Protein Alignment Tep2 and c4b

DIOPT Version :10

• Sequence 1: NP_523506.1
• Gene: Tep2 / 34044
• FlyBaseID: FBgn0041182
• Length: 1420
• Species: Drosophila melanogaster
• Sequence 2: NP_001352066.1
• Gene: c4b / 794635
• ZFINID: ZDB-GENE-100805-2
• Length: 1717
• Species: Danio rerio
• Alignment Length: 1674
• Identity: 414/1674 - (24%)
• Similarity: 675/1674 - (40%)
• Gaps: 378/1674 - (22%)

  Fly    11 LQYALLV-------NATGIYSVVGPGTLRSNSKYNVVVSVHKA----DGPSQIKVSLNGP-SYNE 63
            |.|.||.       |:...:.:..|.......|..:|:.|.:|    ....|::.....| |..|
Zfish     8 LLYLLLCMSCAVQGNSNQRFLITAPSVFHVGVKEPIVIQVGEALVGKPVSCQLETETRVPMSAKE 72

  Fly    64 TKQI-ELPPMSTQNVEF---EVPKLATGN-----YNLSAEGVSGVVFKNSTKLNYADKKPSVFVQ 119
            ||.| :.....|.|:|.   .|..|.:.|     .||:.| |.|.  :..|::..:.....:|:|
Zfish    73 TKTIHQKGKFETVNLEIFANTVSNLKSINGEPPYLNLACE-VDGQ--RQQTRVLVSKHNGYIFIQ 134

  Fly   120 TDKATYKPADLVQFRILFLDENTRPAKIEKPISVIIIDGAQNRIKQLSDVKLTKGVFSGELQLSE 184
            ||:..|.|...|:|||..||.:.|| |:|..:.|.|.:...|::|: |..::..|:.|.:.::.:
Zfish   135 TDQPIYNPTQKVRFRIFTLDHSMRP-KLEMYVYVSIYNADGNKVKK-SKYRVLDGILSKDYKIPD 197

  Fly   185 QPVLGTWKISVSV--DGDNRETKSFEVDKYVLPKFEVIVDTPKAVVIAD-KVIKATIRAKYTYGK 246
            ....|.|||:...  |.||...:.|:|.|:|||.|.|.|.:.||.:.|: |.:..||:|.|:|||
Zfish   198 VSKPGVWKITAHYEDDVDNAAVREFKVQKFVLPSFGVSVHSEKAFLQANAKTLTFTIQASYSYGK 262

  Fly   247 PVKG---------KATVSMERSYGYFGDLNANGNKQE-------KTIDVDGKGHVEFDIIHWAQR 295
            .:.|         |.....:....:...|...|:.:|       ...|:..|.....:.:...|.
Zfish   263 TIDGGFHCRFGIKKGKSENDPEIEFIKGLEKTGSVKEGLAKITVNISDITQKLDTALEELATTQT 327

  Fly   296 GQYLPPIKLFAVVTEELTGNKQNATATVVLHQQRYSIEPYERPEHFEANKSFIYQ--VVVKNVDG 358
            ..|:.     |.||:.|:|..|.:...:.:...||::: ..|...| ...:|..|  |.|::.:|
Zfish   328 QFYIS-----ATVTDILSGEVQESETFLPVVLSRYNVD-LSRTRLF-YTPAFPLQAVVTVRHPNG 385

  Fly   359 SPVTNSAKNVKIGFDKSYSYFHEPSPKTRINFEAPVNENGIATFNVRLPDSDSRYYRIFASFDGS 423
            ||    |:.|::..|.|.|     ..|:.|   ...|:.|||.::..| |.......:.|:.|.:
Zfish   386 SP----AEGVQVKLDVSNS-----KEKSTI---VTTNKEGIAFYSFNL-DGKPPSVLVQATVDNA 437

  Fly   424 ENTIGSISKFEPTPMSREPLKIQVNTKKPRLGE--QVSFDVVSIEDLPYFVYTIVARGNVILSDY 486
            :    ||....|. .|...|.:.|..|....|:  :|||......:.....|.||:||  :|...
Zfish   438 K----SIRAVHPM-KSTSFLYMSVTNKVLSSGQFLEVSFYPKGNPEDGQIYYMIVSRG--MLRST 495

