DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep2 and si:dkey-46g23.5

DIOPT Version :9

Sequence 1:	NP_523506.1	Gene:	Tep2 / 34044	FlyBaseID:	FBgn0041182	Length:	1420	Species:	Drosophila melanogaster
Sequence 2:	NP_001188334.2	Gene:	si:dkey-46g23.5 / 562067	ZFINID:	ZDB-GENE-030131-9306	Length:	1482	Species:	Danio rerio

Alignment Length:	1548	Identity:	423/1548 - (27%)
Similarity:	667/1548 - (43%)	Gaps:	286/1548 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IILQYALLVNATGIYSVVGPGTLRSNSKYNVVVSVHKADGPSQIKVSLNGPSYNETKQIELPPMS 73
            :|:...::||.. |:.|:.|..:.|.|...:.||:.|.:|...:.:||......||:.::   .:
Zfish    60 VIIDEPVIVNGP-IFMVMFPSLIESGSDAKLCVSLLKPEGSLTMTISLVDDKNTETQLVQ---QT 120

  Fly    74 TQN-----VEFEVPKLATGNYNLSAEGVSG--VVFKNSTKLNYADKKPSVFVQTDKATYKPADLV 131
            :|.     ..|:.|:::..:.......|.|  :......|:.:....|..|:||||..|.|...|
Zfish   121 SQRKLHRCFNFQAPQVSGDSVQTVRVVVQGPSITMTEERKVMFRSYLPLTFIQTDKPLYNPGQTV 185

  Fly   132 QFRILFLDENTRPAKIEKPISVIIIDGAQN-RIKQLSDVKLTKGVFSGELQLS-----EQPVLGT 190
            .||::.:.:...|  :::..::::::..:| ||.|.::|..|..:    |:||     |.|| |.
Zfish   186 NFRVVTMSDKLVP--LDQMYNLVVLEDFRNIRINQWTNVSSTNWI----LELSHDLIPESPV-GK 243

  Fly   191 WKISVSVDGDNRETKSFEVDKYVLPKFEVIVDTPKAVVIADKVIKATIRAKYTYGKPVKGKATVS 255
            :.:...: ||...::||:|.|||||||:|.::||:...:||..:|.....|||:|:||.|:..|.
Zfish   244 YTLRAYI-GDRIISQSFDVKKYVLPKFDVTLNTPQTYSVADVGLKVEACGKYTFGQPVPGQVFVE 307

  Fly   256 MERS-YGYFGDLNANG---NKQEKTID---------------VDGKGHVEFDIIHWAQRGQYLPP 301
            :.|. ..|..|.....   .|..||.|               ...:.:::...:
Zfish   308 VCRQPVTYVQDPKVTSVCLKKSTKTTDTGCASLALSTSVFFGTSFENNLQNSFV----------- 361

  Fly   302 IKLFAVVTEELTGNKQNATATVVLHQQRYSIEPYERPEHFEANKSFIYQVVVKNVDGSPVTNSAK 366
              :...:|||.||...:.:.||.:..:...::..:.|:.:....:...::...:.:|:|:.|...
Zfish   362 --INVNITEEGTGVVMSKSTTVSITFEVGKVKFVDLPKFYNYGSTVNGKISASDFNGNPINNKVV 424

  Fly   367 NV-----------------KIGFDKSYSYFHEPSPKTRINFEAPVNENGIATFNVRLPDSDSRYY 414
            .:                 |.|| ..:|.:....||..:|..|.........:|.....:||:..
Zfish   425 YLLDSSQWPHKMLFNLTTNKNGF-AEFSLWTTSFPKADLNLVASATPQSYYGYNSPYFTTDSQVV 488

  Fly   415 RIFASFDGSENTIG--SISKFEPTPMSREPLK----IQVNTKKPRLGE--QVSFDVVSIEDLPYF 471
            |:..:......|..  ||.|.|      :|||    ..|......:||  ..|.|:
Zfish   489 RLSRTAAPDTPTFSDLSIVKLE------QPLKCGTTYPVTVTYSFVGETGDYSADI--------- 538

