Protein Alignment Tep2 and C4b

DIOPT Version :9

• Sequence 1: NP_523506.1
• Gene: Tep2 / 34044
• FlyBaseID: FBgn0041182
• Length: 1420
• Species: Drosophila melanogaster
• Sequence 2: NP_001002805.1
• Gene: C4b / 406161
• RGDID: 1591983
• Length: 1737
• Species: Rattus norvegicus
• Alignment Length: 1688
• Identity: 418/1688 - (24%)
• Similarity: 689/1688 - (40%)
• Gaps: 425/1688 - (25%)

  Fly    24 SVVGPGTLRSNSKYNVVVSVHKADGPS--QIKVSL------NGPSYNETKQIELPPMSTQN---- 76
            |||..||..|       |.|...|.|:  ::|.|:      :||. :..|..:|   |:.|
  Rat    29 SVVNLGTPLS-------VGVQLLDAPAGQEVKGSVYLRNPTSGPC-SPKKDFKL---SSGNDFVL 82

  Fly    77 VEFEVPKLATGNYNL----SAEGVSGVVF----KNS---------TKLNYADKKPSVFVQTDKAT 124
            :..|||.....|..|    .|..:..|.:    ||:         ..|.::.::..:|||||:..
  Rat    83 LRLEVPLEDVRNCGLFDLRRAPHIQLVAYSPWLKNTAPKATETQGVNLLFSSRRGHIFVQTDQPI 147

  Fly   125 YKPADLVQFRILFLDENTRPAKIEKPISVIIIDGAQNRIKQLSDVKLTKGVFSGELQLSEQPVLG 189
            |.|...|::|:..||:..||:.....::|....|.:.|.|.   |.....:|:.:..:.:....|
  Rat   148 YNPGQRVRYRVFALDQKMRPSTDTLTVTVENSHGLRVRKKV---VFAPTSIFTDDFVIPDISEPG 209

  Fly   190 TWKISVSV-DG--DNRETKSFEVDKYVLPKFEVIVDTPKAVVIA----DKVIKATIRAKYTYGKP 247
            |||||... ||  .||.| .|||.|||||.|||.:...|..::.    .:.|:..|:|:|.||||
  Rat   210 TWKISARFSDGLESNRST-HFEVKKYVLPNFEVKLTPWKPYILTVPSYREEIQLDIQARYVYGKP 273

  Fly   248 VKGKATVSMERSYGYFGDLNANGNK------QEKTIDVDGKGHVEFDIIHWAQRGQY-------- 298
            |:|.|       |..|..::..|.|      :.:|..|:|:.|:..      .|.|:
  Rat   274 VQGVA-------YTRFALMDEQGKKTFLRGLETQTKLVEGQTHISI------SRDQFQAALGKVN 325

  Fly   299 -----LPPIKLFAVVT--EELTGNKQNATATV-VLHQQRYSIEPYERPEHFEANKSFIYQVVVKN 355
                 |..::|:|.|.  |...|..:.|..|. ......:|::.....:|......|:.|.:|:.
  Rat   326 TEIGDLEGLRLYAAVAVIESPGGEMEEAELTSWPFVSSAFSLDLSHTKQHLVPGAPFLLQALVRE 390

  Fly   356 VDGS-----PVTNSAKNVKIGFDKSYSYFHEPSPKTRINFEAPVNENGI--ATFNVRLPDSDSRY 413
            :.||     ||..|| .:..|.|.....|.:             |.|||  .:|::.:|.:.:.
  Rat   391 MSGSEASDVPVKVSA-TLLSGSDSKVLDFQQ-------------NTNGIGQVSFSIHVPPTITE- 440

  Fly   414 YRIFASFDGSENTIGSISKFEPTPMSREP--LKIQ-VNTKKPRLGEQVSFDV----VSIEDLPYF 471
            .|:..|.......:..::  ...|.||.|  |.|: ::.:.||:|:....::    :.:....::
  Rat   441 LRLLVSAGSLYPAVAKLT--VQAPPSRGPGFLSIEPLDLRSPRVGDTFILNLRTVGIPVPTFSHY 503

  Fly   472 VYTIVARGNVI------------LSDYVDVPDGQKTYTVKFTPTFSMV--------PKATIYVYY 516
            .|.|::||.::            :|..||         ....|:|..|        |.|...:..
  Rat   504 YYMIISRGQIMAMSREPRTTLTSISVLVD---------HHLAPSFYFVAYFYHQGLPVANSLLIN 559

