Protein Alignment Tep2 and Mug2

DIOPT Version :10

• Sequence 1: NP_523506.1
• Gene: Tep2 / 34044
• FlyBaseID: FBgn0041182
• Length: 1420
• Species: Drosophila melanogaster
• Sequence 2: XP_006505762.1
• Gene: Mug2 / 17837
• MGIID: 99836
• Length: 1490
• Species: Mus musculus
• Alignment Length: 1566
• Identity: 431/1566 - (27%)
• Similarity: 703/1566 - (44%)
• Gaps: 273/1566 - (17%)

  Fly    22 IYSVV-----GPGTLRSNSKYNVVVSVHKADGPSQI------KVSLNGPSYNETKQIELPPMST- 74
            ::||:     ...:|..:|||.|:|       |||:      |:.|:....|||..:....:|.
Mouse    11 LFSVLLAFLPSASSLNGDSKYMVLV-------PSQLYTETPEKICLHLYHLNETVTVTASLVSQT 68

  Fly    75 ----------------QNVEFEVPKLATGNYN----LSAEGVSGVVFKNSTKLNYADKKPSVFVQ 119
                            |.|.|.:|.|.:.:..    :..:|.:....|.:..| ..:|:..||||
Mouse    69 GRRNLFDELVVDKDLFQCVSFIIPTLNSPDEEEFLYVDIKGPTHEFSKRNAVL-VKNKESVVFVQ 132

  Fly   120 TDKATYKPADLVQFRILFLDENTRPAKIEKPISVIIIDGAQNRIKQLSDVKLTKGVFSGELQLSE 184
            |||..|||...|:||::.:|:..||.....|:: .|.|..:|||.|..|:|...|:......|:.
Mouse   133 TDKPVYKPGQSVKFRVVSMDKTLRPLNELLPLA-YIEDPKKNRIMQWRDIKTENGLKQMSFSLAA 196

  Fly   185 QPVLGTWKISVSVDGDNRETKSFEVDKYVLPKFEVIVDTPKAVVIADKVIKATIRAKYTYGKPVK 249
            :|:.|.:||.|......:|..||.|.::|||:|.|.:..|.|:.:.|:|::.|:..||||||||.
Mouse   197 EPIQGPYKIVVHKQSGVKEEHSFTVMEFVLPRFNVDLKVPNAISVNDEVLQVTVCGKYTYGKPVP 261

  Fly   250 GKATVSMERSYGYFGDLNANGNKQEKTIDVDGKGHVEFDIIH-WAQRGQYLPPIKLF---AVVTE 310
            |:..:|:      ..:..|...:....:|.:|....|.:|.. .:::..|  .::||   |.|||
Mouse   262 GQVKISI------CHETEAGCKEVNSKLDNNGCSTQEVNITELQSKKRNY--EVQLFHVNATVTE 318

  Fly   311 ELTGNKQNATATVVLHQQRYSIEPYERPEHFEANKSFIYQVVVKNVDGSPVTNSAKNVK---IGF 372
            |.||.:.|...|..:.:....:...:...||.....|..:|.:.::.|.|:.|....:|   :|:
Mouse   319 EGTGLEFNGYGTTKIERITNKLIFLKADSHFRHGIPFFVKVRLVDIKGDPIPNERVFIKAQVLGY 383

  Fly   373 DKSYSYFHEPSPKTRINFEAPVNENGIATFN--------------VRLPDSDSRYY-----RIFA 418
            ..:                ...:::|:|.|:              |.....||.|:     ..:|
Mouse   384 TSA----------------TTTDQHGLAKFSIDTAGFSGSSLHIKVNHKGKDSCYFFYCMEERYA 432

  Fly   419 SFDGSENTIGSISKFEPTPMSREPLKI----QVNTKKPRLGEQVSF----DVVSIEDLPYFVYTI 475
            |.:.....:.|:|| ....:.:|...|    |::|      .|..|    |:..:::| .|.|.:
Mouse   433 SAEHVAYAVYSLSK-SYIYLVKETSSILPCNQIHT------VQAHFILKGDLGVLKEL-VFYYLV 489