  Fly   487 VDVPDG---QKTYTV--KFTPTFSMVPKATIYVYYVVNNDLQFEEKTIDFEKEFSNSIDVSAPTN 546
            ..|..|   :|:..:  ..||:|.:     |..||:...|:..:...:|.|.......:|....|
Zfish   496 GSVASGSEVKKSIQIHPNMTPSFRL-----IAFYYIKEGDIIADSVWVDVEDTCDGEFEVKLHHN 555

  Fly   547 -------AKPSEEVKLRIKTDADSFVGLLGVDQSVLLLKSGNDLSQDDIFNSLNIYQTSTPWMNG 604
                   .:.:.|:.:.:....::.|.|..||:::..|.:.|.|:|..:|.|:..|....    .
Zfish   556 YGNHNYEPESTAELDIDVGQQKNAKVALQVVDKAIYALGAQNKLTQKQVFASMKSYDLGC----S 616

  Fly   605 YGRYPGQTSGLVTLTNANYPYNTGPLVMSYVFEGSRHPWITRPRYRVGIRGDSGDRISFLSQSLN 669
            ||  .|:.:..|        :|...|..      ..|....|...|.|...:||.|       .|
Zfish   617 YG--GGENTAAV--------FNDAGLAF------ISHSTTIRSAMRKGFSCESGFR-------RN 658

  Fly   670 DRNL--------KEILLKQT-------------PQRTT--------------------------- 686
            .|.:        ||...|:|             |.:.|
Zfish   659 KREIDVQAEMARKEAAFKKTELQKCCRHGFTLIPMKFTCDERAKRVSKTESKDCVNAFRECCEFA 723

  Fly   687 -----------------------------------IRKEFPETWFFENV---GEEEFTLTKKIPD 713
                                               ||..||.::.|:.:   |:....:  .:|.
Zfish   724 TKLRDKKRREDMRTGHGRTINSNEVEEFFDFEIQNIRHYFPPSFEFKQIDVKGKVRHRI--HLPH 786

  Fly   714 TITSWVVTGFSLNPTSGIALTKNPSKIRVFQPFFVSTNLPYSVKRGEVIAIPVVIFNYLDKTLDA 778
            :||:|.:...||:|:.|..:.: |..:..|:|.|:|..|||||||.|.::|..|||||
Zfish   787 SITTWEIQALSLSPSHGFCVAE-PVDLTAFKPVFISLRLPYSVKRYEQLSIVAVIFNY------- 843

  Fly   779 DVVMDNSDQEYEFTEATNEVLEKAIDEVRRVKRVTIP--ANSGKSVSFMIRP---KNVGFTTL-- 836
                  ...|.|.           :..:|:|..:..|  |.|..||.|.::|   :.|.|..:
Zfish   844 ------GKMEMEL-----------VVRMRQVDGLCSPGSATSSSSVRFSLKPASSQTVTFPAVPM 891

  Fly   837 ---KITATSALAG-------DAIHQKLKVEPEGVTLFENRAVFINLKDQPEMSQSLDADIPNEVV 891
               :|..|.|:..       |||.:.|.|:.|||.:.|.....|||..:.:...|::...||..|
Zfish   892 VKGEIPITIAIYDIEEKIEVDAIQKILLVKNEGVEMREELTYLINLDGRSDHRLSINGFFPNNTV 956

  Fly   892 PQSE---FIEF-------SVVGDLLGPTLQNLDNLVRMPYGCGEQNMVNFVPNILVLKYLEVTGR 946
            |:::   |::.       |....||..:  .::||::.|.|||||.|:...|..|.::||:.:.|
Zfish   957 PETDVNLFVKLEEEIFAQSTAVPLLSSS--KVENLIQAPKGCGEQTMIFMSPTALSIRYLDKSQR 1019

  Fly   947 KL---PSVESKARKFLEIGYQRELTYKHDDGSYSAFGKSDASGSTWLTAYVMR-----------S 997
            .|   .....||..|:|..|:|.||:|..||||.|:.::..  ||||||.|::           :
Zfish  1020 WLELEAGSRDKALDFIEQAYERILTFKKTDGSYGAWIQTPT--STWLTALVVKVLSLVAERQIET 1082