  Fly   517 VVNNDLQFE-EKTIDFEKEFSNSIDVSAPTNAKPSEEVKLRIKTDADSFVGLLGVDQSVLLL--K 578
            |...|.:.: |..:|..||:.|            .|.:||:::||:::.|.|..||.::..:  :
  Rat   560 VQPGDCEGKLELKVDGAKEYRN------------GESMKLQLQTDSEALVALGAVDTALYAVGGR 612

  Fly   579 SGNDLSQDDIFNSLNIYQTSTPWMNGYGRYPG---------QTSGL-------VTLT-------- 619
            |...|....:|..:|.|..      |.|  ||         ||:||       :|.|
  Rat   613 SHKPLDMSKVFEVMNSYNL------GCG--PGGGDDALQVFQTAGLAFSDGDRLTQTKEDLSCPK 669

  Fly   620 --------NANY---------PYNT-----------GPLVMSYVFE---------GSRHPWITRP 647
                    |.|:         .|::           ..|.|:...|         ..|.|:::..
  Rat   670 EKISRQKRNVNFQKAISEKLGQYSSPDTKRCCQDGMTKLPMARTCEQRAARVPQPACREPFLSCC 734

  Fly   648 RYRVGIRGDSGDRISFLSQSLNDRNLKEILLKQTPQRTTIRKEFPETWFF--ENVGEEEFTLTKK 710
            ::...:|.:.....:.|:::.|....::::   ......:|..|||.|.:  |.|...:. ||..
  Rat   735 KFAEDLRRNQTRSQAGLARAQNVMQEEDLI---DEDDILVRSFFPENWLWKVEPVDRSKL-LTVW 795

  Fly   711 IPDTITSWVVTGFSLNPTSGIALTKNPSKIRVFQPFFVSTNLPYSVKRGEVIAIPVVIFNYLDKT 775
            :||::|:|.:.|.||:.:.|:.:.| |:::|||:.|.:...||.||:|.|.:.:..|::|||.:
  Rat   796 LPDSLTTWEIHGVSLSKSKGLCVAK-PTRVRVFREFHLHLRLPISVRRFEQLELRPVLYNYLSE- 858

  Fly   776 LDADVVMDNSDQEYEFTEATNEVLEKAIDEVRRVKRVTIPANSGKSVSFMIRPKNVGFTTLKITA 840
             |..|.:..|..| ....|...:|         .::|::||.|.:.|:|.:.|.......||:.|
  Rat   859 -DVTVSVHVSPVE-GLCLAGGGLL---------AQQVSVPAGSARPVAFSVVPTAAASMPLKVVA 912

  Fly   841 TSAL-AGDAIHQKLKVEPEGVTLFENRAVFINLKDQPEMSQSLD---ADIPNEVVPQSEFIEF-- 899
            ..:. .|||:.:.|::|.||.  .....:..||.....:.:||:   :..|| |:|..:|..|
  Rat   913 RGSFDIGDAVSKILQIEKEGA--IHREEIVYNLDPLNNLGRSLEIPGSSDPN-VIPDGDFSSFVR 974

  Fly   900 -------SVVGD--LLGPTLQNLDNLVRMPYGCGEQNMVNFVPNILVLKYLEVTGR--KL-PSVE 952
                   ..:|.  .|.|  ..:.:|:::|.||.||.||...|.:...:||:.|.:  || |..:
  Rat   975 VTASEPLETLGSEGALSP--GGVASLLKLPTGCAEQTMVLLAPTLTASRYLDRTEQWSKLPPETK 1037

  Fly   953 SKARKFLEIGYQRELTYKHDDGSYSAFGKSDASGSTWLTAYVMRSFHQAGTYTDIDPKVITAGLD 1017
            ..|...::.|:.|...::..|||:.|:  .|...||||||:|::....|.......|:.:.....
  Rat  1038 DHAVDLIQKGHMRIQQFRKKDGSFGAW--LDRDSSTWLTAFVLKILSLAQEQIGDSPEKLQETAG 1100

  Fly  1018 FLVSKQKESGEFPEVGKLFDNANQNPL-------ALTSFVLLAFF--------ENHELIPK-YQS 1066
            :|:.:|.:.|.|.:...:.....|..|       |||:||::|..        ||.:.:.| .::
  Rat  1101 WLLGQQLDDGSFHDPCPVIQRGMQGGLVGTDETVALTAFVVIALHHGLAVFQDENSQQLKKRVEA 1165

