DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tep2 and c3b.1

DIOPT Version :9

Sequence 1:NP_523506.1 Gene:Tep2 / 34044 FlyBaseID:FBgn0041182 Length:1420 Species:Drosophila melanogaster
Sequence 2:XP_009294664.1 Gene:c3b.1 / 563665 ZFINID:ZDB-GENE-030131-2211 Length:1768 Species:Danio rerio


Alignment Length:1680 Identity:399/1680 - (23%)
Similarity:685/1680 - (40%) Gaps:403/1680 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 YSVVGPGTLRSNSKYNVVVSVHKA-----------DGP------SQIKVSLNGP-SYNETKQIEL 69
            :|::.|..:|..:|.|::|..|..           |.|      |:..|.||.. :|:..:.:|:
Zfish    46 FSLLAPAKIRPGTKQNILVEGHNLAQVVEVTVVVYDYPNSQTALSRGSVFLNSDNNYSVLQTLEI 110

  Fly    70 -PPMSTQNVEFEVPKLATGNYNL-SAEGVSGVVFKNSTKLNYADKKPSVFVQTDKATYKPADLVQ 132
             |.:...:.:.:..||.....|: .||.|..|.|::.          .:|:||||..|.|.|.|:
Zfish   111 NPNLLLPDGKKKYVKLVAQFSNIYRAEKVMAVSFRSG----------HIFIQTDKPIYNPGDKVR 165

  Fly   133 FRILFLDENTRPAKIEKPISVIIIDGAQNRIKQLSDVKLTKGVFSGELQLSEQPVLGTWKISVSV 197
            ||....|...|.:  |:.||:.|.:.....:..:..||...||||....||.....|.||:....
Zfish   166 FRAFVSDLEFRSS--ERTISLEIQNPDGIAVHGIGRVKAIDGVFSDIFSLSTVVKEGRWKVVAKF 228

  Fly   198 D--GDNRETKSFEVDKYVLPKFEVIVDTPKAVVI---ADKVIKATIRAKYTYGKPVKGKATVSME 257
            |  .:|..::.|||.|||||.|.|.: |||...:   |:| ::..|.|:|.||..|||.|     
Zfish   229 DQGKENVFSREFEVKKYVLPAFNVTL-TPKTSHLSLDAEK-LEVEITARYLYGAQVKGVA----- 286

  Fly   258 RSYGYFGDLNANGNKQE----KTIDVDGKGHVEFDIIHWAQRGQYLPPIKLFAVVTEELTGNKQN 318
              |..|| :..||.|:.    |.||....|.|...:   .:..:..|.|......|..:..:...
Zfish   287 --YVLFG-IEINGEKKRLTSMKQIDDLNGGSVSLTM---EEIKRAYPDINSLLGSTLYVKASVLT 345

  Fly   319 ATATVVLHQQRYSIE----PY-----ERPEHFEANKSFIYQVVVKNVDGSPVTNSAKNVKIGFDK 374
            ::.:.::..::..|:    ||     :.|::::........|:|.|.||||..|..  ||:.|.:
Zfish   346 SSGSDLVEAEKSGIKIVKSPYMLTIKDTPKYYKPGLPLAMTVIVSNHDGSPTPNIP--VKVTFLE 408

  Fly   375 SYSYFHEPS-------PKTRINFEAPVNENGIATFNVRLPDSDSR---------YYRIFASFDGS 423
            |....|..:       |||.|.:      .......|...|...:         |.:.:::|.|.
Zfish   409 SPISVHSGTINIHINMPKTHILY------GNSQILKVETVDPSLKPEQQAIQEVYVKPYSTFSGH 467

  Fly   424 ENTIGSISKFEPTPMSREPLKIQVNTKKPRLGEQVSFDVVSIEDLP-------YFVYTIVARGNV 481
            :|.                |.:.|...:..:|..||..:.....||       :..|.::.:|.:
Zfish   468 DNF----------------LHVSVGASRVVVGGSVSVQMYIKSSLPNHRALVEHLTYIVLNKGKI 516

  Fly   482 ILSDYVDVPDGQKTYTVKFTPTFSMVPKATIYVYYVV----NNDLQFEEKTIDFEKEFSNSIDVS 542
            |.:..|:| .||...:|....|..|:|......|||:    ..::..:...:|.|.....|::| 
Zfish   517 IQAGRVNV-KGQDVTSVHLLITTEMLPAFRFVAYYVLPWQHRAEVVADSVFVDVEDRCVGSLNV- 579

