DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tep2 and c3b.2

DIOPT Version :9

Sequence 1:NP_523506.1 Gene:Tep2 / 34044 FlyBaseID:FBgn0041182 Length:1420 Species:Drosophila melanogaster
Sequence 2:XP_009294666.1 Gene:c3b.2 / 566347 ZFINID:ZDB-GENE-030131-3063 Length:1769 Species:Danio rerio


Alignment Length:1671 Identity:398/1671 - (23%)
Similarity:684/1671 - (40%) Gaps:385/1671 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 YSVVGPGTLRSNSKYNVVVSVHKA-----------DGP------SQIKVSLNGP-SYNETKQIEL 69
            :|::.|..:|..:|.|::|..|..           |.|      |:..||||.. :|:..:.:|:
Zfish    47 FSLLAPAKIRPGTKQNILVEGHNLAKVVKVTVVVYDYPNSQTALSRGSVSLNSDNNYSVLQTLEI 111

  Fly    70 -PPMSTQNVEFEVPKLATGNYNL-SAEGVSGVVFKNSTKLNYADKKPSVFVQTDKATYKPADLVQ 132
             |.:...:.:.:..||.....|: .||.|..|.|::.          .:|:||||..|.|.|.|:
Zfish   112 NPNLLLPDGKKKYVKLVAQFSNIYRAEKVMAVSFRSG----------HIFIQTDKPIYNPGDKVR 166

  Fly   133 FRILFLDENTRPAKIEKPISVIIIDGAQNRIKQLSDVKLTKGVFSGELQLSEQPVLGTWKISVSV 197
            ||....|...|.:  |:.||:.|.:.....:..:..||...||||....||.....|.||:....
Zfish   167 FRAFVSDLEFRSS--ERTISLEIQNPDGIAVHGIGRVKAIDGVFSDIFSLSTVVKEGRWKVVAKF 229

  Fly   198 D--GDNRETKSFEVDKYVLPKFEVIVDTPKAVVI---ADKVIKATIRAKYTYGKPVKGKATVSME 257
            |  .:|..::.|||.|||||.|.|.: |||...:   |:| ::..|.|:|.||..|||.|     
Zfish   230 DQGKENVFSREFEVKKYVLPAFNVTL-TPKTSHLSLDAEK-LEVEITARYLYGAQVKGVA----- 287

  Fly   258 RSYGYFGDLNANGNKQE----KTIDVDGKGHVEFDIIHWAQRGQYLPPIKLFAVVTEELTGNKQN 318
              |..|| :..||.|:.    |.||....|.|...:   .:..:..|.|......|..:..:...
Zfish   288 --YVLFG-IEINGEKKRLTSMKQIDDLNGGSVSLTM---EEIKRAYPDINSLLGSTVYVKASVLT 346

  Fly   319 ATATVVLHQQRYSIE----PY-----ERPEHFEANKSFIYQVVVKNVDGSPVTNSAKNVKIGFDK 374
            ::.:.::..::..|:    ||     :.|::::........|:|.|.||||..|..  ||:.|.|
Zfish   347 SSGSDLVEAEKSGIKIVNSPYMLTIKDTPKYYKPGLPLAMTVIVSNHDGSPTPNIP--VKVTFLK 409

  Fly   375 SYSYFHEPSPKTRINFEAPVNENGIATFNVRLPDSDSRYYRIFASFDGSENTIGSISKFEPTPMS 439
            .....|..:....||..           ..|:|..:|:..::.......:....:|.:....|.|
Zfish   410 RPISVHSGTINIHINMP-----------KKRIPYGNSQMLKVETVDPSLKPEQQAIQEVYVKPYS 463

  Fly   440 R-----EPLKIQVNTKKPRLGEQVSFDVVSIEDLP-------YFVYTIVARGNVILSDYVDVPDG 492
            .     ..|.:.|...:..:|..:|..|.....||       :..|.::.:|.:|.:..|:| .|
Zfish   464 TFRSHGNYLHVSVGASRVVVGGSISVQVYIKSSLPNHRALVEHLTYIVLNKGKIIQAGRVNV-KG 527

  Fly   493 QKTYTVKFTPTFSMVPKATIYVYYVV----NNDLQFEEKTIDFEKEFSNSIDVSAPTNAK----- 548
            |...:|....|..|:|......|||:    ..::..:...:|.|.....|::| .|.:.:     
Zfish   528 QDVTSVHLLITSEMLPAFRFVAYYVLPWQHRAEVVADSVFVDVEDRCVGSLNV-GPVDGEIVSSY 591

