DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment POTEA and ACT1

DIOPT Version :9

Sequence 1:	XP_024302914.1	Gene:	POTEA / 340441	HGNCID:	33893	Length:	559	Species:	Homo sapiens
Sequence 2:	NP_116614.1	Gene:	ACT1 / 850504	SGDID:	S000001855	Length:	375	Species:	Saccharomyces cerevisiae

Alignment Length:	318	Identity:	60/318 - (18%)
Similarity:	114/318 - (35%)	Gaps:	83/318 - (26%)

- Green bases have known domain annotations that are detailed below.

Human   111 NSEVVSLLLDR---QCQLHVFDSKKRTALIKAV----------------------QCQEDECALM 150
            :|||.:|::|.   .|:..........|:..::                      :.|.....|.
Yeast     2 DSEVAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGIMVGMGQKDSYVGDEAQSKRGILT 66

Human   151 L---LQHGTDPNLPDMYGNTALHYAVYNEDKLMAK--TLLLYGADIESK-NKGGLTPLLLAVHGQ 209
            |   ::||...|..||  ....|:..|||.::..:  .:||..|.:..| |:..:|.::.    :
Yeast    67 LRYPIEHGIVTNWDDM--EKIWHHTFYNELRVAPEEHPVLLTEAPMNPKSNREKMTQIMF----E 125

Human   210 KQRMVKFLIKKKANLNALDRFGRTALILAVRCGSASIVSL---------LLQQNIDVFSQDV--- 262
            ...:..|.:..:|.|:.......|.::|....|...:|.:         :|:  ||:..:|:
Yeast   126 TFNVPAFYVSIQAVLSLYSSGRTTGIVLDSGDGVTHVVPIYAGFSLPHAILR--IDLAGRDLTDY 188

Human   263 -----------FGQTAEDYAVSSHHSIICQLLSDYKENQMPNNSSGNSNPEQDLKLTSEE----E 312
                       |..|||...|......:|.:..|:::..  ..::.:|:.|:..:|...:    .
Yeast   189 LMKILSERGYSFSTTAEREIVRDIKEKLCYVALDFEQEM--QTAAQSSSIEKSYELPDGQVITIG 251

Human   313 PQRLKGSENSQHEKV----------TQEPDINKDCDREVEEEMQKHGSNNVGLSENLT 360
            .:|.:..|...|..|          |....|.| ||.:|.:|:.    .|:.:|...|
Yeast   252 NERFRAPEALFHPSVLGLESAGIDQTTYNSIMK-CDVDVRKELY----GNIVMSGGTT 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
POTEA	XP_024302914.1	ANK	93..218	CDD:238125	26/137 (19%)
		ANK repeat	100..129	CDD:293786	6/20 (30%)
		ANK repeat	133..162	CDD:293786	7/53 (13%)
		ANK	159..283	CDD:238125	30/149 (20%)
		ANK repeat	164..195	CDD:293786	8/33 (24%)
		ANK repeat	197..228	CDD:293786	4/30 (13%)
		ANK repeat	230..261	CDD:293786	7/39 (18%)
		SMC_N	<302..538	CDD:330553	16/73 (22%)
		CCDC144C	452..>559	CDD:317340
ACT1	NP_116614.1	NBD_sugar-kinase_HSP70_actin	1..375	CDD:418402	60/318 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910