DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep2 and Tep1

DIOPT Version :9

Sequence 1:	NP_523506.1	Gene:	Tep2 / 34044	FlyBaseID:	FBgn0041182	Length:	1420	Species:	Drosophila melanogaster
Sequence 2:	NP_523578.1	Gene:	Tep1 / 34937	FlyBaseID:	FBgn0041183	Length:	1354	Species:	Drosophila melanogaster

Alignment Length:	1430	Identity:	669/1430 - (46%)
Similarity:	937/1430 - (65%)	Gaps:	89/1430 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFRIFLTGIILQYALLVNATGIYSVVGPGTLRSNSKYNVVVSVHKADGPSQIKVSLNGPSYNETK 65
            |..:.|:..||...||.||.|:|||:.|.||||||.|||||::|.....:::.|||.|||.|..|
  Fly     1 MLWLILSSTILHCVLLSNANGLYSVLAPKTLRSNSAYNVVVAIHNTTRTTEVSVSLTGPSLNSRK 65

  Fly    66 QIELPPMSTQNVEFEVPKLATGNYNLSAEGVSGVVFKNSTKLNYADKKPSVFVQTDKATYKPADL 130
            .:::..||:::|.|::|||..|:|.|...|..|:.|:|||||::|.....:::|:|||||||.|.
  Fly    66 YVDVQSMSSKSVRFDIPKLTEGDYELKVMGSGGIEFQNSTKLSFAPDLNWLYIQSDKATYKPGDK 130

  Fly   131 VQFRILFLDENTRPAKIEKPISVIIIDGAQNRIKQLSDVKLTKGVFSGELQLSEQPVLGTWKISV 195
            :|||:||||:|||||.|:|||.:.|.||.||.||...|:|..|||:|||||||::||||.|.::.
  Fly   131 IQFRVLFLDKNTRPAVIDKPIKIEIRDGDQNLIKSWKDIKPAKGVYSGELQLSDRPVLGNWTVTA 195

  Fly   196 SVDGDNRETKSFEVDKYVLPKFEVIVDTPKAVVIADKVIKATIRAKYTYGKPVKGKATVSMERSY 260
            :|..:.:.|....|||||:|||||:|.|.|.|..:...|:|||:|:||:.|||||....::|
  Fly   196 TVQDEGKVTNVLVVDKYVVPKFEVVVLTAKNVAASAGYIRATIKARYTFKKPVKGHVVATIE--- 257

  Fly   261 GYFGDLNANGNKQEKTIDVDGKGHVEFDIIHWAQRGQYLPPIKLFAVVTEELTGNKQNATATVVL 325
                     |:..|:::.:||:.:|||.|...|:|     .:|:.|:||||||..|.|.||.|.:
  Fly   258 ---------GSSTEQSLPIDGEVNVEFPISATAKR-----LLKITAIVTEELTDIKHNGTAYVTV 308

  Fly   326 HQQRYSIEPYERPEHFEANKSFIYQVVVKNVDGSPVTNSAKNVKIGFDKSYSYFHEPSPKTRINF 390
            ||.|:.:|....|.|:....|..::.||:|:|||||.:|:|.|.         |:....:...||
  Fly   309 HQHRHKLEDLFWPTHYRPGVSSEFKTVVRNLDGSPVMDSSKMVN---------FNVLCCQVSKNF 364

  Fly   391 EAPVNENGIATFNVRLPDSDSRYYRIFASFDGSENTIGSISKFEPTPMSREPLKIQVNTKKPRLG 455
            .|.: :|.|||.::.||:: .:...:.::||.:||....|.|.      .:||.|.:|||||:|.
  Fly   365 SASL-QNSIATEHIMLPET-CQSCLVTSTFDTAENIERYIYKL------NKPLMIAINTKKPQLR 421

  Fly   456 EQVSFDVVSIEDLPYFVYTIVARGNVILSDYVDVPDGQKTYTVKFTPTFSMVPKATIYVYYVVNN 520
            :.:..:::|...||||:.|:|||||::||.:.::.:.:|:..::|.|||::||:|||:|:|:::.
  Fly   422 KLLKINIISDTYLPYFILTVVARGNIVLSLFQEMKEKKKSQEIEFEPTFALVPQATIFVHYIIDG 486

