DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep2 and C4A

DIOPT Version :9

Sequence 1:	NP_523506.1	Gene:	Tep2 / 34044	FlyBaseID:	FBgn0041182	Length:	1420	Species:	Drosophila melanogaster
Sequence 2:	NP_009224.2	Gene:	C4A / 720	HGNCID:	1323	Length:	1744	Species:	Homo sapiens

Alignment Length:	1566	Identity:	385/1566 - (24%)
Similarity:	657/1566 - (41%)	Gaps:	360/1566 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 LNYADKKPSVFVQTDKATYKPADLVQFRILFLDENTRPAKIEKPISVIIIDGAQNRIKQLSDVKL 171
            |.::.::..:|:|||:..|.|...|::|:..||:..||:  ...|:|::.:....|::: .:|.:
Human   132 LLFSSRRGHLFLQTDQPIYNPGQRVRYRVFALDQKMRPS--TDTITVMVENSHGLRVRK-KEVYM 193

  Fly   172 TKGVFSGELQLSEQPVLGTWKISVSV-DG-DNRETKSFEVDKYVLPKFEVIVDTPKAVVIA---- 230
            ...:|..:..:.:....||||||... || ::..:..|||.|||||.|||.:...|..::.
Human   194 PSSIFQDDFVIPDISEPGTWKISARFSDGLESNSSTQFEVKKYVLPNFEVKITPGKPYILTVPGH 258

  Fly   231 -DKVIKATIRAKYTYGKPVKGKATVSMERSYGYFGDLNANGNK------QEKTIDVDGKGHV--- 285
             |: ::..|:|:|.|||||:|.|       |..||.|:.:|.|      :.:|..|:|:.|:
Human   259 LDE-MQLDIQARYIYGKPVQGVA-------YVRFGLLDEDGKKTFFRGLESQTKLVNGQSHISLS 315

  Fly   286 --EF-DIIHWAQRG-QYLPPIKLF--AVVTEELTGNKQNATATV-VLHQQRYSIEPYERPEHFEA 343
              || |.:.....| ..|..::|:  |.:.|...|..:.|..|. ......:|::..:...|...
Human   316 KAEFQDALEKLNMGITDLQGLRLYVAAAIIESPGGEMEEAELTSWYFVSSPFSLDLSKTKRHLVP 380

  Fly   344 NKSFIYQVVVKNVDGSPVTNSAKNVKIGFDKSYSYFHEPSPKTRI-NFEAPVNENGIATFNVRLP 407
            ...|:.|.:|:.:.|||.  |...||:....|     .|.....: :.:...:.:|..:..:.:|
Human   381 GAPFLLQALVREMSGSPA--SGIPVKVSATVS-----SPGSVPEVQDIQQNTDGSGQVSIPIIIP 438

  Fly   408 DSDSRYYRIFASFDGSENTIGSISKFEPTPMSREPLKIQ-VNTKKPRLGEQVSFDVVSI---EDL 468
            .:.|. .::..|.......|..::...|.......|.|: .:::.||:|:.::.::.::   ...
Human   439 QTISE-LQLSVSAGSPHPAIARLTVAAPPSGGPGFLSIERPDSRPPRVGDTLNLNLRAVGSGATF 502

  Fly   469 PYFVYTIVARGNVI------------LSDYVDVPDGQKTYTVKFTPTFSMVPKATIYVYY----V 517
            .::.|.|::||.::            :|.:||.......|.|.|              ||    .
Human   503 SHYYYMILSRGQIVFMNREPKRTLTSVSVFVDHHLAPSFYFVAF--------------YYHGDHP 553

  Fly   518 VNNDLQFE----------EKTIDFEKEFSNSIDVSAPTNAKPSEEVKLRIKTDADSFVGLLGVDQ 572
            |.|.|:.:          |.::|..|::.|            .|.|||.::||:.:.|.|..:|.
Human   554 VANSLRVDVQAGACEGKLELSVDGAKQYRN------------GESVKLHLETDSLALVALGALDT 606

