Protein Alignment Tep2 and A2ML1

DIOPT Version :10

• Sequence 1: NP_523506.1
• Gene: Tep2 / 34044
• FlyBaseID: FBgn0041182
• Length: 1420
• Species: Drosophila melanogaster
• Sequence 2: XP_011518868.1
• Gene: A2ML1 / 144568
• HGNCID: 23336
• Length: 1467
• Species: Homo sapiens
• Alignment Length: 1605
• Identity: 439/1605 - (27%)
• Similarity: 680/1605 - (42%)
• Gaps: 334/1605 - (20%)

  Fly     1 MFRIFLTGIILQYALLVNATGIYSVVGPGTLRSNSKYNVVVSVHKADGPSQIKVSLNGPSYNET- 64
            |:...|.|::.....:......|.|..|..|...|...|.:.:  :.|.|.:|.::...:.::|
Human     1 MWAQLLLGMLALSPAIAEELPNYLVTLPARLNFPSVQKVCLDL--SPGYSDVKFTVTLETKDKTQ 63

  Fly    65 KQIELPPMSTQN---VEFEVPKLATGNYNLSAEGVSGVVFKNSTKLNYADKKP--------SVFV 118
            |.:|...:..::   :.|.||..|.|...::...||||    ...:::.:||.        ..||
Human    64 KLLEYSGLKKRHLHCISFLVPPPAGGTEEVATIRVSGV----GNNISFEEKKKVLIQRQGNGTFV 124

  Fly   119 QTDKATYKPADLVQFRILFLDENTRPAKIEKPISVIIIDGAQNRIKQLSDVKLTKGVFSGELQLS 183
            ||||..|.|...|.|||:.:|.|..|.. :|...|.:.|...|||.|..:|...:|:.....||:
Human   125 QTDKPLYTPGQQVYFRIVTMDSNFVPVN-DKYSMVELQDPNSNRIAQWLEVVPEQGIVDLSFQLA 188

  Fly   184 EQPVLGTWKISVSVDGDNRETKSFEVDKYVLPKFEVIVDTPKAVVIADKVIKATIRAKYTYGKPV 248
            .:.:|||:.::|:   :.:...:|.|::||||||:|.|..||.:....:.....|..:||||||:
Human   189 PEAMLGTYTVAVA---EGKTFGTFSVEEYVLPKFKVEVVEPKELSTVQESFLVKICCRYTYGKPM 250

  Fly   249 KGKATVSM---ERSYGY-------FGDLNAN-GNKQEKT------IDVDGKGHVEFDIIHWAQRG 296
            .|...||:   ..:|.|       ..|...| ..:.:||      :|:     ..||:|.:|
Human   251 LGAVQVSVCQKANTYWYREVEREQLPDKCRNLSGQTDKTGCFSAPVDM-----ATFDLIGYA--- 307

  Fly   297 QYLPPIKLFAVVTEELTGNKQNATATVVLHQQRYSIEPYERPEHFEANKSFIYQVVVKNVDGSPV 361
             |...|.:.|.|.||.||.:.|||..:.:..|..|:...:....:..|..|..::.|:..|.|.:
Human   308 -YSHQINIVATVVEEGTGVEANATQNIYISPQMGSMTFEDTSNFYHPNFPFSGKIRVRGHDDSFL 371

  Fly   362 TNSAKNVKI-GFDKSYSYFHEPSPKTRINFEAPVNENGIATFNVRL------------------- 406
            .|....:.| |.:.::            |.....:.||:|.|.:..
Human   372 KNHLVFLVIYGTNGTF------------NQTLVTDNNGLAPFTLETSGWNGTDVSLEGKFQMEDL 424

  Fly   407 ---PDSDSRYY-------RIF----ASFDGSENTIGSISKFEP---------TPMSREPLKIQVN 448
               |:...|||       |.|    .||.|.....|.:...:|         .|....|
Human   425 VYNPEQVPRYYQNAYLHLRPFYSTTRSFLGIHRLNGPLKCGQPQEVLVDYYIDPADASP------ 483

