DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tep2 and CPAMD8

DIOPT Version :9

Sequence 1:NP_523506.1 Gene:Tep2 / 34044 FlyBaseID:FBgn0041182 Length:1420 Species:Drosophila melanogaster
Sequence 2:XP_011526219.1 Gene:CPAMD8 / 27151 HGNCID:23228 Length:1920 Species:Homo sapiens


Alignment Length:1732 Identity:459/1732 - (26%)
Similarity:724/1732 - (41%) Gaps:436/1732 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 YSVVGPGTLRSNSKYNVVVSVHKADGPSQIKVSLNGPSYNETKQIELPPMSTQNVEFEVPKLATG 87
            |.:..|...|:.  ...|:||...:.|.::           |.|.:|.......::.:||....|
Human    80 YLIAAPSVFRAG--VEEVISVTIFNSPREV-----------TVQAQLVAQDKGTIKLKVPTGLRG 131

  Fly    88 NYNLSAEG-----VSGVVFKNSTKLNYADKKPSVFVQTDKATYKPADLVQFRILFLDENTRPAKI 147
            ...|...|     ..|.:|.|.|.:....:..|||:||||..|:|...|...|..:..|.||  :
Human   132 QALLKVWGRGWQAEEGPLFHNQTSVTVDGRGASVFIQTDKPVYRPQHRVLISIFTVSPNLRP--V 194

  Fly   148 EKPISVIIIDGAQNRIKQLSDVK-LTKGVFSGELQLSEQPVLGTWKISVSVDGDNRETKSFEVDK 211
            .:.:...|:|...:|:.:...:| ...|:.:....||:|||||.|.|.|.:.| :...|||||.|
Human   195 NEKLEAYILDPRGSRMIEWRHLKPFCCGITNMSFPLSDQPVLGEWFIFVEMQG-HAYNKSFEVQK 258

  Fly   212 YVLPKFEVIVDTPKAVVIADKVIKATIRAKYTYGKPVKGKATVSME-RSYGYFGDLNANGNKQEK 275
            |||||||:::|.|:.:...|.....|:||:||:||||.|...::|. ...||:.  :..|....:
Human   259 YVLPKFELLIDPPRYIQDLDACETGTVRARYTFGKPVAGALMINMTVNGVGYYS--HEVGRPVLR 321

  Fly   276 TIDVDGKGHVEFDII-----------HWAQRGQYLPPIKLFAVVTEELTGNKQNA--TATVVLHQ 327
            |..:  .|..:|||.           |:  ||:    :.::|:|| .:.|::|.|  .:|.|..|
Human   322 TTKI--LGSRDFDICVRDMIPADVPEHF--RGR----VSIWAMVT-SVDGSQQVAFDDSTPVQRQ 377

  Fly   328 Q---RYSIEPYERPEHFEANKSFIYQVVVKNVDGSPVTNSAKNVKIGFDKSYSYFHEPSPKTRIN 389
            .   |||   .:..:.|:...:::.:|.:...||||.......:|.          |.:||..|.
Human   378 LVDIRYS---KDTRKQFKPGLAYVGKVELSYPDGSPAEGVTVQIKA----------ELTPKDNIY 429

  Fly   390 FEAPVNENGIATFNV-RLPDSDSRYY-----------RIFASFDGSENTIGSISKFEPTPMSREP 442
            ....|::.|:..|.: .:|.|....:           .:.|.:..|..::|  |.:.|   |:..
Human   430 TSEVVSQRGLVGFEIPSIPTSAQHVWLETKVMALNGKPVGAQYLPSYLSLG--SWYSP---SQCY 489

  Fly   443 LKIQVNTKKPRLGEQVSFDVVSIEDLPY-FVYTIVARGNVILSDYVDVPDGQK------------ 494
            |::|..:...::||:..|.|.|.....: ..|.:.||||::||........|:            
Human   490 LQLQPPSHPLQVGEEAYFSVKSTCPCNFTLYYEVAARGNIVLSGQQPAHTTQQRSKRAAPALEKP 554

  Fly   495 ---TYTVKFTP-------------------TFSMVPKATIYVYYV------VNNDLQFEEKTIDF 531
               |:..:..|                   |.||||...:.|:||      |.:.|||..:|.  
Human   555 IRLTHLSETEPPPAPEAEVDVCVTSLHLAVTPSMVPLGRLLVFYVRENGEGVADSLQFAVETF-- 617

