DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep2 and A2M

DIOPT Version :9

Sequence 1:	NP_523506.1	Gene:	Tep2 / 34044	FlyBaseID:	FBgn0041182	Length:	1420	Species:	Drosophila melanogaster
Sequence 2:	XP_006719119.1	Gene:	A2M / 2	HGNCID:	7	Length:	1512	Species:	Homo sapiens

Alignment Length:	1563	Identity:	438/1563 - (28%)
Similarity:	684/1563 - (43%)	Gaps:	254/1563 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IFLTGIILQYALLVNATGIYSVVGPGTLRSNSKYNVVVSVHKADGPSQIKVSLNGPSYNETKQIE 68
            :.|..::|.....|:....|.|:.|..|.:.:.....|.:...:....:..||.....|.:...:
Human    12 VLLLLVLLPTDASVSGKPQYMVLVPSLLHTETTEKGCVLLSYLNETVTVSASLESVRGNRSLFTD 76

  Fly    69 LPPMSTQN-----VEFEVPKLATGN----YNLSAEGVSGVVFKNSTKLNYADKKPSVFVQTDKAT 124
            |   ..:|     |.|.|||.::..    ..:..:|.: ..||..|.:...::...|||||||:.
Human    77 L---EAENDVLHCVAFAVPKSSSNEEVMFLTVQVKGPT-QEFKKRTTVMVKNEDSLVFVQTDKSI 137

  Fly   125 YKPADLVQFRILFLDENTRPAKIEKPISVIIIDGAQNRIKQLSDVKLTKGVFSGELQLSEQPVLG 189
            |||...|:||::.:|||..|.....|: |.|.|...|||.|....:|..|:......||.:|..|
Human   138 YKPGQTVKFRVVSMDENFHPLNELIPL-VYIQDPKGNRIAQWQSFQLEGGLKQFSFPLSSEPFQG 201

  Fly   190 TWKISVSVDGDNRETKSFEVDKYVLPKFEVIVDTPKAVVIADKVIKATIRAKYTYGKPVKGKATV 254
            ::|:.|......|....|.|:::|||||||.|..||.:.|.::.:..::...|||||||.|..||
Human   202 SYKVVVQKKSGGRTEHPFTVEEFVLPKFEVQVTVPKIITILEEEMNVSVCGLYTYGKPVPGHVTV 266

  Fly   255 SMERSYG----------------YFGDLNANG--NKQEKTIDVDGKGHVEFDIIHWAQRGQYLPP 301
            |:.|.|.                :.|.||::|  .:|.||            .:...:|.:|...
Human   267 SICRKYSDASDCHGEDSQAFCEKFSGQLNSHGCFYQQVKT------------KVFQLKRKEYEMK 319

  Fly   302 IKLFAVVTE-----ELTGNKQNATATVVLHQQRYSIEPYERPEHFEANKSFIYQVVVKNVDGSPV 361
            :...|.:.|     ||||.:.:.....:.......::     .||.....|..||.:.:..|.|:
Human   320 LHTEAQIQEEGTVVELTGRQSSEITRTITKLSFVKVD-----SHFRQGIPFFGQVRLVDGKGVPI 379

  Fly   362 TNSAKNVKIGFDKSYSYFHEPSPKTRINFEAPVNENGIATFN--------------VRLPDSDSR 412
            .|....::......||             .|..:|:|:..|:              |...|....
Human   380 PNKVIFIRGNEANYYS-------------NATTDEHGLVQFSINTTNVMGTSLTVRVNYKDRSPC 431

  Fly   413 YYRIFASFDGSENTIGSISKFEPT-------PMSREPLKIQVNTKKPRL----GEQVSFDVVSIE 466
            |...:.|.:..|....:...|.|:       |||.|.......|.:...    |..:....:|
Human   432 YGYQWVSEEHEEAHHTAYLVFSPSKSFVHLEPMSHELPCGHTQTVQAHYILNGGTLLGLKKLS-- 494