  Fly  1067 AIKKAVRYVAEEADK-TDDQYSLAIAAVALQLAKHPQSEKVIA--KLESVARKENDRMWWSKATE 1128
            :|.||..::.::|.. ....::.||.|.||.|.|..:..:.:|  .|.::|.:..:.::|..|..
  Rat  1166 SIMKANSFLGQKASAGLLGAHASAITAYALTLTKASEDLRNVAHNSLMAMAEETGENLYWGLAIG 1230

  Fly  1129 STGEDGRVFHW-KPRSND----------VEITSYVLL-ALLEKDPAEKALPIIKWLISQRNSNGG 1181
            |  :|..|... .||:..          :|.|:|.|| .||.:...|.|.....||..|.:..||
  Rat  1231 S--QDNVVSSTAAPRNPSEPVPQAPALWIETTAYGLLHLLLREGKGEMADKAATWLTHQGSFQGG 1293

  Fly  1182 FSSTQDTVIGLQALTKF----------------------AYKTG------------------SGS 1206
            |.||||||:.|.||:.:                      .||:.                  |..
  Rat  1294 FRSTQDTVVALDALSAYWIASHTTEEKALNVTLSSMGRNGYKSHLLQLNNHQVKGLEEELKFSLG 1358

  Fly  1207 GTMDIEFSSAGESKNTIKVNPENSLVLQTH---DLPKST---RKVDFTAKG----TGSAMVQLSY 1261
            .|::::.  .|.||.|:|       :|:|:   |:..:|   .:::.|..|    |..|.....|
  Rat  1359 STINVKV--GGNSKGTLK-------ILRTYNVLDMKNTTCQDLRIEVTITGYVEYTREANEDYEY 1414

  Fly  1262 RYNLAEKEKKPSFKVTPTVKDTPNQLLIVDVCAEYVPLE--------DADKDKD----------- 1307
            .|::...: .||....|.   ||.||           .|        :|.|..|
  Rat  1415 DYDMPAAD-DPSVHSQPV---TPLQL-----------FEGRRSRRRREAPKAADEQESRVQYTVC 1464

  Fly  1308 ---------SNMAVMEIALPSGFVGDSTSLGKIQAV-DR-VKRVETKNSDSTVVVYFDSLTPGDV 1361
                     |.||:.:|.|.|||......|.|:.:: || |...||....  |::||||: |...
  Rat  1465 IWRNGNLGLSGMAIADITLLSGFQALRADLEKLTSLSDRYVSHFETDGPH--VLLYFDSV-PTTR 1526

  Fly  1362 RCLPLEASKAHAVAKQKPASVSLYDYYDTERKATEYY------QVKSSLC--DICEGADCGEG 1416
            .|:...|.:..||...:|||..|||||..:.|.:.:|      ::.|:||  |:|:   |.||
  Rat  1527 ECVGFGALQEVAVGLVQPASAVLYDYYSPDHKCSVFYAGPTKSKLLSTLCSADVCQ---CAEG 1586

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep2	NP_523506.1	A2M_N	115..209	CDD:280081	31/96 (32%)
		A2M_N_2	445..576	CDD:285005	32/156 (21%)
		A2M	694..782	CDD:278630	31/89 (35%)
		A2M_2	909..1198	CDD:239227	92/322 (29%)
		A2M_comp	961..1199	CDD:284982	76/290 (26%)
		A2M_recep	1308..1398	CDD:284981	34/91 (37%)
C4b	NP_001002805.1	A2M_N	139..231	CDD:280081	31/95 (33%)
		A2M_N_2	475..608	CDD:285005	31/153 (20%)
		ANATO	684..752	CDD:237984	7/67 (10%)
		A2M	779..866	CDD:278630	31/90 (34%)
		complement_C3_C4_C5	991..1310	CDD:239226	93/324 (29%)
		A2M_comp	1046..1312	CDD:284982	76/269 (28%)
		A2M_recep	1474..1563	CDD:284981	34/91 (37%)
		NTR_complement_C4	1581..1735	CDD:239639	4/9 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343876
Domainoid	1	1.000	50	1.000	Domainoid score	I11352
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.810