DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep2 and Cd109

DIOPT Version :9

Sequence 1:	NP_523506.1	Gene:	Tep2 / 34044	FlyBaseID:	FBgn0041182	Length:	1420	Species:	Drosophila melanogaster
Sequence 2:	NP_001102241.2	Gene:	Cd109 / 363104	RGDID:	1311287	Length:	1442	Species:	Rattus norvegicus

Alignment Length:	1501	Identity:	453/1501 - (30%)
Similarity:	722/1501 - (48%)	Gaps:	225/1501 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 YSVVGPGTLRSNSKYNVVVSVHKADGPSQIKVS---LNGPSYNETKQIE--------------LP 70
            :.|..||.:|..:...:.|.:.: :.|.|:.|.   |...|...|..:|              ||
  Rat    27 FLVTVPGIIRPGANMTIGVELLQ-NSPPQVLVKARVLKIASNRSTTVLEAEGVFNRGHFGILVLP 90

  Fly    71 --PMSTQNVEFEVPKLATGNYNLSAEGVSGVVFKNSTKLNYADKKPSVFVQTDKATYKPADLVQF 133
              |:...|..:|:        ::|.:..:.:||.|.|:|.:..|:.|||:||||..|||...|:|
  Rat    91 ALPLHKANKIYEL--------HISGKSETEIVFSNRTRLTFDSKRISVFIQTDKVIYKPKQEVKF 147

  Fly   134 RILFLDENTRPAKIEKPISVIIIDGAQNRIKQLSDVKLTKGVFSGELQLSEQPVLGTWKISVSVD 198
            |:|.|..:.:|.|  .|:.:.|.|...|.|:|....:...||.|...|||..|:||.|.|.|.|.
  Rat   148 RVLTLFSDLKPYK--TPVDIYIKDPKSNLIQQWLSQEGELGVVSKTFQLSSHPILGDWSIQVQVI 210

  Fly   199 GDNRETKSFEVDKYVLPKFEVIVDTPKAVVIADKVIKATIRAKYTYGKPVKGKATVSMERSYGYF 263
             |....:||:|..||||||||.:.||....:..|.::..:.|||||||||||..:::       |
  Rat   211 -DQLYYQSFQVLDYVLPKFEVTLQTPLYCSLKAKYLRGNVTAKYTYGKPVKGSLSLT-------F 267

  Fly   264 GDLNANGNKQE--KTIDVDGKGHVEFDIIHWAQ-----------RGQY------LP-PIKLFAVV 308
            ..|:..|.|:.  |..:::|..:..||.....:           .|.|      .| |:::.|.|
  Rat   268 IPLSFWGKKKNITKNFEINGFTNFAFDADEMKKVMNLKKATEISDGNYDQVDPVFPGPVEIVATV 332

  Fly   309 TEELTGNKQNATATVVLHQQRYSIEPYERPEHFEANKSFIYQVVVKNVDGSPVT----------- 362
            ||.|||..:.|:..|...|..|.||.::.....:...:|...|.:...||..:|
  Rat   333 TESLTGTSRKASTNVFFKQHDYVIEIFDYTTVLKPTLNFTATVKISRSDGKQLTPEEMENDLVTV 397

  Fly   363 -------NSAKNVKIGFDKSYSYFHEPSPKTRINFEAPVNENGIATFNVRLP-DSDSRYYRIFAS 419
                   |..:....|.|  |....|.|          |..||:.  .|..| .|||...::.||
  Rat   398 VTQKKNDNPTREKAQGTD--YIQMTEYS----------VPHNGVV--KVEFPIMSDSSELQLKAS 448

  Fly   420 FDGSENTIGSISKFEPTPMSREPLKIQVNTKKPRLGEQVSFDVVSIEDLPYFVYTIVARGNVILS 484
            |..|.:::...|.|  |..|...::::...:...:|...:..|...:......|.::::|.::
  Rat   449 FLDSASSVAVHSVF--TSPSNTYIQLKTRDEHITVGSPFNLTVSGNQKFKEISYMVISKGQLV-- 509

