DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tep2 and A2m

DIOPT Version :9

Sequence 1:NP_523506.1 Gene:Tep2 / 34044 FlyBaseID:FBgn0041182 Length:1420 Species:Drosophila melanogaster
Sequence 2:NP_783327.2 Gene:A2m / 232345 MGIID:2449119 Length:1474 Species:Mus musculus


Alignment Length:1585 Identity:429/1585 - (27%)
Similarity:685/1585 - (43%) Gaps:326/1585 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 IILQYALLVNATG----IYSVVGPGTLRSNSKYNVVVSVHKADGPSQIKVSLNGPSYNETKQIEL 69
            ::|...|..||:.    ||.|:.|..|.:.:.....:..:..:....:|||:.....|::...:|
Mouse    20 LLLLLLLPTNASAPQKPIYMVMVPSLLHAGTPEKGCLLFNHLNETVTVKVSMESVRGNQSLFTDL 84

  Fly    70 --------------PPMSTQNVEFEVPKLATGNYNLSAEGVSGVVFKNSTKLNYADKKPSVFVQT 120
                          |..|:..|.|         ..:..:|.:....:.||.| ...|:..||.||
Mouse    85 VVDKDLFHCASFIVPQSSSNEVMF---------LTVQVKGPTHEFRRRSTVL-IKTKESLVFAQT 139

  Fly   121 DKATYKPADLVQFRILFLDENTRPAKIEKPISVIIIDGAQNRIKQLSDVKLTKGVFSGELQLSEQ 185
            ||..|||..:|:||::.||||..|.....|: :.|.|..:|||.|..:.:|..|:......||.:
Mouse   140 DKPIYKPGQMVRFRVVSLDENFHPLNELIPL-LYIQDSKKNRIAQWQNFRLEGGLKQLSFPLSSE 203

  Fly   186 PVLGTWKISVSVDGDNRETKSFEVDKYVLPKFEVIVDTPKAVVIADKVIKATIRAKYTYGKPVKG 250
            |..|::|:.:..:........|.|.::|||||||.|..|:.:.|.::.:..::...|||||||.|
Mouse   204 PTQGSYKVVIRTESGRTVEHPFSVKEFVLPKFEVKVAVPETITILEEEMNVSVCGIYTYGKPVPG 268

  Fly   251 KATVSMERSYGYFGDLNANGNKQEKTI--------DVDGKG-------HVEFDIIHWAQRGQYLP 300
            ..||::.|.|.     |.:....|:::        .:||:|       ...|.:    :|.:|..
Mouse   269 HVTVNICRKYS-----NPSSCFGEESLAFCEKFSQQLDGRGCFSQLVKTKSFQL----KRQEYEM 324

  Fly   301 PIKLFAVVTEELTGNKQNATATVVLHQQRYSIEPYERPEHFEANKSFIYQVVVKNVDGSPVTNSA 365
            .:.:.|.:.||.||.::.......:.:....:.......||.....|:.||::.:..|:|:  ..
Mouse   325 QLDVNAKIQEEGTGVEETGKGLTKITRTITKLSFVNVDTHFRQGIPFVGQVLLVDGRGTPI--PY 387

  Fly   366 KNVKIGFDKSYSYFHEPSPKTRINFEAPVNENGIATFNVRLPDSDSRYYRIFASFDGSENTIG-- 428
            :.:.||.|::..           |.....::||:|.|::...|.......:.|.:..|....|  
Mouse   388 EMIFIGADEANQ-----------NINTTTDKNGLARFSINTDDIMGTSLTVRAKYKDSNVCYGFR 441

  Fly   429 ------------SISKFEPTPMSREPLKIQVNTKKPRLGEQVSFDVVSIEDLPY----------- 470
                        :.:.|.|                       |...|.:|.|||           
Mouse   442 WLTEENVEAWHTANAVFSP-----------------------SRSFVHLESLPYKLRCEQTLAVQ 483

  Fly   471 -----------------FVYTIVARGNVIL--SDYVDVPDGQKT--YTVKFTPTFSMVPKATIYV 514
                             |.|.::|:|.::.  :..:.|..|.|.  :::..:....:.|.|.:.:
Mouse   484 AHYILNDEAVLERKELVFYYLMMAKGGIVRAGTHVLPVTQGHKKGHFSILISMETDLAPVARLVL 548

