DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep2 and A2m

DIOPT Version :9

Sequence 1:	NP_523506.1	Gene:	Tep2 / 34044	FlyBaseID:	FBgn0041182	Length:	1420	Species:	Drosophila melanogaster
Sequence 2:	NP_036620.2	Gene:	A2m / 24153	RGDID:	2004	Length:	1472	Species:	Rattus norvegicus

Alignment Length:	1559	Identity:	429/1559 - (27%)
Similarity:	696/1559 - (44%)	Gaps:	264/1559 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LTGIILQYALLVNATG-------IYSVVGPGTLRSNSKYNVVVSVHKADGPSQIKVSLNGPSYNE 63
            |..::|:..||:..|.       ||.|:.|..|.:.:...........:....::|||.....|:
  Rat    11 LLPLLLRLLLLLLPTDASAPQKPIYMVMVPSLLHAGTPEKACFLFSHLNETVAVRVSLESVRGNQ 75

  Fly    64 TKQIEL--------------PPMSTQNVEFEVPKLATGNYNLSAEGVSGVVFKNSTKLNYADKKP 114
            :...:|              |..|:..|.|         :.:..:|.:....:.||.|  ..||.
  Rat    76 SLFTDLVVDKDLFHCTSFTVPQSSSDEVMF---------FTVQVKGATHEFRRRSTVL--VKKKE 129

  Fly   115 S-VFVQTDKATYKPADLVQFRILFLDENTRPAKIEKPISVIIIDGAQNRIKQLSDVKLTKGVFSG 178
            | ||.||||..|||...|:||::.|||:..|.....|: :.|.|...|||.|..:..|..|:...
  Rat   130 SLVFAQTDKPIYKPGQTVRFRVVSLDESFHPLNELIPL-LYIQDPKNNRIAQWQNFNLEGGLKQL 193

  Fly   179 ELQLSEQPVLGTWKISVSVDGDNRETKSFEVDKYVLPKFEVIVDTPKAVVIADKVIKATIRAKYT 243
            ...||.:|..|::|:.:..:........|.|:::|||||||.|..|:.:.|.::.:..::...||
  Rat   194 SFPLSSEPTQGSYKVVIRTESGRTVEHPFSVEEFVLPKFEVRVTVPETITILEEEMNVSVCGIYT 258

  Fly   244 YGKPVKGKATVSMERSYGYFGDLNANGNK-----QEKTIDVDGKG-------HVEFDIIHWAQRG 296
            |||||.|:.||::.|.|.  ...|..|.:     ::.:..:||:|       ...|.:    :|.
  Rat   259 YGKPVPGRVTVNICRKYS--NPSNCFGEESVAFCEKLSQQLDGRGCFSQLVKTKSFQL----KRQ 317

  Fly   297 QYLPPIKLFAVVTEELTGNKQNATATVVLHQQRYSIEPYERPEHFEANKSFIYQVVVKNVDGSPV 361
            :|...:.:.|.:.||.||.::.......:.:....:.......||.....|:.||::.:..|:|:
  Rat   318 EYEMQLDVHAKIQEEGTGVEETGKGLTKITRTITKLSFVNVDSHFRQGIPFVGQVLLVDGRGTPI 382

  Fly   362 TNSAKNVKIGFDKSYSYFHEPSPKTRINFEAPVNENGIATFNVRLPDSDSRYYRIFASFDGSENT 426
              ..:.:.||.|::..|.:..:.|           :|:|.|::...|.......:.|.:..|...
  Rat   383 --PYETIFIGADEANLYINTTTDK-----------HGLARFSINTDDIMGTSLTVRAKYKDSNAC 434

  Fly   427 IG--------------SISKFEPTPMSREPLKIQVNTKKPRLGEQVSFDV------VSIEDLP-- 469
            .|              :.:.|.|   ||..|.::....|.|..:.:....      .::::|.
  Rat   435 YGFRWLTEENVEAWHTAYAVFSP---SRSFLHLESLPDKLRCDQTLEVQAHYILNGEAMQELKEL 496

