DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep2 and A2ml1

DIOPT Version :9

Sequence 1:	NP_523506.1	Gene:	Tep2 / 34044	FlyBaseID:	FBgn0041182	Length:	1420	Species:	Drosophila melanogaster
Sequence 2:	NP_001001179.2	Gene:	A2ml1 / 232400	MGIID:	3039594	Length:	1456	Species:	Mus musculus

Alignment Length:	1572	Identity:	394/1572 - (25%)
Similarity:	677/1572 - (43%)	Gaps:	298/1572 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IFLTGIILQYALLVNATGIYSVVGPGTLRSNSKYNVVVSVHKADGPSQIKVSL--NGPSYNETKQ 66
            |.|:.::|.:..:|.|...|.:.....::..|.....:.:...:....:.|:|  :|.|.....|
Mouse     5 ILLSALLLHFTDVVAAEPRYILWVSSVVQRFSSEKACLHLLNLNESVSLSVTLEYDGSSTTIFDQ 69

  Fly    67 IELPPMSTQN----VEFEVPKLATGNYNLSAEGVSGVVFKNSTK--LNYADKKPSVFVQTDKATY 125
                |:...|    .:|:|.::::......|..|.|...|.|.:  :..|.::.:.|||||...:
Mouse    70 ----PVDEGNFYACADFKVSQMSSEQLAFVALLVQGNTLKISERRSVAIAAEENATFVQTDTPVH 130

  Fly   126 KPADLVQFRILFLDENTRPAKIEKPISVIIIDGAQNRIKQLSDVKLTKGVFSGELQLSEQPVLGT 190
            ||.|.|.||::.|:...:|.....|: :.:.|...|.|.|..:|...:.:.....||:.:|:||.
Mouse   131 KPGDTVHFRVVTLNIWLKPVDDLYPL-ITVQDPQSNVIFQWINVTTFRNITQLSFQLTPEPILGD 194

  Fly   191 WKISVSVDGDNRETKSFEVDKYVLPKFEVIVDTPKAVVIADKVIKATIRAKYTYGKPVKGKATVS 255
            :.|.:...........|.|::.|||||||.:..|:.:.|||...:....||||||:||:|||.:.
Mouse   195 YTIVIKTQSGTTVMDHFTVNRDVLPKFEVELTAPETITIADSQFQMVTCAKYTYGQPVQGKAQIK 259

  Fly   256 MERSYGYFGDLNANGNKQE----KTIDV-DG-KGHVEFDIIHWAQRGQYLPPIKLFAVVTEELTG 314
            :.|.  .|...:...|:.|    .|:.: || ..|:....:....|......:.:..||||..||
Mouse   260 VCRE--LFSPAHCESNENEICEQFTVQLKDGCASHIINTKVFQLDRSGLFMTLNVNEVVTESGTG 322

  Fly   315 NKQNATATV----VLHQQRY-SIEPYERP--EHFEA-------NKSFIYQVVVKNVDGSPVTNSA 365
            .:.:.|.:|    ||....: :::|:.|.  .:|..       |...:.:::...:||.||.|
Mouse   323 VQMSKTHSVFITSVLGTVSFENMDPFYRRGITYFGTLKFSGPNNTPLVDKLLQLELDGKPVGN-- 385

  Fly   366 KNVKIGFDKSYSYFHEPSPKTRINFEAPVNENGIATFNVRLPD---------------------- 408
                      |:                .:|||.|.|::...:
Mouse   386 ----------YT----------------TDENGEARFSINTSEIFGAQISLKAVYVRPRSCHRSS 424

  Fly   409 -----------SDSRYYRIFASFDGSENTIGSISKFEPTPMSREPLKIQVNTKK---------PR 453
                       |.||:|...:||               |.:..||.::..:.:|         |.
Mouse   425 WLSPEYLDAYFSASRFYSQTSSF---------------TKIILEPKQLPCDQEKMFSVLYSLNPE 474

