Protein Alignment Tep2 and Hc

DIOPT Version :9

• Sequence 1: NP_523506.1
• Gene: Tep2 / 34044
• FlyBaseID: FBgn0041182
• Length: 1420
• Species: Drosophila melanogaster
• Sequence 2: XP_017171158.1
• Gene: Hc / 15139
• MGIID: 96031
• Length: 1684
• Species: Mus musculus
• Alignment Length: 1621
• Identity: 390/1621 - (24%)
• Similarity: 670/1621 - (41%)
• Gaps: 316/1621 - (19%)

  Fly     7 TGIILQYALLVNATGIYSVVGPGTLRSNSKYNVVVSVHKADGPSQIKVSLNGPSYNETK------ 65
            |..:::.|.|:    ||.:..|..||..|..|||:.||.........:||.  ||.:.|
Mouse    15 TRSLVEAATLL----IYVISAPKILRVGSSENVVIQVHGYTEAFDATLSLK--SYPDKKVTFSSG 73

  Fly    66 QIELPPMST-QNVEF------EVPKLATGNYNLSAEGVSGVVFKNSTKLNYADKKPSVFVQTDKA 123
            .:.|.|.:. ||...      :||:..:...::..|.|| ..|..|.|:........:|:.|||.
Mouse    74 YVNLSPENKFQNAALLTLQPNQVPREESPVSHVYLEVVS-KHFSKSKKIPITYNNGILFIHTDKP 137

  Fly   124 TYKPADLVQFRILFLDENTRPAKIEKPISVIIIDGAQNRIKQLSDVKLTKGVFS-GELQLSEQPV 187
            .|.|...|:.|:..|.::.:|||.|..::.|..:|::..|.:.:|.   .|:.| .:.::...|.
Mouse   138 VYTPDQSVKIRVYSLGDDLKPAKRETVLTFIDPEGSEVDIVEENDY---TGIISFPDFKIPSNPK 199

  Fly   188 LGTWKISVSVDGD--NRETKSFEVDKYVLPKFEVIVDTPKAVVIAD--KVIKATIRAKYTYGKPV 248
            .|.|.|..:...|  ...|..||:.:||||:|.|.::..:..:...  |..:.|::|:|.|.|.|
Mouse   200 YGVWTIKANYKKDFTTTGTAYFEIKEYVLPRFSVSIELERTFIGYKNFKNFEITVKARYFYNKVV 264

  Fly   249 KGKATVSMERSYGYFGDLNANGNKQEKTID---------VDGKGHVEFDIIHWAQ---------- 294
            .....      |.:|| |..:...:||.:.         |||...:.||.....:
Mouse   265 PDAEV------YAFFG-LREDIKDEEKQMMHKATQAAKLVDGVAQISFDSETAVKELSYNSLEDL 322

  Fly   295 RGQYLPPIKLFAVVTEELTGNKQNATATVVLHQQRYSIEPY-----ERPEHFEANKSFIYQVVVK 354
            ..:||   .:...|||...|..:.|....|    :|.:.||     ..|...:....|..:..||
Mouse   323 NNKYL---YIAVTVTESSGGFSEEAEIPGV----KYVLSPYTLNLVATPLFVKPGIPFSIKAQVK 380

  Fly   355 N-----VDGSPVTNSAKNVKIGFDKS-----YSYFHE-----------PSPKTRINFEAPVNENG 398
            :     |.|.|||..|:.|.:..:.|     .|..|:           ||..|.:.||
Mouse   381 DSLEQAVGGVPVTLMAQTVDVNQETSDLETKRSITHDTDGVAVFVLNLPSNVTVLKFE------- 438

  Fly   399 IATFNVRLPDSD--SRYYR--IFASFDGSENTIGSISKFEPTPMSREPLKIQVNTKKPRLGEQVS 459
            |.|.:..||:.:  |:.|.  .::|...|...|.....::|. :..|.|.|.|..|.|
Mouse   439 IRTDDPELPEENQASKEYEAVAYSSLSQSYIYIAWTENYKPM-LVGEYLNIMVTPKSP------- 495

