Protein Alignment Tep2 and Cd109

DIOPT Version :10

• Sequence 1: NP_523506.1
• Gene: Tep2 / 34044
• FlyBaseID: FBgn0041182
• Length: 1420
• Species: Drosophila melanogaster
• Sequence 2: NP_694738.1
• Gene: Cd109 / 235505
• MGIID: 2445221
• Length: 1442
• Species: Mus musculus
• Alignment Length: 1499
• Identity: 458/1499 - (30%)
• Similarity: 738/1499 - (49%)
• Gaps: 221/1499 - (14%)

  Fly    23 YSVVGPGTLRSNSKYNVVVSVHKAD-GPSQI-------KVSLN-GPSYNET---------KQIEL 69
            :.|..||.:|..:  ||.:.|...: .|.|:       |::.| ..|..|.         |.:.|
Mouse    27 FLVTAPGIIRPGA--NVTIGVDLLENSPPQVLVKAQVFKIASNKSRSILEAEGVFHRGHFKTLVL 89

  Fly    70 P--PMSTQNVEFEVPKLATGNYNLSAEGVSGVVFKNSTKLNYADKKPSVFVQTDKATYKPADLVQ 132
            |  |:|:.:..:|:        :::.:..:.:||.|.|:|.:..|..||.:|||||.|||...|:
Mouse    90 PALPLSSADKIYEL--------HINGQSENEIVFSNRTRLTFESKSISVLIQTDKAFYKPKQEVK 146

  Fly   133 FRILFLDENTRPAKIEKPISVIIIDGAQNRIKQLSDVKLTKGVFSGELQLSEQPVLGTWKISVSV 197
            ||:|.|..:.:|.:..  :.:.|.|...|.|:|....|...||.|...|||..|:.|.|.|.|.|
Mouse   147 FRVLTLCSDLKPYRTS--VDIFIKDPKSNVIQQWFSQKGDLGVVSKTFQLSSNPIFGDWSIQVQV 209

  Fly   198 DGDNRETKSFEVDKYVLPKFEVIVDTPKAVVIADKVIKATIRAKYTYGKPVKGKATVSMERSYGY 262
            : |.:..:||:|.:||||||||.|.||....:..|.:..::.|||||||||||..:::
Mouse   210 N-DQQYYQSFQVLEYVLPKFEVTVQTPLYCSLKSKQLNGSVIAKYTYGKPVKGSLSLT------- 266

  Fly   263 FGDLNANGNKQE--KTIDVDGKGHVEFDIIHW-----------AQRGQY------LP-PIKLFAV 307
            |..|:..|.|:.  |:.:::|..:..||....           ...|.|      .| |.::.|.
Mouse   267 FLPLSFWGKKKNITKSFEINGFANFSFDNYEMKKVMNLKPLTDVSEGSYENVDPSFPGPAEIIAT 331

  Fly   308 VTEELTGNKQNATATVVLHQQRYSIEPYERPEHFEANKSFIYQVVVKNVDGSPVT-NSAKNVKIG 371
            |||.|||..:.|:..|...|..|.||.::.....:.:.:|...|.|...||:.:| ...:|..:.
Mouse   332 VTESLTGISRMASTNVFFKQHDYIIEIFDYTTVLKPSLNFTATVKVSRSDGNQLTPEEIENDLVT 396

  Fly   372 FDKSYSYFHEPSPKTR-------INFEAPVNENGIATFNVRLP-DSDSRYYRIFASF-DGSEN-T 426
            ........|..|.:.:       :|:..|  :|||  ..:..| .|.|...::.|.| ||:.: |
Mouse   397 VVTQRKNNHPESQRDQEMDYIQTVNYTIP--QNGI--IKIEFPVMSISGELQLKAYFLDGTSSVT 457

