAEMADQAAAWLTRQGSFQGGFRSTQDTVIALDALSAYWIASHTTEERGLNVTL 1331

  Fly  1208 SSQG-----------NNLQI-----GFHYGEGAETIINVNAENSLALQTVELPN--NLKN----- 1249
            ||.|           ||.||     ...:..|::..:.|...:...|:.:...|  ::||
Human  1332 SSTGRNGFKSHALQLNNRQIRGLEEELQFSLGSKINVKVGGNSKGTLKVLRTYNVLDMKNTTCQD 1396

  Fly  1250 LSVSATGRGMALAQVSYTYNTN--------------------VTSAWPRFVLDPTVNR------- 1287
            |.:..|.:|    .|.||...|                    :....|..:.:...||
Human  1397 LQIEVTVKG----HVEYTMEANEDYEDYEYDELPAKDDPDAPLQPVTPLQLFEGRRNRRRREAPK 1457

  Fly  1288 --NSHADYLHLSACASFVSVVGENEQRSNMAVMEVHLPSGFVVDRDTLPTLES-SER-IKKVETQ 1348
              ......:|.:.|......||    .|.||:.:|.|.|||...|..|..|.| |:| :...||:
Human  1458 VVEEQESRVHYTVCIWRNGKVG----LSGMAIADVTLLSGFHALRADLEKLTSLSDRYVSHFETE 1518

  Fly  1349 NRNTKVVIYFDYLDRREVCPTLHAYKTVKVTKHRPVAVVMYDYYDSARRARQFYRAPKSN--ICD 1411
            ..:  |::|||.:.....|....|.:.|.|...:|.:..:||||:..||...||.||..:  :..
Human  1519 GPH--VLLYFDSVPTSRECVGFEAVQEVPVGLVQPASATLYDYYNPERRCSVFYGAPSKSRLLAT 1581

  Fly  1412 ICEHANCGDLCEKAE 1426
            :|.    .::|:.||
Human  1582 LCS----AEVCQCAE 1592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep3	NP_523507.2	YfaS	<128..1399	CDD:441940	370/1552 (24%)
		A2M_2	918..1203	CDD:239227	104/329 (32%)
C4B_2	NP_001229752.1	YfaS	<138..1336	CDD:441940	315/1318 (24%)
		ANATO	686..750	CDD:237984	13/69 (19%)
		A2M	781..869	CDD:459711	21/100 (21%)
		TED_complement	982..1315	CDD:462227	109/346 (32%)
		A2M_recep	1481..1570	CDD:462226	31/90 (34%)
		NTR_complement_C4	1588..1742	CDD:239639	3/5 (60%)