DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep2 and c3a.1

DIOPT Version :9

Sequence 1:	NP_523506.1	Gene:	Tep2 / 34044	FlyBaseID:	FBgn0041182	Length:	1420	Species:	Drosophila melanogaster
Sequence 2:	NP_571317.1	Gene:	c3a.1 / 321046	ZFINID:	ZDB-GENE-990415-35	Length:	1643	Species:	Danio rerio

Alignment Length:	1625	Identity:	398/1625 - (24%)
Similarity:	661/1625 - (40%)	Gaps:	341/1625 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IFLTGIILQYALLVNATGIYSVVGPGTLRSNSKYNVVVSVHK-ADGPSQIKVSL-NGPSYNE--- 63
            :||:.::|..|||.....:|.:..|..||..|..||.|.... :....::|::: |.|..::
Zfish     5 LFLSAVLLSSALLTLCDPLYVLSAPNLLRVGSSENVFVEAQDYSKNAFEVKITVKNHPKKDKQIL 69

  Fly    64 TKQIELPPMSTQN-----VEFEVPKLATGNYNLSAEG-------VSGVVFKNST-----KLNYAD 111
            ||.:.|   :.||     .:.::|    .:.||.::.       ....:|.:.|     .|::
Zfish    70 TKSVNL---NAQNNFQILTDIKIP----DDQNLFSDDPLEKQYVYLQAIFPDHTLEKVVLLSF-- 125

  Fly   112 KKPSVFVQTDKATYKPADLVQFRILFLDENTRPAKIEKPISVIIIDGAQNRIKQLSDVKLTKGVF 176
            :...:||||||..|.|:..||:|.|.|..|.:|.. :..|:|.|:: .||.......|...||:.
Zfish   126 QSGYIFVQTDKPIYTPSSTVQYRTLSLTPNLKPLS-QTGITVEIMN-PQNITVSSDKVYPVKGMK 188

  Fly   177 SGELQLSEQPVLGTWKISVSVDGDNRE--TKSFEVDKYVLPKFEVIVDTPKA-VVIADKVIKATI 238
            ||:..:.|...||.||:........::  |..|||.:||||.|||.:...|. ..:.|:.:...|
Zfish   189 SGKYAIPEVASLGIWKVVTRFANTPQKTFTAEFEVKEYVLPTFEVKLQPSKLFYYVGDESLTVDI 253

  Fly   239 RAKYTYGKPVKGKATVSM-----ERSYGYFGDLNANGNKQEKTIDVDGKGHVEFDIIHWAQRGQY 298
            .|||.:||.|:|.|.|..     |...|..|.|       :|...:.|.|..|.       ..|.
Zfish   254 EAKYLFGKQVEGNAFVMFGVMDGETKTGITGSL-------QKIQILKGVGTAEL-------TKQM 304

  Fly   299 LPPIKLFAVVTEELTGNKQNATATVVLHQQRYSIE-----------PY-----ERPEHFEANKSF 347
            :...|..    ::|.|.....:.:::.......:|           ||     :..:.|:....|
Zfish   305 IETYKSI----DKLVGQSIYVSVSLLTESGSEMVEAERRGIRIVTSPYTINFKKTAQFFKPGMPF 365

  Fly   348 IYQVVVKNVDGSPVTNSAKNVKIGFDKSYSYFHEPSPKTRINFEAPVNENGIATFNVRLPDSDSR 412
            ...:.|.|.|.:|..|....|..|                 ........||||...|
Zfish   366 DVSIYVTNPDETPAQNVIVEVNPG-----------------GVRGQTKANGIAKVTV-------- 405

  Fly   413 YYRIFASFDGSENTIGSISKFEPTPMSREP--------------------------LKIQVNTKK 451
                        ||.|::...|.|..:::|                          |.|.::..:
Zfish   406 ------------NTQGNVLTQEITAQTKDPDITDEEQAVKKMTAHAYVPKGGSKNYLHIGIDAAE 458

  Fly   452 PRLGEQVSFDV-----VSIEDLPYFVYTIVARGNVILSDYVDVPDGQKTYTVKFTPTFSMVPKAT 511
            ..:|:|:..::     ..::|..| .:.|:::|.::..|... ..||...|:....|..|||...
Zfish   459 LEIGDQMKVNLNTGQSPGVKDQDY-TFMILSKGQIVKIDRFK-RQGQALITLSQPVTKEMVPSFR 521