  Fly   476 VARGNVILSDYVDVPDGQKTYTV-------------KFTPTFSMVPKATIYVYYVV-NNDLQFEE 526
            :|:|::|.:       |..|:.|             :....|||.|.|.:.:|.:: :.::..:.
Mouse   490 MAQGSIIQT-------GNHTHQVEPGEAPVKGNFDLEIPVEFSMAPMAKMLIYTILPDGEVIADS 547

  Fly   527 KTIDFEKEFSNSIDVS-APTNAKPSEEVKLRIKTDADSFVGLLGVDQSVLLLKSGNDLSQDDIFN 590
            ...:.||...|.:|:| :.:.:.|:.:.:|::.....|..||..|||||||||..::||...|:|
Mouse   548 VNFEIEKCLRNKVDLSFSSSQSLPASQTRLQVTASPQSLCGLRAVDQSVLLLKPEDELSPSWIYN 612

  Fly   591 SLNIYQTSTPWMNGYGRYPG-QTSGLVTLTNANYPYNTGPLVMSYVFEGSRH-PWITRPR----Y 649
                             .|| |.:..:..::.:.......|..|:|.|  :| .|:...|    |
Mouse   613 -----------------LPGMQHNKFIPSSSLSEDREDCILYSSWVAE--KHTDWVPHGREKDVY 658

  Fly   650 RVGIRGD---------------------SGDRISF-------LSQSLNDRNLKEILLKQTPQR-- 684
            |.....|                     ||.|..|       :|.:|...:.|....::.|:.
Mouse   659 RYVEDMDLKAFTNLKIKLPKICFDSAPMSGPRGKFDLAFSSEVSGTLQKGSSKRPQPEEPPREDP 723

  Fly   685 -------TTIRKEFPETWFFE-------NVGEEEFTLTKKIPDTITSWVVTGFSLNPTSGIALTK 735
                   .||||.|||||.::       .|.|.|.|    :|||||.|......|:..:|:.|:
Mouse   724 PPKDPLAETIRKYFPETWVWDIVTVNSTGVAEVEMT----VPDTITEWKAGALCLSNDTGLGLS- 783

  Fly   736 NPSKIRVFQPFFVSTNLPYSVKRGEVIAIPVVIFNYLDKTLDADVVMDNSDQEYEFTEATNEVLE 800
            :...::.||||||..:|||||.|||...:...:.|||..::...|.::.|.   :||
Mouse   784 SVVPLQAFQPFFVEVSLPYSVVRGEAFMLKATVMNYLPTSMRMSVQLEASP---DFT-------- 837

  Fly   801 KAIDEVRRVKRVTIPANSGKSVSFMIRPKNVGFTTLKIT--------------ATSALAG--DAI 849
             |:..........:.||...:.|:::.||::|.....::              ||....|  |.:
Mouse   838 -AVPVGDDHDSYCLSANGRHTSSWLVTPKSLGNVNFSVSVEAQQSSEPCGSEVATVPETGRKDTV 901

  Fly   850 HQKLKVEPEGVTLFENRAVFINL--KDQPEMSQSLDADIPNEVVPQSEFIEFSVVGDLLGPTLQN 912
            .:.|.|||||:   :....|.:|  ....|:|:.:...:|..||..|....|||:||:|...::|
Mouse   902 VKVLIVEPEGI---KQEHTFNSLFCASDAEISEKMSLVLPPTVVKDSARAHFSVMGDILSSAIKN 963

  Fly   913 LDNLVRMPYGCGEQNMVNFVPNILVLKYLEVTGRKLPSVESKARKFLEIGYQRELTYKHDDGSYS 977
            ..||:.|||||||||||.|.|||.|||||:.|.:....:::||..||..||||||.|||.|||||
Mouse   964 TQNLLHMPYGCGEQNMVLFAPNIYVLKYLDKTQQLTQKIKTKALGFLRAGYQRELNYKHKDGSYS 1028