  Fly   573 SVLLL--KSGNDLSQDDIFNSLNIYQTSTPWMNGYGRYPG---------QTSGLV-------TLT 619
            ::...  ||...|:...:|.::|.|..      |.|  ||         |.:||.       ||:
Human   607 ALYAAGSKSHKPLNMGKVFEAMNSYDL------GCG--PGGGDSALQVFQAAGLAFSDGDQWTLS 663

  Fly   620 ----------------NAN-----------YPYNTG-----------PLVMSYVFEGS------- 639
                            |.|           |...|.           |::.|.....:
Human   664 RKRLSCPKEKTTRKKRNVNFQKAINEKLGQYASPTAKRCCQDGVTRLPMMRSCEQRAARVQQPDC 728

  Fly   640 RHPWITRPRYRVGIRGDSGDRISFLSQSLNDRNLKEILLKQ---TPQRTTIRKEFPETWFFENVG 701
            |.|:::..::...:|..|.|:    .|:...|.| |||.::   ......:|..|||.|.:....
Human   729 REPFLSCCQFAESLRKKSRDK----GQAGLQRAL-EILQEEDLIDEDDIPVRSFFPENWLWRVET 788

  Fly   702 EEEF-TLTKKIPDTITSWVVTGFSLNPTSGIALTKNPSKIRVFQPFFVSTNLPYSVKRGEVIAIP 765
            .:.| .||..:||::|:|.:.|.||:.|.|:.:. .|.::|||:.|.:...||.||:|.|.:.:.
Human   789 VDRFQILTLWLPDSLTTWEIHGLSLSKTKGLCVA-TPVQLRVFREFHLHLRLPMSVRRFEQLELR 852

  Fly   766 VVIFNYLDKTLDADVVMDNSDQEYEFTEATNEVLEKAIDEVRRV---------KRVTIPANSGKS 821
            .|::|||||.|...|                     .:..|..:         ::|.:||.|.:.
Human   853 PVLYNYLDKNLTVSV---------------------HVSPVEGLCLAGGGGLAQQVLVPAGSARP 896

  Fly   822 VSFMIRPKNVGFTTLKITATSAL---AGDAIHQKLKVEPEGVTLFENRAVFINLKDQPEMSQSLD 883
            |:|.:.|......:||:.|..:.   .|||:.:.|::|.||....|.....:|..|....:..:.
Human   897 VAFSVVPTAAAAVSLKVVARGSFEFPVGDAVSKVLQIEKEGAIHREELVYELNPLDHRGRTLEIP 961

  Fly   884 ADIPNEVVPQSEFIEFSVVG-----DLLGP----TLQNLDNLVRMPYGCGEQNMVNFVPNILVLK 939
            .:....::|..:|..:..|.     |.||.    :...:.:|:|:|.|||||.|:...|.:...:
Human   962 GNSDPNMIPDGDFNSYVRVTASDPLDTLGSEGALSPGGVASLLRLPRGCGEQTMIYLAPTLAASR 1026

  Fly   940 YLEVT---GRKLPSVESKARKFLEIGYQRELTYKHDDGSYSAFGKSDASGSTWLTAYVMRSFHQA 1001
            ||:.|   ....|..:..|...::.||.|...::..||||:|:...|:  ||||||:|::....|
Human  1027 YLDKTEQWSTLPPETKDHAVDLIQKGYMRIQQFRKADGSYAAWLSRDS--STWLTAFVLKVLSLA 1089

  Fly  1002 GTYTDIDPKVITAGLDFLVSKQKESGEFPEVGKLFDNA-------NQNPLALTSFVL------LA 1053
            .......|:.:....::|:|:|:..|.|.:...:.|.:       |...:|||:||.      ||
Human  1090 QEQVGGSPEKLQETSNWLLSQQQADGSFQDPCPVLDRSMQGGLVGNDETVALTAFVTIALHHGLA 1154

  Fly  1054 FFENHELIP---KYQSAIKKAVRYVAEEADK-TDDQYSLAIAAVALQLAKHPQSEKVIA--KLES 1112
            .|::....|   :.:::|.||..::.|:|.. ....::.||.|.||.|.|.|.....:|  .|.:
Human  1155 VFQDEGAEPLKQRVEASISKANSFLGEKASAGLLGAHAAAITAYALTLTKAPVDLLGVAHNNLMA 1219

