DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tep3 and WASHC1

DIOPT Version :9

Sequence 1:	NP_523507.2	Gene:	Tep3 / 34045	FlyBaseID:	FBgn0041181	Length:	1469	Species:	Drosophila melanogaster
Sequence 2:	XP_011515961.1	Gene:	WASHC1 / 100287171	HGNCID:	24361	Length:	474	Species:	Homo sapiens

Alignment Length:	339	Identity:	65/339 - (19%)
Similarity:	102/339 - (30%)	Gaps:	105/339 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   392 RTAYSLDASGEIKMKFTVP--IGDRDEFHSIIVDYQGVISEVGKIPSKHLHSKNYITAKVLNDRP 454
            :|...|.|..|.|: |..|  |..|::....:.:....:.::|::|..|:.|       .|.|.|
Human   207 KTHVMLGAETEEKL-FDAPLSISKREQLEQQVPENYFYVPDLGQVPEIHVPS-------YLPDLP 263

  Fly   455 TVNQEISVVVRSFAPIKYFMYQV-VGRGDIILSRNVDVAPGTFHTIKFLASFAMMPRANLLVYTV 518
            .:..::             ||.. :|.|         :||....||..|.:|
Human   264 GIANDL-------------MYSADLGPG---------IAPSAPGTIPELPTF------------- 293

  Fly   519 IDGEFVYDEQVIQLEENLLNAVQVDAPIRAPPGQDIDIGISTKPYSYVGLMLVDQNANDLRSGHD 583
                  :.|....|:.:|.:.|....|...||....::..|..|........|.|.|....|...
Human   294 ------HTEVAEPLKVDLQDGVLTPPPPPPPPPPAPEVLASAPPLPPSTAAPVGQGARQDDSSSS 352

  Fly   584 LTHK----------------RLMDALRSYELSDVNTPMGSPGKESGVITMSNTDYFIEKEAESNP 632
            .:..                .|::::|.         .|..||..   ..|..:..:||:.:...
Human   353 ASPSVQGAPREVVDPSGGWATLLESIRQ---------AGGIGKAK---LRSMKERKLEKQQQKEQ 405

  Fly   633 ALDREVSTGPE-----EDKLTTVRKTDIGPAHKIEVNTLPPGKG--------RYAFSYTPKPFWH 684
            ...|..|.|..     .:||...||...|..         ||.|        |.:.|..|.|...
Human   406 EQVRATSQGGHLMSDLFNKLVMRRKGISGKG---------PGAGEGPGGAFVRVSDSIPPLPPPQ 461

  Fly   685 NPRVHVMRDPADTW 698
            .|:.   .:..|.|
Human   462 QPQA---EEDEDDW 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep3	NP_523507.2	A2M_N	124..215	CDD:280081
		A2M_N_2	448..573	CDD:285005	23/125 (18%)
		A2M	697..787	CDD:278630	1/2 (50%)
		A2M_2	918..1203	CDD:239227
		A2M_comp	967..1200	CDD:284982
		A2M_recep	1313..1402	CDD:284981
WASHC1	XP_011515961.1	WASH_WAHD	59..306	CDD:288773	28/147 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900