DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep3 and a2ml

DIOPT Version :9

Sequence 1:	NP_523507.2	Gene:	Tep3 / 34045	FlyBaseID:	FBgn0041181	Length:	1469	Species:	Drosophila melanogaster
Sequence 2:	XP_001345541.6	Gene:	a2ml / 100006972	ZFINID:	ZDB-GENE-090212-1	Length:	1449	Species:	Danio rerio

Alignment Length:	1519	Identity:	370/1519 - (24%)
Similarity:	656/1519 - (43%)	Gaps:	229/1519 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 SAQGLYSIIAPNTLRPNSQFHVAVSLHNAPESATFKVGILGSSYTDFKTVELRPFSTQLLH---- 86
            :|:..:.:..|..:...|:..:..||....||....:.::..:.:   |:.|:..:.|..|
Zfish    33 AAEPSFMVTFPAVIESGSEAKLCASLLKPNESLVMNIYLVHGNQS---TLLLQENAEQEFHRCFN 94

  Fly    87 FEIPALRTDRYRLTAEGLGGVQF--TNETQLHFESKQHTVLVQTDKSIYKPGDLVHYRVLILDAN 149
            |:.|....:..:.....|.|..|  |.|.::.|:|......:||||.||.||.:|::||:.:|.|
Zfish    95 FKAPLAEAESVQKIKVELQGESFKMTEERKVMFKSYDPLTFIQTDKPIYMPGQIVNFRVVTMDTN 159

  Fly   150 LKPARGYGRVHVDIKDSGDNIIRSYKDIRLTNSIYSNELRLSDSPRFGTWSIVVDVSDQEHTQTF 214
            ..|......:.| ::||.||.|..:.::..|..|......|:...|.|.:.:...:.::.....|
Zfish   160 FAPVDQQYSIIV-LEDSQDNRIGQWTNVSSTRWILQRSYELNPECREGAYKLKAFIGERMILHDF 223

  Fly   215 EILDHILPKFVVDIDTPKHAIYKDGKIAATVRAHYAFGQPIVGEATLSI----------YPTFFG 269
            ::..::||||.|.:..||.....:.::...|.|.|.:|||:.|::.:.:          :|...|
Zfish   224 QVKKYVLPKFEVTLKKPKTVSVVEEELLIEVCAKYTYGQPVPGKSWVKVCRDPLPYIFFFPLCLG 288

  Fly   270 -SLQPFVNDLITRKVVPIDGNAYFEFDIENELH--LKQDYERQYLLDALVEEKSTGSVQNYSTVL 331
             :|:      ||:     .|.|...|.:...|:  ||.:.:....::|:|.|:.|...:..|.
Zfish   289 ETLE------ITK-----TGCAIHNFGLSMILNSTLKNNLKDSLHVEAVVTEEGTEITRTKSE-- 340

  Fly   332 TLHLNHY--RVEAVKVPSYYIPGVPFEATARIARNDGGQLRDFN----PQITAYLT--NVYGSSE 388
            ::||.:.  :...:.:|..|..|...:...:        |.||.    |....||.  ..:.|..
Zfish   341 SVHLTYEIGKATLIDLPKTYEHGSVIKGKIK--------LFDFKDAPIPNKEVYLLEGENWSSKL 397

  Fly   389 MYNRT-------AYSLDASGEIKMK---------------FTVPIGDRD----EFHSIIVDYQGV 427
            :.|.|       ::||:.|...|..               :..|....|    :...|...|...
Zfish   398 LLNLTTDSDGLASFSLNTSSLSKKDISLIASVYPDTRYYGYKTPYFSTDKKTVQLFQIATAYSPT 462

  Fly   428 ISEVGKIPSKHLHSKNYITAKVLNDRPTVNQEISVVVRSFAPIKYF-------------MYQVVG 479
            :||:                 ::.|   :.|.|.......|.:||:             :|.|:.
Zfish   463 LSEL-----------------IIED---IEQPIKCGTEITATVKYYFVGETVEDFSTDIVYMVLS 507

