Protein Alignment Tep2 and c3a.3

DIOPT Version :10

• Sequence 1: NP_523506.1
• Gene: Tep2 / 34044
• FlyBaseID: FBgn0041182
• Length: 1420
• Species: Drosophila melanogaster
• Sequence 2: NP_001032313.2
• Gene: c3a.3 / 565074
• ZFINID: ZDB-GENE-990415-37
• Length: 1651
• Species: Danio rerio
• Alignment Length: 1626
• Identity: 415/1626 - (25%)
• Similarity: 676/1626 - (41%)
• Gaps: 336/1626 - (20%)

  Fly     4 IFLTGIILQYALLVNATGIYSVVGPGTLRSNSKYNVVVSVHK-ADGPSQIKVSL-NGPSYN---E 63
            :||:.::|..|||.....:|.:..|..||..|..||.|.... :.||..:::|: |.|:.|   .
Zfish     6 LFLSAVLLSSALLTLCDPLYVLSAPNLLRVGSSENVFVEAQDYSGGPLNVRISVKNFPAKNVEMM 70

  Fly    64 TKQIELPPMSTQNV-EFEVPKLATGNYNLSAEGVSGVVFKNSTKLNYADKK---PSV-------- 116
            .|.:.|.....|:: :.::|    |:.|         .|.:..|..|...:   |||
Zfish    71 QKTVTLTGAKYQSLTDIQIP----GDRN---------YFSDDEKKQYVYLQAHFPSVTLEKVVMV 122

  Fly   117 -------FVQTDKATYKPADLVQFRILFLDENTRPAKIEKPISVIIIDGAQNRIKQLSDVKLTKG 174
                   ||||||..|.|...|.:||..:..|.:|  ..||...:.|...|........:...||
Zfish   123 SFQSGYLFVQTDKPIYTPGSNVHYRIFSMTPNLKP--FSKPGITVDITNPQGITVASDTIFAEKG 185

  Fly   175 VFSGELQLSEQPVLGTWKISVSVDGDNRE--TKSFEVDKYVLPKFEVIVDTPKAVVIA------- 230
            |.|....:.|...||.||:........::  |..|||.:||||.|||.:.|.|:....
Zfish   186 VKSSIYNIPEVTSLGMWKVVTRYANTPQKTFTAEFEVKEYVLPTFEVKLKTSKSFYYVGDSKPKN 250

  Fly   231 --DKVIKATIRAKYTYGKPVKGKATVSMERSYGYFGDLN-----ANGNKQEKTIDVDGKGHVEF- 287
              |..:...:.|||.:||.:.|.|.|       .||.::     :..|..:|....:|.|..|.
Zfish   251 NEDDSLTVDMEAKYLFGKKMDGNAFV-------VFGVMDGAMKTSIVNSLQKVQVFNGVGTAELT 308

  Fly   288 ---------DIIHWAQRGQYLPPIKLFAVVTEELTGNK---QNATATVVLHQQRYSIEPYERPEH 340
                     :|.....:..|:....|....:|.:...|   |..|:...:|.:|.|       :.
Zfish   309 REMITKTFKNIKDLVGKSIYVSVNLLTESGSEMVEAEKRGIQIVTSPYTIHYKRTS-------QF 366

  Fly   341 FEANKSFIYQVVVKNVDGSPVTNSAKNVKI--------GFDKSYSYFHEPSPKTRINFEAPVNEN 397
            |:........|.|.|.|.:|    |::|::        |.:.          ||:.|..|.|..|
Zfish   367 FKPGMPLGVSVYVTNPDETP----AEDVEVEVLVDGVGGVNS----------KTKANGIAKVTVN 417

  Fly   398 ---GIATFNVRLPDSDSRYYRIFASFDGSENTIGSISKFEPTPM-SREPLKIQVNTKKPRLGEQV 458
               |::|..:.....|..    .|:...::.|:  |::...|.: |:..|.|.:.:.:..:|:|:
Zfish   418 TKAGVSTLKITATTRDPE----LANEQQADKTM--IAQAYKTNLGSKNYLHINIESAEFEIGDQM 476