  Fly   512 IYVYYVVN-NDLQFEEKTIDFEKEFSNSIDV---SAPTNAKPSEEVKLRIKTDADSFVGLLGVDQ 572
            ...||.|. |::..:...:|.:......:.:   :...|....|||||:|..|..:.|||:.||:
Zfish   522 FVAYYHVGANEVVSDSVWVDVKDTCMGKLKLQVKNKQNNYNTGEEVKLQISGDPGARVGLVVVDK 586

  Fly   573 SVLLLKSGNDLSQDDIFNSLNIYQTSTPWMNGYGR------------YPGQTS-GLVTLTNANYP 624
            :|.:|.. |.|:|..|::.:..:.|..  ..|.||            :...|: |..|..|...|
Zfish   587 AVHVLNK-NRLTQTKIWDVIEKHDTGC--TAGGGRDVMGVFSDAGLMFESNTAGGTDTRLNPECP 648

  Fly   625 ----------------YNTGPLVMSYVFEGSRHPWI----------TRPRYRVGIRGDSGDRI-S 662
                            ..|..|...|. :|.|...|          |..| |....||..:.: :
Zfish   649 DPPKRRRRRTESENLRTITATLAGQYA-DGQRQCCIDGMKDNKLGYTCER-RATYIGDGPECVKA 711

  Fly   663 FL---SQSLNDRNLK----EILLKQT---------PQRTTIRKEFPETWFFENVGEEEFTLTKKI 711
            ||   .:....:|:|    |::|.::         .:....|.:|||:|.:     ||..|....
Zfish   712 FLHCCDEMKKRKNIKTEEEEMILARSDDDDDYYTDSEEIVSRTQFPESWLW-----EEIDLCDNC 771

  Fly   712 P-----------DTITSWVVTGFSLNPTSGIALTKNPSKIRVFQPFFVSTNLPYSVKRGEVIAIP 765
            |           |:||:|.|...|::||.||.:.: |.:|.||:..|:...:|||..|||.:.|.
Zfish   772 PASAMEKAMYLKDSITTWQVLAVSMSPTLGICVAE-PEEIVVFKSLFIDLKMPYSAVRGEQLEIK 835

  Fly   766 VVIFNYLDKTLDADVVMDNSDQEYEFTEATNEVLEKAIDEVRRVKRVTIPANSGKSVSFMIRPKN 830
            .:|.||         ..|......||.|:. :|...|..:.:....||||..|..||.::|.|..
Zfish   836 AIIHNY---------TPDKRKVRVEFMESA-DVCSLASKKGKYRTTVTIPKESSLSVPYVIIPMT 890

  Fly   831 VG--FTTLKITATSALAGDAIHQKLKVEPEGVTLFENRAVFINLK-----DQPEMSQSLDADIPN 888
            :|  ...:|..|..|:..|.:.:.|||..||| ||..:...:.|.     |.|.:   :.||||.
Zfish   891 LGNHMIEVKAAAYDAVYTDGVRKGLKVVSEGV-LFPLQRPNVELNPVKNGDSPII---VRADIPA 951

  Fly   889 EVVPQS-EFIEFSVVGDLLGPTLQN------LDNLVRMPYGCGEQNMVNFVPNILVLKYLEVTGR 946
            :.||.: .....|:.|:.:..|::.      :..|:..|:|||||||:.....::...||:.| .
Zfish   952 DRVPGTPAHTHISITGEEISQTVEQAISGSFMGQLIVQPHGCGEQNMIFMTLPVIATHYLDST-N 1015

  Fly   947 KLPSVESKARK----FLEIGYQRELTYKHDDGSYSAFGKSDASGSTWLTAYVMRSFHQAGTYTDI 1007
            :..::..|.|.    .::.||.|:..|:..||||:|:  .|...||||||||.:.|..|.....|
Zfish  1016 QWEAIGMKRRDEAIGHIKTGYNRQQAYRKPDGSYAAW--IDRPSSTWLTAYVAKIFAMANDLITI 1078