  Fly   454 LGEQVSFDVVSIEDLPYFVYTIVARGNVILSDYVDVPDGQKTYTVK-FTPTFS--------MVPK 509
            ..::.| ||.       |.|.::.||.:..|       |||...|: :...||        :.|.
Mouse   475 AYKEAS-DVT-------FFYLVMVRGGISRS-------GQKQVRVQAWNGNFSFPISINADLAPS 524

  Fly   510 ATIYVYYV-VNNDLQFEEKTIDFEKEFSNSIDVSAPTNAK-PSEEVKLRIKTDADSFVGLLGVDQ 572
            |.::||.: .:.::..:...:..||.|.|.:.::...:.. |.....:.::...|||..|..||:
Mouse   525 ADLFVYTLHPSGEIVADNVRLQIEKCFKNKVSINFSRDKDLPGSNTSVHLQAAPDSFCALRAVDK 589

  Fly   573 SVLLLKSGNDLSQDDI-------------FNSLNI-YQTSTP-------WMNGYGRYP------G 610
            |.|||..|.:::.:.:             :|.||: .|.:.|       :.||....|      |
Mouse   590 SALLLNHGQEMTPESVYFTLPYIHQYGYFYNGLNLDDQQAEPCIPQKDLFYNGLYYTPTGNIWDG 654

  Fly   611 QTS------GLVTLTNANY-------PYNTGPLVMSYVFEGSRHPWITRPRYRVGIRGDSGDRIS 662
            ..|      ||...||.:|       .....||:.::          ..|..|:.:.|......|
Mouse   655 DLSNLLSNMGLKIFTNLHYRKPEVCSSQENQPLLRTF----------DHPNERIMMYGGGAPPSS 709

  Fly   663 FLSQSLNDRNLKEILLKQTPQRTTIRKEFPETWFFENVGEEE---FTLTKKIPDTITSWVVTGFS 724
            ....|::..:..::.:|:     |:|..||.||.:..|..:.   ..::..:|||||.|..:.|.
Mouse   710 AFHDSVDSISHAKVAIKE-----TVRTNFPRTWIWNLVSVDSSGTANVSFLVPDTITQWEASAFC 769

  Fly   725 LNPTSGIALTKNPSKIRVFQPFFVSTNLPYSVKRGEVIAIPVVIFNYLDKTLDADVVMDNSDQEY 789
            :|..:|..::...| :::.|||||....|:||.|.|...:.|.:||||...::..|.::.|
Mouse   770 VNGNAGFGISPKVS-LQISQPFFVEVTSPFSVVRSEQSDMVVTVFNYLTTCVEISVQLEAS---- 829

  Fly   790 EFTEATNEVLEKAIDEVRRVKRVTIPANSGKSVSFMIRPKNVGFTTLKITATS----ALAGDA-- 848
                   |..|.:|:..|......:.|...|:..:.|.||.:|...:.:.|||    |...||
Mouse   830 -------ENYEASINTQRNTDSEVLQAGEQKTYVWTIIPKTLGKVNVTVVATSKQSRACPNDASK 887

  Fly   849 ---IHQK------LKVEPEGVTLFENRAVFINLKDQPEMSQSLDADIPNEVVPQSEFIEFSVVGD 904
               :|.|      :.||.||:.....::..|..|......|:| .::|:.||..|.....::|||
Mouse   888 EQDVHWKDTVVKTMLVEAEGIEKEATQSFLICPKGTKASKQTL-LELPSNVVEGSVRSFVTIVGD 951

  Fly   905 LLGPTLQNLDNLVRMPYGCGEQNMVNFVPNILVLKYLEVTGRKLPSVESKARKFLEIGYQRELTY 969
            :||..:|||::|::|||||||||:.....::.:|.||:.|.:....::|||::.|..|||..|::
Mouse   952 ILGVAMQNLESLLQMPYGCGEQNIAQLASDVYILDYLKATDQLTEELKSKAQRLLSNGYQNHLSF 1016

  Fly   970 KHDDGSYSAFGKSDASGSTWLTAYVMRSFHQAGTYTDIDPKVITAGLDFLVSKQKESGEFPEVGK 1034
            |:.||||..|.:|:..|||||:|...::..:...|..|:..|....|.:||.|||.:|.|....|
Mouse  1017 KNYDGSYDVFCQSNQEGSTWLSALSFKTVEKMKEYIFIEETVPKQTLIWLVKKQKSNGCFRRDEK 1081

