DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tep2 and Cd109

DIOPT Version :9

Sequence 1:NP_523506.1 Gene:Tep2 / 34044 FlyBaseID:FBgn0041182 Length:1420 Species:Drosophila melanogaster
Sequence 2:NP_694738.1 Gene:Cd109 / 235505 MGIID:2445221 Length:1442 Species:Mus musculus


Alignment Length:1499 Identity:458/1499 - (30%)
Similarity:738/1499 - (49%) Gaps:221/1499 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 YSVVGPGTLRSNSKYNVVVSVHKAD-GPSQI-------KVSLN-GPSYNET---------KQIEL 69
            :.|..||.:|..:  ||.:.|...: .|.|:       |::.| ..|..|.         |.:.|
Mouse    27 FLVTAPGIIRPGA--NVTIGVDLLENSPPQVLVKAQVFKIASNKSRSILEAEGVFHRGHFKTLVL 89

  Fly    70 P--PMSTQNVEFEVPKLATGNYNLSAEGVSGVVFKNSTKLNYADKKPSVFVQTDKATYKPADLVQ 132
            |  |:|:.:..:|:        :::.:..:.:||.|.|:|.:..|..||.:|||||.|||...|:
Mouse    90 PALPLSSADKIYEL--------HINGQSENEIVFSNRTRLTFESKSISVLIQTDKAFYKPKQEVK 146

  Fly   133 FRILFLDENTRPAKIEKPISVIIIDGAQNRIKQLSDVKLTKGVFSGELQLSEQPVLGTWKISVSV 197
            ||:|.|..:.:|.:..  :.:.|.|...|.|:|....|...||.|...|||..|:.|.|.|.|.|
Mouse   147 FRVLTLCSDLKPYRTS--VDIFIKDPKSNVIQQWFSQKGDLGVVSKTFQLSSNPIFGDWSIQVQV 209

  Fly   198 DGDNRETKSFEVDKYVLPKFEVIVDTPKAVVIADKVIKATIRAKYTYGKPVKGKATVSMERSYGY 262
            : |.:..:||:|.:||||||||.|.||....:..|.:..::.|||||||||||..:::       
Mouse   210 N-DQQYYQSFQVLEYVLPKFEVTVQTPLYCSLKSKQLNGSVIAKYTYGKPVKGSLSLT------- 266

  Fly   263 FGDLNANGNKQE--KTIDVDGKGHVEFDIIHW-----------AQRGQY------LP-PIKLFAV 307
            |..|:..|.|:.  |:.:::|..:..||....           ...|.|      .| |.::.|.
Mouse   267 FLPLSFWGKKKNITKSFEINGFANFSFDNYEMKKVMNLKPLTDVSEGSYENVDPSFPGPAEIIAT 331

  Fly   308 VTEELTGNKQNATATVVLHQQRYSIEPYERPEHFEANKSFIYQVVVKNVDGSPVT-NSAKNVKIG 371
            |||.|||..:.|:..|...|..|.||.::.....:.:.:|...|.|...||:.:| ...:|..:.
Mouse   332 VTESLTGISRMASTNVFFKQHDYIIEIFDYTTVLKPSLNFTATVKVSRSDGNQLTPEEIENDLVT 396

  Fly   372 FDKSYSYFHEPSPKTR-------INFEAPVNENGIATFNVRLP-DSDSRYYRIFASF-DGSEN-T 426
            ........|..|.:.:       :|:..|  :|||  ..:..| .|.|...::.|.| ||:.: |
Mouse   397 VVTQRKNNHPESQRDQEMDYIQTVNYTIP--QNGI--IKIEFPVMSISGELQLKAYFLDGTSSVT 457

  Fly   427 IGSISKFEPTPMSREPLK--IQVNTKKPRLGEQVSFDVV-----SIEDLPYFVYTIVARGNVILS 484
            :.|        |...|.|  ||:.|:...:.....||::     ..:||.|.|   :::|.::.:
Mouse   458 VHS--------MFTSPSKTYIQLKTRDEYIKVGSPFDLMVSGNRQFKDLSYMV---ISKGQLVAA 511