  Fly   543 APTNAK------PSEEVKLRIKTDADSFVGLLGVDQSVLLLKSGNDLSQDDIFNSLN-------- 593
            .|.:.:      |....|.::|.|..:.|.|:.||.::.|| |.|.|:|..::..::        
Zfish   580 GPVDGEIVSSYSPGSSFKFQVKGDVGAKVSLVAVDNAIFLL-SKNRLTQKKVWEVVDQADMGCTA 643

  Fly   594 ---------------IYQTST-------------------------------------------- 599
                           ::.:||                                            
Zfish   644 GGGKDNMGVFSDAGLMFHSSTGGSTDSKEDCSSKTKRRRRSAAKLQLRDQLEKAYSDELLQRCCV 708

  Fly   600 ---------------------PW------MNGYGRYPGQTSGLVTL---TNAN---YPYNTGP-- 629
                                 .|      :.....|.|:..|::|.   |.|.   .|..|.|  
Zfish   709 DGMKEIPMPYSCYRRSLYITEDWSCVLAFLRCCAEYRGEELGVITRPPPTTAPPTIAPPTTSPPT 773

  Fly   630 --LVMSYVFEGSRHP-WITRPRYR------------VGIRGDSGDRI----------SFLSQSLN 669
              ||....:.....| :..|.|..            ||:|.||...:          .|....|:
Zfish   774 LFLVPHLEYHFPEQPVFFVRDRVLQSMPKLHAEANVVGVRQDSYREVVVEEEEEAASVFEEDDLS 838

  Fly   670 DRNLKEILLKQTPQRTTIRKEFPETWFFENV---------GEEEFTLTKKIPDTITSWVVTGFSL 725
            |  |::|.         :|.:|.|:|.:.::         |...|.:...:||:||.|.....|.
Zfish   839 D--LEDIY---------VRSKFFESWLWTDIRLPSTAKSDGLAVFPVDTVLPDSITQWGFLAVSA 892

  Fly   726 NPTSGIALTKNPSKIRVFQPFFVSTNLPYSVKRGEVIAIPVVIFNYLDKTLDADVVMDNSDQEYE 790
            :|..|:.:.: |..:||::|||:...||:||.|.|.:.|..||.||.:.||:..|::        
Zfish   893 SPEKGVCVAE-PYNVRVWKPFFIDLRLPHSVSRNEQVEIKAVIHNYKNSTLEVMVIL-------- 948

  Fly   791 FTEATNEVLEKAIDEVRRVKRVTIPANSGKSVSFMIRPKNVGFTTLKITATSA--LAGDAIHQKL 853
              |.|.::...|.....| ::||:.|.|.|.:::.|.|...|...|::||.:|  :..||:.:.|
Zfish   949 --EKTEDMCSVAYTGQHR-QQVTVAAGSSKLITYTIIPLKTGELPLQVTAVAASFMGQDAVKKNL 1010

  Fly   854 KVEPEGVTLFENRAVFINLKDQ-----PEMSQ----SLDADIPNEVVPQSEFIEFSVVGDLLGPT 909
            :|..||:...:.|:..:|..::     .::.|    .|||.:|.. ||:: |:  :|.||||..:
Zfish  1011 RVVVEGIQTLKVRSFVLNPSEKGGSAGQQLIQVKKMQLDAVVPKS-VPET-FV--NVRGDLLADS 1071

  Fly   910 LQN------LDNLVRMPYGCGEQNMVNFVPNILVLKYL------EVTGRKLPSVESKARKFLEIG 962
            :.|      |..|:|||.||.|||:......::...||      |:.|   .|...:|.|:::.|
Zfish  1072 IDNSIKEDSLAALIRMPGGCVEQNLARITLPLIAAHYLDRSADWEIVG---ISRREEAIKYIQRG 1133

  Fly   963 YQRELTYKHDDGSYSAFGKSDASGSTWLTAYVMRSFHQAGTYTDIDPKVITAGLDFLV-SKQKES 1026
            |:.:|.||..|.||..:  ::...|||:||||::.|..|.::.:::.|.:...|.:|: :||...
Zfish  1134 YENQLNYKKSDDSYPPY--ANEGTSTWITAYVVKVFSMAHSFINVNEKHLCGPLLYLLKNKQGYD 1196

