DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tep2 and PZP

DIOPT Version :9

Sequence 1:NP_523506.1 Gene:Tep2 / 34044 FlyBaseID:FBgn0041182 Length:1420 Species:Drosophila melanogaster
Sequence 2:XP_011519106.1 Gene:PZP / 5858 HGNCID:9750 Length:1500 Species:Homo sapiens


Alignment Length:1534 Identity:417/1534 - (27%)
Similarity:683/1534 - (44%) Gaps:268/1534 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 YSVVGPGTLRSNS-KYNVVVSVHKADGPSQIKVSLNGPSYNETKQIELPPMSTQN----VEFEVP 82
            |.|:.|..|.:.: |...|:..|..:   .:.||.:..|..|.:.:....::.::    |.|.:|
Human    30 YMVLVPSLLHTEAPKKGCVLLSHLNE---TVTVSASLESGRENRSLFTDLVAEKDLFHCVSFTLP 91

  Fly    83 KLATGN----YNLSAEGVSGVVFKNSTKLNYADKKPSVFVQTDKATYKPADLVQFRILFLDENTR 143
            :::..:    .::..:|.:....|.:|.| ..:.:..|||||||..|||...|:||::.:|||.|
Human    92 RISASSEVAFLSIQIKGPTQDFRKRNTVL-VLNTQSLVFVQTDKPMYKPGQTVRFRVVSVDENFR 155

  Fly   144 PAKIEKPISVIIIDGAQNRIKQLSDVKLTKGVFSGELQLSEQPVLGTWKISVSVDGDNRETKSFE 208
            |.....|: :.:.:..:|||.|...:||..|:......||.:|:.|::::.|..:...|....|.
Human   156 PRNELIPL-IYLENPRRNRIAQWQSLKLEAGINQLSFPLSSEPIQGSYRVVVQTESGGRIQHPFT 219

  Fly   209 VDKYVLPKFEVIVDTPKAVVIADKVIKATIRAKYTYGKPVKGKATVSMERSYG------------ 261
            |:::|||||||.|..||.:.|.|:.:..|:..:|||||||.|.||||:.|...            
Human   220 VEEFVLPKFEVKVQVPKIISIMDEKVNITVCGEYTYGKPVPGLATVSLCRKLSRVLNCDKQEVCE 284

  Fly   262 -YFGDLNANG----NKQEKTIDVDGKGHVEFDIIHWAQRGQYLPPIKLFAVVTE-----ELTGNK 316
             :...||:||    ....|.:.:...|   |::           .:::.|.:.|     |:|.|:
Human   285 EFSQQLNSNGCITQQVHTKMLQITNTG---FEM-----------KLRVEARIREEGTDLEVTANR 335

  Fly   317 QNATATVVLHQQRYSIEPYERPEHFEANKSFIYQVVVKNVDGSPVTNSAKNVKIGFDKSYSYFHE 381
            .:....:|...:...::     .||.....|..||::.:..|.|:.|....:.:.....||    
Human   336 ISEITNIVSKLKFVKVD-----SHFRQGIPFFAQVLLVDGKGVPIPNKLFFISVNDANYYS---- 391

  Fly   382 PSPKTRINFEAPVNENGIATFNVRL----------------PDSDSRYYRIFASFDGSENTI--- 427
                     .|..||.|:|.|::..                |:....|..:.....|:::|.   
Human   392 ---------NATTNEQGLAQFSINTTSISVNKLFVRVFTVHPNLCFHYSWVAEDHQGAQHTANRV 447

  Fly   428 ----GSISKFEPT----PMSR-EPLKIQVNTKKPRLGEQVSFDVVSIEDLPYFVYTIVARGNVIL 483
                ||....||.    |... |.:.......:..:||        :.:|. |.|.|:|:|.::.
Human   448 FSLSGSYIHLEPVAGTLPCGHTETITAHYTLNRQAMGE--------LSELS-FHYLIMAKGVIVR 503

