Protein Alignment Tep2 and Tep4

DIOPT Version :10

• Sequence 1: NP_523506.1
• Gene: Tep2 / 34044
• FlyBaseID: FBgn0041182
• Length: 1420
• Species: Drosophila melanogaster
• Sequence 2: NP_001260590.1
• Gene: Tep4 / 35248
• FlyBaseID: FBgn0041180
• Length: 1498
• Species: Drosophila melanogaster
• Alignment Length: 1534
• Identity: 627/1534 - (40%)
• Similarity: 887/1534 - (57%)
• Gaps: 163/1534 - (10%)

  Fly     5 FLTGIILQYALL-----VNATGIYSVVGPGTLRSNSKYNVVVSVHKADGPSQIKVSLNGPSYNET 64
            |...:.:..|||     |.|.|.|::|||||:.|:..|||.|:||:...|..:||.:.|||||:|
  Fly     7 FAVSLCVILALLQTMEPVKAEGKYTIVGPGTIHSHRDYNVAVAVHQTKEPVTLKVGITGPSYNKT 71

  Fly    65 KQIELPPMST-QNVEFEVPKLATGNYNLSAEGVSGVVFKNSTKLNYADKKPSVFVQTDKATYKPA 128
            :.:||..... :.:.|::|.|..|.|||:||||.|:.||||||||:.:.||.:.:||||..|||.
  Fly    72 ETVELATAGEFKQITFKLPPLEAGEYNLTAEGVKGLEFKNSTKLNWENFKPYIKIQTDKGKYKPG 136

  Fly   129 DLVQFRILFLDENTRPAKIEKPISVIIIDGAQNRIKQLSDVKLTKGVFSGELQLSEQPVLGTWKI 193
            |.:.:|::|||||.||...:..:.|...|..:|||||...:|.|.||::|:.:|||...||:|.:
  Fly   137 DTINYRVIFLDENLRPDTAKDEVVVWFEDSKRNRIKQEKHIKTTGGVYTGKFELSEFATLGSWSL 201

  Fly   194 SVSVDGDNR------------------------ETKSFEVDKYVLPKFEVIVDTPKAVVIADKVI 234
            .|. :||..                        |..:|||:||||||:.|.:|..:.|.:.|...
  Fly   202 HVQ-NGDQHHDGGIYFGGRKQFGGFGHRWHRSDELVNFEVEKYVLPKYSVKMDATQQVSVRDGEF 265

  Fly   235 KATIRAKYTYGKPVKGKATVSMERSYGYFGDLNANGNKQEKTIDVD--------------GKGHV 285
            ...::|.|||||||.||..|::     :....::..|...||:..|              ||..:
  Fly   266 NVVLKANYTYGKPVNGKVLVNV-----HLDSTSSWENVDGKTVQTDYPGHSVVGTADMVGGKAKL 325

  Fly   286 EFDIIHWAQRGQYLPP------IKLFAVVTEELTGNKQNATATVVLHQQRY--SIEPYERPEHFE 342
            ..|:..:|   .|||.      .::.|.|.|:.||.|.|.|..|.|:..||  |...|.....|:
  Fly   326 TMDLKDFA---SYLPHKTSSSYAQITATVEEDFTGVKLNETGGVQLYPYRYEMSCTDYSSCFSFK 387

  Fly   343 ANKSFIYQVVVKNVDGSPVTNSAKNVKI----GFDKSYSYF------HEPS----PKTRINFEAP 393
            .:|.......:..||||.:|::...||.    |..::|:::      .||.    .|....||:.
  Fly   388 PDKEHELNFKITYVDGSLITDTKSVVKAKFTEGIRRNYAFYAFGTDHQEPELPTIEKKTFVFESH 452

  Fly   394 VNENGIATFNVRLPD-----SDSRYYRIFASF-DGSENTIGSISKFEP----TPMSREPLK-IQV 447
            :|.:|:|.|.|.|||     :.:|||.|...| |...:...:....||    .|.|.|..: .:.
  Fly   453 LNASGVAPFKVVLPDLPDIANFTRYYSIELEFVDEKRDLYTTYPYREPKQIENPSSEEEKEWFRA 517

