Protein Alignment Tep2 and Mcr

DIOPT Version :9

• Sequence 1: NP_523506.1
• Gene: Tep2 / 34044
• FlyBaseID: FBgn0041182
• Length: 1420
• Species: Drosophila melanogaster
• Sequence 2: NP_524688.1
• Gene: Mcr / 44071
• FlyBaseID: FBgn0267488
• Length: 1760
• Species: Drosophila melanogaster
• Alignment Length: 1663
• Identity: 405/1663 - (24%)
• Similarity: 710/1663 - (42%)
• Gaps: 349/1663 - (20%)

  Fly    23 YSVVGPGTLRSNSKYNVVVSVHKADGPSQIK-------VSLNGPSYN------ETKQIELPPMST 74
            |.:|....:|....|.|.||:.:|..|..:.       |.::|.|.:      ||..:.:||.|
  Fly   132 YFIVASRMVRPGLIYQVSVSILQAQYPITVHASIACDGVQISGDSKDVKEGIPETLLMRIPPTS- 195

  Fly    75 QNVEFEVPKLATGNYNLSAEG-----VSGVVFKNSTKLNYADKKPSVFVQTDKATYKPADLVQFR 134
                      .||:|.|..||     ..|:.|.|.|:|:::.:..::||||||..|...:.|:||
  Fly   196 ----------VTGSYKLRVEGFYQNVFGGLAFLNETRLDFSQRSMTIFVQTDKPLYMQGETVRFR 250

  Fly   135 ILFLDENTRPAKIEKPISVIIIDGAQNRIKQLSDVKLTKGVFSGELQLSEQPVLGTWKISVSVDG 199
            .:.:  .|.....:.|:.|.::|..::.:|:....:...|..|.|.:||:||..|.|.|.|...|
  Fly   251 TIPI--TTELKGFDNPVDVYMLDPNRHILKRWLSRQSNLGSVSLEYKLSDQPTFGEWTIRVIAQG 313

  Fly   200 DNRETKSFEVDKYVLPKFEVIVDTPKAVVIADKVIKATIRAKYTYGKPVKGKATVSME-RSYGYF 263
            ...|: .|.|::|...:|||.|..|......|..|...:.|.:|.|.||:|..|:... |..|||
  Fly   314 QQEES-HFTVEEYYQTRFEVNVTMPAYFFTTDPFIYGRVMANFTSGLPVRGNLTIKATIRPIGYF 377

  Fly   264 GDL--------------------------NANGNKQEK-----TIDVDG---------------K 282
            .:.                          |.|.|.|.:     .:..||               :
  Fly   378 SNQVLNEKYRLGRSPLEQTNLYNERWRYNNPNQNPQVQYNVPGQLPQDGADLSQDILYRNQYVVE 442

  Fly   283 GHVEFD--IIHWAQRGQY---------------LP-------------PIKLFAVVTEELTGNKQ 317
            .|.:||  ...|.::.:|               ||             |::...::...|..::.
  Fly   443 RHYQFDEEWPFWVRKPEYQDSSYEAWSGTYRKTLPYLRYFNGTFDFKWPLRELELLVPNLANSEV 507

  Fly   318 NATATVVLHQQRYS--IEPY----------------ERPEHFEANKSFIYQVVVKNVDGSPVTNS 364
            ..||||  .::.|.  |..|                :.|:.|:....|...:.|:..||||:..:
  Fly   508 LITATV--GEKFYDEIISGYSVARVYNSSLRVVFLGDSPQVFKPAMPFTTYLAVEYHDGSPIDPN 570

  Fly   365 AKNVKI----GFDKSYSYFHEPSPKTRINFEAPVNE----------------------------N 397
            .....:    ||.:|.:......|..|:    |:::                            |
  Fly   571 LLRQGLMEVSGFVESRNGGRRDWPAQRL----PMSQQSDGIWEVKIDIRNDLNLDDRPQARDFLN 631

  Fly   398 GIATFNVRLPDSDSRYYRIFASFDGSENTIGSISKFEPTPMSREPLKIQVNTKKPRLGEQVSFDV 462
            |:....::....|.|..||       :..:..:|.:.|   ..:.:|:..:|:||.:||.:.|.:
  Fly   632 GVQNMRLQANFVDPRGERI-------QTELLLVSHYSP---RNQHIKVTTSTEKPVVGEYIIFHI 686