  Fly   485 DYVDVPDGQKTYTVKFTPTFSMVPKATIYVYYV-----VNNDLQFEEKTIDFEKEFSNSIDVS-A 543
                ....|.:.|...||..|..|||.|.|||:     |.:|:    ..|..:.:|.|.|.:| :
  Rat   510 ----AVGKQSSRTFSLTPEASWAPKACIIVYYIEQDGEVISDI----LKIPVQLDFKNKIKLSWS 566

  Fly   544 PTNAKPSEEVKLRIK-TDADSFVGLLGVDQSVLLLKSGNDLSQDDIFNSLNIYQTS---TPWMNG 604
            ....|||::|.|||. |.:.|.||::.||:||.|:.:.||::.:::.:.|.:|.|.   ..::|.
  Rat   567 KPRVKPSDKVSLRISVTQSYSLVGIVAVDKSVKLIGNSNDITMENVVHELELYNTEYYLGMFLNS 631

  Fly   605 YGRYPGQTSGLVTLTNANYPYNTGPLVMSYVFEGSRHPWITRPRYRVGIRGDSGDRISFLSQSLN 669
            :..:  |..||..||:||       ||...:.|             |....:..:|.:    ..|
  Rat   632 FAVF--QECGLWVLTDAN-------LVRDNIDE-------------VYDTQEYSERFA----EEN 670

  Fly   670 DRNLKEILLKQTPQRTTIRKEFPETW-----FFENVGEEEFTLTKKIPDTITSWVVTGFSLNPTS 729
            :.||.:.....:...:.:||.|||:|     :..:...||:.:|  :||:|||||.:.|.::...
  Rat   671 EANLVDFEDTSSASNSHVRKHFPESWIWLDFYMGSKNHEEYEVT--VPDSITSWVASAFVISEDL 733

  Fly   730 GIALTKNPSKIRVFQPFFVSTNLPYSVKRGEVIAIPVVIFNYLDKTLDADVVMDNSDQEYEFTEA 794
            |..||..|:::..|||||:|.||||||.|||..|:.|.|.|||..|....|:::.|| .::....
  Rat   734 GFGLTATPAELHAFQPFFISLNLPYSVIRGEEFALEVSIVNYLKDTTKVVVLIEESD-SFDILMF 797

  Fly   795 TNEVLEKAIDEVRRVKRVTIPANSGKSVSFMIRPKNVGFTTLKITATSALAGDAIHQKLKVEPEG 859
            :|:     |:.....|...:|..:..::.|.|:|.::|...:.:||.|..:.|.:.:.:.|:|||
  Rat   798 SND-----INNTIYRKTALVPRENSVTLVFPIKPTHLGNVPITVTAASPTSSDVVTRTIVVKPEG 857

  Fly   860 VTLFENRAVFINLKDQPEMSQ--SLDADIPNEVVPQSEFIEFSVVGDLLGPTLQNLDNLVRMPYG 922
            |....:::|.:.|.|:.:.::  ||....|.:.:..||.|:.:.:||:||.::..|.:|:|:|||
  Rat   858 VAKSYSQSVLLELIDKKQQTEPKSLSFSFPPDTISGSERIQITAIGDILGSSINGLSSLIRLPYG 922

  Fly   923 CGEQNMVNFVPNILVLKYLEVTGRKLPSVESKARKFLEIGYQRELTYKHDDGSYSAFGKSDASGS 987
            |||||||...||:.:|.||....:...:::.||..|:..||||||.|:.:|||:||||.||:|||
  Rat   923 CGEQNMVYLAPNVYILDYLTKQKQLTVNLKEKALSFMRQGYQRELLYQREDGSFSAFGNSDSSGS 987

  Fly   988 TWLTAYVMRSFHQAGTYTDIDPKVITAGLDFLVSKQKESGEFPEVGKL----FDNANQNPLALTS 1048
            |||:|:|:|.|.:|..|.|||..|:.....:|.:.:|.:|||.|.|::    ....|::|:.||:
  Rat   988 TWLSAFVLRCFMEAAQYIDIDQDVLHRTYSWLEAHKKTNGEFWEPGRVIHIELQGGNKSPITLTA 1052

