DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep2 and C3

DIOPT Version :9

Sequence 1:	NP_523506.1	Gene:	Tep2 / 34044	FlyBaseID:	FBgn0041182	Length:	1420	Species:	Drosophila melanogaster
Sequence 2:	NP_000055.2	Gene:	C3 / 718	HGNCID:	1318	Length:	1663	Species:	Homo sapiens

Alignment Length:	1649	Identity:	399/1649 - (24%)
Similarity:	673/1649 - (40%)	Gaps:	382/1649 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IILQYALLVNATGIYSVVGPGTLRSNSKYNVVVSVHKADGPSQIKVSLNG-PSYN---ETKQIEL 69
            ::|.:..|...:.:||::.|..||..|:..:|:..|.|.|...:.|:::. |...   .:::..|
Human    12 LLLTHLPLALGSPMYSIITPNILRLESEETMVLEAHDAQGDVPVTVTVHDFPGKKLVLSSEKTVL 76

  Fly    70 PPMSTQ--NVEFEVP------------KLATGNYNLSAEGVSGVVFKNSTKLNYADKKPSVFVQT 120
            .|.:..  ||.|.:|            |..|.......:.|..||.. |.:..|      :|:||
Human    77 TPATNHMGNVTFTIPANREFKSEKGRNKFVTVQATFGTQVVEKVVLV-SLQSGY------LFIQT 134

  Fly   121 DKATYKPADLVQFRILFLDENTRP------AKIEKPISVIIIDGAQNRIKQLSDVKLTKGVFSGE 179
            ||..|.|...|.:||..::....|      ..||.|..:.:...:.:...||       ||....
Human   135 DKTIYTPGSTVLYRIFTVNHKLLPVGRTVMVNIENPEGIPVKQDSLSSQNQL-------GVLPLS 192

  Fly   180 LQLSEQPVLGTWKISVSVDGDNRETKS--FEVDKYVLPKFEVIVD-TPKAVVI-ADKVIKATIRA 240
            ..:.|...:|.|||....:...::..|  |||.:||||.|||||: |.|...| .:|.::.||.|
Human   193 WDIPELVNMGQWKIRAYYENSPQQVFSTEFEVKEYVLPSFEVIVEPTEKFYYIYNEKGLEVTITA 257

  Fly   241 KYTYGKPVKGKATVSMERSYG-YFGDLNANGNKQEKTIDV-DGKGHVEFD---IIHWAQRGQYLP 300
            ::.|||.|:|.|.|    .:| ..|:...:..:..|.|.: ||.|.|...   ::...|..:
Human   258 RFLYGKKVEGTAFV----IFGIQDGEQRISLPESLKRIPIEDGSGEVVLSRKVLLDGVQNPR--- 315

  Fly   301 PIKLFAVVTEELTGNKQNATATVVLHQ-------QRYSI----EPYE-----RPEHFEANKSFIY 349
                    .|:|.|.....:|||:||.       :|..|    .||:     .|::|:....|..
Human   316 --------AEDLVGKSLYVSATVILHSGSDMVQAERSGIPIVTSPYQIHFTKTPKYFKPGMPFDL 372

  Fly   350 QVVVKNVDGSPVTNSAKNVKIGFDKSYSYFHEPSPKTRINFEAPVNENGIATFNVRLPDSDSRYY 414
            .|.|.|.||||.                                                    |
Human   373 MVFVTNPDGSPA----------------------------------------------------Y 385

  Fly   415 RIFASFDGSENTIGSISKFE-------PTPMSREPLKIQVNTKKPRLGE---------------- 456
            |:..:..| |:|:.|:::.:       .|..|::||.|.|.|||..|.|
Human   386 RVPVAVQG-EDTVQSLTQGDGVAKLSINTHPSQKPLSITVRTKKQELSEAEQATRTMQALPYSTV 449

  Fly   457 ----------------------QVSF----DVVSIEDLPYFVYTIVARGNVILSDYVDVPDGQKT 495
                                  .|:|    |......:.|:.|.|:.:|.::.:.......||..
Human   450 GNSNNYLHLSVLRTELRPGETLNVNFLLRMDRAHEAKIRYYTYLIMNKGRLLKAGRQVREPGQDL 514