  Fly   463 VSIEDLPYFVYTIVARGNVILSDYVDVPDGQKTYTVKFTPTFSMVPKATIYVY------YVVNND 521
            .:...|..|.|.|:::|.::::|...:.:|.||..|..:.  .|.|.|||.|:      .||.:.
  Fly   687 RTNFYLEEFNYLIMSKGVILVNDRETITEGIKTIAVVLSS--EMAPVATIVVWKINQQGQVVADS 749

  Fly   522 LQFEEKTI---DFEKEFSNSIDVSAPTNAKPSEEVKLRIKTDADSFVGLLGVDQSVLLLKSGNDL 583
            |.|....|   :|....:|       ..|:..|:|::.|..:..|:|||.|:|.:...:::||:|
  Fly   750 LTFPVNGISRNNFTVYINN-------RKARTGEKVEVAIFGEPGSYVGLSGIDSAFYTMQAGNEL 807

  Fly   584 SQDDIFNSLNIYQTSTP------WMNGYGR------YPGQTSGLVTLTNANYPYNTGPLVMSYVF 636
            :...|...::.:...|.      |.:..|.      :|..:.|:.  .|..:.| :|.:|.:..:
  Fly   808 TYAKIITKMSNFDEQTNGTYKHIWYSHEGNPDELVYFPASSFGVD--ANRTFEY-SGLIVFTDGY 869

  Fly   637 EGSRHPWITRPR----------YRVGIR-------GDSGDRISFLSQSLNDRNLKEILLKQTPQR 684
            ...|.....|..          ||:..:       .|..|.|     :.:.||..|:|..:..:.
  Fly   870 VPRRQDTCNRTLGFGECLSGRCYRLEKQCDGLFDCDDGTDEI-----NCHARNDTELLNYRKYRF 929

  Fly   685 TTIRKEFPETWFFE--NVGEE-EFTLTKKIPDTITSWVVTGFSLNPTSGIALTKNPSKIRVFQPF 746
            ..:.:.:...|.::  |:|.. .:....::||....|:|:.||::|:.|..:.....:....|||
  Fly   930 NRVLRHYENVWLWKDVNIGPHGRYIFNVEVPDRPAYWMVSAFSVSPSKGFGMMNKALEYVGVQPF 994

  Fly   747 FVSTNLPYSVKRGEVIAIPVVIFNYLDKTLDADVVMDNSDQEYEFTEATNEVLEKAIDEVRRVKR 811
            |::..:|.:.::||.:.|.|.:|||:...::|.||:.:| .:|:|.....:.:.::.:
  Fly   995 FINVEMPEACRQGEQVGIRVTVFNYMITPIEAIVVLHDS-PDYKFVHVEEDGIVRSYN------- 1051

  Fly   812 VTIPANS-------------GKSVSFM-IRPKNVGFTTLKITATSALAGDAIHQKLKVEPEGVTL 862
               |..|             |.:|.:: :.|:.:|...:.:...:.|..|.|.:.|.||.:|:..
  Fly  1052 ---PRTSFGEHQFFIYLEAQGTTVVYVPVVPQRLGNVDVTLHVATLLGTDTITRTLHVESDGLPQ 1113

  Fly   863 FENRAVFINLKDQPEMSQSLDA------DIPNEV----VPQSEFIEFSVVGDLLGPTLQ----NL 913
            :.:::|.::|.::..:.:.:..      :||.:|    |..|.....|||||::||...    |.
  Fly  1114 YRHQSVLLDLSNRAYVLEYMHVNVTQTPEIPYQVDRYFVYGSNKARISVVGDVVGPIFPTMPVNA 1178

  Fly   914 DNLVRMPYGCGEQNMVNFVPNILVLKYLEVTGRKLPSVESKARKFLEIGYQRELTYKHDDGSYSA 978
            .:|:.:|...||||..:|..|:..:.|:.:..::..::|..|...:.|||||:|::...|||:|.
  Fly  1179 SSLLSLPMESGEQNAFSFAANLYTIMYMRLINQRNKTLEKNAFYHMNIGYQRQLSFMRPDGSFSL 1243