  Fly   449 TKKPRLGEQVSFDVVSIEDLPYFVYTIVARGNVILSDYVDVPDGQK-----------TYTVKFTP 502
                  .:::||.           |.::.:|::::       :|||           ::::..|.
Human   484 ------DQEISFS-----------YYLIGKGSLVM-------EGQKHLNSKKKGLKASFSLSLTF 524

  Fly   503 TFSMVPKATIYVYY------VVNNDLQFEEKTIDFEKEFSNSIDV--------------SAPTNA 547
            |..:.|..::.:|.      ||.:.:||     ..|..|.|..|:              .:|:..
Human   525 TSRLAPDPSLVIYAIFPSGGVVADKIQF-----SVEMCFDNQADLIPKLYLSLPQVSLGFSPSQQ 584

  Fly   548 KPSEEVKLRIKTDADSFVGLLGVDQSVLLLKSGNDLSQDDIFNSLNIYQTSTPWMNGYGRYPGQT 612
            .|..||:|:::....|...|..||:|||||:...:||...::.....:         ||.||.|.
Human   585 LPGAEVELQLQAAPGSLCALRAVDESVLLLRPDRELSNRSVYGMFPFW---------YGHYPYQV 640

  Fly   613 SGLVTLTNANYPYNTGPLVMSYVF-----------EGSRHPWITRPRYRVGIRGDSGDRISFLS- 665
            :          .|:..|:...:.|           ..|:...|.||.:..|.     |..||..
Human   641 A----------EYDQCPVSGPWDFPQPLIDPMPQGHSSQRSIIWRPSFSEGT-----DLFSFFRD 690

  Fly   666 ---QSLNDRNLK-----------------------EILLKQTP----QRTTIRKEFPETWFFE-- 698
               :.|::..:|                       |.....||    :.:.:|:.|||||.::
Human   691 VGLKILSNAKIKKPVDCSHRSPEYSTAMGAGGGHPEAFESSTPLHQAEDSQVRQYFPETWLWDLF 755

  Fly   699 ---NVGEEEFTLTKKIPDTITSWVV--------TGFSLNPTSGIALTKNPSKIRVFQPFFVSTNL 752
               |.|:|...:|  :||.||.|..        .||.|:||.|:.         .|:||||...|
Human   756 PIGNSGKEAVHVT--VPDAITEWKAMSFCTSQSRGFGLSPTVGLT---------AFKPFFVDLTL 809

  Fly   753 PYSVKRGEVIAIPVVIFNYLDKTLDADVVMDNSDQEYEFTEATNEVLEKAIDEVRRVKRVTIPAN 817
            ||||.|||...:...|||||...:.....:..| .||:        ||...|.   .....:.|:
Human   810 PYSVVRGESFRLTATIFNYLKDCIRVQTDLAKS-HEYQ--------LESWADS---QTSSCLCAD 862

  Fly   818 SGKSVSFMIRPKNVG---FT-TLKITATSALAG------------DAIHQKLKVEPEGVTLFENR 866
            ..|:..:.|....:|   || :.||..::...|            |.:.:.:.|:||||.:.:..
Human   863 DAKTHHWNITAVKLGHINFTISTKILDSNEPCGGQKGFVPQKGRSDTLIKPVLVKPEGVLVEKTH 927

  Fly   867 AVFINLKDQPEMSQSLDADIPNEVVPQSEFIEFSVVGDLLGPTLQNLDNLVRMPYGCGEQNMVNF 931
            :..:..|.: ..|:|:..::|.::||.|.....:|:||::|..|||||.||:||.||||||||.|
Human   928 SSLLCPKGK-VASESVSLELPVDIVPDSTKAYVTVLGDIMGTALQNLDGLVQMPSGCGEQNMVLF 991

