Protein Alignment Tep2 and c3a.3

DIOPT Version :9

• Sequence 1: NP_523506.1
• Gene: Tep2 / 34044
• FlyBaseID: FBgn0041182
• Length: 1420
• Species: Drosophila melanogaster
• Sequence 2: NP_001032313.2
• Gene: c3a.3 / 565074
• ZFINID: ZDB-GENE-990415-37
• Length: 1651
• Species: Danio rerio
• Alignment Length: 1622
• Identity: 415/1622 - (25%)
• Similarity: 676/1622 - (41%)
• Gaps: 328/1622 - (20%)

  Fly     4 IFLTGIILQYALLVNATGIYSVVGPGTLRSNSKYNVVVSVHK-ADGPSQIKVSL-NGPSYN---E 63
            :||:.::|..|||.....:|.:..|..||..|..||.|.... :.||..:::|: |.|:.|   .
Zfish     6 LFLSAVLLSSALLTLCDPLYVLSAPNLLRVGSSENVFVEAQDYSGGPLNVRISVKNFPAKNVEMM 70

  Fly    64 TKQIELPPMSTQNV-EFEVPKLATGNYNLSAEGVSGVVFKNSTKLNYADKK---PSV-------- 116
            .|.:.|.....|:: :.::|    |:.|         .|.:..|..|...:   |||
Zfish    71 QKTVTLTGAKYQSLTDIQIP----GDRN---------YFSDDEKKQYVYLQAHFPSVTLEKVVMV 122

  Fly   117 -------FVQTDKATYKPADLVQFRILFLDENTRPAKIEKPISVIIIDGAQNRIKQLSDVKLTKG 174
                   ||||||..|.|...|.:||..:..|.:|  ..||...:.|...|........:...||
Zfish   123 SFQSGYLFVQTDKPIYTPGSNVHYRIFSMTPNLKP--FSKPGITVDITNPQGITVASDTIFAEKG 185

  Fly   175 VFSGELQLSEQPVLGTWKISVSVDGDNRE--TKSFEVDKYVLPKFEVIVDTPKAVVIA------- 230
            |.|....:.|...||.||:........::  |..|||.:||||.|||.:.|.|:....
Zfish   186 VKSSIYNIPEVTSLGMWKVVTRYANTPQKTFTAEFEVKEYVLPTFEVKLKTSKSFYYVGDSKPKN 250

  Fly   231 --DKVIKATIRAKYTYGKPVKGKATVSMERSYGYFGDLN-----ANGNKQEKTIDVDGKGHVEF- 287
              |..:...:.|||.:||.:.|.|.|       .||.::     :..|..:|....:|.|..|.
Zfish   251 NEDDSLTVDMEAKYLFGKKMDGNAFV-------VFGVMDGAMKTSIVNSLQKVQVFNGVGTAELT 308

  Fly   288 ---------DIIHWAQRGQYLPPIKLFAVVTEELTGNK---QNATATVVLHQQRYSIEPYERPEH 340
                     :|.....:..|:....|....:|.:...|   |..|:...:|.:|.|       :.
Zfish   309 REMITKTFKNIKDLVGKSIYVSVNLLTESGSEMVEAEKRGIQIVTSPYTIHYKRTS-------QF 366

  Fly   341 FEANKSFIYQVVVKNVDGSPVTNSAKNVKI--------GFDKSYSYFHEPSPKTRINFEAPVNEN 397
            |:........|.|.|.|.:|    |::|::        |.:.          ||:.|..|.|..|
Zfish   367 FKPGMPLGVSVYVTNPDETP----AEDVEVEVLVDGVGGVNS----------KTKANGIAKVTVN 417

  Fly   398 ---GIATFNVRLPDSDSRYYRIFASFDGSENTIGSISKFEPTPM-SREPLKIQVNTKKPRLGEQV 458
               |::|..:.....|..    .|:...::.|:  |::...|.: |:..|.|.:.:.:..:|:|:
Zfish   418 TKAGVSTLKITATTRDPE----LANEQQADKTM--IAQAYKTNLGSKNYLHINIESAEFEIGDQM 476

