Protein Alignment Tep2 and LOC569025

DIOPT Version :9

• Sequence 1: NP_523506.1
• Gene: Tep2 / 34044
• FlyBaseID: FBgn0041182
• Length: 1420
• Species: Drosophila melanogaster
• Sequence 2: XP_697477.6
• Gene: LOC569025 / 569025
• -ID: -
• Length: 1479
• Species: Danio rerio
• Alignment Length: 1593
• Identity: 440/1593 - (27%)
• Similarity: 702/1593 - (44%)
• Gaps: 316/1593 - (19%)

  Fly     1 MFRIFLTGIILQYALLVNATGI----YSVVGPGTLRSNSKYNVVVSVHKADGPSQIKVSLNGPSY 61
            |..|...|:::...||..:.|.    :.|..|..:||.|:..:.:|:.|.:...|:.::|...:.
Zfish     2 MALIHKRGLLITCFLLFVSQGTSKPNFMVTFPAIIRSGSEAKLCMSLLKPEKNLQLTITLVSSNQ 66

  Fly    62 NETKQIELPPMSTQN-----VEFEVPKLAT---------GNYNLSAEGVSGVVFKNSTKLNYADK 112
            |.|    |....|:.     ::|:.|:.|:         |.|....|         ..|:.:...
Zfish    67 NRT----LLQEKTEKEFHRCLDFQAPESASVQEIYVEAQGKYTHLIE---------KRKVKFVSH 118

  Fly   113 KPSVFVQTDKATYKPADLVQFRILFLDENTRPAKIEKPISVIII-DGAQNRIKQLSDVKLTKGVF 176
            .|...::|||..|.|...|||||..:|.:.:|  :::...:|.| |...|||.|..:...|.|..
Zfish   119 NPLTLIKTDKPIYNPGKTVQFRIFTIDFDFKP--VDETYKLIAIQDNRGNRINQWINATSTHGKI 181

  Fly   177 SGELQLSE----QPVLGTWKISVSVDGDNRETKSFEVDKYVLPKFEVIVDTPKAVVIADKVIKAT 237
               ||||.    :..:|.:::||..: ..:..:.|:|.:||||||||.:..||.|...:|.:|..
Zfish   182 ---LQLSHSLNPEASVGLYELSVETN-KGKFLEFFQVKEYVLPKFEVKIHKPKLVRGNEKEVKLG 242

  Fly   238 IRAKYTYGKPVKGKATVSMERS---YGYFGD-------------LNANGNKQEKTIDVDGKGHVE 286
            :..:||:|:||.|:..:::..|   ..|||.             ||..|...|.
Zfish   243 VCGRYTHGRPVLGRVKMTLCSSRIINSYFGSHYQIPFCVTGSAVLNKTGCAFEM----------- 296

  Fly   287 FDIIHWAQRG--QYL--PPIKLFAVVTEELTGNKQNATATVVLHQQRYSIEPYERPEHFEANKSF 347
            |.:..:.|:.  :|:  ..::..|.:|||.||..:..|..|.|.....:::..:.|:.:|.....
Zfish   297 FPLSSFIQKSVVEYITSQSLEFTASITEEGTGITEGGTEKVTLSYIIGTVKFIDVPDFYEEGSVI 361

  Fly   348 IYQVVVKNVDGSPVTNSAKNVKIGFDKSYSYFHEPSPKTRINFEAPVNENGIATFNVRLPDSDSR 412
            ..:|.|:..:|.||:    |:|:       ..:.||...    |...:.||:|.|.:     |:.
Zfish   362 KAKVKVELFNGQPVS----NIKL-------VVYVPSGIG----ELITDINGLANFTI-----DTS 406

  Fly   413 Y-----------------YRIFASFDGSENTIGSISKFEPTPMSR-------EPLKIQVN---TK 450
            :                 :..| |||.:..|:....|.:....|:       ||||..|.   |.
Zfish   407 FGIGTTLILTASLLSTPEFVPF-SFDSAHKTLQKKPKQDSFNKSQLDIKALEEPLKCGVEISVTV 470