  Fly   470 YFVYTIVARGNVILSDYVDVP--DGQKT--YTVKFTPTFSMVPKATIYVYYVV-NNDLQFEEKTI 529
            .|.|.::|:|.::.:....:|  .||..  :::..:....:.|.|.:.:|.:: |.::..:....
  Rat   497 VFYYLMMAKGGIVRAGTHVLPLKQGQMRGHFSILISMETDLAPVARLVLYAILPNGEVVGDTAKY 561

  Fly   530 DFEKEFSNSID-VSAPTNAKPSEEVKLRIKTDADSFVGLLGVDQSVLLLKSGNDLSQDDIFNSLN 593
            :.|...:|.:| |..|.:..|:....|.:.....|..||..|||||||:|...:||...|::.|.
  Rat   562 EIENCLANKVDLVFRPNSGLPATRALLSVMASPQSLCGLRAVDQSVLLMKPETELSASLIYDLLP 626

  Fly   594 IYQ-TSTP-------------------WMNGYGRYPGQTS------------GLVTLTNANYPYN 626
            :.. |..|                   ::||....|.|.:            ||...||:|
  Rat   627 VKDLTGFPQGADQREEDTNGCVKQNDTYINGILYSPVQNTNEEDMYGFLKDMGLKVFTNSN---- 687

  Fly   627 TGPLVMSYVFEGSRHPWITRPRYRVGIRGDSGDRISF--LSQSLNDRNLKEILLKQTPQRTTIRK 689
                             |.:|:....:|.:.|...::  :|||..|..|:.   .::|..|. |.
  Rat   688 -----------------IRKPKVCERLRDNKGIPAAYHLVSQSHMDAFLES---SESPTETR-RS 731

  Fly   690 EFPETWFFE-------NVGEEEFTLTKKIPDTITSWVVTGFSLNPTSGIALTKNPSKIRVFQPFF 747
            .|||||.::       .|.|.|.|    :|||||.|....|.|:..:|:.|:. ..:.:.|||||
  Rat   732 YFPETWIWDLVVVDSAGVAEVEVT----VPDTITEWKAGAFCLSNDTGLGLSP-VVQFQAFQPFF 791

  Fly   748 VSTNLPYSVKRGEVIAIPVVIFNYLDKTLDADVVMDNSDQEYEFTEATNEVLEKAIDEVRRVKRV 812
            |...:||||.|||...:...:.|||...:...|.:          ||:.:.|  |..|.:..:..
  Rat   792 VELTMPYSVIRGEAFTLKATVLNYLPTCIRVAVQL----------EASPDFL--AAPEEKEQRSH 844

  Fly   813 TIPANSGKSVSFMIRPKNVGFTTLKITA----TSALAG------------DAIHQKLKVEPEGVT 861
            .|..|...:.|:.:.||::|.....::|    :..|.|            |.|.:.|.|||||:
  Rat   845 CICMNQRHTASWAVIPKSLGNVNFTVSAEALNSKELCGNEVPVVPEQGKKDTIIKSLLVEPEGL- 908

  Fly   862 LFENRAVFINL--KDQPEMSQSLDADIPNEVVPQSEFIEFSVVGDLLGPTLQNLDNLVRMPYGCG 924
              ||...|.:|  ....|:|:.:...:|::||.:|.....:|:||:||..:||..:|::||||||
  Rat   909 --ENEVTFNSLLCPMGAEVSELIALKLPSDVVEESARASVTVLGDILGSAMQNTQDLLKMPYGCG 971

  Fly   925 EQNMVNFVPNILVLKYLEVTGRKLPSVESKARKFLEIGYQRELTYKHDDGSYSAFGKSDASG--- 986
            |||||.|.|||.||.||..|.:....:::||..:|..||||:|.|||.|||||.||  |..|
  Rat   972 EQNMVLFAPNIYVLDYLNETQQLTQEIKTKAIAYLNTGYQRQLNYKHRDGSYSTFG--DKPGRNH 1034