  Fly   932 VPNILVLKYLEVTGRKLPSVESKARKFLEIGYQRELTYKHDDGSYSAFGKSDASGSTWLTAYVMR 996
            .|.|.||:|||..|.....:.|:|..|||||||:||.|||.:|||||||:.|.:|:|||||:|.:
Human   992 APIIYVLQYLEKAGLLTEEIRSRAVGFLEIGYQKELMYKHSNGSYSAFGERDGNGNTWLTAFVTK 1056

  Fly   997 SFHQAGTYTDIDPKVITAGLDFLVSKQKESGEFPEVGKLFDNANQ----NPLALTSFVLLAFFEN 1057
            .|.||..:..||||.|...|.::...|..||.:..||.|...|.:    :.::||::|..|..|.
Human  1057 CFGQAQKFIFIDPKNIQDALKWMAGNQLPSGCYANVGNLLHTAMKGGVDDEVSLTAYVTAALLEM 1121

  Fly  1058 HELIPKYQSAIKKAVRYVAEEADKTDDQYSLAIAAVALQLAKHPQSEKVIAK-LESVARKENDRM 1121
            .:.:.  ...:.:.:|.:...|..|.:.|:.|:.|....||.......::.| |:..|....:.:
Human  1122 GKDVD--DPMVSQGLRCLKNSATSTTNLYTQALLAYIFSLAGEMDIRNILLKQLDQQAIISGESI 1184

  Fly  1122 WWS-KATESTGEDGRVFHW-KPRSNDVEITSYVLLALLEKDPA------EKALPIIKWLISQRNS 1178
            :|| |.|.|:...    .| :|.:.|||:|:|.|||.|.| |:      .||..|:.||..|.|:
Human  1185 YWSQKPTPSSNAS----PWSEPAAVDVELTAYALLAQLTK-PSLTQKEIAKATSIVAWLAKQHNA 1244

  Fly  1179 NGGFSSTQDTVIGLQALTKFAYKTGSGSGTMDIEFSSAGESKNTIKVNPENSLVLQTHDLPKSTR 1243
            .||||||||||:.||||.|:|......|..:::...|....:.|..:...|.||.|...||....
Human  1245 YGGFSSTQDTVVALQALAKYATTAYMPSEEINLVVKSTENFQRTFNIQSVNRLVFQQDTLPNVPG 1309

  Fly  1244 KVDFTAKGTGSAMVQLSYRYNLAEKEKKPSFKVTPTV------KDTPNQLLIVDVCAEYVPLEDA 1302
            .....|.|.|...||...|||:.......:|.::..:      :.|..:.|.:.:...||
Human  1310 MYTLEASGQGCVYVQTVLRYNILPPTNMKTFSLSVEIGKARCEQPTSPRSLTLTIHTSYV----- 1369

  Fly  1303 DKDKDSNMAVMEIALPSGFVGDSTSLGKIQAV---DRVKRVETKNSDSTVVVYFDSLTPGDVRCL 1364
            .....||||::|:.:.|||   |...|..|.:   ..||:||.  ...|:.:|.|.|.. :.:..
Human  1370 GSRSSSNMAIVEVKMLSGF---SPMEGTNQLLLQQPLVKKVEF--GTDTLNIYLDELIK-NTQTY 1428

  Fly  1365 PLEASKAHAVAKQKPASVSLYDYYDTERKATEYYQVKSSLCDICE 1409
            ....|::..|...|||::.:||||..:.:||..|.      |.||
Human  1429 TFTISQSVLVTNLKPATIKVYDYYLPDEQATIQYS------DPCE 1467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep2	NP_523506.1	YfaS	<72..1395	CDD:441940	418/1517 (28%)
		A2M_2	909..1198	CDD:239227	126/301 (42%)
A2ML1	XP_011518868.1	YfaS	<123..1431	CDD:441940	398/1433 (28%)
		A2M_2	969..1264	CDD:239227	126/301 (42%)