  Fly  1008 DPKVITAGLDFLV-SKQKESGEFPE---------VGKLFDNANQNPLALTSFVLLAFFENHEL-- 1060
            :.:|:.:.|.:|| ::|...|.|.|         ||.:  .......:||:||.:|..|..||
Zfish  1079 EEQVLCSALKWLVLNRQLPDGSFEEKAAVVHGEMVGDV--QGRDAEASLTAFVTIAMQEGRELCG 1141

  Fly  1061 --IPKYQSAIKKAVRYVAEEADKTDDQYSLAIAAVAL----QLAKHPQSEKVIAKLESVARKEND 1119
              :.....:|:|||.::..:.:|..:.|::|:.:.|:    :|.|        |.|...:.|...
Zfish  1142 AIVGSLPESIRKAVSFLEGKLNKLTNPYAVALTSYAMAGADKLNK--------AVLMKFSTKGEA 1198

  Fly  1120 RMWWSKATESTGEDGRVFHWKPRSNDVEITSYVLLALLEKDPAEKALPIIKWLISQRNSNGGFSS 1184
            ..:|:       ..|:.:|.:      |.|||.:|||::......|...:.||.||..|.||..:
Zfish  1199 GTYWN-------VPGQQYHTR------EATSYAVLALVKARDFNAAGEAVHWLGSQHYSYGGSGT 1250

  Fly  1185 TQDTVIGLQALTKFAYKT---GSGSGTMDIEFSSAGESKNTIKVNPENSLVLQTHDLPKSTRKVD 1246
            ||.|::..||:.:  |:|   .|.:..:::|.:..|.||      |....:.:.:.....:.|||
Zfish  1251 TQATIMVFQAVAE--YRTQVKDSQNFNLEVELAVEGRSK------PSRYTIKRDNRHVSRSDKVD 1307

  Fly  1247 F------TAKGTGSAMVQLSYRYNLAEKEKKPS---FKVTPTVKDTPNQLLIVDVCAEYVPLED- 1301
            .      ||||||.|.:.:...|.....|||..   |.::..:...| :....|....:....|
Zfish  1308 INKDFNVTAKGTGKATLSVLTLYYARPVEKKSDCTLFDLSVKIDKDP-ETKHADAIETFKLTMDF 1371

  Fly  1302 --ADKDKDSNMAVMEIALPSGFVGDSTSL-----GKIQAVDRVKRVETKNSDSTVVVYFDSLTPG 1359
              .:....:.|.:::|.:|:||..:...|     ||.:.:::.:..:..:...::::|...::..
Zfish  1372 FYKNPKSPATMTILDIGIPTGFTVEYNDLEELTRGKEKYLEKFEMDKALSDRGSLILYLKMVSNK 1436

  Fly  1360 DVRCLPLEASKAHAVAKQKPASVSLYDYYDTERKATEYYQ-----VKSSLC--DICEGADCGEGC 1417
            :...:.....|...|...:||:|::|:||....:.|:|:.     |...||  |:|:.|:  |.|
Zfish  1437 ESERIAFRMHKMLNVGLLQPAAVTIYEYYSPNARCTKYFHPEREGVIYRLCKGDMCQCAE--ENC 1499

Fly 1418 1417
Zfish 1500 1499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep2	NP_523506.1	A2M_N	115..209	CDD:280081	32/95 (34%)
		A2M_N_2	445..576	CDD:285005	34/139 (24%)
		A2M	694..782	CDD:278630	30/98 (31%)
		A2M_2	909..1198	CDD:239227	90/316 (28%)
		A2M_comp	961..1199	CDD:284982	75/255 (29%)
		A2M_recep	1308..1398	CDD:284981	18/94 (19%)
c3a.1	NP_571317.1	A2M_N	129..223	CDD:280081	32/95 (34%)
		A2M_N_2	452..588	CDD:285005	33/137 (24%)
		ANATO	666..735	CDD:237984	16/70 (23%)
		A2M	759..851	CDD:278630	31/106 (29%)
		complement_C3_C4_C5	979..1264	CDD:239226	89/312 (29%)
		A2M_comp	1034..1264	CDD:284982	75/256 (29%)
		A2M_recep	1380..1475	CDD:284981	18/94 (19%)
		NTR_complement_C3	1494..1641	CDD:239638	3/8 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584206
Domainoid	1	1.000	56	1.000	Domainoid score	I10957
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	6	5.800