  Fly   978 AFG--KSDASGSTWLTAYVMRSFHQAGTYTDIDPKVITAGLDFLVSKQKESGEFPEVGKLFDN-- 1038
            |||  ..:..|:|||||:|::||.||..:..||...||....:|..:||::|.|...|.||.|
Mouse  1029 AFGDQNGEREGNTWLTAFVLKSFAQARAFIFIDESHITHAFTWLSQQQKDNGCFRSSGSLFHNDI 1093

  Fly  1039 --ANQNPLALTSFVLLAFFEN-----HELIPKYQSAIKKAVRYVAEEADKTDDQYSLAIAAVALQ 1096
              ...:.:.|::::.:|..|:     |.::.|..|.::.:.:.: |:....:..|:.|:.|.|..
Mouse  1094 KGGVDDEMTLSAYITMALLESSLPARHPVVSKALSCLESSWKTI-EQGRNANFVYTKALMAYAFA 1157

  Fly  1097 LA-KHPQSEKVIAKLESVARKENDRMWWSKATESTGEDGRVFHWKPRSNDVEITSYVLLALLEKD 1160
            || ...:..:::..|:..|.||::.:.|.:..:....:..::..:..|.:||:.:||:||.|...
Mouse  1158 LAGNQDKRNEILKSLDEEAIKEDNSIHWERPQKPRKSEHNLYKPQASSVEVEMNAYVVLARLTAQ 1222

  Fly  1161 PAEK------ALPIIKWLISQRNSNGGFSSTQDTVIGLQALTKFAYKTGS-GSGTMDIEFSSAGE 1218
            ||..      :...|.||..|:|||||||||||||:.|.||:|:...|.| ...|..:...|.|.
Mouse  1223 PAPSPEDLTLSRSTIMWLTKQQNSNGGFSSTQDTVVALDALSKYGAVTFSRRQKTSLVTIQSTGS 1287

  Fly  1219 SKNTIKVNPENSLVLQTHDLPKSTRKVDFTAKGTGSAMVQLSYRYNLAEKEKKPSF----KVTPT 1279
            .....:|...|.|:||...||........:..|.|....|.:.|||:..::::.:|    :..|.
Mouse  1288 FSQKFQVENSNCLLLQQVPLPDIPGDYTISVSGEGCVYAQTTLRYNMHLEKQQSAFALRVQTVPL 1352

  Fly  1280 VKDTP--NQLLIVDVCAEYVPLEDADKDKDSNMAVMEIALPSGFVGDSTSLGKIQAVDRVKRVET 1342
            ..:.|  :....:.:...|.....|     |||.:.::.:.|||:....::.|::.::.:.|.|.
Mouse  1353 TCNNPKGHNSFQISLEISYTGSRPA-----SNMVIADVKMLSGFIPLKPTVKKLERLEHISRTEV 1412

  Fly  1343 KNSDSTVVVYFDSLTPGDVRCLPLEASKAHAVAKQKPASVSLYDYYDTERKATEYYQVKSSLCDI 1407
            .|::  |::|.|.:| ...........:..:|...:||.|.:||||:|:..|   |...||.|..
Mouse  1413 SNNN--VLLYLDQVT-NQTLAFSFIIQQDISVRNLQPAIVKVYDYYETDEVA---YAEYSSPCSS 1471

  Fly  1408 CEGADC 1413
            .|...|
Mouse  1472 GEHPAC 1477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep2	NP_523506.1	YfaS	<72..1395	CDD:441940	408/1485 (27%)
		A2M_2	909..1198	CDD:239227	117/306 (38%)
Mug2	XP_006505762.1	YfaS	<99..1332	CDD:441940	371/1313 (28%)
		A2M	740..830	CDD:459711	33/94 (35%)
		A2M_2	960..1266	CDD:239227	117/306 (38%)
		A2M_recep	1376..1466	CDD:462226	26/100 (26%)