  Fly   521 DLQFEEKTIDFEKEFSNSIDVSAPTNAKPSEEVKLRIKTDADSFVGLLGVDQSVLLLKSGNDLSQ 585
            .|..:|||:|.|::|.|:|::.....|.|.:||.|::||:..|||||||||||||||:|||||::
  Fly   487 VLMSDEKTVDIERDFENTIEILTTNEALPRDEVSLKVKTNPHSFVGLLGVDQSVLLLRSGNDLNR 551

  Fly   586 DDIFNSLNIYQTSTPWMNGYGRYPGQTSGLVTLTNANYPYNTGPLVMSYVFEGSRHPWITRPRYR 650
            |.|.|:|..|.|.                ||.|||||        :..|...|..:   |.|.|
  Fly   552 DLILNNLATYSTD----------------LVILTNAN--------INIYRSSGGCY---TNPGY- 588

  Fly   651 VGIRGDSGDRISFLSQSLNDRNLKEILLKQTPQRT--TIRKEFPETWFFENV----GEEEFTLTK 709
            ....|....|..|.::...:.....|:.....|.:  .:||.|||||.|.|:    ...|:.:.:
  Fly   589 TNCTGSLIGRTMFKNEPTKNSGPVPIVGSTRAQASLPPVRKLFPETWLFSNITDVGANGEYIIKE 653

  Fly   710 KIPDTITSWVVTGFSLNPTSGIALTKNPSKIRVFQPFFVSTNLPYSVKRGEVIAIPVVIFNYLDK 774
            .:|||:||||:|||||:|.||:|:|:|||:||||||||::|||||||||||||||||::||||..
  Fly   654 TVPDTLTSWVITGFSLSPQSGLAVTRNPSRIRVFQPFFITTNLPYSVKRGEVIAIPVIVFNYLGM 718

  Fly   775 TLDADVVMDNSDQEYEFTEATNEVLEKAIDEVRRVKRVTIPANSGKSVSFMIRPKNVGFTTLKIT 839
            .:.|.|:|||||.:|||.|.||:.:.:.:..|||.|.:.||||:|:.:|||||||.||.||||||
  Fly   719 DVKAKVLMDNSDGQYEFIETTNKNVSQYLRGVRRKKTLWIPANTGRGISFMIRPKKVGLTTLKIT 783

  Fly   840 ATSALAGDAIHQKLKVEPEGVTLFENRAVFINLK-------DQPEMSQSLDADIPNEVVPQSEFI 897
            |.|..|||.:||.||||.:||..:.|:||.||::       ..||  :::..:..:.|:..||.:
  Fly   784 AISKYAGDRLHQILKVEADGVQKYVNKAVLINVQRLNRRSLAPPE--KTIIIEKADNVIEGSETV 846

  Fly   898 EFSVVGDLLGPTLQNLDNLVRMPYGCGEQNMVNFVPNILVLKYLEVTGRKLPSVESKARKFLEIG 962
            ||.|.|....|.|::||:||.:|.|||||||.||||:||.|.||:...|:...:|:||::::|.|
  Fly   847 EFEVCGTSQAPQLEHLDDLVHLPCGCGEQNMFNFVPSILALSYLKAKNRQDQEIENKAKRYVETG 911

  Fly   963 YQRELTYKHDDGSYSAFGKSDASGSTWLTAYVMRSFHQAGTYTDIDPKVITAGLDFLVSKQKESG 1027
            ||.||.||.:|||:||:|:.||.|||||||||:||||||..|.|||..|:.||||||||:|...|
  Fly   912 YQIELNYKRNDGSFSAWGQHDALGSTWLTAYVIRSFHQAAKYIDIDKNVLVAGLDFLVSRQSTDG 976