  Fly   427 IGSISKFEPTPMSREPLK--IQVNTKKPRLGEQVSFDVV-----SIEDLPYFVYTIVARGNVILS 484
            :.|        |...|.|  ||:.|:...:.....||::     ..:||.|.|   :::|.::.:
Mouse   458 VHS--------MFTSPSKTYIQLKTRDEYIKVGSPFDLMVSGNRQFKDLSYMV---ISKGQLVAA 511

  Fly   485 DYVDVPDGQKTYTVKFTPTFSMVPKATIYVYYV-----VNNDLQFEEKTIDFEKEFSNSIDV--S 542
                  ..|.:.|...||..|..|||.|..||:     :.||:    ..|..:..|.|.:.:  |
Mouse   512 ------GKQSSRTFSLTPEASWAPKACIIAYYIAEDGEIINDI----LKIPVQLVFENKVKLFWS 566

  Fly   543 APTNAKPSEEVKLRIK-TDADSFVGLLGVDQSVLLLKSGNDLSQDDIFNSLNIYQTS---TPWMN 603
            .|| .|||::|.|||. |.:||.||::.||:||.|:::.|.::.:.:.:.|.:|.|.   ..:||
Mouse   567 KPT-VKPSDKVSLRISATQSDSLVGIVAVDKSVTLMENSNSITMETMVHELELYNTEYYLGMFMN 630

  Fly   604 GYGRYPGQTSGLVTLTNANYPYNTGPLVMSYVFEGSRHPWITRPRYRVGIRGDSGDRI------- 661
            .:..:  |..||..||:|..                             || ||.|.:
Mouse   631 SFAVF--QECGLWVLTDATL-----------------------------IR-DSIDEVYDTEEYS 663

  Fly   662 -SFLSQSLNDRNLKEILLKQTPQRTTIRKEFPETWFFEN--VGE---EEFTLTKKIPDTITSWVV 720
             .|..:  |:.||.:.....:.....:||.|||||.:.:  :|.   |||.:|  :||:|||||.
Mouse   664 ERFAEE--NEANLVDFEDASSVNNVHVRKNFPETWIWLDAYMGSKIYEEFEVT--VPDSITSWVA 724

  Fly   721 TGFSLNPTSGIALTKNPSKIRVFQPFFVSTNLPYSVKRGEVIAIPVVIFNYLDKTLDADVVMDNS 785
            :.|.::...|..||..|::::.|||||:..||||||.|||..|:.|.|.|||..|:...::::.|
Mouse   725 SAFVISEDLGFGLTTVPAELQAFQPFFLFLNLPYSVIRGEEFALEVSIVNYLKDTIKVVILIEES 789

  Fly   786 DQEYEFTEATNEVLEKAIDEVRRVKRVTIPANSGKSVSFMIRPKNVGFTTLKITATSALAGDAIH 850
            | .::....:|:    ....:.| |.|.:|.::|.::.|.|:|.::|...:.:||.|..|.||:.
Mouse   790 D-SFDILMTSND----TNGTIYR-KTVQVPRDNGVTLVFPIKPTHLGEIPITVTAASPTASDAVT 848

  Fly   851 QKLKVEPEGVTLFENRAVFINLKDQ--PEMSQSLDADIPNEVVPQSEFIEFSVVGDLLGPTLQNL 913
            |.:.|:|||:....:::|.::|.|.  ....||:....|.:.|..||.::.:.:||:||.::..|
Mouse   849 QTIVVKPEGIEKSYSKSVLLDLTDSNVESKQQSMRFSFPPDTVIGSERVQITAIGDILGSSINGL 913

  Fly   914 DNLVRMPYGCGEQNMVNFVPNILVLKYLEVTGRKLPSVESKARKFLEIGYQRELTYKHDDGSYSA 978
            .:|:|||||||||||:.|.|||.:|.||....:...:::.||..::..||||||.|:.:|||:||
Mouse   914 SSLIRMPYGCGEQNMIYFAPNIYILDYLTKQKQLTVNLKEKALSYMRQGYQRELLYQREDGSFSA 978