  Fly   485 DYVDVPDGQKTYTVKFTPTFSMVPKATIYVYYV-----VNNDLQFEEKTIDFEKEFSNSIDV--S 542
                  ..|.:.|...||..|..|||.|..||:     :.||:    ..|..:..|.|.:.:  |
Mouse   512 ------GKQSSRTFSLTPEASWAPKACIIAYYIAEDGEIINDI----LKIPVQLVFENKVKLFWS 566

  Fly   543 APTNAKPSEEVKLRIK-TDADSFVGLLGVDQSVLLLKSGNDLSQDDIFNSLNIYQTS---TPWMN 603
            .|| .|||::|.|||. |.:||.||::.||:||.|:::.|.::.:.:.:.|.:|.|.   ..:||
Mouse   567 KPT-VKPSDKVSLRISATQSDSLVGIVAVDKSVTLMENSNSITMETMVHELELYNTEYYLGMFMN 630

  Fly   604 GYGRYPGQTSGLVTLTNANYPYNTGPLVMSYVFEGSRHPWITRPRYRVGIRGDSGDRI------- 661
            .:..:  |..||..||:|..                             || ||.|.:       
Mouse   631 SFAVF--QECGLWVLTDATL-----------------------------IR-DSIDEVYDTEEYS 663

  Fly   662 -SFLSQSLNDRNLKEILLKQTPQRTTIRKEFPETWFFEN--VGE---EEFTLTKKIPDTITSWVV 720
             .|..:  |:.||.:.....:.....:||.|||||.:.:  :|.   |||.:|  :||:|||||.
Mouse   664 ERFAEE--NEANLVDFEDASSVNNVHVRKNFPETWIWLDAYMGSKIYEEFEVT--VPDSITSWVA 724

  Fly   721 TGFSLNPTSGIALTKNPSKIRVFQPFFVSTNLPYSVKRGEVIAIPVVIFNYLDKTLDADVVMDNS 785
            :.|.::...|..||..|::::.|||||:..||||||.|||..|:.|.|.|||..|:...::::.|
Mouse   725 SAFVISEDLGFGLTTVPAELQAFQPFFLFLNLPYSVIRGEEFALEVSIVNYLKDTIKVVILIEES 789

  Fly   786 DQEYEFTEATNEVLEKAIDEVRRVKRVTIPANSGKSVSFMIRPKNVGFTTLKITATSALAGDAIH 850
            | .::....:|:    ....:.| |.|.:|.::|.::.|.|:|.::|...:.:||.|..|.||:.
Mouse   790 D-SFDILMTSND----TNGTIYR-KTVQVPRDNGVTLVFPIKPTHLGEIPITVTAASPTASDAVT 848

  Fly   851 QKLKVEPEGVTLFENRAVFINLKDQ--PEMSQSLDADIPNEVVPQSEFIEFSVVGDLLGPTLQNL 913
            |.:.|:|||:....:::|.::|.|.  ....||:....|.:.|..||.::.:.:||:||.::..|
Mouse   849 QTIVVKPEGIEKSYSKSVLLDLTDSNVESKQQSMRFSFPPDTVIGSERVQITAIGDILGSSINGL 913

  Fly   914 DNLVRMPYGCGEQNMVNFVPNILVLKYLEVTGRKLPSVESKARKFLEIGYQRELTYKHDDGSYSA 978
            .:|:|||||||||||:.|.|||.:|.||....:...:::.||..::..||||||.|:.:|||:||
Mouse   914 SSLIRMPYGCGEQNMIYFAPNIYILDYLTKQKQLTVNLKEKALSYMRQGYQRELLYQREDGSFSA 978

  Fly   979 FGKSDASGSTWLTAYVMRSFHQAGTYTDIDPKVITAGLDFLVSKQKESGEFPEVGKL----FDNA 1039
            ||..|:||||||:|:|:|.|.:|..|.|||..|:.....:|.:.:|.:|||.|.|::    ....
Mouse   979 FGDIDSSGSTWLSAFVLRCFLEADYYIDIDQDVLHRTYTWLNAHKKFNGEFWEPGRVIHSELQGG 1043

  Fly  1040 NQNPLALTSFVLLAFFENHELIPKYQSAI--KKAVRYVAEEADK-TDDQYSLAIAAVALQLAKHP 1101
            .::|:.||::::.:...    ..|||..|  :.:::::..|..: ..|.|:|||.:.||.....|
Mouse  1044 TKSPVTLTAYIVTSVLG----YKKYQPNIDVQDSIKFLEFEFSRGISDNYTLAIISYALSTVGSP 1104