  Fly   467 DLPYFVYTIVARGNVILSD----YVDVPDGQKTYTVKFTPTFSMVPKATIYVYYVV-NNDLQFEE 526
                |.|.|:|:|.::.:.    .|...|.:..:::.......:.|.|.:.:|.|: ..|:..:.
Human   495 ----FYYLIMAKGGIVRTGTHGLLVKQEDMKGHFSISIPVKSDIAPVARLLIYAVLPTGDVIGDS 555

  Fly   527 KTIDFEKEFSNSIDVS-APTNAKPSEEVKLRIKTDADSFVGLLGVDQSVLLLKSGNDLSQDDIFN 590
            ...|.|...:|.:|:| :|:.:.|:....||:.....|...|..|||||||:|...:||...::|
Human   556 AKYDVENCLANKVDLSFSPSQSLPASHAHLRVTAAPQSVCALRAVDQSVLLMKPDAELSASSVYN 620

  Fly   591 SL------------------------NIYQTSTPWMNGYGRYPGQTSGLVTLTNANYPYNTGPLV 631
            .|                        |:|      :||....|      |:.||....|:....:
Human   621 LLPEKDLTGFPGPLNDQDNEDCINRHNVY------INGITYTP------VSSTNEKDMYSFLEDM 673

  Fly   632 MSYVFEGSRHPWITRPR-----YRVGIRGDSGDRISFLSQSLNDRNLKEILLKQTPQRTTIRKEF 691
            ....|..|:   |.:|:     .:..:.|..|.|:.|....:..|....::..:.|...|:||.|
Human   674 GLKAFTNSK---IRKPKMCPQLQQYEMHGPEGLRVGFYESDVMGRGHARLVHVEEPHTETVRKYF 735

  Fly   692 PETWFFE-----NVGEEEFTLTKKIPDTITSWVVTGFSLNPTSGIALTKNPSKIRVFQPFFVSTN 751
            ||||.::     :.|..|..:|  :|||||.|....|.|:..:|:.::...| :|.||||||...
Human   736 PETWIWDLVVVNSAGVAEVGVT--VPDTITEWKAGAFCLSEDAGLGISSTAS-LRAFQPFFVELT 797

  Fly   752 LPYSVKRGEVIAIPVVIFNYLDKTLDADVVMDNSDQEYEFTEATNEVLEKAIDEVRRVKRVTIPA 816
            :||||.|||...:...:.|||.|.:...|.:          ||:...|...:::.:...  .|.|
Human   798 MPYSVIRGEAFTLKATVLNYLPKCIRVSVQL----------EASPAFLAVPVEKEQAPH--CICA 850

  Fly   817 NSGKSVSFMIRPKNVGFTTLKITA----TSALAG------------DAIHQKLKVEPEGVTLFEN 865
            |..::||:.:.||::|.....::|    :..|.|            |.:.:.|.|||||:   |.
Human   851 NGRQTVSWAVTPKSLGNVNFTVSAEALESQELCGTEVPSVPEHGRKDTVIKPLLVEPEGL---EK 912

  Fly   866 RAVFINL--KDQPEMSQSLDADIPNEVVPQSEFIEFSVVGDLLGPTLQNLDNLVRMPYGCGEQNM 928
            ...|.:|  ....|:|:.|...:|..||.:|.....||:||:||..:||..||::||||||||||
Human   913 ETTFNSLLCPSGGEVSEELSLKLPPNVVEESARASVSVLGDILGSAMQNTQNLLQMPYGCGEQNM 977

  Fly   929 VNFVPNILVLKYLEVTGRKLPSVESKARKFLEIGYQRELTYKHDDGSYSAFGK--SDASGSTWLT 991
            |.|.|||.||.||..|.:..|.::|||..:|..||||:|.|||.|||||.||:  ....|:||||
Human   978 VLFAPNIYVLDYLNETQQLTPEIKSKAIGYLNTGYQRQLNYKHYDGSYSTFGERYGRNQGNTWLT 1042

  Fly   992 AYVMRSFHQAGTYTDIDPKVITAGLDFLVSKQKESGEFPEVGKLFDNA----NQNPLALTSFVLL 1052
            |:|:::|.||..|..||...||..|.:|..:||::|.|...|.|.:||    .::.:.|::::.:
Human  1043 AFVLKTFAQARAYIFIDEAHITQALIWLSQRQKDNGCFRSSGSLLNNAIKGGVEDEVTLSAYITI 1107