  Fly   451 KPRLGEQVSFDVVSIEDLPYFVYTIVARGNVILSDYVD--------VPDGQKTYTVKFTPTFSMV 507
            :..:..:.:..|.       .||.:::|..::...|..        |..|:.|:.|.|..  .|.
Zfish   471 QYTIARETAESVT-------IVYLVLSRAQIVSHGYESIELKGSDRVVKGEVTFKVPFRS--RMA 526

  Fly   508 PKATIYVYYVV-NNDLQFEEKTIDFEKEFSNSIDVS-APTNAKPSEEVKLRIKTDADSFVGLLGV 570
            |:.....|.|: :.::....||...||.|.|.:.:. :||.|.|.||..|::.....|..|:..|
Zfish   527 PEIQFLAYCVLPSENVLAASKTFQTEKCFENKVSLRFSPTTAVPGEENTLQLSAQPGSLCGISAV 591

  Fly   571 DQSVLLLKSGNDLSQDDIFNSLNIYQTST-----------------------PWMNGYGRYP--- 609
            |||||:|:||..|..|.:|..|   .|.|                       |.::.||..|
Zfish   592 DQSVLILESGQRLDADKVFKML---PTMTFTYDVEDQMECLKFRSKRSLRFMPAISQYGAVPSYH 653

  Fly   610 -------GQTSGLV--TLTNANYPYNTGPLVMSYVFEGSRHPWITRPR----------YRVGI-- 653
                   |.|...|  |..|......|..::        |.|...:.|          |.||.
Zfish   654 NMYPPLSGSTGDAVFETFKNMGLKVATNLVI--------RIPHCIKFRDVLFQRAYGGYGVGFGY 710

  Fly   654 ----RGDSGDRISFL-------------------SQSLNDRNLKEILLKQTPQRTTIRKEFPETW 695
                ||.....|..|                   ::.|....|..:.:...|:. |||..|||||
Zfish   711 GAVPRGIDPPAIPALAGAPGAGALIPARGGVVAEAERLIPSPLPTLSISLLPEE-TIRTFFPETW 774

  Fly   696 FFENV-----GEEEFTLTKKIPDTITSWVVTGFSLNPTSGIALTKNPSKIRVFQPFFVSTNLPYS 755
            .:|.|     |..|..:|  :|||||||....|.|:.| |:.|.. |:|:.||||||:..:||||
Zfish   775 IWEIVEVGDSGSAEVPVT--VPDTITSWATEAFCLSST-GLGLAP-PAKLIVFQPFFLELSLPYS 835

  Fly   756 VKRGEVIAIPVVIFNYLDKTLDADV---------VMDNSDQEYEFTEATNEVLEKAIDEVRRVKR 811
            :.|||:..:...:|||..|.:...|         :..:||.:|.
Zfish   836 IVRGEIFELKATVFNYQSKCIMVKVSPAPSSDYTLKASSDDQYS--------------------- 879

  Fly   812 VTIPANSGKSVSFMIRPKNVGFTTLKITATSALAG----------------DAIHQKLKVEPEGV 860
            ..:.||..|:..:::.|..:|...:.::|.:..:.                |.:.:.|:|..||:
Zfish   880 SCLCANGRKTFKWILTPSVLGVVNVTVSAEAEASQTVCDNEIVSVPERGRIDTVTRSLRVNAEGI 944

  Fly   861 TLFENRAVFINLKDQPEMSQSLDADIPNEVVPQSEFIEFSVVGDLLGPTLQNLDNLVRMPYGCGE 925
            ...::.:..:..|.|..: :.::...|..|:..|.....||:|||||..|:|||.|:||||||||
Zfish   945 EKTKSHSWLLCPKGQNHL-EEVELAFPQNVIEGSGRATVSVLGDLLGRALKNLDGLLRMPYGCGE 1008

  Fly   926 QNMVNFVPNILVLKYLEVTGRKLPSVESKARKFLEIGYQRELTYKHDDGSYSAFGKSDASGSTWL 990
            ||:....|||.:|:|||.|.:...::..:|..||:.||||:|.|.:.||||:.||:.:  |:|||
Zfish  1009 QNIAVLSPNIYILQYLENTNQLTSAIRERASGFLKSGYQRQLNYLNLDGSYTTFGQGE--GNTWL 1071