  Fly   480 RGDI---------ILSRNVDVAPGTFHTIKFLASFAMMPRANLLVYTVIDGE-FVYDEQVIQLEE 534
            ||.|         :.|.:..||.||. :.|......:.|...:|.|.|:..| .:...:.:..|:
Zfish   508 RGVIVHHGFEKVEVKSSSNGVASGTM-SFKLSVGADLTPVVQILAYCVLPSENVIAANKTLDTEK 571

  Fly   535 NLLNAVQVD-APIRAPPGQDIDIGISTKPYSYVGLMLVDQNANDLRSGHDLTHKRLMDALRSYEL 598
            ...|.|.:. :|.:|.||:...:.:|.:|.|..||..|||:...|.||..|...::.:.|..:.:
Zfish   572 CFGNKVSLQFSPAKAVPGEKNTLQLSAQPGSLCGLSAVDQSVLILESGKRLEADKIFNLLPVHSV 636

  Fly   599 SDVNTPMGSPGKESGVITMSNTDYFIEKEAESNPALDREVSTGPEEDKLTTVRKTDI----GPA- 658
            ||.  |......::.:..........:...|:..::..:::|.      ..||..:.    |.|
Zfish   637 SDY--PYSVEDGQACLYVRPRRSLLTDNTYETLKSVGLKMATN------LAVRVPECLLYKGLAY 693

  Fly   659 HKIEV----NTLPPGKGRYAFSYTPKPFWHNPRVHVMRDPADTWLFLNISASSDGRNSIHRRIPS 719
            ||..|    |...||......:.......::|.|.:.....:||::........|...:..::|.
Zfish   694 HKNFVMYRQNAPAPGMFAQGMAGVDGLVGNSPSVTIRTVFPETWIWELAEVGDSGSAEVPVKVPD 758

  Fly   720 EMTSWVVSAFALDPVNGLGLSPPNGKLEAYKEFYISTELPYSIKRDELIAIPFVVHNNRDSDLNV 784
            .:|:|...||.|.. .||||:|| .:|..::.|::...|||||.|.|:..:...|.|.....:.|
Zfish   759 TITTWETEAFCLSS-TGLGLAPP-AQLTVFQPFFLELSLPYSIIRGEIFELKATVFNYLSKCIMV 821

  Fly   785 EVTFYNSALDFDFPQLDPKATNQPKVELYRRRSLQVPGRSARSVSFIVTPKRVGPLLVKAMAASS 849
            :|:...|: |:..     ||::..:..    ..|...||  ::..:|:||..:|.:.| .::|.:
Zfish   822 KVSPAPSS-DYTL-----KASSDDQYS----SCLCANGR--KTFKWILTPSVLGVVNV-TVSAEA 873

  Fly   850 QAGDTVEQNLLVEHP--GAMERINRGFLFELNSNAQNRRN--------------VTIAVPRNAIP 898
            :|..||..|.:|..|  |.::.:.|..|.:.....:...|              |.:.:|::.|.
Zfish   874 EASQTVCDNEIVSVPERGRIDIVTRSLLVQAEGIEKTETNSWLLCPKGDSLSEKVDLTLPKDVIE 938

  Fly   899 ESTRIEVSAVGDLIGSLVGNLDSLILLPTGCGEQTMVNFVPNLIVLRYLGRLRQLTPEVELRATN 963
            .|.:..||.:||::|..:.||..|:.:|.|||||.|....||:.:|:||...:|||..:..:|::
Zfish   939 GSAKSSVSVIGDILGRALQNLHGLLRMPYGCGEQNMAVLSPNIYILQYLENTKQLTSAIREKASS 1003