  Fly   496 YTVKFTPTFSMVPKATIYVYYVV-----NNDLQFEEKTIDFEKEFSNSIDV----SAPTNAKPSE 551
            ..:..:.|...:|...:..||.:     ..::..:...:|.:.....|:.|    |......|.:
Human   515 VVLPLSITTDFIPSFRLVAYYTLIGASGQREVVADSVWVDVKDSCVGSLVVKSGQSEDRQPVPGQ 579

  Fly   552 EVKLRIKTDADSFVGLLGVDQSVLLLKSGNDLSQDDIFNSLNIYQTS-TPWMNGYGR-YPG---- 610
            ::.|:|:.|..:.|.|:.||:.|.:|...|.|:|..|::.:...... ||   |.|: |.|
Human   580 QMTLKIEGDHGARVVLVAVDKGVFVLNKKNKLTQSKIWDVVEKADIGCTP---GSGKDYAGVFSD 641

  Fly   611 ------QTSGLVTLTNA--------------------------NYP----------YNTGPLVMS 633
                  .:||..|...|                          .||          ....|:..|
Human   642 AGLTFTSSSGQQTAQRAELQCPQPAARRRRSVQLTEKRMDKVGKYPKELRKCCEDGMRENPMRFS 706

  Fly   634 --------YVFEGSRHPWITRPRYRVGIRGDSGDRISFLSQSLNDRNLKEILLKQTPQRTTIRKE 690
                    .:.|..:..::....|...:|.... |.|.|  .|...||.|.::.:  :....|.|
Human   707 CQRRTRFISLGEACKKVFLDCCNYITELRRQHA-RASHL--GLARSNLDEDIIAE--ENIVSRSE 766

  Fly   691 FPETWFF--ENVGE--EEFTLTKK----IPDTITSWVVTGFSLNPTSGIALTKNPSKIRVFQPFF 747
            |||:|.:  |::.|  :....||.    :.|:||:|.:...|::...||.:. :|.::.|.|.||
Human   767 FPESWLWNVEDLKEPPKNGISTKLMNIFLKDSITTWEILAVSMSDKKGICVA-DPFEVTVMQDFF 830

  Fly   748 VSTNLPYSVKRGEVIAIPVVIFNYLDKTLDADVVMDNSDQEYEFTEATNEVLEK------AIDEV 806
            :...|||||.|.|.:.|..|::||            ..:||   .:...|:|..      |..:.
Human   831 IDLRLPYSVVRNEQVEIRAVLYNY------------RQNQE---LKVRVELLHNPAFCSLATTKR 880

  Fly   807 RRVKRVTIPANSGKSVSFMIRPKNVGFTTLKITAT--SALAGDAIHQKLKVEPEGVTLFENRAVF 869
            |..:.||||..|..||.::|.|...|...:::.|.  .....|.:.:.|||.|||:.:  |:.|.
Human   881 RHQQTVTIPPKSSLSVPYVIVPLKTGLQEVEVKAAVYHHFISDGVRKSLKVVPEGIRM--NKTVA 943

  Fly   870 INLKDQPEMSQS--LDADIP----NEVVPQSE-----FIEFSVVGDLLGPTL--QNLDNLVRMPY 921
            :...|...:.:.  ...|||    ::.||.:|     .::.:.|..:....:  :.|.:|:..|.
Human   944 VRTLDPERLGREGVQKEDIPPADLSDQVPDTESETRILLQGTPVAQMTEDAVDAERLKHLIVTPS 1008

  Fly   922 GCGEQNMVNFVPNILVLKYLEVTGRKLPSVESKARKFLEI---GYQRELTYKHDDGSYSAFGKSD 983
            |||||||:...|.::.:.||:.|.:.......|.:..||:   ||.::|.::....:::||.|
Human  1009 GCGEQNMIGMTPTVIAVHYLDETEQWEKFGLEKRQGALELIKKGYTQQLAFRQPSSAFAAFVK-- 1071

  Fly   984 ASGSTWLTAYVMRSFHQAGTYTDIDPKVITAGLDFLV-SKQKESGEFPE---------VGKLFDN 1038
            .:.||||||||::.|..|.....||.:|:...:.:|: .|||..|.|.|         :|.|.:|
Human  1072 RAPSTWLTAYVVKVFSLAVNLIAIDSQVLCGAVKWLILEKQKPDGVFQEDAPVIHQEMIGGLRNN 1136