  Fly   472 VYTIVARGNVILSDYVDVPDGQKTYTVKFTPTF------SMVPKATIYVYYVV-NNDLQFEEKTI 529
            :|.:::||.:||..::.|.........|.|.||      .|.|...|.||.|: :..:.....:.
Zfish   539 IYMVMSRGVIILHGFISVQALASDTLTKGTVTFDLSIVAKMAPVVQILVYSVLPSQTVVTGSASF 603

  Fly   530 DFEKEFSNSIDVS-APTNAKPSEEVKLRIKTDADSFVGLLGVDQSVLLLKSGNDLSQDDIFNSLN 593
            |.||.|||.:.:. :|..|.|.|...|.:...|.|..||..:|||||:::||..||.:.:||.|.
Zfish   604 DTEKCFSNQVSLQFSPATAVPGEGSILTVSAQAGSLCGLSAIDQSVLIMQSGGRLSAEAVFNLLP 668

  Fly   594 IYQTSTPWMNGYGRYP-----GQTSGLVTLTNA---NYPYNT---------------GPLVMSY- 634
            :...|        .||     .|....|....|   |..|||               .|..|:|
Zfish   669 LQSLS--------NYPPGAEDQQNCFYVRSRRAVPTNQAYNTFKSVGIKIATNLPVRAPPCMTYK 725

  Fly   635 -----------------VFEGSRHPWITRPRYRVGIRGDSGDRISFLSQSLNDRNLKEILLKQTP 682
                             ||..:|.  ...|..:..:.|.|...:
Zfish   726 DVIYFPNFRGVVPLQEAVFAMARE--APAPIAKAEVAGSSSVDV--------------------- 767

  Fly   683 QRTTIRKEFPETWFFE-----NVGEEEFTLTKKIPDTITSWVVTGFSLNPTS-GIALTKNPSKIR 741
               |||..|||||.::     :.|.....||  :|||||:|....|.|:.:. |:||   |..:.
Zfish   768 ---TIRTYFPETWIWQLAHVGDSGSSSVPLT--VPDTITTWDTEAFCLSSSGFGLAL---PVLLT 824

  Fly   742 VFQPFFVSTNLPYSVKRGEVIAIPVVIFNYLDKTLDADVVMDNSDQEYEFTEATNEVLEKAIDEV 806
            .|||||:...||||:.|||...:...:||||.:.:...|..         |.::|..|:...|:
Zfish   825 SFQPFFLELTLPYSIIRGEFFELKATVFNYLSQCIKVQVTP---------TPSSNFTLKSLDDQ- 879

  Fly   807 RRVKRVTIPANSGKSVSFMIRPKNVGFTTLKITA------TSALAG------------DAIHQKL 853
               ...||.||..|:..:.:....:|  ||.:|.      :..|.|            |.:.:.|
Zfish   880 ---DSSTISANGRKTFKWALTASVIG--TLNVTVSGEASPSQELCGNQDVTVPSRGRIDIVTRSL 939

  Fly   854 KVEPEGVTLFENRAVFINLKDQPEMSQSLDADIPNEVVPQSEFIEFSVVGDLLGPTLQNLDNLVR 918
            .|..|||.....|:..:..|. ..:|:.:....|..|:..|.....||:||::|..|:|||||:|
Zfish   940 LVLAEGVERTFIRSWLLCPKG-TTLSEVVKITFPTNVIQGSAKCSVSVIGDIMGRALKNLDNLLR 1003

  Fly   919 MPYGCGEQNMVNFVPNILVLKYLEVTGRKLPSVESKARKFLEIGYQRELTYKHDDGSYSAFGKSD 983
            ||.|||||||:...|||.:|:||.||.:..|.:...|..:|:||||.||.|:|.|||:|.||...
Zfish  1004 MPSGCGEQNMIILAPNIYILRYLTVTAQLTPVIRDTATGYLQIGYQGELNYRHTDGSFSTFGYDP 1068