  Fly   515 YYVV-NNDLQFEEKTIDFEKEFSNSID-VSAPTNAKPSEEVKLRIKTDADSFVGLLGVDQSVLLL 577
            |.:: |.::..:....:.||..:|.:| |..|....|:....|.:.....|..||..|||||||.
Mouse   549 YTILPNGEVVGDTVKYEIEKCLANKVDLVFHPNIGLPATRAFLSVMASPQSLCGLRAVDQSVLLT 613

  Fly   578 KSGNDLSQDDIFNSLNIYQ-TSTP-------------------WMNGYGRYPGQTS--------- 613
            |...:||...:::.|.:.. |..|                   ::||....|.|.:         
Mouse   614 KPEAELSASLVYDLLPVKDLTGFPKGVNQQEEDTNGCLKQNDTYINGILYSPVQNTNEEDMYGFL 678

  Fly   614 ---GLVTLTNANYPYNTGPLVMSYVFEGSRHPWITRPRY--RVGIRG--------DSGDRISFLS 665
               ||...||.|                     |.:|:.  |:|:..        ..|...:||.
Mouse   679 KDMGLKVFTNLN---------------------IRKPKVCERLGVNKIPAAYHLVSQGHMDAFLE 722

  Fly   666 QSLNDRNLKEILLKQTPQRTTIRKEFPETWFF-----ENVGEEEFTLTKKIPDTITSWVVTGFSL 725
            .|            ::|..|| |..|||||.:     ::.|..|..:|  :|||||.|....|.|
Mouse   723 SS------------ESPTETT-RSYFPETWIWDLVIVDSTGVAEMEVT--VPDTITEWKAGAFCL 772

  Fly   726 NPTSGIALTKNPSKIRVFQPFFVSTNLPYSVKRGEVIAIPVVIFNYLDKTLDADVVMDNSDQEYE 790
            :..:|:.|:. ....:.||||||...:||||.|||...:...:.|||...:...|.:        
Mouse   773 SNDTGLGLSP-VIDFQAFQPFFVDLTMPYSVIRGEAFTLKATVLNYLQTCIRVGVQL-------- 828

  Fly   791 FTEATNEVLEKAIDEVRRVKRVTIPANSGKSVSFMIRPKNVGFTTLKITATSALAG--------- 846
              ||:.:.|  |..|.:..|...|..|...::|:.:.||::|.....::| .||..         
Mouse   829 --EASPDFL--ATPEEKEQKSHCICMNERHTMSWAVIPKSLGNVNFTVSA-EALDSKELCRNEVP 888

  Fly   847 --------DAIHQKLKVEPEGVTLFENRAVFINL--KDQPEMSQSLDADIPNEVVPQSEFIEFSV 901
                    |.|.:.|.|||||:   ||...|.:|  ....|:|:.:...:|::||.:|.....:|
Mouse   889 VVPERGKKDTIIKSLLVEPEGL---ENEVTFNSLLCPTGAEVSEQISLKLPSDVVEESARASVTV 950

  Fly   902 VGDLLGPTLQNLDNLVRMPYGCGEQNMVNFVPNILVLKYLEVTGRKLPSVESKARKFLEIGYQRE 966
            :||:||..:||..:|::|||||||||||.|.|||.||.||..|.:....:::||..:|..||||:
Mouse   951 LGDILGSAMQNTQDLLKMPYGCGEQNMVLFAPNIYVLDYLNETEQLTQEIKTKAITYLNTGYQRQ 1015

  Fly   967 LTYKHDDGSYSAFGKSDASG----STWLTAYVMRSFHQAGTYTDIDPKVITAGLDFLVSKQKESG 1027
            |.|||.|||||.||  |..|    :|||||:|::||.||..|..||...||..|.:|..:||::|
Mouse  1016 LNYKHRDGSYSTFG--DKPGRSHANTWLTAFVLKSFAQARRYIFIDESHITQALTWLSQQQKDNG 1078