  Fly   549 -PSEEVKLRIKTDADSFVGLLGVDQSVLLLKSGNDLSQDDIFNSLN------------------- 593
             |....|.::|.|..:.|.|:.||.::.|| |.|.|:|..::..::                   
Zfish   592 SPGSSFKFQVKGDVGAKVSLVAVDNAIFLL-SKNRLTQKKVWEVVDQADMGCTAGGGKDNMGVFS 655

  Fly   594 ----IYQTST------------------------------------------------------- 599
                ::.:||                                                       
Zfish   656 DAGLMFHSSTGGSTDSKEDCSSKTKRRRRSAAKLQLRDQLEKAYSDELLQRCCVDGMKEIPMPYS 720

  Fly   600 ----------PW------MNGYGRYPGQTSGLVT---LTNANYPYNTGPLVMS--------YV-F 636
                      .|      :.....|.|:..|::|   .|.|  |..|.|...|        |: :
Zfish   721 CYRRSLYITEDWSCVLAFLRCCAEYRGEELGVITRPPTTTA--PPTTAPPTTSLPTLFDLPYLEY 783

  Fly   637 EGSRHPWITRPRY------------RVGIRGDSGDRI-----------SFLSQSLNDRNLKEILL 678
            :......|.|.|.            .||:|.||...:           .|....|:|  |::|. 
Zfish   784 DYMEEKVILRARMIEPMPKLYARANDVGVRQDSYREVVVEEEEEEAASVFEEDDLSD--LEDIY- 845

  Fly   679 KQTPQRTTIRKEFPETWFFENV---------GEEEFTLTKKIPDTITSWVVTGFSLNPTSGIALT 734
                    :|.:|.|:|.:.::         |...|.:...:||:||.|.....|.:|..|:.:.
Zfish   846 --------VRSKFFESWLWTDIRLPSTAKSDGLAVFPVDTVLPDSITQWGFLAVSASPEKGVCVA 902

  Fly   735 KNPSKIRVFQPFFVSTNLPYSVKRGEVIAIPVVIFNYLDKTLDADVVMDNSDQEYEFTEATNEVL 799
            : |..:||::|||:...||:||.|.|.:.|..||.||.:.||:..|::          |.|.::.
Zfish   903 E-PYNVRVWKPFFIDLRLPHSVSRNEQVEIKAVIHNYKNSTLEVMVIL----------EKTEDMC 956

  Fly   800 EKAIDEVRRVKRVTIPANSGKSVSFMIRPKNVGFTTLKITATSA--LAGDAIHQKLKVEPEGVTL 862
            ..|.....| ::||:.|.|.|.:::.|.|...|...|::||.:|  :..||:.:.|:|..||:..
Zfish   957 SVAYTGQHR-QQVTVAAGSSKLITYTIIPLKTGELPLQVTAVAASFMGQDAVKKNLRVVVEGIQT 1020

  Fly   863 FENRAVFINLKDQ-----PEMSQ----SLDADIPNEVVPQSEFIEFSVVGDLLGPTLQN------ 912
            .:.|:..:|..::     .::.|    .|||.:|.. ||:: |:  :|.||||..::.|      
Zfish  1021 LKVRSFVLNPSEKGGSAGQQLIQVKKLQLDAVVPKS-VPET-FV--NVRGDLLADSIDNSIKEDS 1081

  Fly   913 LDNLVRMPYGCGEQNMVNFVPNILVLKYL------EVTGRKLPSVESKARKFLEIGYQRELTYKH 971
            |..|:|||.||.|||:......::...||      |:.|   .|...:|.|:::.||:.:|.||.
Zfish  1082 LAALIRMPGGCVEQNLARITLPLIAAHYLDRSADWEIVG---ISRREEAIKYIQKGYENQLNYKK 1143

  Fly   972 DDGSYSAFGKSDASGSTWLTAYVMRSFHQAGTYTDIDPKVITAGLDFLV-SKQKESGEFPEVGKL 1035
            .|.||..:  ::...|||:||||::.|..|.::..::.|.:...|.:|: :||...|.|.|...:
Zfish  1144 SDDSYPPY--ANEGTSTWITAYVVKVFSMAHSFITVNEKHLCGPLLYLLKNKQGYDGTFQEDNPV 1206