  Fly   460 FDVVSIEDLPYFVYTIVARGNVILSDYVDVPDGQK------TY-TVKFTPTFSMVPKATIYVYYV 517
                .|:.:.::.|.|:::|.::  .|     |.:      || .:....|.:|||.|.:.|||:
Mouse   496 ----YIDKITHYNYLILSKGKIV--QY-----GTREKLFSSTYQNINIPVTQNMVPSARLLVYYI 549

  Fly   518 VNN----DLQFEEKTIDFEKEFSNSIDVSAPTNA---KPSEEVKLRIKTDADSFVGLLGVDQSVL 575
            |..    :|..:...|:.|::..|.:.|....:.   .|.:.|.|.:.|:|||:|.|..||::|.
Mouse   550 VTGEQTAELVADAVWINIEEKCGNQLQVHLSPDEYVYSPGQTVSLDMVTEADSWVALSAVDRAVY 614

  Fly   576 LLKSGNDLSQDDIFNSLNIYQTSTPWMNGYGRYPG----QTSGLVTLTNAN-----YPYNTGPLV 631
            .::.....:...:|.:|:  :.|.......|.:..    ..:||..|||||     |..::
Mouse   615 KVQGNAKRAMQRVFQALD--EKSDLGCGAGGGHDNADVFHLAGLTFLTNANADDSHYRDDS---- 673

  Fly   632 MSYVFEGSRHPWITR-------PRYRVGIRGD---SGDRISFLSQSLNDR--------------- 671
            ...:....|:..:.|       .:|:..:...   .|.|::|. ::..:|
Mouse   674 CKEILRSKRNLHLLRQKIEEQAAKYKHSVPKKCCYDGARVNFY-ETCEERVARVTIGPLCIRAFN 737

  Fly   672 ---NLKEILLKQTP-----------------QRTTIRKEFPETWFFE--NVGEEEFTLTKKIPDT 714
               .:...:.|::|                 .:..||..|||:|.:|  .|.:.: .|...:||:
Mouse   738 ECCTIANKIRKESPHKPVQLGRIHIKTLLPVMKADIRSYFPESWLWEIHRVPKRK-QLQVTLPDS 801

  Fly   715 ITSWVVTGFSLNPTSGIALTKNPSKIRVFQPFFVSTNLPYSVKRGEVIAIPVVIFNYLDKTLDAD 779
            :|:|.:.|..:: .:||.:. :..|.:||:..|:..|:||||.|||.|.:...::||:.......
Mouse   802 LTTWEIQGIGIS-DNGICVA-DTLKAKVFKEVFLEMNIPYSVVRGEQIQLKGTVYNYMTSGTKFC 864

  Fly   780 VVMD---------NSDQEYEFTEATNEVLEKAIDEVRRVKRVTIPANSGKSVSFMIRPKNVGFTT 835
            |.|.         :|......:..:..|.::            |..:|...|:|.:.|..:|..:
Mouse   865 VKMSAVEGICTSGSSAASLHTSRPSRCVFQR------------IEGSSSHLVTFTLLPLEIGLHS 917

  Fly   836 LKITATSALAGDAIHQKLKVEPEGVTLFENRAVFIN---LKDQPEMSQSLDADIPNEVVPQSEF- 896
            :..:..::...|.:.:.|:|.||||.......|.::   ::......:.....||.::||:::.
Mouse   918 INFSLETSFGKDILVKTLRVVPEGVKRESYAGVILDPKGIRGIVNRRKEFPYRIPLDLVPKTKVE 982

  Fly   897 ----IEFSVVGDLLGPTL--QNLDNLVRMPYGCGEQNMVNFVPNILVLKYLEV----------TG 945
                ::..:||:.|...|  :.::.|..:|.|..|..:::..|...|..|||.          |.
Mouse   983 RILSVKGLLVGEFLSTVLSKEGINILTHLPKGSAEAELMSIAPVFYVFHYLEAGNHWNIFYPDTL 1047

  Fly   946 RKLPSVESKARKFLEIGYQRELTYKHDDGSYSAFGKSDASGSTWLTAYVMRSFHQAGTYTDIDPK 1010
            .|..|:|.|.::    |....::|::.|.|||.:  ..||.||||||:.:|...|...|...|..
Mouse  1048 SKRQSLEKKIKQ----GVVSVMSYRNADYSYSMW--KGASASTWLTAFALRVLGQVAKYVKQDEN 1106