  Fly  1028 EFPEVGKLFDNAN----QNPLALTSFVLLAFFENHELIPKYQSAIKKAVRYVAEEADKT------ 1082
            .|...|.|.:||.    ::.:.|::::.:|..|..  :|.....::.|: :..:.|.|:      
Mouse  1079 CFRSSGSLLNNAMKGGVEDEVTLSAYITIALLEMS--LPVTHPVVRNAL-FCLDTAWKSARRGAS 1140

  Fly  1083 -DDQYSLAIAAVALQLAKHPQSEKVIAK-LESVARKENDRMWWSKATESTGEDGRVFHWKPR--- 1142
             :..|:.|:.|.|..||.:..::|.|.| |:..|.||::.:.|::|.            |||   
Mouse  1141 GNHVYTKALLAYAFALAGNQDTKKEILKSLDEEAVKEDNSVHWTRAQ------------KPRVPA 1193

  Fly  1143 ---------SNDVEITSYVLLALL------EKDPAEKALPIIKWLISQRNSNGGFSSTQDTVIGL 1192
                     |.:||:|:|||||.|      .::....|:.|:|||..|:||:||||||||||:.|
Mouse  1194 DLWYQPQAPSAEVEMTAYVLLAYLTTELVPTREDLTAAMLIVKWLTKQQNSHGGFSSTQDTVVAL 1258

  Fly  1193 QALTKFAYKTGS-GSGTMDIEFSSAGESKNTIKVNPENSLVLQTHDLPKSTRKVDFTAK--GTGS 1254
            .||:|:...|.: ......:...|:|......:||.:|.|:||...||  |...|:|||  |.|.
Mouse  1259 HALSKYGAATFTRAKKAAHVTIQSSGAFYTKFQVNNDNQLLLQRVTLP--TVPGDYTAKVAGEGC 1321

  Fly  1255 AMVQLSYRYNLAEKEKK-PSFKVTPTVKDTPNQL-----LIVDVCAEYVPLEDADKDKDSNMAVM 1313
            ..:|.|.:|::..:||: |...|..|:..|...|     ..:.:...|:     ....|||||:.
Mouse  1322 VYLQTSLKYSVLPREKEFPFALVVQTLPGTCEDLKAHTTFQISLNISYI-----GSRSDSNMAIA 1381

  Fly  1314 EIALPSGFVGDSTSLGKIQAVDRVKRVETKNSDSTVVVYFDSLTPGDVRCLPLEASKAHAVAKQK 1378
            ::.:.|||:....::..::....|.|.|..|:.  |::|.|.:: ..:..|.....:...|...|
Mouse  1382 DVKMVSGFIPLKPTVKMLERSVHVSRTEVSNNH--VLIYLDKVS-NQMLTLFFMVQQDIPVRDLK 1443

  Fly  1379 PASVSLYDYYDTERKATEYYQVKSS 1403
            ||.|.:||||:.:..|...|....|
Mouse  1444 PAIVKVYDYYEKDEFAVAKYSAPCS 1468

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tep2NP_523506.1 A2M_N 115..209 CDD:280081 32/93 (34%)
A2M_N_2 445..576 CDD:285005 33/164 (20%)
A2M 694..782 CDD:278630 32/92 (35%)
A2M_2 909..1198 CDD:239227 124/322 (39%)
A2M_comp 961..1199 CDD:284982 99/271 (37%)
A2M_recep 1308..1398 CDD:284981 25/89 (28%)
A2mNP_783327.2 A2M_N 135..227 CDD:280081 32/92 (35%)
A2M_N_2 473..612 CDD:285005 27/138 (20%)
Bait region. /evidence=ECO:0000250|UniProtKB:P01023 623..752 30/162 (19%)
A2M 738..828 CDD:278630 32/92 (35%)
A2M_2 958..1264 CDD:239227 124/322 (39%)
A2M_comp 1010..1266 CDD:284982 99/272 (36%)
A2M_recep 1376..1463 CDD:284981 25/89 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167840021
Domainoid 1 1.000 227 1.000 Domainoid score I2492
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D177369at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100452
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X292
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
76.650

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