DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep2 and C5

DIOPT Version :9

Sequence 1:	NP_523506.1	Gene:	Tep2 / 34044	FlyBaseID:	FBgn0041182	Length:	1420	Species:	Drosophila melanogaster
Sequence 2:	NP_001304092.1	Gene:	C5 / 727	HGNCID:	1331	Length:	1682	Species:	Homo sapiens

Alignment Length:	1627	Identity:	380/1627 - (23%)
Similarity:	671/1627 - (41%)	Gaps:	349/1627 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 YSVVGPGTLRSNSKYNVVVSVHKADGPSQIKVSLNGPSYNETK------QIELPPMSTQNVEFE- 80
            |.:..|...|..:..|:|:.|:.........:|:.  ||.:.|      .:.|   |::| :|:
Human    29 YVISAPKIFRVGASENIVIQVYGYTEAFDATISIK--SYPDKKFSYSSGHVHL---SSEN-KFQN 87

  Fly    81 ------VPKLATGNYNLSAEGVSGVV---FKNSTKLNYADKKPSVFVQTDKATYKPADLVQFRIL 136
                  .||...|..|..:.....||   |..|.::........:|:.|||..|.|...|:.|:.
Human    88 SAILTIQPKQLPGGQNPVSYVYLEVVSKHFSKSKRMPITYDNGFLFIHTDKPVYTPDQSVKVRVY 152

  Fly   137 FLDENTRPAKIEKPISVIIIDGAQ-NRIKQLSDVKLTKGVFS-GELQLSEQPVLGTWKISVSV-- 197
            .|:::.:|||.|..::.|..:|:: :.::::..:    |:.| .:.::...|..|.|.|....
Human   153 SLNDDLKPAKRETVLTFIDPEGSEVDMVEEIDHI----GIISFPDFKIPSNPRYGMWTIKAKYKE 213

  Fly   198 DGDNRETKSFEVDKYVLPKFEVIVDTPKAVVIADKVIK---ATIRAKYTYGKPVKGKATVSMERS 259
            |.....|..|||.:||||.|.|.:: |:...|..|..|   .||:|:|.|.|.|. :|.|.:  :
Human   214 DFSTTGTAYFEVKEYVLPHFSVSIE-PEYNFIGYKNFKNFEITIKARYFYNKVVT-EADVYI--T 274

  Fly   260 YGYFGDLNANGNK-----QEKTIDVDGKGHVEFD-------IIHWA---QRGQYLPPIKLFAVVT 309
            :|...||..:..:     .:.|:.::|...|.||       :.:::   ...:||    ..||..
Human   275 FGIREDLKDDQKEMMQTAMQNTMLINGIAQVTFDSETAVKELSYYSLEDLNNKYL----YIAVTV 335

  Fly   310 EELTGN-KQNATATVVLHQQRYSIEPYE-----RPEHFEANKSFIYQVVVKN-----VDGSPVTN 363
            .|.||. .:.|....:    :|.:.||:     .|...:....:..:|.||:     |.|.|||.
Human   336 IESTGGFSEEAEIPGI----KYVLSPYKLNLVATPLFLKPGIPYPIKVQVKDSLDQLVGGVPVTL 396

  Fly   364 SAKNVKIGFDKSYSYFHEPSPK-TRINFEAPVNENGIATFNVRLP-------------------D 408
            :|:.:.:..:.|..   :||.. ||:       ::|:|:|.:.||                   :
Human   397 NAQTIDVNQETSDL---DPSKSVTRV-------DDGVASFVLNLPSGVTVLEFNVKTDAPDLPEE 451

  Fly   409 SDSRY-YRIFA---------SFDGSEN----TIGSISKFEPTPMSREPLKIQVNTKKPRLGEQVS 459
            :.:|. ||..|         ..|.::|    .:|            |.|.|.|..|.|
Human   452 NQAREGYRAIAYSSLSQSYLYIDWTDNHKALLVG------------EHLNIIVTPKSP------- 497

  Fly   460 FDVVSIEDLPYFVYTIVARGNVI-------LSDYVDVPDGQKTY-TVKFTPTFSMVPKATIYVYY 516
                .|:.:.::.|.|:::|.:|       .||        .:| ::....|.:|||.:.:.|||
Human   498 ----YIDKITHYNYLILSKGKIIHFGTREKFSD--------ASYQSINIPVTQNMVPSSRLLVYY 550

