Protein Alignment Tep2 and Mug5

DIOPT Version :10

• Sequence 1: NP_523506.1
• Gene: Tep2 / 34044
• FlyBaseID: FBgn0041182
• Length: 1420
• Species: Drosophila melanogaster
• Sequence 2: XP_038963365.1
• Gene: Mug5 / 297568
• RGDID: 1584999
• Length: 1484
• Species: Rattus norvegicus
• Alignment Length: 1529
• Identity: 437/1529 - (28%)
• Similarity: 690/1529 - (45%)
• Gaps: 237/1529 - (15%)

  Fly    31 LRSNSKYNVVVSVHKADGPSQI------KVSLNGPSYNETKQIELPPMSTQN------------- 76
            |..||||.|:|       |||:      |:.|:....|||..:....:|.:.
  Rat    25 LNGNSKYMVLV-------PSQLYTETPEKICLHLYHLNETVTVTASLISQRGTRKLFDELVVDKD 82

  Fly    77 ----VEFEVPKLATGNYNLSAE-GVSGVVFKNSTK--LNYADKKPSVFVQTDKATYKPADLVQFR 134
                |.|.:|:|.:.....|.: .:.|...|.|.:  :...:|:..|||||||..|||...|:||
  Rat    83 LFHCVSFTIPRLPSSEEEESLDINIEGAKHKFSERRVVLVKNKESVVFVQTDKPMYKPGQSVKFR 147

  Fly   135 ILFLDENTRPAKIEKPISVIIIDGAQNRIKQLSDVKLTKGVFSGELQLSEQPVLGTWKISVSVDG 199
            ::.:|:|..|.....|:: .|.|...|||.|..|||...|:......||.:|:.|.:||.:....
  Rat   148 VVSMDKNLHPLNELFPLA-YIEDPKMNRIMQWQDVKTENGLKQLSFSLSAEPIQGPYKIVILKQS 211

  Fly   200 DNRETKSFEVDKYVLPKFEVIVDTPKAVVIADKVIKATIRAKYTYGKPVKGKATVSMERSYGYFG 264
            ..:|..||.|.::|||:|.|.|..|.|:.:.|::|..|..|.|||||||.|...:|:......|.
  Rat   212 GVKEEHSFTVMEFVLPRFGVDVKVPNAISVYDEIINVTACATYTYGKPVPGHVKISLCHGNPTFS 276

  Fly   265 DLNANGNKQEKT-IDVDGKGHVEFDIIHWAQRGQYLPPIKLF---AVVTEELTGNKQNATATVVL 325
            ....:..|:|.: :|.:|....|.:|..:..:..||...:.|   |.||||.||::.:.:..:.:
  Rat   277 SETKSACKEEDSRLDNNGCSTQEVNITEFQLKENYLKMHQAFHVNATVTEEGTGSEFSGSGRIEV 341

  Fly   326 HQQRYSIEPYERPEHFEANKSFIYQVVVKNVDGSPVTNSAKNVKIGFDKSYSYFHEPSPKTRINF 390
            .:.|......:...||.....|..:|.:.::.|.|:.|....:| ..|..|:............|
  Rat   342 ERTRNKFLFLKADSHFRHGIPFFVKVRLVDIKGDPIPNEQVLIK-ARDAGYTNATTTDQHGLAKF 405

  Fly   391 EAPVNENGIATFNVRLPDSDSRYYRIFASFDGSENT-------------IGSISK---FEPTPMS 439
            .  ::.:||:.:::.:    ..|::..:|...|..|             :.|:||   :..|...
  Rat   406 S--IDTSGISDYSLNI----KVYHKEESSCIHSSCTAERHAEAHHTAYAVYSLSKSYIYLDTEAG 464

  Fly   440 REPLKIQVNTKKPRLGEQVSF----DVVSIEDLPYFVYTIVARGNVIL----SDYVDVPDG--QK 494
            ..|.. |::|      .|..|    .|:.:.....|.|.::|:|:::.    :..|:..:.  |.
  Rat   465 VLPCN-QIHT------VQAHFILKGQVLGVLQQIVFHYLVMAQGSILQTGNHTHQVEPGESQVQG 522

  Fly   495 TYTVKFTPTFSMVPKATIYVYYVV-NNDLQFEEKTIDFEKEFSNSIDVS-APTNAKPSEEVKLRI 557
            .:.::....|||||.|.:.:|.:: :.::..:......||...|.:.:| :|:.:.|:.:..:|:
  Rat   523 NFALEIPVEFSMVPVAKMLIYTILPDGEVIADSVKFQVEKCLRNKVQLSFSPSQSLPASQTHMRV 587

  Fly   558 KTDADSFVGLLGVDQSVLLLKSGNDLSQDDIFN-----------SLN----------IYQTSTPW 601
            .....|..||..|||||||.|...:||...|::           |.|          :||.....
  Rat   588 TASPQSLCGLRAVDQSVLLQKPEAELSPSLIYDLPGMQDSNFIASSNDPFEDEDYCLMYQPIARE 652

  Fly   602 MNGYGRYPGQTSGLVTLTN--------ANYPYNTGPLVMSYVFEGSRHPWITRPRYRVGIRGDSG 658
            .:.| ||..:| ||:..||        .|..|:..||.:..|
  Rat   653 KDVY-RYVRET-GLMAFTNLKIKLPTYCNTDYDMVPLAVPAV----------------------- 692

  Fly   659 DRISFLSQSLNDRNLKEIL--------LKQTPQR----------TTIRKEFPETWFFENV----- 700
                 ...|..||.:.|.|        |.|.|.|          .|||..|||||.::.|
  Rat   693 -----ALDSSTDRGMYESLPVVAVKSPLPQEPPRKDPPPKDPVIETIRNYFPETWIWDLVTVNSS 752