  Fly   987 -STWLTAYVMRSFHQAGTYTDIDPKVITAGLDFLVSKQKESGEFPEVGKLFDNAN----QNPLAL 1046
             :|||||:|::||.||..|..||...||..|.:|..:||::|.|...|.|.:||.    ::.:.|
  Rat  1035 ANTWLTAFVLKSFAQARKYIFIDEVHITQALLWLSQQQKDNGCFRSSGSLLNNAMKGGVEDEVTL 1099

  Fly  1047 TSFVLLAFFENHELIPKYQSAIKKAVRYVAEEADKT-------DDQYSLAIAAVALQLAKHPQSE 1104
            ::::.:|..|..  :|.....::.|: :..:.|.|:       ...|:.|:.|.|..||.:..::
  Rat  1100 SAYITIALLEMS--LPVTHPVVRNAL-FCLDTAWKSARGGAGGSHVYTKALLAYAFALAGNQDTK 1161

  Fly  1105 KVIAK-LESVARKENDRMWWSKATESTGEDGRVFHWKPRSNDVEITSYVLLALLEKDPA------ 1162
            |.|.| |:..|.||.|.:.|::..:.:......:..:..|.:||:|:|||||.|..:||
  Rat  1162 KEILKSLDEEAVKEEDSVHWTRPQKPSVSVALWYQPQAPSAEVEMTAYVLLAYLTTEPAPTQEDL 1226

  Fly  1163 EKALPIIKWLISQRNSNGGFSSTQDTVIGLQALTKFAYKTGSGSGTM-------DIEFSSAGESK 1220
            ..|:.|:|||..|:||:||||||||||:.|.||:|:      ||.|.       .:...|:|...
  Rat  1227 TAAMLIVKWLTKQQNSHGGFSSTQDTVVALHALSKY------GSATFTRAKKAAQVTIHSSGTFS 1285

  Fly  1221 NTIKVNPENSLVLQTHDLPKSTRKVDFTAKGTGSAMV--QLSYRYNLAEKEKKPSFKVTPTVKDT 1283
            ...:||..|.|:||...||  |...|:|.|.||...|  |.|.:|::..:|::  |..|..|:..
  Rat  1286 TKFQVNNNNQLLLQRVTLP--TVPGDYTVKVTGEGCVYLQTSLKYSVLPREEE--FPFTVVVQTL 1346

  Fly  1284 PNQLLIVDVCAE---------YVPLEDADKDKDSNMAVMEIALPSGFVGDSTSLGKIQAVDRVKR 1339
            |.      .|.:         .:.:.......:||||:.::.:.|||:....::..::....|.|
  Rat  1347 PG------TCEDPKAHTSFQISLNISYTGSRSESNMAIADVKMVSGFIPLKPTVKMLERSVHVSR 1405

  Fly  1340 VETKNSDSTVVVYFDSLTPGDVRCLPLEASKAHAVAKQKPASVSLYDYYDTERKATEYYQVKSS 1403
            .|..|:.  |::|.|.::...|. |.....:...:...|||.|.:||||:.:..|...|....|
  Rat  1406 TEVSNNH--VLIYLDKVSNQTVN-LSFTVQQDIPIRDLKPAVVKVYDYYEKDEFAVAKYSAPCS 1466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep2	NP_523506.1	A2M_N	115..209	CDD:280081	32/94 (34%)
		A2M_N_2	445..576	CDD:285005	29/144 (20%)
		A2M	694..782	CDD:278630	33/94 (35%)
		A2M_2	909..1198	CDD:239227	123/310 (40%)
		A2M_comp	961..1199	CDD:284982	98/259 (38%)
		A2M_recep	1308..1398	CDD:284981	25/89 (28%)
A2m	NP_036620.2	A2M_N	132..224	CDD:280081	31/92 (34%)
		A2M_N_2	464..609	CDD:285005	29/144 (20%)
		Bait region	620..750		30/154 (19%)
		A2M	736..826	CDD:278630	33/94 (35%)
		A2M_2	956..1262	CDD:239227	123/310 (40%)
		A2M_comp	1008..1263	CDD:284982	98/265 (37%)
		A2M_recep	1374..1461	CDD:284981	25/89 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343868
Domainoid	1	1.000	77	1.000	Domainoid score	I8631
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100452
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X292
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650