  Fly   979 FGKSDASGSTWLTAYVMRSFHQAGTYTDIDPKVITAGLDFLVSKQKESGEFPEVGKL----FDNA 1039
            ||..|:||||||:|:|:|.|.:|..|.|||..|:.....:|.:.:|.:|||.|.|::    ....
Mouse   979 FGDIDSSGSTWLSAFVLRCFLEADYYIDIDQDVLHRTYTWLNAHKKFNGEFWEPGRVIHSELQGG 1043

  Fly  1040 NQNPLALTSFVLLAFFENHELIPKYQSAI--KKAVRYVAEEADK-TDDQYSLAIAAVALQLAKHP 1101
            .::|:.||::::.:...    ..|||..|  :.:::::..|..: ..|.|:|||.:.||.....|
Mouse  1044 TKSPVTLTAYIVTSVLG----YKKYQPNIDVQDSIKFLEFEFSRGISDNYTLAIISYALSTVGSP 1104

  Fly  1102 QSEKVIAKLESVARKENDRMWW-SKATESTGEDGRVFHWKPRSNDVEITSYVLLALLEKDPAEKA 1165
            ::|:.:..|...:.||.|..:| |.....:|.      |:|||.|:||.:|.|||......:| .
Mouse  1105 KAEEALNLLMQRSEKEGDTQFWLSSGPALSGS------WQPRSVDIEIAAYALLAHTLHHVSE-G 1162

  Fly  1166 LPIIKWLISQRNSNGGFSSTQDTVIGLQALTKFAYKTGSGSGTMDIEFSSAGESKNT-IKVNPEN 1229
            :|:::|||.||||.|||.||||||:.|:||::|:......:..:.:..:..|..::. .:::.:|
Mouse  1163 IPVMRWLIQQRNSLGGFVSTQDTVVALKALSEFSALVHKENTDIQLTVTGPGIPRSIHFRIDSQN 1227

  Fly  1230 SLVL---QTHDLPKSTRKVDFTAKGTGSAMVQLSYRYNL---------AEKEKKPSFKVTPTVKD 1282
            ..:|   :.|.|...|  |:.:|.|:|.|:.||:..||:         ...|.:..|.:...|.:
Mouse  1228 LFLLHQEELHALDPIT--VNVSAHGSGFAICQLNVDYNVKGSGSSKRRRSTENQEVFDLDVIVNN 1290

  Fly  1283 TPN-QLLIVDVCAEYVPLEDADKDKDSNMAVMEIALPSGFVGDSTSLGKIQAVDRVKRVETKNSD 1346
            ..: ..|.::||..::..|      .:.|.:||:.|.|||   |.|...|...:.:|:||..|
Mouse  1291 EDDISHLNLNVCTSHLGSE------RTGMVLMEVNLLSGF---SASSDSIPLSETLKKVEYDN-- 1344

  Fly  1347 STVVVYFDSLTPGDVRCLPLEASKAHAVAKQKPASVSLYDYYDTERKATEYY--QVKSSLCDICE 1409
            ..:.:|.||:..... |:.:...:.:.|:..:..|||:.|||:..|:|...|  |||.|.|.:..
Mouse  1345 GKLNLYLDSVNESQF-CVNIPTVRDYKVSNIRDGSVSVMDYYEPRRQAVRSYNTQVKLSSCYLSP 1408

  Fly  1410 GADC 1413
            ..:|
Mouse  1409 DTNC 1412

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep2	NP_523506.1	YfaS	<72..1395	CDD:441940	433/1408 (31%)
		A2M_2	909..1198	CDD:239227	116/296 (39%)
Cd109	NP_694738.1	YfaS	<124..1212	CDD:441940	378/1176 (32%)
		Bait region (approximate). /evidence=ECO:0000250	595..704		32/142 (23%)
		A2M_2	909..1195	CDD:239227	116/296 (39%)
		A2M_recep	1309..1396	CDD:462226	28/98 (29%)