DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep2 and C5

DIOPT Version :9

Sequence 1:	NP_523506.1	Gene:	Tep2 / 34044	FlyBaseID:	FBgn0041182	Length:	1420	Species:	Drosophila melanogaster
Sequence 2:	NP_444179.1	Gene:	C5 / 362119	RGDID:	2237	Length:	1688	Species:	Rattus norvegicus

Alignment Length:	1623	Identity:	389/1623 - (23%)
Similarity:	647/1623 - (39%)	Gaps:	337/1623 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 YSVVGPGTLRSNSKYNVVVSVHKADGPSQIKVSLNGPSYNETKQIELPPMSTQNVEFEVPKLATG 87
            |.:..|...|..|..|||:..|.........:||.  ||.:.|           |.:     ::|
  Rat    28 YVISAPKIFRVGSSENVVIQAHGYTEAFDATISLK--SYPDKK-----------VTY-----SSG 74

  Fly    88 NYNLSAEG----------------------------VSGVVFKNSTKLNYADKKPSVFVQTDKAT 124
            ..|||.|.                            |..:.|..|.|:........:|:.|||..
  Rat    75 YVNLSPENKFQNSALLTLPPKQFPRDENPVSHVYLEVVSMHFSKSKKIPITYDNGFLFIHTDKPV 139

  Fly   125 YKPADLVQFRILFLDENTRPAKIEKPISVIIIDGAQNRIKQLSDVKLTKGVFS-GELQLSEQPVL 188
            |.|...|:.|:..|.::.:|||.|..::.:..:|.:..|.:.:|.   .|:.| .:.::...|..
  Rat   140 YTPDQSVKIRVYSLSDDLKPAKRETVLTFVDPEGTEVDIVEENDY---TGIISFPDFKIPSNPKY 201

  Fly   189 GTWKISVSVDGD--NRETKSFEVDKYVLPKFEVIVDTPKAVVIADKVIK---ATIRAKYTYGKPV 248
            |.|.|......|  ...|..|||.:||||:|.|.:: |::..|..|..|   .|::|:|.|.|.|
  Rat   202 GVWTIKAKYKKDFTTTGTAYFEVKEYVLPRFSVSIE-PESNFIGYKNFKNFEITVKARYFYNKMV 265

  Fly   249 KGKATVSMERSYGYFGDLNANGNKQEKTID---------VDGKGHVEFDIIHWAQ---------- 294
            .....      |.:|| |..:..:.||.:.         |:|...:.||.....:
  Rat   266 PDAEV------YIFFG-LREDIKEDEKQMMHKAMQAATLVNGVAQISFDSETAVKELSYESLEDL 323

  Fly   295 RGQYLPPIKLFAVVTEELTGNKQNATATVVLHQQRYSIEPY-----ERPEHFEANKSFIYQVVVK 354
            ..:||   .:...|||...|..:.|....:    :|.:.||     ..|...:....|..:|.||
  Rat   324 NNKYL---YIAVTVTESSGGFSEEAEIPGI----KYVLSPYTLNLVATPLFLKPGIPFSIKVQVK 381

  Fly   355 N-----VDGSPVTNSAKNVKIGFDKSYSYFHEPSPKTRINFEAPVNENGIATFNVRLP------- 407
            :     |.|.|||..|:.|.:..:.|     :..||..|...|    :|:|:|.|.||
  Rat   382 DSLEQLVGGVPVTLMAQTVNVNQETS-----DLEPKRSITHSA----DGVASFVVNLPSEVTSLK 437

  Fly   408 -------------DSDSRYYR--IFASFDGSENTIGSISKFEPTPMSREPLKIQVNTKKPRLGEQ 457
                         :..|:.|.  .::|...|...||....::|. :..|.|.|.|..|.|
  Rat   438 FEVKTDAPELPEENQASKEYEAVTYSSLSQSYIYIGWTENYKPM-LVGEYLNIIVTPKSP----- 496

  Fly   458 VSFDVVSIEDLPYFVYTIVARGNVI---------LSDY--VDVPDGQKTYTVKFTPTFSMVPKAT 511
                  .|:.:.::.|.|:::|.::         .|.|  :::|           .|..|||.|.
  Rat   497 ------YIDKITHYNYLILSKGKIVQYGTKEKLLYSSYQNINIP-----------VTQDMVPSAR 544