  Fly  1039 ANQNPLALTSFVLLAFFEN----HELIPKYQSAIKKAVRYVAEEADKTDDQYSLAIAAVAL-QLA 1098
             |:..:|||:|||::..|.    .|.:.....:|.||..::..........|::|||..|| |:.
Human  1137 -NEKDMALTAFVLISLQEAKDICEEQVNSLPGSITKAGDFLEANYMNLQRSYTVAIAGYALAQMG 1200

  Fly  1099 --KHPQSEKVIAKLESVARKENDRMWWSKATESTGED-GRVFHWKPRSNDVEITSYVLLALLEKD 1160
              |.|    ::.|..:.|:.:|  .|         || |:..:      :||.|||.|||||:..
Human  1201 RLKGP----LLNKFLTTAKDKN--RW---------EDPGKQLY------NVEATSYALLALLQLK 1244

  Fly  1161 PAEKALPIIKWLISQRNSNGGFSSTQDTVIGLQALTKFAYKTGSGSGTMDIEFS---SAGESKNT 1222
            ..:...|:::||..||...||:.|||.|.:..|||.:: .|.......::::.|   .:..||.|
Human  1245 DFDFVPPVVRWLNEQRYYGGGYGSTQATFMVFQALAQY-QKDAPDHQELNLDVSLQLPSRSSKIT 1308

  Fly  1223 IKVNPENSLVLQTHDLPKSTRKVDFTAKGTGSAMVQLSYRYNLAEKEK--------KPSFKVTPT 1279
            .:::.|::.:|::.: .|.......||:|.|...:.:...|:...|::        |.:.|..|.
Human  1309 HRIHWESASLLRSEE-TKENEGFTVTAEGKGQGTLSVVTMYHAKAKDQLTCNKFDLKVTIKPAPE 1372

  Fly  1280 VKDTP---NQLLIVDVCAEYVPLEDADKDKDSNMAVMEIALPSGFVGDSTSLGKI-QAVDR-VKR 1339
            .:..|   ...:|:::|..|      ..|:|:.|::::|::.:||..|:..|.:: ..||| :.:
Human  1373 TEKRPQDAKNTMILEICTRY------RGDQDATMSILDISMMTGFAPDTDDLKQLANGVDRYISK 1431

  Fly  1340 VETKNSDS---TVVVYFDSLTPGDVRCLPLEASKAHAVAKQKPASVSLYDYYDTERKATEYYQVK 1401
            .|...:.|   |:::|.|.::..:..||..:..:...|...:|.:|.:|.||:.|...|.:|..:
Human  1432 YELDKAFSDRNTLIIYLDKVSHSEDDCLAFKVHQYFNVELIQPGAVKVYAYYNLEESCTRFYHPE 1496

  Fly  1402 ------SSLC--DICEGADCGEGC 1417
                  :.||  ::|..|:  |.|
Human  1497 KEDGKLNKLCRDELCRCAE--ENC 1518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep2	NP_523506.1	A2M_N	115..209	CDD:280081	25/101 (25%)
		A2M_N_2	445..576	CDD:285005	33/181 (18%)
		A2M	694..782	CDD:278630	28/95 (29%)
		A2M_2	909..1198	CDD:239227	98/311 (32%)
		A2M_comp	961..1199	CDD:284982	81/258 (31%)
		A2M_recep	1308..1398	CDD:284981	24/94 (26%)
C3	NP_000055.2	A2M_N	129..224	CDD:280081	26/107 (24%)
		A2M_N_2	458..604	CDD:285005	26/145 (18%)
		ANATO	678..747	CDD:237984	10/71 (14%)
		A2M	770..866	CDD:278630	30/111 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	954..973		4/18 (22%)
		complement_C3_C4_C5	996..1282	CDD:239226	98/309 (32%)
		A2M_comp	1051..1282	CDD:284982	81/254 (32%)
		A2M_recep	1398..1493	CDD:284981	24/94 (26%)
		NTR_complement_C3	1513..1661	CDD:239638	3/8 (38%)
		Interaction with CFP/properdin. /evidence=ECO:0000269\|PubMed:28264884, ECO:0000269\|PubMed:31507604	1634..1659
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149988
Domainoid	1	1.000	53	1.000	Domainoid score	I11337
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.800