DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment POTEA and Act88F

DIOPT Version :9

Sequence 1:	XP_024302914.1	Gene:	POTEA / 340441	HGNCID:	33893	Length:	559	Species:	Homo sapiens
Sequence 2:	NP_524367.1	Gene:	Act88F / 41885	FlyBaseID:	FBgn0000047	Length:	376	Species:	Drosophila melanogaster

Alignment Length:	232	Identity:	45/232 - (19%)
Similarity:	84/232 - (36%)	Gaps:	57/232 - (24%)

- Green bases have known domain annotations that are detailed below.

Human   152 LQHGTDPNLPDMYGNTALHYAVYNEDKLMAK--TLLLYGADIESK-NKGGLTPLLLAVHGQKQRM 213
            ::||...|..||  ....|:..|||.::..:  .:||..|.:..| |:..:|.::..........
  Fly    72 IEHGIITNWDDM--EKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNSPAMY 134

Human   214 VKFLIKKKANLNALDRFGRTALILAVRCGSASIVSL---------LLQQNIDVFSQDV------- 262
            |  .|:...:|.|..|  .|.::|....|.:..|.:         :|:  :|:..:|:
  Fly   135 V--AIQAVLSLYASGR--TTGIVLDSGDGVSHTVPIYEGFALPHAILR--LDLAGRDLTDYLMKI 193

Human   263 -------FGQTAEDYAVSSHHSIICQLLSDYKENQMPNNSSGNSNPEQDLKLTSEE--------- 311
                   |..|||...|......:|.:..|:::...  .::.:::.|:..:|...:
  Fly   194 LTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMA--TAAASTSLEKSYELPDGQVITIGNERF 256

Human   312 -------EPQRLKGSENSQHEKVTQ-----EPDINKD 336
                   :|..|.......||.|..     :.||.||
  Fly   257 RCPEALFQPSFLGMESCGIHETVYNSIMKCDVDIRKD 293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
POTEA	XP_024302914.1	ANK	93..218	CDD:238125	16/68 (24%)
		ANK repeat	100..129	CDD:293786
		ANK repeat	133..162	CDD:293786	3/9 (33%)
		ANK	159..283	CDD:238125	31/149 (21%)
		ANK repeat	164..195	CDD:293786	8/33 (24%)
		ANK repeat	197..228	CDD:293786	5/30 (17%)
		ANK repeat	230..261	CDD:293786	6/39 (15%)
		SMC_N	<302..538	CDD:330553	11/56 (20%)
		CCDC144C	452..>559	CDD:317340
Act88F	NP_524367.1	PTZ00281	1..376	CDD:173506	45/232 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910