  Fly  1011 VITAGLDFLVSK-QKESGEFPE---------VGKLFDNANQNPLALTSFVLLAFFENHELIP--K 1063
            .|...|.:||.| |.|:|.|.|         .|.|...|.:..|.||:|.::...:..::.|  |
Mouse  1107 SICNSLLWLVEKCQLENGSFKENSQYLPIKLQGTLPAEAQEKTLYLTAFSVIGIRKAVDICPTMK 1171

  Fly  1064 YQSAIKKAVRYVAEEADKTDDQYSLAIAAVALQLA--KHPQSEKVIAKLESVARKEND----RMW 1122
            ..:|:.||..::.|....:...::|||.|.||.|.  .||:...:::.|...|..:.|    |.|
Mouse  1172 IHTALDKADSFLLENTLPSKSTFTLAIVAYALSLGDRTHPRFRLIVSALRKEAFVKGDPPIYRYW 1236

  Fly  1123 W------SKATESTGEDGRVFHWKPRSNDVEITSYVLLALLEKDPAEKALPIIKWLISQRNSNGG 1181
            .      ..:..|:|..|.          ||.|:|.|||.|:......|.||||||..::...||
Mouse  1237 RDTLKRPDSSVPSSGTAGM----------VETTAYALLASLKLKDMNYANPIIKWLSEEQRYGGG 1291

  Fly  1182 FSSTQDTVIGLQALTKFAYKTGSGSGTMDIEFSSAGESK-NTIKVNPENSL-----VLQTHDLPK 1240
            |.|||||:..::.||:::.........|||..:...|.. :..||..::.|     |....||..
Mouse  1292 FYSTQDTINAIEGLTEYSLLLKQIHLDMDINVAYKHEGDFHKYKVTEKHFLGRPVEVSLNDDLVV 1356

  Fly  1241 STRKVDFTAKGTGSAMVQLS---YRYNLAEK-------------EKKPSFKVTPTVKDTPNQLLI 1289
            |      |...:|.|.|.:.   ::.:::|:             |....|:::    |:..:.:|
Mouse  1357 S------TGYSSGLATVYVKTVVHKISVSEEFCSFYLKIDTQDIEASSHFRLS----DSGFKRII 1411

  Fly  1290 VDVCAEYVPLEDADKDKDSNMAVMEIALPSGFVGDSTSL-GKIQAVDRVKRVETKNSDSTVVVYF 1353
              .||.|.|.:: :....|:.|||:|:||:|...:...| ..::.||:: ..:.:..|..|::..
Mouse  1412 --ACASYKPSKE-ESTSGSSHAVMDISLPTGIGANEEDLRALVEGVDQL-LTDYQIKDGHVILQL 1472

  Fly  1354 DSLTPGDVRCLPLEASKAHAVAKQKPASVSLYDYYDTERKATEYYQVKSS-LCDICEGADC 1413
            :|:...|..|:.....:...|....||:.::|:|:..:::.|..|.:..: |..:||||.|
Mouse  1473 NSIPSRDFLCVRFRIFELFQVGFLNPATFTVYEYHRPDKQCTMIYSISDTRLQKVCEGAAC 1533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep2	NP_523506.1	A2M_N	115..209	CDD:280081	26/96 (27%)
		A2M_N_2	445..576	CDD:285005	38/144 (26%)
		A2M	694..782	CDD:278630	27/89 (30%)
		A2M_2	909..1198	CDD:239227	98/324 (30%)
		A2M_comp	961..1199	CDD:284982	83/261 (32%)
		A2M_recep	1308..1398	CDD:284981	22/90 (24%)
Hc	XP_017171158.1	MG1	27..124	CDD:375333	27/99 (27%)
		A2M_N	130..223	CDD:376626	26/95 (27%)
		MG3	225..309	CDD:375334	24/90 (27%)
		MG4	358..461	CDD:375332	25/109 (23%)
		A2M_N_2	474..614	CDD:377903	40/158 (25%)
		ANATO	690..758	CDD:237984	7/68 (10%)
		A2M	780..867	CDD:365945	27/89 (30%)
		complement_C3_C4_C5	1003..1308	CDD:239226	97/320 (30%)
		A2M_recep	1427..1517	CDD:369460	22/90 (24%)
		NTR_like	1535..1683	CDD:382999

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840005
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.800