  Fly  1049 FV---LLAFFENHELIPKYQS--AIKKAVRYVAEEADK-TDDQYSLAIAAVALQLAKHPQSEKVI 1107
            :|   ||.:       .|||.  .|:.:::::..|.:: ..|.|:||:...||.....|::|:.:
  Rat  1053 YVVTSLLGY-------KKYQPNIEIQDSIKFLENEFNRGISDNYTLALVTYALSAVGSPKAEEAL 1110

  Fly  1108 AKLESVARKENDRMWWSKATESTGEDGRVFHWKPRSNDVEITSYVLLALLEKDPAEKALPIIKWL 1172
            ..|...|.||.|..:|..:|..:.|.     |:..|..:||.:|.|||..:....| .:||:|||
  Rat  1111 TMLTQQAEKEGDTQFWLSSTSESSES-----WQSLSAQIEIAAYALLAHTQHHVPE-GIPIMKWL 1169

  Fly  1173 ISQRNSNGGFSSTQDTVIGLQALTKFA---YKTGSGSGTMDIEFSSAG-----------ESKNTI 1223
            |.||||.|||.||||||:.|:||::|:   ||.     ..|::.:..|           :|:|..
  Rat  1170 IKQRNSLGGFVSTQDTVMALKALSEFSALVYKE-----NRDMQVTIKGPNVPKPIRFWIDSQNLF 1229

  Fly  1224 KVNPENSLVLQTHDLPKSTRKVDFTAKGTGSAMVQLSYRYNLAEKEKKPSFKVTPTVKDTPNQLL 1288
            |::.|..       .|.....|:.:|.|:|.|:.||:..||:   :...|||...::::.....|
  Rat  1230 KLHKEEL-------APLDPIAVNVSAHGSGFAICQLNVDYNV---KASSSFKRRRSMENPIGFDL 1284

  Fly  1289 IVDVCAE----YVPLEDADKDKD---SNMAVMEIALPSGF--VGDSTSLGKIQAVDRVKRVETKN 1344
            .|||..|    |:.|........   :.||::|:.|.|||  ..||..|.:|     :|:||.:
  Rat  1285 DVDVNDEHDLRYMKLNVCTSHLGPGRTGMALLEVNLLSGFTATSDSIPLSEI-----LKKVEYE- 1343

  Fly  1345 SDSTVVVYFDSLTPGDVRCLPLEASKAHAVAKQKPASVSLYDYYDTERKATEYY--QVKSSLCDI 1407
             ...:.:|.|.:..... |:.:...:...|:..:...||:.|||:..|:|...|  |:|.|.|.:
  Rat  1344 -PGKLNLYLDHVNETQF-CVKIPTVRDFKVSNIRDGLVSIVDYYEPSRQAVRSYNTQMKLSSCYL 1406

  Fly  1408 CEGADC 1413
            ....:|
  Rat  1407 SADPNC 1412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep2	NP_523506.1	A2M_N	115..209	CDD:280081	39/93 (42%)
		A2M_N_2	445..576	CDD:285005	38/137 (28%)
		A2M	694..782	CDD:278630	39/92 (42%)
		A2M_2	909..1198	CDD:239227	119/298 (40%)
		A2M_comp	961..1199	CDD:284982	98/247 (40%)
		A2M_recep	1308..1398	CDD:284981	25/91 (27%)
Cd109	NP_001102241.2	YfaS	<122..>1019	CDD:225248	304/966 (31%)
		A2M_N_2	470..601	CDD:400170	38/140 (27%)
		A2M	695..784	CDD:395153	38/90 (42%)
		A2M_2	909..1195	CDD:239227	119/298 (40%)
		A2M_recep	1311..1395	CDD:400149	25/91 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343856
Domainoid	1	1.000	229	1.000	Domainoid score	I2388
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	570	1.000	Inparanoid score	I1022
OMA	1	1.010	-	-		QHG45959
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	1	1.000	-	-		FOG0002157
OrthoInspector	1	1.000	-	-		otm44434
orthoMCL	1	0.900	-	-		OOG6_100452
Panther	1	1.100	-	-	LDO	PTHR11412
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.910