  Fly   532 EKEFSNSIDVSAPTN-AKPSEEVKLRIKTDADSFVGLLGVDQSVLLLKSGNDLSQDDIFNSLNIY 595
               |.|.:.|:...| .:|.|.|.|||:....|.|.:..||:||.||:||..|:...:|..|..|
Human   618 ---FENQVSVTYSANETQPGEVVDLRIRAARGSCVCVAAVDKSVYLLRSGFRLTPAQVFQELEDY 679

  Fly   596 QTSTPWMNGYGRYPGQTSGLVTLTNANYPYNTGPLVMSYVFEGSRHPWITRPRYRVGIRGDSG-- 658
            ..|..:  |..|..|             |:....|........|..||      ..||..|||  
Human   680 DVSDSF--GVSREDG-------------PFWWAGLTAQRRRRSSVFPW------PWGITKDSGFA 723

  Fly   659 ----------DRISFLSQSLNDR-------------------NLKEILLKQTPQRTTIRKE--FP 692
                      ||:     |||.|                   :|..:...:.|.||..||.  ||
Human   724 FTETGLVVMTDRV-----SLNHRQDGGLYTDEAVPAFQPHTGSLVAVAPSRHPPRTEKRKRTFFP 783

  Fly   693 ETWFFE--NVGEE--EFTLTKKIPDTITSWVVTGFSLNPTSGIALTKNPSKIRVFQPFFVSTNLP 753
            |||.:.  |:.:.  |.||:.|:||:|||||....:|:.:.|:.:.: ||.::.|:||||...||
Human   784 ETWIWHCLNISDPSGEGTLSVKVPDSITSWVGEAVALSTSQGLGIAE-PSLLKTFKPFFVDFMLP 847

  Fly   754 YSVKRGEVIAIPVVIFNYLDKTLDADVVMDNSDQEYEFTEATNEVLEKAIDEV-----RRV-KRV 812
            ..:.|||.:.||:.::||:...  |:|.|..|             :.|.|..|     |.| |::
Human   848 ALIIRGEQVKIPLSVYNYMGTC--AEVYMKLS-------------VPKGIQFVGHPGKRHVTKKM 897

  Fly   813 TIPANSGKSVSFMIRPKNVGFTTLKITATSALAGDA---------------------------IH 850
            .:.....:.:..::...::|..  .|||.:...||.                           :.
Human   898 CVAPGEAEPIWVVLSFSDLGLN--NITAKALAYGDTNCCRDGRSSKHPEENHADRRVPIGVDHVR 960

  Fly   851 QKLKVEPEGV-----------------------------------TLFE---------------- 864
            :.:.||.|||                                   |.|:                
Human   961 RSVMVEAEGVPRAYTYSAFFCPSERVHISTPNKYEFQYVQRPLRLTRFDVAVRAHNDARVALSSG 1025

  Fly   865 ----------------------------------------------------------------- 864
                                                                             
Human  1026 PQDTAGMIEIVLGGHQNTRSWISTSKMGEPVASAHTAKILSWDEFRTFWISWRGGLIQVGHGPEP 1090

  Fly   865 -NRAVFI--NLKDQPEM---------------------------SQSLDADIPNEVVPQSEFIEF 899
             |.:|.:  .|...||:                           |::....:|:..:|.||....
Human  1091 SNESVIVAWTLPRPPEVQFIGFSTGWGSMGEFRIWRKMEVDESYSEAFTLGVPHGAIPGSERATA 1155

  Fly   900 SVVGDLLGPTLQNLDNLVRMPYGCGEQNMVNFVPNILVLKYLEVTGRKLPSVESKARKFLEIGYQ 964
            |::||::||||.:|:||:|:|:|||||||::|.||:.|||||:.|.:..|.||.:...:|..|||
Human  1156 SIIGDVMGPTLNHLNNLLRLPFGCGEQNMIHFAPNVFVLKYLQKTQQLSPEVERETTDYLVQGYQ 1220

  Fly   965 RELTYKHDDGSYSAFGKSDASGSTWLTAYVMRSFHQAGTYTDIDPKVITAGLDFLVSKQKESGEF 1029
            |:||||..||||||||:.|||||.||||:|::||.||.::..:||:.:.|...:::.:|:..|.|
Human  1221 RQLTYKRQDGSYSAFGERDASGSMWLTAFVLKSFAQARSFIFVDPRELAAAKSWIIQQQQADGSF 1285