  Fly   448 NTKKP------RLGEQVSFDVVSIEDLPYFVYTIVARGNVILSDYVDVPDGQKTYTVKFTPTFSM 506
            ..::|      ::|::....:.|...|.||||.||.|||::.:..||:.:.|.|..|...|||..
  Fly   518 EVQRPKDVWNLKIGQEYQVILNSSRPLKYFVYNIVGRGNILETKRVDLAEPQTTVNVTIKPTFLT 582

  Fly   507 VPKATIYVYYV-VNNDLQFEEKTIDFEKEFSNSIDVSAPTNAKPSEEVKLRIKTDADSFVGLLGV 570
            .|...:|.||| ...:.::.|:|...|.|..|.|::.||...||..:|.|.|||...||||||.|
  Fly   583 TPYGRVYFYYVDETGEFRYTEETFSVEVELQNQIEIKAPAEVKPGADVALEIKTSPKSFVGLLAV 647

  Fly   571 DQSVLLLKSGNDLSQDDIFNSLNIYQTSTPWMNGYGRYPGQTSGLVTLTNANYPYN-TGP--LVM 632
            |||||||.|.|||:::.....||.|.|||||..||..|||:.:|:||:|||.:.|| |.|  .::
  Fly   648 DQSVLLLGSNNDLNKESFNWRLNGYDTSTPWQGGYSYYPGERTGVVTMTNAYFFYNRTAPDYNIL 712

  Fly   633 SYVFEGSR---------------HPWITRPRYRVGIRGDSGDRISFLSQSLNDRNLKEILLKQTP 682
            :..|.||.               |.....|...||...:|.                     ...
  Fly   713 TEGFGGSSFAMRKTTVAHDSHVFHSGAGGPTQAVGFSAESA---------------------SAS 756

  Fly   683 QRTTIRKEFPETWFF---ENVGEEEFTLTKKIPDTITSWVVTGFSLNPTSGIALTKNPSKIRVFQ 744
            ....:||.|.|||.|   |:..||.|...|.||||||:||||||||:|..|:.:|.:.:.|:.||
  Fly   757 AAPVVRKNFAETWIFADIESTEEEVFKWVKTIPDTITNWVVTGFSLHPQKGLGVTNDQTNIKTFQ 821

  Fly   745 PFFVSTNLPYSVKRGEVIAIPVVIFNYLDKTLDADVVMDNSDQEYEFTEATNEVLEKAIDEVRRV 809
            |||||..|||||||||||.:|.::||||.||||.::.:||.||||:|.:|:|||    |.:.:|.
  Fly   822 PFFVSVRLPYSVKRGEVINVPALVFNYLPKTLDVELTLDNEDQEYDFVDASNEV----IGDQKRT 882

  Fly   810 KRVTIPANSGKSVSFMIRPKNVGFTTLKITATSALAGDAIHQKLKVEPEGVTLFENRAVFINLKD 874
            :.:.:.||.....||:||||.:|...||..|.|.|||||||:.|||.|||:|.::|||.||||||
  Fly   883 QNIRVGANEAAGASFLIRPKVIGNILLKFKAISPLAGDAIHKPLKVVPEGITQYQNRAFFINLKD 947

  Fly   875 QPEMSQSLDADIPNEVVPQSEFIEFSVVGDLLGPTLQNLDNLVRMPYGCGEQNMVNFVPNILVLK 939
            ..|...:.:.::|.:|||.||.:||.:|||||||.::||:||:|:|.|||||.|...|||.||..
  Fly   948 TGEFKNTFELEVPEDVVPDSERVEFGLVGDLLGPVVKNLENLLRLPSGCGEQTMSKLVPNYLVRD 1012