  Fly   459 SF-----DVVSIEDLPYFVYTIVARGNVILSDYVDVPDGQKTYTVKFTPTFSMVPKATIYVYYVV 518
            :.     :...::|.. |.|.|:::|.::|::... ..||...::....|..|||......||.|
Zfish   477 TVYLNTGESPGVKDQD-FTYMILSKGQIVLAERFK-RQGQTLVSLSLPVTKDMVPSFRFVAYYHV 539

  Fly   519 NNDLQFEEKT-IDFEKEFSNSIDVSAPTNAK---PSEEVKLRIKTDADSFVGLLGVDQSVLLLKS 579
            ..|....:.. :|.:......:.|......|   ...||.|:|..|..:.|||:.||::|.:|..
Zfish   540 GKDEVVSDSVWVDVKDTCMGKLKVEVTEKQKFYETGNEVNLQISGDFGARVGLVVVDKAVQVLNK 604

  Fly   580 GNDLSQDDIFNSLNIYQTSTPWMNGYGRYPGQTS-----------------GLVTLTNANYPYN- 626
             |.|:|..|::.:..:.|.   ..|.|   |:.|                 |..|.|....|..
Zfish   605 -NRLTQSKIWDVIEKHDTG---CTGGG---GKDSMGVFSDAGLMFESDPAGGTNTRTEPKCPAPP 662

  Fly   627 ------------TGPLVMSYV-------FEGSRHPWI-----TRPRYRVGIRGDSGDRI-SFLSQ 666
                        |..|...|.       ::|.|:..|     .|..|.:    |..:.: :||..
Zfish   663 KRKRRSESLQTITTTLAGQYTEKIRPCCYDGMRNNRIGYTCERRASYVI----DGEECVKAFLHC 723

  Fly   667 SLNDRNLKE------ILLKQTPQRT-----------TIRKEFPETWFFENVGEEEFTLTKK---- 710
            ....:|.||      ||.::..:.|           |.||:|||:|.:     |||.|..|
Zfish   724 CKEVKNHKETEEEELILARKDDEETYEEDYEDYDDITSRKQFPESWLW-----EEFDLCDKCSKP 783

  Fly   711 -------IPDTITSWVVTGFSLNPTSGIALTKNPSKIRVFQPFFVSTNLPYSVKRGEVIAIPVVI 768
                   :.|:||:|.:...||:||.||.:.: |.:|.||:.||:...:|||..|||.:.|..:|
Zfish   784 SKNKVTYLKDSITTWQILAISLSPTHGICVAE-PEEIVVFKSFFIDLKVPYSAVRGEQVEIKAII 847

  Fly   769 FNYLDKTLDADVVMDNSDQEYEFTEATNEVLEKAIDEVRRVKRVTIPANSGKSVSFMIRPKNVGF 833
            .||..|.|        .....||.| |..|...|..:.:....|.:..:|..:|||:|.|..:..
Zfish   848 HNYTPKHL--------KKVRVEFLE-TAGVCSAASKKGKYRATVNVDKDSSIAVSFVIVPMTLES 903

  Fly   834 TTLKITATSALAGDAIHQKLKVEPEGV-TLFENRAVFINLKDQPEMSQSLDADIPNEVVPQ---- 893
            ..:::.|:.....|.:.:.|||..||| |.|:::.:.:|...:.|....|.|.||.:.||.
Zfish   904 QHIEVKASILDYTDGVRKTLKVVSEGVLTKFQSQKLELNPAKKGEQPLLLRAGIPGDQVPGTPVH 968

  Fly   894 ----------SEFIEFSVVGDLLGPTLQNLDNLVRMPYGCGEQNMVNFVPNILVLKYLEVTGRKL 948
                      |:.||.::.|..:|       .|::.|.|||||||......::...||:.| .:.
Zfish   969 SYITVTGEEISQSIEHAINGSFMG-------ELIKRPGGCGEQNMAKMTLPVVATHYLDNT-NQW 1025

  Fly   949 PSVESKARK----FLEIGYQRELTYKHDDGSYSAFGKSDASGSTWLTAYVMRSFHQAGTYTDIDP 1009
            .||....||    .::.||..:|.|:..||||:.:  .:...||||||||.:.|..|..:..|:.
Zfish  1026 ESVGIDRRKVAINHIKTGYDGQLKYRKPDGSYAIW--INTPSSTWLTAYVAKVFAMANDFFAIEE 1088