  Fly  1030 PEVGKLFDNANQ----NPLALTSFVLLAFFENHELIPKYQSAIKKAVRYVAEEADKTDDQYSLAI 1090
            ..||::.:...|    ..:.||::|::|..|......:.:.:..||..::...|....|.||.|:
Human  1286 LAVGRVLNKDIQGGIHGTVPLTAYVVVALLETGTASEEERGSTDKARHFLESAAPLAMDPYSCAL 1350

  Fly  1091 AAVALQLAKHPQSEKVIAKLESVARKENDRMWWSKATESTGEDGRVFHWKPR------SNDVEIT 1149
            ...||.|.:.|.:.:.:.||.|:|...:....||.:.....:.|....:..|      |.:||:|
Human  1351 TTYALTLLRSPAAPEALRKLRSLAIMRDGVTHWSLSNSWDVDKGTFLSFSDRVSQSVVSAEVEMT 1415

  Fly  1150 SYVLLALLEKDPAEKALPIIKWLISQRNSNGGFSSTQDTVIGLQALTKFAYKTGSGSGTMDIEFS 1214
            :|.||..........|||::|||..|||:.|||||||||.:.||||.::|..:.:|...:.:..:
Human  1416 AYALLTYTLLGDVAAALPVVKWLSQQRNALGGFSSTQDTCVALQALAEYAILSYAGGINLTVSLA 1480

  Fly  1215 SAG-ESKNTIKVNPENSLVLQTHDLPKSTRKVDFTAKGTGSAMVQLSYRYNLAEKEKKPSFKVTP 1278
            |.. :.:.|.:::..|..||||..:|.....:..:|||.|..::|:...||:.:...||:|::..
Human  1481 STNLDYQETFELHRTNQKVLQTAAIPSLPTGLFVSAKGDGCCLMQIDVTYNVPDPVAKPAFQLLV 1545

  Fly  1279 TVKDTPNQLLIVDVCA--------EYVPLEDADKDKD---------------------SNMAVME 1314
            ::::...|.....:.|        ::.|.:|.|...|                     |||||:|
Human  1546 SLQEPEAQGRPPPMPASAAEGSRGDWPPADDDDPAADQHHQEYKVMLEVCTRWLHAGSSNMAVLE 1610

  Fly  1315 IALPSGFVGDSTSLGKIQAVDR---VKRVETKNSDSTVVVYFDSLTPGDVRCLPLEASKAHAVAK 1376
            :.|.|||..|..||.:: .:|:   :||.|.  :...|:.|||.:....:.|:...|.:...|.:
Human  1611 VPLLSGFRADIESLEQL-LLDKHMGMKRYEV--AGRRVLFYFDEIPSRCLTCVRFRALRECVVGR 1672

  Fly  1377 QKPASVSLYDYYDTERKATEYYQVK--SSLC-DICEGADCGE 1415
            .....||:||||:...:||.:|.|.  |.|. ::|.|..|.|
Human  1673 TSALPVSVYDYYEPAFEATRFYNVSTHSPLARELCAGPACNE 1714

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tep2NP_523506.1 A2M_N 115..209 CDD:280081 33/94 (35%)
A2M_N_2 445..576 CDD:285005 45/172 (26%)
A2M 694..782 CDD:278630 34/91 (37%)
A2M_2 909..1198 CDD:239227 119/298 (40%)
A2M_comp 961..1199 CDD:284982 92/247 (37%)
A2M_recep 1308..1398 CDD:284981 32/92 (35%)
CPAMD8XP_011526219.1 A2M_N 164..256 CDD:280081 33/94 (35%)
A2M_N_2 492..660 CDD:285005 45/172 (26%)
A2M 785..876 CDD:278630 35/93 (38%)
Methyltransf_FA 1020..1121 CDD:289052 5/100 (5%)
A2M_2 1176..1464 CDD:239227 113/287 (39%)
A2M_comp 1217..1466 CDD:284982 92/248 (37%)
A2M_recep 1604..1694 CDD:284981 32/92 (35%)
KAZAL 1747..>1779 CDD:197624
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 239 1.000 Domainoid score I2285
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D177369at33208
OrthoFinder 1 1.000 - - FOG0002157
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.820

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