  Fly   517 VVNN----DLQFEEKTIDFEKEFSNSIDVSAPTNA---KPSEEVKLRIKTDADSFVGLLGVDQSV 574
            :|..    :|..:...::.|::..|.:.|....:|   .|.:.|.|.:.|..||:|.|..||.:|
Human   551 IVTGEQTAELVSDSVWLNIEEKCGNQLQVHLSPDADAYSPGQTVSLNMATGMDSWVALAAVDSAV 615

  Fly   575 LLLKSGNDLSQDDIF----------------NSLNIYQTSTPWMNGYGRYPGQTSGLVTLTNAN- 622
            ..::.|.....:.:|                |:.|::               ..:||..|||||
Human   616 YGVQRGAKKPLERVFQFLEKSDLGCGAGGGLNNANVF---------------HLAGLTFLTNANA 665

  Fly   623 --------------YPYNTGPLVMSYVFEGSRHPWITRPRY----------------RVGIRGDS 657
                          .|..|....:..:....:|..:.:..|                |:.:
Human   666 DDSQENDEPCKEILRPRRTLQKKIEEIAAKYKHSVVKKCCYDGACVNNDETCEQRAARISL---- 726

  Fly   658 GDR------------------ISFLSQSLNDRNLKEILLKQTPQRTTIRKEFPETWFFE-NVGEE 703
            |.|                  ||.....|...::|.:|....|:   ||..|||:|.:| ::...
Human   727 GPRCIKAFTECCVVASQLRANISHKDMQLGRLHMKTLLPVSKPE---IRSYFPESWLWEVHLVPR 788

  Fly   704 EFTLTKKIPDTITSWVVTGFSLNPTSGIALTKNPSKIRVFQPFFVSTNLPYSVKRGEVIAIPVVI 768
            ...|...:||::|:|.:.|..::.| ||.:. :..|.:||:..|:..|:||||.|||.|.:...:
Human   789 RKQLQFALPDSLTTWEIQGVGISNT-GICVA-DTVKAKVFKDVFLEMNIPYSVVRGEQIQLKGTV 851

  Fly   769 FNYLDKTLDADVVMDNSDQEYEFTEATNEVLEKAIDEVRRVKRVTIPANSGKSVSFMIRPKNVGF 833
            :||....:...|.|...:   ....:.:.|::....:..:..|..:..:|...|:|.:.|..:|.
Human   852 YNYRTSGMQFCVKMSAVE---GICTSESPVIDHQGTKSSKCVRQKVEGSSSHLVTFTVLPLEIGL 913

  Fly   834 TTLKITATSALAGDAIHQKLKVEPEGV-------TLFENRAVFINLKDQPEMSQSLDADIPNEVV 891
            ..:..:..:....:.:.:.|:|.||||       ...:.|.::..:..:.|....    ||.::|
Human   914 HNINFSLETWFGKEILVKTLRVVPEGVKRESYSGVTLDPRGIYGTISRRKEFPYR----IPLDLV 974

  Fly   892 PQSEF-----IEFSVVGDLLGPTL--QNLDNLVRMPYGCGEQNMVNFVPNILVLKYLEVTGRKL- 948
            |::|.     ::..:||::|...|  :.::.|..:|.|..|..:::.||...|..||| ||...
Human   975 PKTEIKRILSVKGLLVGEILSAVLSQEGINILTHLPKGSAEAELMSVVPVFYVFHYLE-TGNHWN 1038

  Fly   949 -----PSVE-SKARKFLEIGYQRELTYKHDDGSYSAFGKSDASGSTWLTAYVMRSFHQAGTYTDI 1007
                 |.:| .|.:|.|:.|....::|::.|.|||.:  ...|.||||||:.:|...|...|.:.
Human  1039 IFHSDPLIEKQKLKKKLKEGMLSIMSYRNADYSYSVW--KGGSASTWLTAFALRVLGQVNKYVEQ 1101