  Fly   940 YLEVTGRKLPSVESKARKFLEIGYQRELTYKHDDGSYSAFGKSD-------ASGSTWLTAYVMRS 997
            ||:...:..|:::::.::.|:.|||..|.|:|||||:|:||.:.       .:|||||||||:||
  Fly  1013 YLKSIKKLTPALDTRIKRNLQDGYQHMLHYRHDDGSFSSFGPTKWRQEDPVRNGSTWLTAYVLRS 1077

  Fly   998 FHQAGTYTDIDPKVITAGLDFLVSKQKESGEFPEVGKLFDNANQNPLALTSFVLLAFFENHELIP 1062
            |.:.....|:|.:::..|.:||:::|.|:|.|.|.|:.|.::.::.|.||:..|||..|..:  |
  Fly  1078 FSKIKDIIDLDEQILAKGYEFLLTRQAENGSFTEHGEYFYSSQRSLLTLTANSLLALLEEEK--P 1140

  Fly  1063 KYQSAIKKAVRYVAEEADKTDDQYSLAIAAVALQLAKHPQSEKVIAKLESVARKENDRMWWSKAT 1127
            . |:||.|||.|::....::.:....:||..|||.||.|::.|.:|.|:|:|:.|:||.||::..
  Fly  1141 N-QAAIDKAVAYLSANTAESIELLPKSIAIYALQKAKAPEAAKQVASLKSLAKHEDDRTWWTEDL 1204

  Fly  1128 E---STGEDGRVFHWKPRSNDVEITSYVLLALLEKD--PAEKALPIIKWLISQRNSNGGFSSTQD 1187
            :   ::...||.:.| ..|.|||||||.||:||:.|  .|:..|..::|||:|||..|||:|:||
  Fly  1205 DKLRASKNCGRWWCW-IWSQDVEITSYALLSLLDSDQETADSVLNTVRWLIAQRNGFGGFASSQD 1268

  Fly  1188 TVIGLQALTKFAYKTGSGSGTMDIEFSSAGESKNTIKVN--PENSLVLQTHDLPKSTRKVDFTAK 1250
            ||:||.||.|||.|:|..:...::..|:.|:.:.|.|:|  .||.|:|||.:.|:.|:.::|.||
  Fly  1269 TVVGLTALIKFAEKSGYEAAKWEVTVSNKGKREKTEKLNTSEENDLLLQTVEFPQGTKSLEFEAK 1333

  Fly  1251 GTGSAMVQLSYRYNLAEKEKKPSFKVTPTV--KDTPNQLLIVDVCAEYVPLEDADKDKDSNMAVM 1313
            |||:||||:||:|||.|||.|||||:..||  :.:|..|.: .||.:||   :..:.|:||||::
  Fly  1334 GTGAAMVQISYQYNLVEKEPKPSFKIQTTVLPESSPANLEL-SVCVDYV---EEGESKESNMAIL 1394

  Fly  1314 EIALPSGFVGDSTSLGKIQAVDRVKRVETKNSDSTVVVYFDSLTPGDVRCLPLEASKAHAVAKQK 1378
            |::||||:..|..|...|:.::||:.|||||.||.||:||::|...:.:|:.:||.:.||||.||
  Fly  1395 EVSLPSGYTADEDSFADIRNIERVRLVETKNGDSVVVIYFENLAKNEEKCIRIEAYRTHAVANQK 1459

  Fly  1379 PASVSLYDYYDTERKATEYYQVKSSLCDICEGADCGEGC 1417
            |:||.|||||||.:||||||.:||.|||||||.||...|
  Fly  1460 PSSVVLYDYYDTNKKATEYYSIKSKLCDICEGDDCKSKC 1498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep2	NP_523506.1	YfaS	<72..1395	CDD:441940	579/1438 (40%)
		A2M_2	909..1198	CDD:239227	127/300 (42%)
Tep4	NP_001260590.1	YfaS	<76..1411	CDD:441940	545/1376 (40%)
		A2M_2	982..1279	CDD:239227	127/300 (42%)
		A2M_recep	1387..1480	CDD:462226	51/92 (55%)