DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep3 and zgc:165518

DIOPT Version :9

Sequence 1:	NP_523507.2	Gene:	Tep3 / 34045	FlyBaseID:	FBgn0041181	Length:	1469	Species:	Drosophila melanogaster
Sequence 2:	NP_001093623.2	Gene:	zgc:165518 / 100101650	ZFINID:	ZDB-GENE-070720-15	Length:	1455	Species:	Danio rerio

Alignment Length:	1500	Identity:	393/1500 - (26%)
Similarity:	644/1500 - (42%)	Gaps:	212/1500 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 LYSIIAPNTLRPNSQFHVAVSLHNAPESATFKVGILGSSYTDFKTVELRPFSTQLLH----FEIP 90
            |:.:..|:.:...|...:.|||.....|.|..:.::....|:.:.|  |..|.:.||    |:.|
Zfish    48 LFMVAFPSLIESGSDAKLCVSLLKHTGSLTITISLVDDQKTETQLV--RQTSRRKLHQCFTFQAP 110

  Fly    91 ALRTDRYRLTAEGLGGVQF--TNETQLHFESKQHTVLVQTDKSIYKPGDLVHYRVLILDANLKPA 153
            .:..|..:.....:.|..|  |.|:::.|.|......:||||.:|.||..|:.||:.:.....|.
Zfish   111 LVNGDSVQTVRVVVQGPSFKMTEESKVMFRSYLPLTFIQTDKPLYNPGQKVNIRVVTMSDQFVPQ 175

  Fly   154 RGYGRVHVDIKDSGDNIIRSYKDIRLTNSIYSNELRLSDSPRFGTWSIVVDVSDQEHTQTFEILD 218
            .....: |.::|.....||.:.::...|.|......|:...:.||:::...:.|:..:|:|::..
Zfish   176 EQMYSL-VVLEDLHGIRIRQWANVSSINWILELSHVLNPEAQTGTYTLKAYIGDRILSQSFDVKQ 239

  Fly   219 HILPKFVVDIDTPKHAIYKDGKIAATVRAHYAFGQPIVGEATLSIYPTFFGSLQ-PFVNDLITRK 282
            ::||||.|.::.|:.....|..:.....|.|.:|||:.|:..:.:....|..:| |.|..:...|
Zfish   240 YVLPKFDVTVNAPQTYSVADVGLKVEACAKYTYGQPVPGQVVVEVCRQPFIYIQDPKVTSVCLSK 304

  Fly   283 ----------VVPIDGNAYFEFDIENELHLKQDYERQYLLDALVEEKSTGSVQNYSTVLTLHLNH 337
                      .:.:..:::|...:||.|      :..::::..|.|:.||.|.:.|..:::....
Zfish   305 STKTNNTGCASLTLTTSSFFGTSLENSL------QNSFVVNVNVTEEGTGVVISKSNTVSITFEV 363

  Fly   338 YRVEAVKVPSYYIPGVPFEATARIARNDGGQLRDFNPQ-ITAYLTNVYGSSEMYNRTAYSLDASG 401
            .:|..|.:|.:|..|........::        |||.. |.:....|..||...|:..::|..:.
Zfish   364 GKVTFVDLPKFYDYGSTLNGKISVS--------DFNGNPINSKAVYVLDSSTWPNKLLFNLTTNK 420

  Fly   402 EIKMKFTVPIGDRDEFHSIIVDYQGVISEVGKIPSKHL-HSKNYITA---------KVLNDRPTV 456
            .....|::   |...|..  .|...|.|..   |..:. ::..|.|.         ....|.|:.
Zfish   421 NGLAMFSL---DTTAFPK--ADLNLVASAT---PQSYFSYNSPYFTTDTRLVQLFQTAAPDNPSF 477

  Fly   457 NQEISVVVRSFAPIK-------YFMYQVVGR-GD-------IILSRNVDVAPGTFHTIKFLA--- 503
            : ::|:|... .|:|       ...|..||. ||       :::|:.|.:..| |.|::.||
Zfish   478 S-DLSIVTLE-QPLKCGNTYPVTVKYSFVGETGDYSADIIYMVMSKGVIILHG-FKTVQALAFDT 539