  Fly   484 SDYVDVP----DGQKTYTVKFTPTFSMVPKATIYVYYVV-NNDLQFEEKTIDFEKEFSNSIDVS- 542
            |....:|    |.:.::.:.|.....:.|.|.::::.:: :.::..:.:..:.|...:|.:|:| 
Human   504 SGTHTLPVESGDMKGSFALSFPVESDVAPIARMFIFAILPDGEVVGDSEKFEIENCLANKVDLSF 568

  Fly   543 APTNAKPSEEVKLRIKTDADSFVGLLGVDQSVLLLKSGNDLSQDDIFNSLNIYQTST-------- 599
            :|..:.|:....|::.....|...|..|||||||:|...:||...::|.|.:...:.        
Human   569 SPAQSPPASHAHLQVAAAPQSLCALRAVDQSVLLMKPEAELSVSSVYNLLTVKDLTNFPDNVDQQ 633

  Fly   600 ---------PWM--NG-------------YGRYPGQTSGLVTLTNANYPYNTGPLVMSYVFEGSR 640
                     |:.  ||             |....|.  ||...||:.........|:..|..|: 
Human   634 EEEQGHCPRPFFIHNGAIYVPLSSNEADIYSFLKGM--GLKVFTNSKIRKPKSCSVIPSVSAGA- 695

  Fly   641 HPWITRPRYRVGIRGDSGDRISFLSQ----SLNDRNLKEILLKQT--PQRTTIRKEFPETWFFEN 699
                      || :|..|..:..:.:    .|...|:..:..:|:  |...|:|..|||||.:|.
Human   696 ----------VG-QGYYGAGLGVVERPYVPQLGTYNVIPLNNEQSSGPVPETVRSYFPETWIWEL 749

  Fly   700 V-----GEEEFTLTKKIPDTITSWVVTGFSLNPTSGIALTKNPSKIRVFQPFFVSTNLPYSVKRG 759
            |     |..|..:|  :|||||.|....|.|:..:|:.::...| :|.||||||...:||||.||
Human   750 VAVNSSGVAEVGVT--VPDTITEWKAGAFCLSEDAGLGISSTAS-LRAFQPFFVELTMPYSVIRG 811

  Fly   760 EVIAIPVVIFNYLDKTLDADVVMDNSDQEYEFTEATNEVLEKAIDEVRRVKRVTIPANSGKSVSF 824
            ||..:...:.|||.|.:...|.:..|.   .|..:.|...|::         ..|..|..:::|:
Human   812 EVFTLKATVLNYLPKCIRVSVQLKASP---AFLASQNTKGEES---------YCICGNERQTLSW 864

  Fly   825 MIRPKNVGFTTLKITATS----ALAG------------DAIHQKLKVEPEGVTLFENRAVFINL- 872
            .:.||.:|.....::|.:    .|.|            |.:.:.|.||.||:   |....|.:: 
Human   865 TVTPKTLGNVNFSVSAEAMQSLELCGNEVVEVPEIKRKDTVIKTLLVEAEGI---EQEKTFSSMT 926

  Fly   873 -KDQPEMSQSLDADIPNEVVPQSEFIEFSVVGDLLGPTLQNLDNLVRMPYGCGEQNMVNFVPNIL 936
             .....:|:.|...:|:.||.:|....|||:||:||..:||:.||::|||||||||||.|.|||.
Human   927 CASGANVSEQLSLKLPSNVVKESARASFSVLGDILGSAMQNIQNLLQMPYGCGEQNMVLFAPNIY 991

  Fly   937 VLKYLEVTGRKLPSVESKARKFLEIGYQRELTYKHDDGSYSAFGK--SDASGSTWLTAYVMRSFH 999
            ||.||..|.:....:::||..:|..||||:|.|||.|||||.||:  ....|:|||||:|:::|.
Human   992 VLNYLNETQQLTQEIKAKAVGYLITGYQRQLNYKHQDGSYSTFGERYGRNQGNTWLTAFVLKTFA 1056