  Fly   979 FGKSD---ASGSTWLTAYVMRSFHQAGTY-----TDIDPKVITAGLDFLVSKQKESGEFPEVGKL 1035
            | :||   :..|.|||:|.:|.|.:|..|     ..||..:|...:.:|:..|...|.|.||..|
  Fly  1244 F-RSDWNNSDSSVWLTSYCLRVFQEASFYEWENFIWIDATIIEKNMRWLLQHQTPQGSFFEVTWL 1307

  Fly  1036 FD------NANQNPLALTSFVLLAFFENHELIPKYQS----AIKKAVRYVAEEADKTDDQ---YS 1087
            .|      |.::| :.|||.||:......::.....|    |.::|:.|:....|....|   :.
  Fly  1308 PDRKMNRTNFDKN-ITLTSHVLITLATVKDISGTLGSRVALATQRALAYIERNMDFLRHQAQPFD 1371

  Fly  1088 LAIAAVALQLAKHPQSEKVIAKLESVARKENDRMWWSKATESTGEDGRVFH---W--KPR----- 1142
            :||.|.||||...|.:|:|.|.|...||...|.|:|  ..:...:..|...   |  .||
  Fly  1372 VAITAYALQLCNSPIAEEVFAILRRQARTIGDFMYW--GNQEIPQPPRKLENQKWFSLPRLPYEY 1434

  Fly  1143 -SNDVEITSYVLLALLEKDPAEKAL---PIIKWLISQRNSNGGFSSTQDTVIGLQALTKFAYKT- 1202
             |.::|.|:|.||..:    |.:..   ||::||.|||.::||::|||||...|:||.::..::
  Fly  1435 DSLNIETTAYALLVYV----ARREFFVDPIVRWLNSQRLNDGGWASTQDTSAALKALVEYTVRSR 1495

  Fly  1203 --GSGSGTMDIEFSSAGESKNTIKVNPENSLVLQTHDLPKSTRKVDFTAKGTGSAMVQLSYRYNL 1265
              ...|.|::||.||.|....|:.::..|...||:.::|.:...:...|||.|.|::|:..:||:
  Fly  1496 LREVSSLTVEIEASSQGGKTQTLYIDDTNLAKLQSIEIPDAWGTIKVQAKGAGYAILQMHVQYNV 1560

  Fly  1266 -----AEKEKKPSFKV-TPTVKDTPNQLLIVDV-CAEYVPLEDADKDKDSNMAVMEIALPSGFVG 1323
                 ..|...|:|.: |..:....||..|..| |..::...::::   |.|||:::|:|:|:..
  Fly  1561 DIEKFQTKPPVPAFGLHTKAIFHGRNQSHISYVACQNWINQNESER---SGMAVLDVAIPTGYWI 1622

  Fly  1324 DSTSL------GKIQAVDRVKRVETKNSDSTVVVYFDSLTPGDVRCLPLEASKAHAVAK-QKPAS 1381
            ....|      .:::.:.|.:.:|.|     :|.|||.|...|: |:.....:.:.||. .:...
  Fly  1623 QQQKLDTYVLSNRVRNLRRARYLERK-----IVFYFDYLDHEDI-CVNFTIERWYPVANMSRYLP 1681

  Fly  1382 VSLYDYYDTER------KATEYYQVKSSLCDICEGADC 1413
            |.:||||..||      .|...|.:  ::|::|..:.|
  Fly  1682 VRIYDYYAPERFNESIFDALPTYLL--NICEVCGSSQC 1717

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep2	NP_523506.1	A2M_N	115..209	CDD:280081	29/93 (31%)
		A2M_N_2	445..576	CDD:285005	39/139 (28%)
		A2M	694..782	CDD:278630	25/90 (28%)
		A2M_2	909..1198	CDD:239227	103/327 (31%)
		A2M_comp	961..1199	CDD:284982	91/272 (33%)
		A2M_recep	1308..1398	CDD:284981	28/102 (27%)
Mcr	NP_524688.1	A2M_N	232..332	CDD:280081	32/102 (31%)
		A2M_N_2	669..799	CDD:285005	39/138 (28%)
		LDLa	886..913	CDD:238060	5/31 (16%)
		A2M	940..1030	CDD:278630	25/89 (28%)
		ISOPREN_C2_like	1177..1490	CDD:298658	103/320 (32%)
		A2M_comp	1226..1492	CDD:284982	91/273 (33%)
		A2M_recep	1607..1695	CDD:284981	27/93 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2373
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	76	1.000	Inparanoid score	I382
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10215at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.970