  Fly   964 NLAIGYQRILYYRHENGAFSAFGLDIKRSSTWLTAYVARSLRQAAPFTQVDSNVLQKALTYLGSV 1028
            .|..||||.|.|:|.:||:|.||..  ..:|||||:|.||..:|..:|.:|..::|.|..:|.|.
Zfish  1004 FLKSGYQRQLNYKHFDGAYSTFGYG--DGNTWLTAFVLRSFGKAQKYTFIDPQIIQSAKDWLISR 1066

  Fly  1029 QSANGGFEERGDVFE---RFG-DDGISLTAFVTLALMENVDLYPEYRNNINKALDFITRGLDGSS 1089
            :.::|.|.::|.:|.   :.| :|.:::||::|.:|:|...  |.....|.|.|..:...::...
Zfish  1067 RDSDGCFIQQGRLFNNRMKGGVNDNVTMTAYITASLLELET--PVTDPVITKGLSCLRSVIEEVK 1129

  Fly  1090 NLHAMAIGTYVLSRA-NHNAKAAFLQRLDSMATNKDGLKWWNKTAPAGEQQSPWYNATRSVNIEI 1153
            |.:..|:..|..|.| :.|.:.....:|:.:|.:...|..|:::|.|.:        :.|:::||
Zfish  1130 NTYTTALLAYTFSLARDTNTRQQLFNKLEDLAISDGPLVHWSQSASADD--------SASLDVEI 1186

  Fly  1154 SAYAALALLENNL-----VGDALPVLNWLMDQRNPKGGFVASQDTVVGLQALLMFAER-FSSQGN 1212
            |:|..||:|..:.     :|.|..:::||:.|:|..|||.::|||||.||||.::|.: |||.|:
Zfish  1187 SSYVLLAVLTADSLTTADLGFANRIVSWLVKQQNAYGGFSSTQDTVVALQALSLYATKVFSSDGS 1251

  Fly  1213 NLQIGFHYGEGAETIINVNAENSLALQTVELPNNLKNLSVSATGRGMALAQVSYTYNTNVTSAWP 1277
            :.......|:...  .:||.:|.|..|..:|.|.....|:...|......|::..||....:...
Zfish  1252 STVTVQSAGDSHH--FDVNQDNKLLYQEKQLANVPGKYSIEVKGSACVSVQIAQFYNIPTPTEAK 1314

  Fly  1278 RFVLDPTVNRNSHADYLHLSACASFVSVVGEN------------EQRSNMAVMEVHLPSGFVVDR 1330
            ...:|..:..:..|              :|:|            |:::|||::::.|.|||..|.
Zfish  1315 TLSIDAKIEGDCEA--------------LGQNFIFDFTVKYDGPEEKTNMAIVDIKLLSGFTADT 1365

  Fly  1331 DTLPTLESSERIKKVE-TQNRNTKVVIYFDYLDRREVCPTLHAYKTVKVTKH-RPVAVVMYDYYD 1393
            ..|.| .|...:..|| ..:::..|::|...:.:..........|.|...|: :|..|.:||||.
Zfish  1366 SALGT-SSGTYVSLVERVDSKDDHVIVYLKEIPKNVAMNYQIQMKQVLPVKNLKPAVVKVYDYYQ 1429

  Fly  1394 SARRARQFYRAPKSNICDICEHAN 1417
            ::.::...|    |..|:..::.|
Zfish  1430 TSDQSEIEY----SFHCEALKNIN 1449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep3	NP_523507.2	A2M_N	124..215	CDD:280081	25/90 (28%)
		A2M_N_2	448..573	CDD:285005	35/148 (24%)
		A2M	697..787	CDD:278630	27/89 (30%)
		A2M_2	918..1203	CDD:239227	100/294 (34%)
		A2M_comp	967..1200	CDD:284982	78/242 (32%)
		A2M_recep	1313..1402	CDD:284981	24/90 (27%)
a2ml	XP_001345541.6	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584165
Domainoid	1	1.000	217	1.000	Domainoid score	I2610
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	517	1.000	Inparanoid score	I1243
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6406
orthoMCL	1	0.900	-	-		OOG6_100452
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.700