  Fly   701 GEEEFTLTKKIPDTITSWVVTGFSLNPTSGIALTKNPSKIRVFQPFFVSTNLPYSVKRGEVIAIP 765
            |..|..:|  :|||||.|......|:..:|:.|: :.:..:.||||||...:||||.|||...:.
  Rat   753 GVTELEMT--VPDTITEWKAGALCLSNDTGLGLS-SVASFQAFQPFFVELTMPYSVIRGEAFTLK 814

  Fly   766 VVIFNYLDKTLDADVVMDNSDQEYEFTEATNEVLEKAIDEVRRVKRVTIPANSGKSVSFMIRPKN 830
            ..:.|||..:|...|:::.|.   :||         |:..........:.||...:.|:::.||:
  Rat   815 ATVLNYLPTSLPMAVLLEASP---DFT---------AVPVENNQDSYCLGANGRHTSSWLVTPKS 867

  Fly   831 VGFTTLKITATSALA----------------GDAIHQKLKVEPEGVTLFENRAVFINL--KDQPE 877
            :|.....::|.:..:                .|.:.:.|.|||||:   :....|.:|  ....|
  Rat   868 LGNVNFSVSAEARQSPGPCGSEVATVPETGRKDTVVKVLIVEPEGI---KKEHTFSSLLCASDAE 929

  Fly   878 MSQSLDADIPNEVVPQSEFIEFSVVGDLLGPTLQNLDNLVRMPYGCGEQNMVNFVPNILVLKYLE 942
            :|::|...:|..||..|....|||:||:|...::|..||::|||||||||||.|.|||.|||||.
  Rat   930 LSETLSLLLPPTVVKDSARAHFSVMGDILSSAIKNTQNLIQMPYGCGEQNMVLFAPNIYVLKYLN 994

  Fly   943 VTGRKLPSVESKARKFLEIGYQRELTYKHDDGSYSAFG--KSDASGSTWLTAYVMRSFHQAGTYT 1005
            .|.:....::|||..:|..||||||.|||.||||||||  .....|:|||||:|::||.||..:.
  Rat   995 ETQQLTEKIKSKALGYLRAGYQRELNYKHKDGSYSAFGDHNGQGQGNTWLTAFVLKSFAQARAFI 1059

  Fly  1006 DIDPKVITAGLDFLVSKQKESGEFPEVGKLFDNANQ----NPLALTSFVLLAFFENHELIPKYQS 1066
            .||...||....:|..:||:||.|...|.|.:||.:    :.:.|::::.:|..|:.  :|....
  Rat  1060 FIDESHITDAFTWLSKQQKDSGCFRSSGSLLNNAMKGGVDDEITLSAYITMALLESS--LPDTDP 1122

  Fly  1067 AIKKAVRYV------AEEADKTDDQYSLAIAAVALQLAKHPQSEKVIAK-LESVARKENDRMWWS 1124
            .:.||:..:      .|:.......|:.|:.|.|..||.:.:....|.| |:..|.||::.:.|.
  Rat  1123 VVSKALSCLESSWENIEQGGNGSFVYTKALMAYAFALAGNQEKRNEILKSLDKEAIKEDNSIHWE 1187

  Fly  1125 KATESTGEDGRVFHWKPRSNDVEITSYVLLALLEKDPAEK------ALPIIKWLISQRNSNGGFS 1183
            :..:.|..:|.::..:..|.:||:::||:||.|...||..      ::..||||..|:||.||||
  Rat  1188 RPQKPTKSEGYLYTPQASSAEVEMSAYVVLARLTAQPAPSPEDLALSMGTIKWLTKQQNSYGGFS 1252

  Fly  1184 STQDTVIGLQALTKFAYKTGSGS-GTMDIEFSSAGESKNTIKVNPENSLVLQTHDLPKSTRKVDF 1247
            ||||||:.|.||:|:...|.|.| .|..:...|:|......:|:..|.|:||...||........
  Rat  1253 STQDTVVALDALSKYGAATFSKSQKTPSVTVQSSGSFSQKFQVDKSNRLLLQQVSLPYIPGNYTV 1317

  Fly  1248 TAKGTGSAMVQLSYRYNLAEKEKKPSF----KVTPTVKDTPNQLLIVDVCAE--YVPLEDADKDK 1306
            :..|.|....|.:.|||:..::::|:|    :..|...:.|.......:..|  |.....|
  Rat  1318 SVSGEGCVYAQTTLRYNVPLEKQQPAFALKVQTVPLTCNNPKGQNSFQISLEISYTGSRPA---- 1378

  Fly  1307 DSNMAVMEIALPSGFVGDSTSLGKIQAVDRVKRVETKNSDSTVVVYFDSLTPGDVRCLPLEASKA 1371
             |||.:.::.:.|||:....::.|::.:..|.|.|.  :.:.|::|.|.:| ...........:.
  Rat  1379 -SNMVIADVKMLSGFIPLKPTVKKLERLGHVSRTEV--TTNNVLLYLDQVT-NQTLSFSFIIQQD 1439

  Fly  1372 HAVAKQKPASVSLYDYYDTERKATEYYQVKSSLC 1405
            ..|...:||.|.:||||:|:..|...|   ||.|
  Rat  1440 IPVKNLQPAIVKVYDYYETDEVAFAEY---SSPC 1470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep2	NP_523506.1	YfaS	<72..1395	CDD:441940	417/1470 (28%)
		A2M_2	909..1198	CDD:239227	122/307 (40%)
Mug5	XP_038963365.1	YfaS	<129..1349	CDD:441940	379/1284 (30%)
		A2M_2	961..1267	CDD:239227	122/307 (40%)
		A2M_recep	1377..1467	CDD:462226	26/100 (26%)