  Fly   984 ASGSTWLTAYVMRSFHQAGTYTDIDPKVITAGLDFLVSKQKESGEFPEVGKLF---------DNA 1039
            :  :|||||:|||:|..|.::|.|||.|:.:..|:|:|.|...|.|.:.|.|:         ||
Zfish  1069 S--NTWLTAFVMRTFGLARSFTYIDPNVLKSAKDWLISTQGSDGGFVQQGTLYHKDMKGGVGDN- 1130

  Fly  1040 NQNPLALTSFVLLAFFENHELIPKYQSAIKKAVRYVAEEADKTDDQYSLAIAAVALQLAKHPQSE 1104
                :.:|.:::|:..|..  :|.....|.||:.::........:.|..|:.|....||....:.
Zfish  1131 ----VTMTGYIVLSLLEIG--VPVTDPVITKALSFLRPLVGNLGNTYVTALLAYTFSLAGETSTR 1189

  Fly  1105 -KVIAKLESVARKENDRMWWSKATESTGEDGRVFHWKPRSND---VEITSYVLLALLEKDPAEK- 1164
             :::..|.:.|..|...:.||:.|               |.|   |||::|||||:|...|...
Zfish  1190 AQLLHSLRNTAISEGTTLHWSQTT---------------SGDTLAVEISAYVLLAVLTVHPVTTA 1239

  Fly  1165 ----ALPIIKWLISQRNSNGGFSSTQDTVIGLQALTKFAYKTGS--GSGTMDIEFS-SAGESKNT 1222
                |..|:.||::|:|..|||:||||||:.||||..:|.:..|  ||.|:.::.| .||:..|
Zfish  1240 NLGYANRIVNWLVAQQNPYGGFTSTQDTVVALQALALYAAQVFSPGGSSTVTVQSSVPAGDVFN- 1303

  Fly  1223 IKVNPENSLVLQTHDLPKSTRKVDFTAKGTGSAMVQLSYRYNL-----AEKEKKPSFKVTPTVKD 1282
            ..|.|.|.|:.|.:.|..........|:|:..|.||:|..||:     ..|......|||...:.
Zfish  1304 FAVTPNNRLLYQRNSLNNVPGTYSVVARGSACASVQVSCFYNIPTPITVSKTLSVVAKVTGNCQA 1368

  Fly  1283 TPNQLLIVDVCAEYVPLEDADKDKDSNMAVMEIALPSGFVGDSTSLGK-IQAVDRVKRVETKNSD 1346
            .|..|::.      ..::.......:||.:::|.:.|||..|::.||. ......|:|||:....
Zfish  1369 APVNLMLT------FTVKYTGPKPTTNMVLVDIKVLSGFTADTSLLGSPPNFTPFVQRVESDGDH 1427

  Fly  1347 STVVVYFDSLTPGDVRCLPLEASKAHAVAKQKPASVSLYDYYDTERKATEYYQ 1399
              |:||...:..|......::.::|.||...|||.:.:||||....|....|:
Zfish  1428 --VLVYLQEVPKGVPVTFSIQLTQAVAVQNLKPAVIYIYDYYQRNDKFETTYK 1478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep2	NP_523506.1	A2M_N	115..209	CDD:280081	28/99 (28%)
		A2M_N_2	445..576	CDD:285005	40/140 (29%)
		A2M	694..782	CDD:278630	34/93 (37%)
		A2M_2	909..1198	CDD:239227	115/306 (38%)
		A2M_comp	961..1199	CDD:284982	88/255 (35%)
		A2M_recep	1308..1398	CDD:284981	28/90 (31%)
si:dkey-46g23.5	NP_001188334.2	A2M_N	170..261	CDD:280081	28/98 (29%)
		A2M_N_2	506..650	CDD:285005	45/158 (28%)
		A2M	776..864	CDD:278630	33/92 (36%)
		A2M_2	994..1269	CDD:239227	110/298 (37%)
		A2M_comp	1046..1269	CDD:284982	83/246 (34%)
		A2M_recep	1388..1477	CDD:284981	28/90 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584138
Domainoid	1	1.000	217	1.000	Domainoid score	I2610
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	517	1.000	Inparanoid score	I1243
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6406
orthoMCL	1	0.900	-	-		OOG6_100452
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X292
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.700