  Fly  1035 LFDNA------NQNPLALTSFVLLAFFE--NHELIPKYQSAIKKAVRYVAEEA--DKTDDQYSLA 1089
            ..|.|      :|..:|||::|:..|.|  .:...|..::.:     |..|||  :...:.|:.|
Mouse  1082 HVDTAQEGREGDQEDIALTAYVVGVFLEVGLNASFPALRNGL-----YCLEEAFSNGVTNGYTQA 1141

  Fly  1090 IAAVALQLA-KHPQSEKVIAKLESVARKENDRMWWSKATESTGEDGRVFHWKPRSNDVEITSYVL 1153
            |.|....|| |..|::.:::.|:..|.|.|:.::|.:..:...::...|.....|.:.|.|.|||
Mouse  1142 ILAYVFALAGKEQQAKSLLSILDKSATKTNNMIYWERDEKPETDNSPSFIPSALSGETEKTCYVL 1206

  Fly  1154 LALLEKD--PAEKALPIIKWLISQRNSNGGFSSTQDTVIGLQALTKFAYKTGSG-SGTMDIEFSS 1215
            ||:|.:|  ..:.|..|::||..:.||:||||:.|||.:.|.|||::...|||. ..|:.:   |
Mouse  1207 LAVLSQDTQDLDYASKIVQWLAQRMNSHGGFSAMQDTTVCLLALTQYMKLTGSNPQNTITL---S 1268

  Fly  1216 AGESKNTIKVNPENSLVLQTHDLPKSTRKVDFTAKGTGSAMVQLSYRYNL--------------- 1265
            :.||:....||....|::|...:.|..::.....:|.|.:.:|.:.|||:
Mouse  1269 SEESEEVFYVNRNKRLLVQHSKVSKGHQQYTVDVEGDGCSFIQATLRYNVPLPKEASGFSLSVKT 1333

  Fly  1266 ----AEKEKKPSFKVTPTVKDTPNQLLIVDVCAEYVPLEDADKDKDSNMAVM-EIALPSGFVGDS 1325
                :..|.:..|::|.|:..|                    ..::|::.|: ::.:.|||....
Mouse  1334 GKSNSSDEFQTKFELTVTLTYT--------------------GARESSVTVLVDVKMLSGFTPVV 1378

  Fly  1326 TSLGKIQAVDRVKRVETKNSDSTVVVYFDSLTPGDVRCLPLEASKAHAVAKQKPASVSLYDYYDT 1390
            :|..:::...:|.:.:.||..  |:.|.::: |.:...|.....:.:.||..:||.|::|.|...
Mouse  1379 SSTEELKFNSQVTKTDIKNGH--VLFYLENV-PKEATSLTFSIEQTNHVANIQPAPVTVYSYEKG 1440

  Fly  1391 ERKATEYYQVKS 1402
            | .|.:.|.:.|
Mouse  1441 E-YAFDSYNINS 1451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep2	NP_523506.1	A2M_N	115..209	CDD:280081	26/93 (28%)
		A2M_N_2	445..576	CDD:285005	32/150 (21%)
		A2M	694..782	CDD:278630	29/90 (32%)
		A2M_2	909..1198	CDD:239227	105/301 (35%)
		A2M_comp	961..1199	CDD:284982	84/250 (34%)
		A2M_recep	1308..1398	CDD:284981	22/90 (24%)
A2ml1	NP_001001179.2	A2M_N	121..204	CDD:280081	25/83 (30%)
		A2M_N_2	450..593	CDD:285005	34/157 (22%)
		A2M	736..826	CDD:278630	29/90 (32%)
		A2M_2	956..1253	CDD:239227	105/301 (35%)
		A2M_comp	1008..1253	CDD:284982	84/249 (34%)
		A2M_recep	1364..1447	CDD:284981	21/86 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840017
Domainoid	1	1.000	66	1.000	Domainoid score	I9869
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100452
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.650