  Fly  1000 QAGTYTDIDPKVITAGLDFLVSKQKESGEFPEVGKLFDNA----NQNPLALTSFVLLAFFENHEL 1060
            ||.:|..||...||..|.:|...||::|.|...|.|.:||    .::...|:::|.:|..|..  
Human  1057 QARSYIFIDEAHITQSLTWLSQMQKDNGCFRSSGSLLNNAIKGGVEDEATLSAYVTIALLEIP-- 1119

  Fly  1061 IPKYQSAIKKAV------RYVAEEADKTDDQYSLAIAAVALQ-LAKHPQSEKVIAKLESVARKEN 1118
            :|.....::.|:      ..||:|.......|:.|:.|.|.. |.|..|:.:::..|:..|.||:
Human  1120 LPVTNPIVRNALFCLESAWNVAKEGTHGSHVYTKALLAYAFSLLGKQNQNREILNSLDKEAVKED 1184

  Fly  1119 DRMWWSKATESTGEDGRVFHWKPRSNDVEITSYVLLALLEKDPA------EKALPIIKWLISQRN 1177
            :.:.|.:........|.::..:..|.:||:|||||||.|...||      ..|..|:||::.|:|
Human  1185 NLVHWERPQRPKAPVGHLYQTQAPSAEVEMTSYVLLAYLTAQPAPTSGDLTSATNIVKWIMKQQN 1249

  Fly  1178 SNGGFSSTQDTVIGLQALTKFAYKTGSGS-GTMDIEFSSAGESKNTIKVNPENSLVLQTHDLPKS 1241
            :.||||||||||:.|.||:::...|.:.: .|..:....:.......:|:..|.|:||...||:.
Human  1250 AQGGFSSTQDTVVALHALSRYGAATFTRTEKTAQVTVQDSQTFSTNFQVDNNNLLLLQQISLPEL 1314

  Fly  1242 TRKVDFTAKGTGSAMVQLSYRYN-LAEKEKKP-------------------SFKVTPTVKDTPNQ 1286
            ..:...|..|.....:|.|.:|| |.|||..|                   ||:::.|:..|.|:
Human  1315 PGEYVITVTGERCVYLQTSMKYNILPEKEDSPFALKVQTVPQTCDGHKAHTSFQISLTISYTGNR 1379

  Fly  1287 LLIVDVCAEYVPLEDADKDKDSNMAVMEIALPSGFVGDSTSLGKIQAVDRVKRVETKNSDSTVVV 1351
                               ..|||.::::.:.|||:....::..::....|.|.|..|:.  |::
Human  1380 -------------------PASNMVIVDVKMVSGFIPLKPTVKMLERSSSVSRTEVSNNH--VLI 1423

  Fly  1352 YFDSLTPGDVRCLPLEASKAHAVAKQKPASVSLYDYYDT 1390
            |.:.:| ...........:...|...|||.|.:||||:|
Human  1424 YVEQVT-NQTLSFSFMVLQDIPVGDLKPAIVKVYDYYET 1461

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tep2NP_523506.1 A2M_N 115..209 CDD:280081 33/93 (35%)
A2M_N_2 445..576 CDD:285005 28/136 (21%)
A2M 694..782 CDD:278630 37/92 (40%)
A2M_2 909..1198 CDD:239227 121/307 (39%)
A2M_comp 961..1199 CDD:284982 94/256 (37%)
A2M_recep 1308..1398 CDD:284981 23/83 (28%)
PZPXP_011519106.1 A2M_N 128..220 CDD:280081 33/92 (36%)
A2M_N_2 457..602 CDD:285005 32/153 (21%)
A2M 744..834 CDD:278630 37/92 (40%)
SVA <796..891 CDD:283081 30/106 (28%)
A2M_2 964..1270 CDD:239227 121/307 (39%)
A2M_comp 1016..1272 CDD:284982 94/257 (37%)
A2M_recep 1382..1464 CDD:284981 23/83 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165149984
Domainoid 1 1.000 84 1.000 Domainoid score I8230
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D177369at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100452
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X292
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.650

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