  Fly   998 FHQAGTYTD--IDPKVITAGLDFLVSKQKESGEFPEVGKLFDNANQNPL-------ALTSFVLLA 1053
            ..|.|| |:  |..:.|...:.:|:..|:..|.|.:...::....|..:       :||:|:.:|
Zfish  1083 RQQHGT-TERMISQEDIRQAVTYLIKTQRSDGSFTDAHPVYHREMQGGIGGVEQDASLTAFITIA 1146

  Fly  1054 F-----FENHELIPKYQSAIKKAVRYVAEEADKTDDQYSLAIAAVALQ--LAKHPQSEKVIAKLE 1111
            .     |.:.|.....|| |.:|..::.:..|.....|:|||.|..|.  |.:..|:.....||:
Zfish  1147 LCRSMPFLDQEATAVSQS-IARATNFLLKRVDNLKRPYALAITAYCLSTCLTERTQALSAWKKLQ 1210

  Fly  1112 SVARKENDRMWWSKATESTGEDGRVFHWKPRSN--------DVEITSYVLLALLEKDPAEKALPI 1168
            |:.:.|.|.:.|     ...:|.|:.: :.:||        .||.|:|.||..|.....:.|...
Zfish  1211 SLGKPEGDCLVW-----QDDDDVRLVN-EAKSNRVPHRVALKVETTAYALLTALAHSDLKTAQSA 1269

  Fly  1169 IKWLISQRNSNGGFSSTQDTVIGLQALTKFAYK-TGSGSGTMDIEFSSAGESKNTIKVN---PEN 1229
            :.:|.||.|..|||.|||||::.|:||:::|.. ..:...|::.:|:..|.|:.. |:|   .||
Zfish  1270 VCFLSSQENYEGGFKSTQDTIVALEALSEYALSLPETPITTINAQFTVTGRSEME-KMNLEKSEN 1333

  Fly  1230 SLVLQTHDLPKSTRKVDFTAKGTGSAMVQLSYRYNLAEKEKKPSFKVTPTVKDTPNQLLIV---- 1290
            .:..:...|......|:.:.||.....|..:| |.|.|........:..||........:|
Zfish  1334 KVEAELKRLVGQEINVNLSGKGKAKMKVAKAY-YTLKEDGNCADLSINVTVVGKVEYTSVVQEDY 1397

  Fly  1291 DVCAEYVPLEDADKDKD-----------------------------------------SNMAVME 1314
            :...:|...|:.::::|                                         |.||:.:
Zfish  1398 NYYEDYGQAEETNEEEDLPRSAIEWFDARSRQKRETSKNTKEDVVYTVCVSHTQGRKLSGMAIAD 1462

  Fly  1315 IALPSGFVGDSTSLGKIQA-VDR-VKRVETKNSDSTVVVYFDSLTPGDVRCLPLEASKAHAVAKQ 1377
            |.|.|||...:|.|.|::. ||: :...|.  :...|::||:.:..|:. |:...|.::..:...
Zfish  1463 ITLLSGFEAINTDLEKLKGLVDKYISHYEV--TRGRVLLYFNEIDGGEA-CIAFGAEQSVPIGLV 1524

  Fly  1378 KPASVSLYDYYDTERKATEYY------QVKSSLC--DICEGADCGE-GC 1417
            :||....||||:.:|:.:..|      ::.|.||  |:|:   |.| ||
Zfish  1525 QPAPALFYDYYEPDRRCSVLYSAPKRSKMVSVLCSDDVCQ---CAERGC 1570

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep2	NP_523506.1	YfaS	<72..1395	CDD:441940	387/1567 (25%)
		A2M_2	909..1198	CDD:239227	99/326 (30%)
c4b	NP_001352066.1	YfaS	<113..1540	CDD:441940	377/1533 (25%)
		complement_C3_C4_C5	982..1299	CDD:239226	99/328 (30%)
		NTR_complement_C4	1563..1715	CDD:239639	5/11 (45%)