  Fly   512 IYVYYVVNN----DLQFEEKTIDFEKEFSNSIDVSAPTNA---KPSEEVKLRIKTDADSFVGLLG 569
            :.|||:|..    :|..:...|:.|::..|.:.|....:.   .|.:.|.|.:.|:|||:|.|..
  Rat   545 LLVYYIVTGEQTAELVADAVWINIEEKCGNQLQVHLSPDKDVYSPGQTVSLDMVTEADSWVALSA 609

  Fly   570 VDQSVLLLKSGNDLSQDDIFNSLNIYQTSTPWMNGYGRYPGQ-------TSGLVTLTNAN----- 622
            ||.:|..::.....:...:|.:.:.....     |.|...|:       .:||..|||||
  Rat   610 VDSAVYGVRGKAKRAMQRVFQAFDDKSDL-----GCGAGGGRDNVDVFHLAGLTFLTNANADDSQ 669

  Fly   623 ----------YPYNTGPLVMSYV----------------FEGSRHPWITRPRYRVG--------- 652
                      .|.....|:...|                ::|:|.........||.
  Rat   670 YHDDSCKEILRPKRDLQLLHQKVEEQAAKYKHRVPKKCCYDGARENKYETCEQRVARVTIGPHCI 734

  Fly   653 ------------IRGDSGDRISFLSQSLNDRNLKEILLKQTPQRTTIRKEFPETWFFE--NVGEE 703
                        ||.:|..:...|.:.    .:|.:|   ...:..||..|||:|.:|  .|.:.
  Rat   735 RAFNECCTIADKIRKESHHKGMLLGRI----QIKALL---PVMKAEIRSYFPESWLWEVHRVPKR 792

  Fly   704 EFTLTKKIPDTITSWVVTGFSLNPTSGIALTKNPSKIRVFQPFFVSTNLPYSVKRGEVIAIPVVI 768
            . .|...:||::|:|.:.|..:: .:||.:. :..|.:||:..|:..|:||||.|||.|.:...:
  Rat   793 N-QLQVALPDSLTTWEIQGIGIS-DNGICVA-DTLKAKVFKDVFLEMNIPYSVVRGEQIQLKGTV 854

  Fly   769 FNYLDKTLDADVVMDNSDQEYEFTEATNEVLEKAIDEVRRVKRVTIPANSGKSVSFMIRPKNVGF 833
            :||  :|......:..|..|...|..::....:.....|.| |..|..:|...|:|.:.|..:|.
  Rat   855 YNY--RTSGTMFCVKMSAVEGICTPGSSAASPQTSRSSRCV-RQRIEGSSSHLVTFSLLPLEIGL 916

  Fly   834 TTLKITATSALAGDAIHQKLKVEPE--------GVTLFENRAVFINLKDQPEMSQSLDADIPNEV 890
            .::..:..::...:.:.:.|:|.||        |||| :.|.|:..:..:.|....    ||.::
  Rat   917 HSINFSLETSFGKEILVKTLRVVPEGIKRESYAGVTL-DPRGVYGIVNRRKEFPYR----IPLDL 976

  Fly   891 VPQSEF-----IEFSVVGDLLGPTL--QNLDNLVRMPYGCGEQNMVNFVPNILVLKYLEVTGR-- 946
            ||::..     ::..::|:.|...|  :.:|.|..:|.|..|..:::.||...|..|||....
  Rat   977 VPKTNVKRILSVKGLLIGEFLSTVLSKEGIDILTHLPKGSAEAELMSIVPVFYVFHYLEAGNHWN 1041

  Fly   947 -----KLPSVESKARKFLEIGYQRELTYKHDDGSYSAFGKSDASGSTWLTAYVMRSFHQAGTYTD 1006
                 .|...:|..:|..| |....::|::.|.|||.:  ..||.|.||||:.:|...|...|..
  Rat  1042 IFHPDTLARKQSLQKKIKE-GLVSVMSYRNADYSYSMW--KGASSSAWLTAFALRVLGQVNKYVK 1103