  Fly  1027 GEFPEVGKLFDNA-------NQNPLALTSFVLLAFFENHELIPKYQSAI------KKAVRYVAEE 1078
            |.|.|...::|.:       ::...:||:|||:|..|..:.:......:      ::|..|:.|.
Zfish  1197 GTFQEDNPVYDTSMTGAMRGSEYKASLTAFVLIALAEAQDKVTCQDQEVNIRDKSRQAAGYLTEH 1261

  Fly  1079 ADKTDDQYSLAIAAVALQLAKHPQSEKVIAKLESVARKENDRMWWSKATESTGEDGRVFHWKPRS 1143
            ..:....|:.|||..||.::.:...:.::.|..|....                     || |.|
Zfish  1262 FSRLTRPYTAAIACYALAVSNNACVKSMLLKFASPDHS---------------------HW-PDS 1304

  Fly  1144 ND----VEITSYVLLALLEKDPAEKALPIIKWLISQRNSNGGFSSTQDTVIGLQALTKFAYKTGS 1204
            |:    :|.|.|.||||::....|:|....:||...|...||:.|||.|::.||||:::..|...
Zfish  1305 NNYFFTLEATGYALLALIKSGHMEEAEAPFRWLNEHRGIGGGYGSTQSTMVVLQALSEYLVKRPP 1369

  Fly  1205 GSG-TMDIEFSSAGESKNTIKVNPENSLVLQTHDLPKSTRKVDFTAKGTGSAMVQLSYRY----- 1263
            .|. .:.::.|..|.|......||..:.|.::..:|.. ::....|.|.|..::::...|     
Zfish  1370 PSDLNLLVQLSVPGRSDVRWTFNPNLAYVARSSRVPLD-QEFSVAASGNGKGVLEVVTVYHQLPD 1433

  Fly  1264 --------------NLAEKEKKPSFKVTPTVKDTPNQLLIVDVCAEYVPLEDADKDKDSNMAVME 1314
                          ::||..:|.|..|..:.:      |.|:|.|    ||    ::...|.:::
Zfish  1434 VYENSTCNGFQLDVSIAETNEKTSSDVEKSFR------LNVNVRA----LE----ERQVRMVILD 1484

  Fly  1315 IALPSGFVGDSTSLGKI-QAVDR----VKRVETKNSDSTVVVYFDSLTPGDVRCLPLEASKAHAV 1374
            |.||:||..:::.|..: .:|||    .:.|:..:...:::::...::..:...:....::...|
Zfish  1485 IGLPTGFEPENSDLELLTNSVDRYINNFQVVDNLSDRGSLIIHLFKVSNKEAEMISFRLNQKFKV 1549

  Fly  1375 AKQKPASVSLYDYYDTERKATEYY---QVKSSLCDICEGADC----GEGC--KKD 1420
            ...:|::|.:|.||:.::..:.:|   :.|..|..||||..|    |:.|  |:|
Zfish  1550 GLLQPSTVKVYQYYNKDKSCSRFYSPPEDKQQLDQICEGDVCRCSQGDCCVMKED 1604

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tep2NP_523506.1 A2M_N 115..209 CDD:280081 31/95 (33%)
A2M_N_2 445..576 CDD:285005 33/147 (22%)
A2M 694..782 CDD:278630 31/96 (32%)
A2M_2 909..1198 CDD:239227 89/318 (28%)
A2M_comp 961..1199 CDD:284982 71/255 (28%)
A2M_recep 1308..1398 CDD:284981 17/94 (18%)
c3b.1XP_009294664.1 A2M_N 149..242 CDD:280081 31/94 (33%)
A2M_N_2 500..619 CDD:285005 27/120 (23%)
ANATO 691..747 CDD:237984 2/55 (4%)
A2M 852..948 CDD:278630 31/96 (32%)
TRAPPC10 <939..>991 CDD:289361 15/62 (24%)
complement_C3_C4_C5 1079..1363 CDD:239226 88/310 (28%)
A2M_comp 1133..1363 CDD:284982 71/253 (28%)
A2M_recep 1480..1573 CDD:284981 17/92 (18%)
NTR_like 1593..1766 CDD:295338 4/12 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170584210
Domainoid 1 1.000 48 1.000 Domainoid score I11904
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11412
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
76.800

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