  Fly  1113 VARKENDRMWWSKATESTGEDGRVFHWKPRSND------------VEITSYVLL-ALLEKDPAEK 1164
            :|::..|.::|...   ||.........|...:            :|.|:|.|| .||.:..||.
Human  1220 MAQETGDNLYWGSV---TGSQSNAVSPTPAPRNPSDPMPQAPALWIETTAYALLHLLLHEGKAEM 1281

  Fly  1165 ALPIIKWLISQRNSNGGFSSTQDTVIGLQALTKF--AYKTGSGSGTMDIEFSSAGE--------- 1218
            |.....||..|.:..|||.|||||||.|.||:.:  |..|....| :::..||.|.
Human  1282 ADQASAWLTRQGSFQGGFRSTQDTVIALDALSAYWIASHTTEERG-LNVTLSSTGRNGFKSHALQ 1345

  Fly  1219 ------------------SKNTIKV--NPENSL-VLQTH---DLPKST---RKVDFTAKGTGSAM 1256
                              ||..:||  |.:.:| ||:|:   |:..:|   .:::.|.||.....
Human  1346 LNNRQIRGLEEELQFSLGSKINVKVGGNSKGTLKVLRTYNVLDMKNTTCQDLQIEVTVKGHVEYT 1410

  Fly  1257 VQLSYRYNLAEKEKKPSFKVTPTVKDTPNQLLIVDVCAEYVPLE-----------DADKDKD--- 1307
            ::.:..|...|.::.|:       ||.|:..|     ....||:           :|.|..:
Human  1411 MEANEDYEDYEYDELPA-------KDDPDAPL-----QPVTPLQLFEGRRNRRRREAPKVVEEQE 1463

  Fly  1308 -----------------SNMAVMEIALPSGFVGDSTSLGKIQAV-DR-VKRVETKNSDSTVVVYF 1353
                             |.||:.::.|.|||......|.|:.:: || |...||:...  |::||
Human  1464 SRVHYTVCIWRNGKVGLSGMAIADVTLLSGFHALRADLEKLTSLSDRYVSHFETEGPH--VLLYF 1526

  Fly  1354 DSLTPGDVRCLPLEASKAHAVAKQKPASVSLYDYYDTERKATEYY------QVKSSLC--DICEG 1410
            ||: |....|:..||.:...|...:|||.:|||||:.||:.:.:|      ::.::||  ::|:
Human  1527 DSV-PTSRECVGFEAVQEVPVGLVQPASATLYDYYNPERRCSVFYGAPSKSRLLATLCSAEVCQ- 1589

  Fly  1411 ADCGEG 1416
              |.||
Human  1590 --CAEG 1593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep2	NP_523506.1	A2M_N	115..209	CDD:280081	26/95 (27%)
		A2M_N_2	445..576	CDD:285005	32/160 (20%)
		A2M	694..782	CDD:278630	32/88 (36%)
		A2M_2	909..1198	CDD:239227	96/323 (30%)
		A2M_comp	961..1199	CDD:284982	81/271 (30%)
		A2M_recep	1308..1398	CDD:284981	34/91 (37%)
C4A	NP_009224.2	A2M_N	141..233	CDD:280081	26/94 (28%)
		A2M_N	141..233		26/94 (28%)
		A2M_N_2	478..610	CDD:285005	31/157 (20%)
		A2M_N_2	478..610		31/157 (20%)
		ANATO	686..750	CDD:237984	9/67 (13%)
		ANATO	686..750		9/67 (13%)
		A2M	782..869	CDD:278630	32/108 (30%)
		A2M	782..869		32/108 (30%)
		complement_C3_C4_C5	996..1315	CDD:239226	96/323 (30%)
		complement_C3_C4_C5	996..1315		96/323 (30%)
		A2M_comp	1051..1317	CDD:284982	81/270 (30%)
		A2M_comp	1051..1317		81/270 (30%)
		A2M_recep	1481..1570	CDD:284981	34/91 (37%)
		A2M_recep	1481..1570		34/91 (37%)
		NTR_complement_C4	1588..1742	CDD:239639	4/9 (44%)
		NTR_complement_C4	1588..1742		4/9 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149976
Domainoid	1	1.000	53	1.000	Domainoid score	I11337
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.810