  Fly  1028 EFPEVGKLFDNANQNPLALTSFVLLAFFENHELIPKYQSAIKKAVRYVAEEADKTDDQYSLAIAA 1092
            :|.|:|.:..|::.:||||||||||.||||.|.:|||:..|.:||.:|..|..::::.|.|||||
  Fly   977 KFKELGMVIHNSHGSPLALTSFVLLTFFENEEYMPKYKHVIDRAVEFVVTEVHQSNEPYDLAIAA 1041

  Fly  1093 VALQLAKHPQSEKVIAKLESVARKENDRMWWSKATESTGEDGRVFHWKPRSNDVEITSYVLLALL 1157
            :||.||::..:.||:.||:.:|.:..|..||      ||.|      |.:|::||.|||||||||
  Fly  1042 LALSLARNRNAYKVLDKLDKLATRRGDHKWW------TGSD------KCKSSEVETTSYVLLALL 1094

  Fly  1158 EKDPAEKALPIIKWLISQRNSNGGFSSTQDTVIGLQALTKFAYKTGSGSGTMDIEFSSAGESKNT 1222
            |.:.:::..||:.||||:|||||||.|:||||:|:.||||:..::.:.:..:||||....|.|..
  Fly  1095 EHNISDEPKPIVDWLISKRNSNGGFVSSQDTVVGIMALTKYELQSHASTEAIDIEFWHLNEDKKH 1159

  Fly  1223 IKVNPENSLVLQTHDLPKSTRKVDFTAKGTGSAMVQLSYRYNLAEKEKKPSFKVTPTVKDTPNQL 1287
            ::|..||...:|||.||::|.:|...|||.|.|.|||:||||:|.||.:||||:|.|||.:....
  Fly  1160 VRVTKENEFKVQTHQLPENTNEVKLLAKGQGRAQVQLTYRYNVATKEARPSFKLTTTVKKSHKGR 1224

  Fly  1288 LIVDVCAEYVPLEDADKDKDSNMAVMEIALPSGFVGDSTSLGKIQAVDRVKRVETKNSDSTVVVY 1352
            ||:.:|..|.|:..::::|.:|||:|::.||||:|.|......|:|:..||||||||.|:.|.:|
  Fly  1225 LILGICGTYTPIAASERNKTTNMALMQVQLPSGYVCDIEPFADIEAISDVKRVETKNEDTEVHIY 1289

  Fly  1353 FDSLTPGDVRCLPLEASKAHAVAKQKPASVSLYDYYDTERKATEYYQVKSSLCDICEGADCGEGC 1417
            |:.|:|||.:||.|||...||||..||:.|.|||||.|||.|||:|.|.:||||||.|.:||..|
  Fly  1290 FEKLSPGDRKCLTLEAIYTHAVANLKPSWVRLYDYYATERSATEFYHVDTSLCDICHGNECGNMC 1354

Fly 1418 1417
Fly 1355 1354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep2	NP_523506.1	A2M_N	115..209	CDD:280081	51/93 (55%)
		A2M_N_2	445..576	CDD:285005	60/130 (46%)
		A2M	694..782	CDD:278630	56/91 (62%)
		A2M_2	909..1198	CDD:239227	156/288 (54%)
		A2M_comp	961..1199	CDD:284982	130/237 (55%)
		A2M_recep	1308..1398	CDD:284981	51/89 (57%)
Tep1	NP_523578.1	A2M_N	116..201	CDD:280081	50/84 (60%)
		A2M_N_2	411..542	CDD:285005	60/130 (46%)
		A2M	634..726	CDD:278630	56/91 (62%)
		A2M_2	859..1135	CDD:239227	156/287 (54%)
		A2M_comp	910..1135	CDD:284982	129/236 (55%)
		A2M_recep	1245..1335	CDD:284981	51/89 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469025
Domainoid	1	1.000	217	1.000	Domainoid score	I2610
eggNOG	1	0.900	-	-		E1_COG2373
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	517	1.000	Inparanoid score	I1243
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10215at33392
OrthoFinder	1	1.000	-	-		FOG0002157
OrthoInspector	1	1.000	-	-		mtm6406
orthoMCL	1	0.900	-	-		OOG6_100452
Panther	1	1.100	-	-	P	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X292
	11	10.800