Protein Alignment Tep2 and C4b

DIOPT Version :10

• Sequence 1: NP_523506.1
• Gene: Tep2 / 34044
• FlyBaseID: FBgn0041182
• Length: 1420
• Species: Drosophila melanogaster
• Sequence 2: XP_006523594.1
• Gene: C4b / 12268
• MGIID: 88228
• Length: 1758
• Species: Mus musculus
• Alignment Length: 1671
• Identity: 403/1671 - (24%)
• Similarity: 676/1671 - (40%)
• Gaps: 390/1671 - (23%)

  Fly    24 SVVGPGTLRSNSKYNVVVSVHKADGP--SQIKVSL-----NGPSYNETKQIELPPMSTQN----V 77
            |||..||..|       |.|...|.|  .::|.|:     .|.|.:..|..:|   |:.:    :
Mouse    29 SVVNLGTPLS-------VGVQLLDAPPGQEVKGSVFLRNPKGGSCSPKKDFKL---SSGDDFVLL 83

  Fly    78 EFEVP---KLATGNYNL----------SAEGVSGVVFK----NSTKLNYADKKPSVFVQTDKATY 125
            ..|||   ..:.|.::|          .:..:....||    ....|.::.::..:|||||:..|
Mouse    84 SLEVPLEDVRSCGLFDLRRAPHIQLVAQSPWLRNTAFKATETQGVNLLFSSRRGHIFVQTDQPIY 148

  Fly   126 KPADLVQFRILFLDENTRPAKIEKPISVIIIDGAQNRIKQLSDVKLTKGVFSGELQLSEQPVLGT 190
            .|...|::|:..||:..||:   .....|.::.:........::..:..:|.....:.:....||
Mouse   149 NPGQRVRYRVFALDQKMRPS---TDFLTITVENSHGLRVLKKEIFTSTSIFQDAFTIPDISEPGT 210

  Fly   191 WKISVSV-DG--DNRETKSFEVDKYVLPKFEVIVDTPKAVVI-----ADKVIKATIRAKYTYGKP 247
            ||||... ||  .||.| .|||.|||||.|||.:...|..::     :|: |:..|:|:|.||||
Mouse   211 WKISARFSDGLESNRST-HFEVKKYVLPNFEVKITPWKPYILMVPSNSDE-IQLDIQARYIYGKP 273

  Fly   248 VKGKATVSMERSYGYFGDLNANGNK--------QEKTIDVDGKGHVE---------FDIIHWAQR 295
            |:|.|       |..|..::..|.:        |.|.  |:|:.|:.         .|.|:...|
Mouse   274 VQGVA-------YTRFALMDEQGKRTFLRGLETQAKL--VEGRTHISISKDQFQAALDKINIGVR 329

  Fly   296 GQYLPPIKLFA--VVTEELTGNKQNATATV-VLHQQRYSIEPYERPEHFEANKSFIYQVVVKNVD 357
            .  |..::|:|  .|.|...|..:.|..|. ......:|::......|......|:.|.:|:.:.
Mouse   330 D--LEGLRLYAATAVIESPGGEMEEAELTSWRFVSSAFSLDLSRTKRHLVPGAHFLLQALVQEMS 392

  Fly   358 GS-----PVTNSAKNVKIGFDKSYSYFHEPSPKTRINFEAPVNENGIATFNVRLPDSDS-RYYRI 416
            ||     ||..||..|. |.|...             .:...:.|||...::..|...: ...|:
Mouse   393 GSEASNVPVKVSATLVS-GSDSQV-------------LDIQQSTNGIGQVSISFPIPPTVTELRL 443

  Fly   417 FASFDGSENTIGSISKFEPTP-----MSREPLKIQVNTKKPRLGEQVSFDV----VSIEDLPYFV 472
            ..|.......|..::...|..     :|.|||    :.:.|.:|:....::    :......::.
Mouse   444 LVSAGSLYPAIARLTVQAPPSRGTGFLSIEPL----DPRSPSVGDTFILNLQPVGIPAPTFSHYY 504

  Fly   473 YTIVARGNVILSDYVDVPDGQKTYTV-------KFTPTFSMVPKATIYVY---YVVNNDLQFEEK 527
            |.|::||.::...    .:.:||.|.       :..|:|..|    .|.|   :.|.|.|....:
Mouse   505 YMIISRGQIMAMG----REPRKTVTSVSVLVDHQLAPSFYFV----AYFYHQGHPVANSLLINIQ 561

  Fly   528 TIDFEKEFSNSIDVSAPTNAKPSEEVKLRIKTDADSFVGLLGVDQSVLLL--KSGNDLSQDDIFN 590
            :.|.|.:....:|  .....:.::.:||||:||:.:.|.|..||.::..:  :|...|....:|.
Mouse   562 SRDCEGKLQLKVD--GAKEYRNADMMKLRIQTDSKALVALGAVDMALYAVGGRSHKPLDMSKVFE 624