  Fly  1053 AFFE-----NHELIPKYQSAIKKAVRYVAEEADKTDDQYSLAIAAVALQLAKHPQSEK-VIAKLE 1111
            |..|     .|.::......::.|.: .|:|.|.....|:.|:.|.|..||.:....| |:..|.
Human  1108 ALLEIPLTVTHPVVRNALFCLESAWK-TAQEGDHGSHVYTKALLAYAFALAGNQDKRKEVLKSLN 1171

  Fly  1112 SVARKENDRMWWSKATESTGEDGRVFHWKPRSNDVEITSYVLLALLEKDPA------EKALPIIK 1170
            ..|.|:::.:.|.:..:.....|..:..:..|.:||:|||||||.|...||      ..|..|:|
Human  1172 EEAVKKDNSVHWERPQKPKAPVGHFYEPQAPSAEVEMTSYVLLAYLTAQPAPTSEDLTSATNIVK 1236

  Fly  1171 WLISQRNSNGGFSSTQDTVIGLQALTKFAYKTGSGSG-TMDIEFSSAGESKNTIKVNPENSLVLQ 1234
            |:..|:|:.||||||||||:.|.||:|:...|.:.:| ...:...|:|...:..:|:..|.|:||
Human  1237 WITKQQNAQGGFSSTQDTVVALHALSKYGAATFTRTGKAAQVTIQSSGTFSSKFQVDNNNRLLLQ 1301

  Fly  1235 THDLPKSTRKVDFTAKGTGSAMVQLSYRYN-LAEKEKKP---SFKVTPTVKDTP--NQLLIVDVC 1293
            ...||:...:......|.|...:|.|.:|| |.|||:.|   ..:..|...|.|  :....:.:.
Human  1302 QVSLPELPGEYSMKVTGEGCVYLQTSLKYNILPEKEEFPFALGVQTLPQTCDEPKAHTSFQISLS 1366

  Fly  1294 AEYVPLEDADKDKDSNMAVMEIALPSGFVGDSTSLGKIQAVDRVKRVET----------KNSDST 1348
            ..|.....|     ||||::::.:.|||:....::..::..:.|.|.|.          |.|:.|
Human  1367 VSYTGSRSA-----SNMAIVDVKMVSGFIPLKPTVKMLERSNHVSRTEVSSNHVLIYLDKVSNQT 1426

  Fly  1349 VVVYFDSLTPGDVRCLPLEASKAHAVAKQKPASVSLYDYYDTERKATEYYQVKSSLCDICEGADC 1413
            :.::|..|....||.|             |||.|.:||||:|:..|...|           .|.|
Human  1427 LSLFFTVLQDVPVRDL-------------KPAIVKVYDYYETDEFAIAEY-----------NAPC 1467

  Fly  1414 GEG 1416
            .:|
Human  1468 SKG 1470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep2	NP_523506.1	A2M_N	115..209	CDD:280081	35/93 (38%)
		A2M_N_2	445..576	CDD:285005	31/140 (22%)
		A2M	694..782	CDD:278630	34/92 (37%)
		A2M_2	909..1198	CDD:239227	122/306 (40%)
		A2M_comp	961..1199	CDD:284982	94/255 (37%)
		A2M_recep	1308..1398	CDD:284981	28/99 (28%)
A2M	XP_006719119.1	YfaS	<124..>1071	CDD:225248	294/1016 (29%)
		A2M_N	129..221	CDD:280081	35/92 (38%)
		A2M_N_2	461..606	CDD:285005	35/150 (23%)
		A2M	738..828	CDD:278630	34/92 (37%)
		A2M_2	958..1264	CDD:239227	122/306 (40%)
		A2M_comp	1010..1266	CDD:284982	94/256 (37%)
		A2M_recep	1376..1463	CDD:284981	28/99 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149968
Domainoid	1	1.000	84	1.000	Domainoid score	I8230
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100452
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X292
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.650