  Fly  1036 FDNA-------NQNPLALTSFVLLAFFENHELIPKYQSAI------KKAVRYVAEEADKTDDQYS 1087
            :|.:       ::...:||:|||:|..|..:.:......:      ::|..|:.|...:....|:
Zfish  1207 YDTSMTGAMRGSEYKASLTAFVLIALAEAQDKVTCQDQEVNIRDKSRQAAGYLTEHFSRLTRPYT 1271

  Fly  1088 LAIAAVALQLAKHPQSEKVIAKLESVARKENDRMWWSKATESTGEDGRVFHWKPRSND----VEI 1148
            .|||..||.::.:...:.::.|..|....                     || |.||:    :|.
Zfish  1272 AAIACYALAVSNNACVKSMLLKFASPDHS---------------------HW-PDSNNYFFTLEA 1314

  Fly  1149 TSYVLLALLEKDPAEKALPIIKWLISQRNSNGGFSSTQDTVIGLQALTKFAYKTGSGSG-TMDIE 1212
            |.|.||||::....|:|....:||...|...||:.|||.|::.||||:::..|....|. .:.::
Zfish  1315 TGYALLALIKSGHMEEAEAPFRWLNEHRGIGGGYGSTQSTMVVLQALSEYLVKRPPPSDLNLLVQ 1379

  Fly  1213 FSSAGESKNTIKVNPENSLVLQTHDLPKSTRKVDFTAKGTGSAMVQLSYRY-------------- 1263
            .|..|.|......||..:.|.::..:|.. ::....|.|.|..::::...|              
Zfish  1380 LSVPGRSDVRWTFNPNLAYVARSSRVPLD-QEFSVAASGNGKGVLEVVTVYHQLPDVYENSTCNG 1443

  Fly  1264 -----NLAEKEKKPSFKVTPTVKDTPNQLLIVDVCAEYVPLEDADKDKDSNMAVMEIALPSGFVG 1323
                 ::||..:|.|..|..:.:      |.|:|.|    ||    ::...|.:::|.||:||..
Zfish  1444 FQLDVSIAETNEKTSSDVEKSFR------LNVNVRA----LE----ERQVRMVILDIGLPTGFEP 1494

  Fly  1324 DSTSLGKI-QAVDR----VKRVETKNSDSTVVVYFDSLTPGDVRCLPLEASKAHAVAKQKPASVS 1383
            :::.|..: .:|||    .:.|:..:...:::::...::..:...:....::...|...:|::|.
Zfish  1495 ENSDLELLTNSVDRYINNFQVVDNLSDRGSLIIHLFKVSNKEAEIISFRLNQRFKVGLLQPSTVK 1559

  Fly  1384 LYDYYDTERKATEYY---QVKSSLCDICEGADC----GEGC--KKD 1420
            :|.||:.::..:.:|   :.|..|..||||..|    |:.|  |:|
Zfish  1560 VYQYYNKDKSCSRFYSPPEDKQQLDQICEGDVCRCSQGDCCVMKED 1605

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tep2NP_523506.1 A2M_N 115..209 CDD:280081 31/95 (33%)
A2M_N_2 445..576 CDD:285005 33/147 (22%)
A2M 694..782 CDD:278630 31/96 (32%)
A2M_2 909..1198 CDD:239227 89/318 (28%)
A2M_comp 961..1199 CDD:284982 71/255 (28%)
A2M_recep 1308..1398 CDD:284981 17/94 (18%)
c3b.2XP_009294666.1 A2M_N 150..243 CDD:280081 31/94 (33%)
A2M_N_2 489..620 CDD:285005 30/132 (23%)
ANATO 692..748 CDD:237984 2/55 (4%)
A2M 853..949 CDD:278630 31/96 (32%)
TRAPPC10 <940..>992 CDD:289361 15/62 (24%)
complement_C3_C4_C5 1080..1364 CDD:239226 88/310 (28%)
A2M_comp 1133..1364 CDD:284982 71/254 (28%)
A2M_recep 1481..1574 CDD:284981 17/92 (18%)
NTR_like 1594..1767 CDD:295338 4/12 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170584202
Domainoid 1 1.000 56 1.000 Domainoid score I10957
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11412
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
65.800

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