  Fly   991 TAYVMRSFHQAGTYTDIDPKVITAGLDFLVSKQKESGEFPEVGKLFDNANQ----NPLALTSFVL 1051
            ||:|:|:|.:|..|..|||..|....::|||.|:..|.:...||||:|..:    :.:.:|:::.
Zfish  1072 TAFVLRTFGKAQDYIFIDPPKIEKSKEWLVSHQRPDGSYQIKGKLFNNRMKGGVSDSVTITAYIT 1136

  Fly  1052 LAFFENHELIPKYQSAIKKAVRYVAEEADKTDDQYSLAIAAVALQLAKHPQ-SEKVIAKLESVAR 1115
            .:..|.:  ||....|:.|.:.::.:.|....:.|:.|:.:....|||..: .:.::.||:::|.
Zfish  1137 ASLLELN--IPVTDPAVSKGLSHLKQYAGDIRNLYTSALLSYTFSLAKDKEVRDSLLNKLKNIAI 1199

  Fly  1116 KENDRMWWSKATESTGEDGRVFHWKPRSNDVEITSYVLLALLEKDPAEK-----ALPIIKWLISQ 1175
            .|...:.||::..:...|         |.||||:||||||:|..|....     |..|:.||:.|
Zfish  1200 SEGPLVHWSQSASADDSD---------SLDVEISSYVLLAVLTADSLTTADLGFANRIVSWLVKQ 1255

  Fly  1176 RNSNGGFSSTQDTVIGLQALTKFAYKTGSGSGTMDIEFSSAGESKNTIKVNPENSLVLQTHDLPK 1240
            :|:.||||||||||:.||||:.:|.|..|..|:..:...|||:|.: ..||.:|.|:.|...|..
Zfish  1256 QNAYGGFSSTQDTVVALQALSLYATKVFSSDGSSTVTVQSAGDSHH-FDVNQDNKLLYQEKQLAN 1319

  Fly  1241 STRKVDFTAKGTGSAMVQLSYRYNLAEKEKKP----SFKVTPTVKDTPNQLLIVDVCAEYVPLED 1301
            ...|.....||:....||:|..||:...:|..    |.|...|.::|..|:|.|.:...|..::.
Zfish  1320 VPGKYSIEVKGSACVSVQMSLFYNIPTPKKSNKLEFSVKTEGTCQNTDWQILDVILNIVYKGIQY 1384

  Fly  1302 ADKDKDSNMAVMEIALPSGFVGDSTSLGKI-QAVDRVKRVETKNSDSTVVVYFDSLTPGDVRCLP 1365
            .:   .|||.::::.|.|||..:...:.:: :||.||     ::||..::||.:.:.......||
Zfish  1385 IE---TSNMIIVDMKLLSGFSAEPIFMDEVKKAVSRV-----ESSDEHIIVYLNEIRNNINYRLP 1441

  Fly  1366 LEASKAHAVAKQKPASVSLYDYYDT-ERKATEY 1397
            ....:..:|...|||.:.:||||.| ||...||
Zfish  1442 FRIKRIFSVKNLKPAVIKVYDYYQTSERAEAEY 1474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep2	NP_523506.1	A2M_N	115..209	CDD:280081	29/98 (30%)
		A2M_N_2	445..576	CDD:285005	36/143 (25%)
		A2M	694..782	CDD:278630	39/101 (39%)
		A2M_2	909..1198	CDD:239227	115/298 (39%)
		A2M_comp	961..1199	CDD:284982	89/247 (36%)
		A2M_recep	1308..1398	CDD:284981	30/92 (33%)
LOC569025	XP_697477.6	A2M_N	126..214	CDD:280081	29/93 (31%)
		A2M_N_2	453..596	CDD:285005	39/151 (26%)
		A2M	773..861	CDD:278630	38/91 (42%)
		A2M_2	992..1278	CDD:239227	115/298 (39%)
		A2M_comp	1044..1280	CDD:284982	89/248 (36%)
		A2M_recep	1388..1474	CDD:284981	28/90 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010