  Fly   504 ------SF------AMMPRANLLVY------TVIDGEFVYDEQVIQLEENLLNAVQVD-APIRAP 549
                  ||      .|.|...:|.:      ||:.|...:|     .|:...|.|.:. :|..|.
Zfish   540 ITSGTVSFDLSILANMAPMVQILAFCVLPSQTVVAGSASFD-----TEKCFSNQVSLQFSPASAV 599

  Fly   550 PGQDIDIGISTKPYSYVGLMLVDQNANDLRSGHDLTHKRLMDALRSYELSDVNTPMGSPGKES-- 612
            ||:...:.:|.:..|..||..:||:...|:||..||.:.:...|....|.|.     .||.|.
Zfish   600 PGEGSVLTVSAQAGSLCGLSAIDQSVLILQSGGRLTAEAVFGLLPVQSLYDY-----PPGVEDQQ 659

  Fly   613 ---------GVITMSNTDYFIE---KEAESNPALDREVST--------GPEEDKLTTVRKTDIGP 657
                     .|.|....:.|..   |.|.:.|..:.|..|        ......|..:.|....|
Zfish   660 DCLQVRPRRAVPTDQAYNTFKGVGIKMATNLPVREPECLTYRRLNFYRNFRRPMLFAMDKVLAAP 724

  Fly   658 AHKIEVNTLPPGKGRYAFSYTPKPFWHNPRVHVMRDPADTWLFLNISASSDGRNSIHRRIPSEMT 722
            |...|:...|.|.   ....|.:.|:           .:||::........|..|:...:|..:|
Zfish   725 AAVSEIAGSPSGS---PVDVTIRTFF-----------PETWIWQLTPVGDSGSTSVALTVPDTIT 775

  Fly   723 SWVVSAFALDPVNGLGLSPPNGKLEAYKEFYISTELPYSIKRDELIAIPFVVHNNRDSDLNVEVT 787
            :|...||.|.. ||.||:|| ..|.|::.|::...|||||.|.|:..:...|.|.....:.|:||
Zfish   776 TWKTEAFCLSS-NGFGLAPP-ALLTAFQPFFLELTLPYSIIRGEVFELKATVFNYLSQCIKVQVT 838

  Fly   788 FYNSALDFDFPQLDPKATNQPKVELYRRRSLQVPGRSARSVSFIVTPKRVGP--LLVKAMAASSQ 850
            ...|: :|....||..::           :|...||  ::..:.:|...:|.  :.:.|.|..||
Zfish   839 PTPSS-NFTLNSLDQSSS-----------TLVANGR--KTFKWALTASVIGTVNVTISAQANPSQ 889

  Fly   851 --AG------------DTVEQNLLVEHPGAMERINRGFLFELNSNAQNRRNVTIAVPRNAIPEST 901
              .|            |.|.::|||...|......|.:|. ....:....:|.|..|:|.|..|.
Zfish   890 ELCGNRVVTVPSRGRIDIVTRSLLVLAEGVKRTFTRSWLL-CPKGSMLSEDVRITFPKNVIQGSA 953

  Fly   902 RIEVSAVGDLIGSLVGNLDSLILLPTGCGEQTMVNFVPNLIVLRYLGRLRQLTPEVELRATNNLA 966
            |..||.:||::|..:.||.:|:.:|.|||||.|:...||:.:||||....||||.::..|...|.
Zfish   954 RCSVSVIGDIMGRALKNLANLLQMPYGCGEQNMIILGPNIYILRYLKVTAQLTPAIQDTAMTYLQ 1018

  Fly   967 IGYQRILYYRHENGAFSAFGLDIKRSSTWLTAYVARSLRQAAPFTQVDSNVLQKALTYLGSVQSA 1031
            .|||..|.|||.:|:||.||.|  .|:|||||:|.|:...|..||.:|.||||.|..:|.|.|.:
Zfish  1019 SGYQGQLNYRHSDGSFSTFGYD--ESNTWLTAFVMRTFGLARSFTYIDPNVLQSAKDWLISKQGS 1081