  Fly  1007 IDPKVITAGLDFLVSK-QKESGEFPE---------VGKLFDNANQNPLALTSFVLLAFFENHELI 1061
            .|...|...|.:|:.| |.|:|.|.|         .|.|...|.:|.|.||:|.::...:...:.
  Rat  1104 QDQYSICNSLLWLIEKCQLENGSFKENSQYLPIKLQGTLPAEAQENTLYLTAFSVIGIRKAIGIC 1168

  Fly  1062 P--KYQSAIKKAVRYVAEEADKTDDQYSLAIAAVALQLA--KHPQSEKVIAKLESVARKEND--- 1119
            |  |..:|:.||..::.|....:...::|||.|.||.|.  .||:...:::.|:..|..:.|
  Rat  1169 PTEKIYTALAKADSFLLERTLPSKSTFTLAIVAYALSLGDRTHPKFRSIVSALKREALVKGDPPI 1233

  Fly  1120 -RMWW------SKATESTGEDGRVFHWKPRSNDVEITSYVLLALLEKDPAEKALPIIKWLISQRN 1177
             |.|.      ..:..::|..|.          ||.|:|.||..|.........||||||..::.
  Rat  1234 YRFWRDTLQRPDSSAPNSGTAGM----------VETTAYALLTSLNLKETSYVNPIIKWLSEEQR 1288

  Fly  1178 SNGGFSSTQDTVIGLQALTKFAYKTGSGSGTMDIEFSSAGESK-NTIKVNPENSLVLQTHDLPKS 1241
            ..|||.|||||:..::.||:::.........|||..|...:.. ...||..:|.|. :..::|.:
  Rat  1289 YGGGFYSTQDTINAIEGLTEYSLLVKQLHLDMDINVSYKHKGDFYQYKVTEKNFLG-RPVEVPLN 1352

  Fly  1242 TRKVDFTAKGTGSAMVQLS---YRYNLAEKEKKPSFKVTPTVKDTPNQLLIVD-------VCAEY 1296
            ...:..|...:|.|.|.:.   ::.::||:......|:.....:..:.|...|       .||.|
  Rat  1353 DDLIVTTGYSSGLATVYVKTVVHKTSVAEEFCSFYLKIDTQEVEASSYLSYSDSGHKRIIACASY 1417

  Fly  1297 VPLEDADKDKDSNMAVMEIALPSGFVGDSTSL-GKIQAVDRVKRVETKNSDSTVVVYFDSLTPGD 1360
            .|.:: :....|:.|||:|.||:|...:...| ..::.||:: ..:.:..||.|::..:|:...|
  Rat  1418 KPSKE-ESASGSSHAVMDILLPTGIGANQEDLRALVEGVDQL-LTDYQIKDSHVILQLNSIPSRD 1480

  Fly  1361 VRCLPLEASKAHAVAKQKPASVSLYDYYDTERKATEYYQVK-SSLCDICEG-------ADCGE 1415
            ..|:.....:...|....||:.::|:|:..:::.|..|... ::|..:|||       ||||:
  Rat  1481 FLCVRFRIFELFQVGFLNPATFTVYEYHRPDKQCTMIYSTSDTNLQRVCEGAACKCVEADCGQ 1543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep2	NP_523506.1	A2M_N	115..209	CDD:280081	25/96 (26%)
		A2M_N_2	445..576	CDD:285005	37/148 (25%)
		A2M	694..782	CDD:278630	27/89 (30%)
		A2M_2	909..1198	CDD:239227	95/321 (30%)
		A2M_comp	961..1199	CDD:284982	79/261 (30%)
		A2M_recep	1308..1398	CDD:284981	23/90 (26%)
C5	NP_444179.1	MG1	25..125	CDD:375333	23/114 (20%)
		A2M_N	131..224	CDD:376626	25/95 (26%)
		MG3	226..310	CDD:375334	26/91 (29%)
		MG4	359..462	CDD:375332	25/111 (23%)
		A2M_N_2	475..615	CDD:377903	39/162 (24%)
		ANATO	691..759	CDD:237984	8/67 (12%)
		A2M	781..868	CDD:365945	27/91 (30%)
		complement_C3_C4_C5	1004..1309	CDD:239226	94/317 (30%)
		A2M_recep	1428..1518	CDD:369460	23/90 (26%)
		NTR_like	1536..1685	CDD:382999	4/8 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343852
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940