  Fly  1008 DPKVITAGLDFLVSK-QKESGEFPE---------VGKLFDNANQNPLALTSFVLLAFFENHELIP 1062
            :...|...|.:||.. |.::|.|.|         .|.|...|.:|.|.||:|.::...:..::.|
Human  1102 NQNSICNSLLWLVENYQLDNGSFKENSQYQPIKLQGTLPVEARENSLYLTAFTVIGIRKAFDICP 1166

  Fly  1063 --KYQSAIKKAVRYVAEEADKTDDQYSLAIAAVALQLA--KHPQSEKVIAKLESVARKEND---- 1119
              |..:|:.||..::.|........::|||:|.||.|.  .|||...:::.|:..|..:.:
Human  1167 LVKIDTALIKADNFLLENTLPAQSTFTLAISAYALSLGDKTHPQFRSIVSALKREALVKGNPPIY 1231

  Fly  1120 RMW------WSKATESTGEDGRVFHWKPRSNDVEITSYVLLALLEKDPAEKALPIIKWLISQRNS 1178
            |.|      ...:..:||          .:..||.|:|.||..|.........|:||||..::..
Human  1232 RFWKDNLQHKDSSVPNTG----------TARMVETTAYALLTSLNLKDINYVNPVIKWLSEEQRY 1286

  Fly  1179 NGGFSSTQDTVIGLQALTKFAYKTGSGSGTMDIEFSSAGE-SKNTIKVNPENSL-----VLQTHD 1237
            .|||.|||||:..::.||:::........:|||:.|...: :.:..|:..:|.|     ||...|
Human  1287 GGGFYSTQDTINAIEGLTEYSLLVKQLRLSMDIDVSYKHKGALHNYKMTDKNFLGRPVEVLLNDD 1351

  Fly  1238 LPKSTRKVDFTAKGTGSAMVQL-SYRYNLAEKEKKPSFKVTPTVKDTP---------NQLLIVDV 1292
            |..|      |..|:|.|.|.: :..:..:..|:..||.:....:|..         :....:..
Human  1352 LIVS------TGFGSGLATVHVTTVVHKTSTSEEVCSFYLKIDTQDIEASHYRGYGNSDYKRIVA 1410

  Fly  1293 CAEYVPLEDADKDKDSNMAVMEIALPSGFVGDSTSL-GKIQAVDRVKRVETKNSDSTVVVYFDSL 1356
            ||.|.|..: :....|:.|||:|:||:|...:...| ..::.||:: ..:.:..|..|::..:|:
Human  1411 CASYKPSRE-ESSSGSSHAVMDISLPTGISANEEDLKALVEGVDQL-FTDYQIKDGHVILQLNSI 1473

  Fly  1357 TPGDVRCLPLEASKAHAVAKQKPASVSLYDYYDTERKATEYYQVKS-SLCDICEG-------ADC 1413
            ...|..|:.....:...|....||:.::|:|:..:::.|.:|...: .:..:|||       |||
Human  1474 PSSDFLCVRFRIFELFEVGFLSPATFTVYEYHRPDKQCTMFYSTSNIKIQKVCEGAACKCVEADC 1538

  Fly  1414 GE 1415
            |:
Human  1539 GQ 1540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep2	NP_523506.1	A2M_N	115..209	CDD:280081	24/97 (25%)
		A2M_N_2	445..576	CDD:285005	36/145 (25%)
		A2M	694..782	CDD:278630	27/88 (31%)
		A2M_2	909..1198	CDD:239227	94/321 (29%)
		A2M_comp	961..1199	CDD:284982	76/261 (29%)
		A2M_recep	1308..1398	CDD:284981	22/90 (24%)
C5	NP_001304092.1	A2M_N	132..225	CDD:280081	24/96 (25%)
		A2M_N_2	478..616	CDD:285005	39/168 (23%)
		ANATO	688..756	CDD:237984	7/71 (10%)
		A2M	778..865	CDD:278630	27/88 (31%)
		complement_C3_C4_C5	999..1306	CDD:239226	93/319 (29%)
		A2M_comp	1057..1307	CDD:284982	76/261 (29%)
		A2M_recep	1427..1515	CDD:284981	21/88 (24%)
		NTR_complement_C5	1533..1682	CDD:239637	4/8 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149960
Domainoid	1	1.000	53	1.000	Domainoid score	I11337
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.810