  Fly   459 SF-----DVVSIEDLPYFVYTIVARGNVILSDYVDVPDGQKTYTVKFTPTFSMVPKATIYVYYVV 518
            :.     :...::|.. |.|.|:::|.::|::... ..||...::....|..|||......||.|
Zfish   477 TVYLNTGESPGVKDQD-FTYMILSKGQIVLAERFK-RQGQTLVSLSLPVTKDMVPSFRFVAYYHV 539

  Fly   519 NNDLQFEEKT-IDFEKEFSNSIDVSAPTNAK---PSEEVKLRIKTDADSFVGLLGVDQSVLLLKS 579
            ..|....:.. :|.:......:.|......|   ...||.|:|..|..:.|||:.||::|.:|..
Zfish   540 GKDEVVSDSVWVDVKDTCMGKLKVEVTEKQKFYETGNEVNLQISGDFGARVGLVVVDKAVQVLNK 604

  Fly   580 GNDLSQDDIFNSLNIYQTSTPWMNGYGRYPGQTS-----------------GLVTLTNANYPYN- 626
             |.|:|..|::.:..:.|.   ..|.|   |:.|                 |..|.|....|..
Zfish   605 -NRLTQSKIWDVIEKHDTG---CTGGG---GKDSMGVFSDAGLMFESDPAGGTNTRTEPKCPAPP 662

  Fly   627 ------------TGPLVMSYV-------FEGSRHPWITRPRYRVG----------IRGDSGDRIS 662
                        |..|...|.       ::|.|:       .|:|          |.|:...: :
Zfish   663 KRKRRSESLQTITTTLAGQYTEKIRPCCYDGMRN-------NRIGYTCERRASYVIDGEECVK-A 719

  Fly   663 FLSQSLNDRNLKE------ILLKQTPQRT-----------TIRKEFPETWFFENVGEEEFTLTKK 710
            ||......:|.||      ||.::..:.|           |.||:|||:|.:     |||.|..|
Zfish   720 FLHCCKEVKNHKETEEEELILARKDDEETYEEDYEDYDDITSRKQFPESWLW-----EEFDLCDK 779

  Fly   711 -----------IPDTITSWVVTGFSLNPTSGIALTKNPSKIRVFQPFFVSTNLPYSVKRGEVIAI 764
                       :.|:||:|.:...||:||.||.:.: |.:|.||:.||:...:|||..|||.:.|
Zfish   780 CSKPSKNKVTYLKDSITTWQILAISLSPTHGICVAE-PEEIVVFKSFFIDLKVPYSAVRGEQVEI 843

  Fly   765 PVVIFNYLDKTLDADVVMDNSDQEYEFTEATNEVLEKAIDEVRRVKRVTIPANSGKSVSFMIRPK 829
            ..:|.||..|.|        .....||.| |..|...|..:.:....|.:..:|..:|||:|.|.
Zfish   844 KAIIHNYTPKHL--------KKVRVEFLE-TAGVCSAASKKGKYRATVNVDKDSSIAVSFVIVPM 899

  Fly   830 NVGFTTLKITATSALAGDAIHQKLKVEPEGV-TLFENRAVFINLKDQPEMSQSLDADIPNEVVPQ 893
            .:....:::.|:.....|.:.:.|||..||| |.|:::.:.:|...:.|....|.|.||.:.||.
Zfish   900 TLESQHIEVKASILDYTDGVRKTLKVVSEGVLTKFQSQKLELNPAKKGEQPLLLRAGIPGDQVPG 964

  Fly   894 --------------SEFIEFSVVGDLLGPTLQNLDNLVRMPYGCGEQNMVNFVPNILVLKYLEVT 944
                          |:.||.::.|..:|       .|::.|.|||||||......::...||:.|
Zfish   965 TPVHSYITVTGEEISQSIEHAINGSFMG-------ELIKRPGGCGEQNMAKMTLPVVATHYLDNT 1022

  Fly   945 GRKLPSVESKARK----FLEIGYQRELTYKHDDGSYSAFGKSDASGSTWLTAYVMRSFHQAGTYT 1005
             .:..||....||    .::.||..:|.|:..||||:.:  .:...||||||||.:.|..|..:.
Zfish  1023 -NQWESVGIDRRKVAINHIKTGYDGQLKYRKPDGSYAIW--INTPSSTWLTAYVAKVFAMANDFF 1084