  Fly  1102 QSEKVIAKLESVARKENDRMWW-SKATESTGEDGRVFHWKPRSNDVEITSYVLLALLEKDPAEKA 1165
            ::|:.:..|...:.||.|..:| |.....:|.      |:|||.|:||.:|.|||......:| .
Mouse  1105 KAEEALNLLMQRSEKEGDTQFWLSSGPALSGS------WQPRSVDIEIAAYALLAHTLHHVSE-G 1162

  Fly  1166 LPIIKWLISQRNSNGGFSSTQDTVIGLQALTKFAYKTGSGSGTMDIEFSSAGESKNT-IKVNPEN 1229
            :|:::|||.||||.|||.||||||:.|:||::|:......:..:.:..:..|..::. .:::.:|
Mouse  1163 IPVMRWLIQQRNSLGGFVSTQDTVVALKALSEFSALVHKENTDIQLTVTGPGIPRSIHFRIDSQN 1227

  Fly  1230 SLVL---QTHDLPKSTRKVDFTAKGTGSAMVQLSYRYNL---------AEKEKKPSFKVTPTVKD 1282
            ..:|   :.|.|...|  |:.:|.|:|.|:.||:..||:         ...|.:..|.:...|.:
Mouse  1228 LFLLHQEELHALDPIT--VNVSAHGSGFAICQLNVDYNVKGSGSSKRRRSTENQEVFDLDVIVNN 1290

  Fly  1283 TPN-QLLIVDVCAEYVPLEDADKDKDSNMAVMEIALPSGFVGDSTSLGKIQAVDRVKRVETKNSD 1346
            ..: ..|.::||..::..|      .:.|.:||:.|.|||   |.|...|...:.:|:||..|  
Mouse  1291 EDDISHLNLNVCTSHLGSE------RTGMVLMEVNLLSGF---SASSDSIPLSETLKKVEYDN-- 1344

  Fly  1347 STVVVYFDSLTPGDVRCLPLEASKAHAVAKQKPASVSLYDYYDTERKATEYY--QVKSSLCDICE 1409
            ..:.:|.||:..... |:.:...:.:.|:..:..|||:.|||:..|:|...|  |||.|.|.:..
Mouse  1345 GKLNLYLDSVNESQF-CVNIPTVRDYKVSNIRDGSVSVMDYYEPRRQAVRSYNTQVKLSSCYLSP 1408

  Fly  1410 GADC 1413
            ..:|
Mouse  1409 DTNC 1412

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tep2NP_523506.1 A2M_N 115..209 CDD:280081 37/93 (40%)
A2M_N_2 445..576 CDD:285005 45/143 (31%)
A2M 694..782 CDD:278630 40/92 (43%)
A2M_2 909..1198 CDD:239227 116/296 (39%)
A2M_comp 961..1199 CDD:284982 94/245 (38%)
A2M_recep 1308..1398 CDD:284981 27/89 (30%)
Cd109NP_694738.1 YfaS <122..>1002 CDD:225248 308/957 (32%)
A2M_N 129..220 CDD:280081 37/93 (40%)
A2M_N_2 475..598 CDD:285005 40/136 (29%)
Bait region (approximate). /evidence=ECO:0000250 595..704 32/142 (23%)
A2M 695..782 CDD:278630 40/88 (45%)
A2M_2 909..1195 CDD:239227 116/296 (39%)
A2M_comp 961..1197 CDD:284982 95/246 (39%)
A2M_recep 1311..1395 CDD:284981 27/89 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167840009
Domainoid 1 1.000 75 1.000 Domainoid score I9015
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 558 1.000 Inparanoid score I1099
Isobase 1 0.950 - 0 Normalized mean entropy S6085
OMA 1 1.010 - - QHG45959
OrthoDB 1 1.010 - - D177369at33208
OrthoFinder 1 1.000 - - FOG0002157
OrthoInspector 1 1.000 - - otm42370
orthoMCL 1 0.900 - - OOG6_100452
Panther 1 1.100 - - LDO PTHR11412
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4041
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1413.790

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