  Fly  1010 KVITAGLDFLV-SKQKESGEFPEVGKLFDNA------NQN-PLALTSFVLLAFFENHEL----IP 1062
            .||.:.|.:|| .||...|.|.|...::|.:      .|| .::||:|||:|..|..|:    :.
Zfish  1089 NVICSALKWLVMHKQLPDGSFKEDAPVYDKSIMGGIEGQNTDVSLTAFVLIAMQEGKEICGGTVG 1153

  Fly  1063 KYQSAIKKAVRYVAEEADKTDDQYSLAIAAVALQLAKHPQSEKVIAKLESVARKENDRMWWSKAT 1127
            ....:::|||.::.::..|..:.|::|:.:.|  ||......|.|..:.|.  |.||..:|:...
Zfish  1154 SLHESMRKAVAFLKDQLPKLTNPYAVALTSYA--LANADSLNKAILMMHST--KVNDERFWNVPE 1214

  Fly  1128 ESTGEDGRVFHWKPRSNDVEITSYVLLALLEKDPAEKALPIIKWLISQRNSNGGFSSTQDTVIGL 1192
                   |.::      .:|.|:|.:|||::....:.|...:.||..|::|:||:.:||.|::..
Zfish  1215 -------RQYY------SIEATAYAVLALVKAKDYDTAGEAVHWLAKQKSSHGGYDTTQVTIMVF 1266

  Fly  1193 QALTKFAYKTGS-GSGTMDIEFSSAGESKN---TIKVNPENSLVLQTHDLPKSTRKVDFT--AKG 1251
            ||:.::..:|.. .:..:::|....|..|.   ||:.:..:.......||.|     |||  |||
Zfish  1267 QAVAEYHAQTQDLNNFDLNVELVVPGRRKTDRWTIQRSNVHLARSGNVDLNK-----DFTVIAKG 1326

  Fly  1252 TGSAMVQLSYRYNLAEKEKK---------------PSFKVTPTVKDTPNQLLIVDVCAEYVPLED 1301
            ||||::.:...|.....|||               |..|  |....|.|  .|:|...:
Zfish  1327 TGSAILSVLTLYYARPFEKKTDCTFFDLSVKLDKIPETK--PGTNGTYN--FILDFFYK------ 1381

  Fly  1302 ADKDKDSNMAVMEIALPSGFVGDSTSL-----GKIQAVDRVKRVETKNSDSTVVVYFDSLTPGDV 1361
             :|..|:.|.:::|.||:||..|...|     ||.:.:.:.::.:..:...::::|.:.::....
Zfish  1382 -NKKNDATMTILDIGLPTGFDIDEADLKQLSTGKERYIQKYEKNKVLSERGSLIIYLNKVSHEVS 1445

  Fly  1362 RCLPLEASKAHAVAKQKPASVSLYDYYDTERKATEYYQVK---SSLCDICEGADC---GEGC 1417
            ..|.....|...||..:||||::|:||..:.:..:||..:   |:|..:|:|..|   .|.|
Zfish  1446 EKLVFRMHKTFNVALLQPASVTIYEYYSPDARCKKYYHPEREDSALYRLCKGDLCVCAEENC 1507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep2	NP_523506.1	A2M_N	115..209	CDD:280081	30/110 (27%)
		A2M_N_2	445..576	CDD:285005	33/139 (24%)
		A2M	694..782	CDD:278630	34/98 (35%)
		A2M_2	909..1198	CDD:239227	91/304 (30%)
		A2M_comp	961..1199	CDD:284982	75/249 (30%)
		A2M_recep	1308..1398	CDD:284981	22/94 (23%)
c3a.3	NP_001032313.2	A2M_N	128..222	CDD:280081	28/95 (29%)
		A2M_N_2	463..599	CDD:285005	32/137 (23%)
		ANATO	674..737	CDD:237984	14/66 (21%)
		A2M	768..861	CDD:278630	34/106 (32%)
		complement_C3_C4_C5	987..1272	CDD:239226	93/311 (30%)
		A2M_comp	1042..1272	CDD:284982	75/248 (30%)
		A2M_recep	1387..1482	CDD:284981	22/94 (23%)
		NTR_complement_C3	1502..1649	CDD:239638	2/6 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584190
Domainoid	1	1.000	56	1.000	Domainoid score	I10957
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	6	5.800