  Fly  1006 DIDPKVITAGLDFLV-SKQKESGEFPEVGKLFDNA------NQN-PLALTSFVLLAFFENHEL-- 1060
            .|:..||.:.|.:|| .||...|.|.|...::|.:      .|| .::||:|||:|..|..|:
Zfish  1085 AIEENVICSALKWLVMHKQLPDGSFKEDAPVYDKSIMGGIEGQNTDVSLTAFVLIAMQEGKEICG 1149

  Fly  1061 --IPKYQSAIKKAVRYVAEEADKTDDQYSLAIAAVALQLAKHPQSEKVIAKLESVARKENDRMWW 1123
              :.....:::|||.::.::..|..:.|::|:.:.|  ||......|.|..:.|.  |.||..:|
Zfish  1150 GTVGSLHESMRKAVAFLKDQLPKLTNPYAVALTSYA--LANADSLNKAILMMHST--KVNDERFW 1210

  Fly  1124 SKATESTGEDGRVFHWKPRSNDVEITSYVLLALLEKDPAEKALPIIKWLISQRNSNGGFSSTQDT 1188
            :...       |.::      .:|.|:|.:|||::....:.|...:.||..|::|:||:.:||.|
Zfish  1211 NVPE-------RQYY------SIEATAYAVLALVKAKDYDTAGEAVHWLAKQKSSHGGYDTTQVT 1262

  Fly  1189 VIGLQALTKFAYKTGS-GSGTMDIEFSSAGESKN---TIKVNPENSLVLQTHDLPKSTRKVDFT- 1248
            ::..||:.::..:|.. .:..:::|....|..|.   ||:.:..:.......||.|     |||
Zfish  1263 IMVFQAVAEYHAQTQDLNNFDLNVELVVPGRRKTDRWTIQRSNVHLARSGNVDLNK-----DFTV 1322

  Fly  1249 -AKGTGSAMVQLSYRYNLAEKEKK---------------PSFKVTPTVKDTPNQLLIVDVCAEYV 1297
             |||||||::.:...|.....|||               |..|  |....|.|  .|:|...:
Zfish  1323 IAKGTGSAILSVLTLYYARPFEKKTDCTFFDLSVKLDKIPETK--PGTNGTYN--FILDFFYK-- 1381

  Fly  1298 PLEDADKDKDSNMAVMEIALPSGFVGDSTSL-----GKIQAVDRVKRVETKNSDSTVVVYFDSLT 1357
                 :|..|:.|.:::|.||:||..|...|     ||.:.:.:.::.:..:...::::|.:.::
Zfish  1382 -----NKKNDATMTILDIGLPTGFDIDEADLKQLSTGKERYIQKYEKNKVLSERGSLIIYLNKVS 1441

  Fly  1358 PGDVRCLPLEASKAHAVAKQKPASVSLYDYYDTERKATEYYQVK---SSLCDICEGADC---GEG 1416
            ......|.....|...||..:||||::|:||..:.:..:||..:   |:|..:|:|..|   .|.
Zfish  1442 HEVSEKLVFRMHKTFNVALLQPASVTIYEYYSPDARCKKYYHPEREDSALYRLCKGDLCVCAEEN 1506

  Fly  1417 C 1417
            |
Zfish  1507 C 1507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep2	NP_523506.1	YfaS	<72..1395	CDD:441940	384/1523 (25%)
		A2M_2	909..1198	CDD:239227	91/304 (30%)
c3a.3	NP_001032313.2	MG1	22..123	CDD:465508	26/113 (23%)
		YfaS	<127..1339	CDD:441940	339/1311 (26%)
		A2M	768..862	CDD:459711	34/107 (32%)
		complement_C3_C4_C5	987..1272	CDD:239226	93/311 (30%)
		A2M_recep	1385..1483	CDD:462226	24/97 (25%)
		NTR_complement_C3	1502..1649	CDD:239638	2/6 (33%)