  Fly  1032 NGGFEERGDVFE---RFG-DDGISLTAFVTLALMENVDLYPEYRNNINKALDFITRGLDGSSNLH 1092
            ||.|.::|.::.   |.| .|.:::|.::..||:| :.: |.....|.|||.|:...:....|.:
Zfish  1082 NGCFVQQGTLYHNDMRGGVGDNVTMTGYIVAALLE-IGV-PVTDPVITKALSFLRPLVGNLGNTY 1144

  Fly  1093 AMAIGTYVLSRANH-NAKAAFLQRLDSMATNKDGLKWWNKTAPAGEQQSPWYNATRSVNIEISAY 1156
            ..|:..|..|.|.. :.:|..|..|.:.|.::.....|::|. :|:          ::.:|||||
Zfish  1145 VTALLAYTFSLAGETSTRAQLLNSLRNTAISEGTTLHWSQTT-SGD----------TLAVEISAY 1198

  Fly  1157 AALALLE-----NNLVGDALPVLNWLMDQRNPKGGFVASQDTVVGLQALLMFAERFSSQGNNLQI 1216
            ..||:|.     ...:|.|..::|||:.|:||.|||.::|||||.|||:.::|....|.|.:..:
Zfish  1199 VLLAVLNVQPVTTATLGYANRIVNWLVAQQNPYGGFTSTQDTVVALQAMALYASLVFSSGGSSTV 1263

  Fly  1217 GFHYGEGAETIIN--VNAENSLALQTVELPNNLKNLSVSATGRGMALAQVSYTYN--TNVTSAWP 1277
            .......|..:.|  |...|.|..|...|.|.....||.|:|......||:..||  |.|..|..
Zfish  1264 TVQSSVPAGDVYNFAVTPNNRLLYQESPLNNFPGTYSVVASGSTCVSVQVACFYNIPTPVVVAKT 1328

  Fly  1278 RFVLDPTVNRNSHADYLHLSACASFVSVVGENEQRSNMAVMEVHLPSGFVVDRDTLPTLES-SER 1341
            ..|: ..|..|..|..::|....: |...|. :..:||.::::.:.|||..|...|.:..: |..
Zfish  1329 LSVV-AKVTGNCKASPVNLMLTFT-VKYTGP-KPTTNMLLVDIKVLSGFTADTSLLGSPPNFSPL 1390

  Fly  1342 IKKVETQNRNTKVVIYFDYLDRR-EVCPTLHAYKTVKVTKHRPVAVVMYDYYDSARRARQFYRAP 1405
            :::|:|:  ..:|::|...:.:. .|..::...:||.|...:|..:.:||||..:......|
Zfish  1391 VQRVDTE--GDRVLVYLQEVPKGVPVTYSIQLTQTVAVKNLKPAVINVYDYYQRSESFETTY--- 1450

  Fly  1406 KSNIC 1410
             :::|
Zfish  1451 -TSVC 1454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep3	NP_523507.2	A2M_N	124..215	CDD:280081	22/90 (24%)
		A2M_N_2	448..573	CDD:285005	38/161 (24%)
		A2M	697..787	CDD:278630	29/89 (33%)
		A2M_2	918..1203	CDD:239227	111/294 (38%)
		A2M_comp	967..1200	CDD:284982	88/242 (36%)
		A2M_recep	1313..1402	CDD:284981	21/90 (23%)
zgc:165518	NP_001093623.2	A2M_N	146..237	CDD:280081	23/91 (25%)
		A2M_N_2	482..626	CDD:285005	37/150 (25%)
		A2M	750..838	CDD:278630	29/89 (33%)
		A2M_2	967..1250	CDD:239227	111/297 (37%)
		A2M_comp	1019..1251	CDD:284982	89/246 (36%)
		A2M_recep	1361..1450	CDD:284981	21/90 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584177
Domainoid	1	1.000	217	1.000	Domainoid score	I2610
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	517	1.000	Inparanoid score	I1243
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6406
orthoMCL	1	0.900	-	-		OOG6_100452
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.700