  Fly   591 SLNIYQTSTPWMNGYGRYPG---------QTSGL-------VTLT----------------NANY 623
            .:|.|..      |.|  ||         |.:||       :|.|                |.|:
Mouse   625 VINSYNV------GCG--PGGGDDALQVFQDAGLAFSDGDRLTQTREDLSCPKEKKSRQKRNVNF 681

  Fly   624 PYNTGPLVMSYVF-----------------------------EGSRHPWITRPRYRVGIRGDSGD 659
            .......:..|..                             :..|.|:::..::...:|.:...
Mouse   682 QKAVSEKLGQYSSPDAKRCCQDGMTKLPMKRTCEQRAARVPQQACREPFLSCCKFAEDLRRNQTR 746

  Fly   660 RISFLSQSLNDRNLKEILLKQTPQRTTIRKEFPETWFF--ENVGEEEFTLTKKIPDTITSWVVTG 722
            ..:.|:::.::...:|.|:.:  ....:|..|||.|.:  |.|...:. ||..:||::|:|.:.|
Mouse   747 SQAHLARNNHNMLQEEDLIDE--DDILVRTSFPENWLWRVEPVDSSKL-LTVWLPDSMTTWEIHG 808

  Fly   723 FSLNPTSGIALTKNPSKIRVFQPFFVSTNLPYSVKRGEVIAIPVVIFNYLDKTLDADVVMDNSDQ 787
            .||:.:.|:.:.| |:::|||:.|.:...||.|::|.|...:..|::|||:..:...|
Mouse   809 VSLSKSKGLCVAK-PTRVRVFRKFHLHLRLPISIRRFEQFELRPVLYNYLNDDVAVSV------- 865

  Fly   788 EYEFTEATNEVLEKAIDEVRRVKRVTIPANSGKSVSFMIRPKNVGFTTLKITATSAL-AGDAIHQ 851
              ..|......|...   ....::||:||.|.:.|:|.:.|.......||:.|.... .|||:.:
Mouse   866 --HVTPVEGLCLAGG---GMMAQQVTVPAGSARPVAFSVVPTAAANVPLKVVARGVFDLGDAVSK 925

  Fly   852 KLKVEPEGVTLFENRAVFINLKDQPEMSQSLD---ADIPNEVVPQSEFIEFSVVGDLLGPTLQNL 913
            .|::|.||.  .....:..||.....:.::|:   :..|| :||..:|  .|:|.......|:.:
Mouse   926 ILQIEKEGA--IHREELVYNLDPLNNLGRTLEIPGSSDPN-IVPDGDF--SSLVRVTASEPLETM 985

  Fly   914 D-----------NLVRMPYGCGEQNMVNFVPNILVLKYLEVTGR--KL-PSVESKARKFLEIGYQ 964
            .           :|:|:|.||.||.|:...|.:....||:.|.:  || |..:..|...::.||.
Mouse   986 GSEGALSPGGVASLLRLPQGCAEQTMIYLAPTLTASNYLDRTEQWSKLSPETKDHAVDLIQKGYM 1050

  Fly   965 RELTYKHDDGSYSAFGKSDASGSTWLTAYVMRSFHQAGTYTDIDPKVITAGLDFLVSKQKESGEF 1029
            |...::.:|||:.|:...|:  ||||||:|::....|.......|:.:.....:|:::|...|.|
Mouse  1051 RIQQFRKNDGSFGAWLHRDS--STWLTAFVLKILSLAQEQVGNSPEKLQETASWLLAQQLGDGSF 1113

  Fly  1030 PEVGKLFDNANQNPL-------ALTSFVLLAF------FEN---HELIPKYQSAIKKAVRYVAEE 1078
            .:...:...|.|..|       |||:||::|.      |::   .:|..:.:::|.||..::.::
Mouse  1114 HDPCPVIHRAMQGGLVGSDETVALTAFVVIALHHGLDVFQDDDAKQLKNRVEASITKANSFLGQK 1178

  Fly  1079 ADK-TDDQYSLAIAAVALQLAKHPQSEKVIA--KLESVARKENDRMWWSKATESTGEDGRVFH-W 1139
            |.. ....::.||.|.||.|.|..:..:.:|  .|.::|.:..:.::|.....|  :|..|.. .
Mouse  1179 ASAGLLGAHAAAITAYALTLTKASEDLRNVAHNSLMAMAEETGEHLYWGLVLGS--QDKVVLRPT 1241

  Fly  1140 KPRSND----------VEITSYVLLALLEKD----PAEKALPIIKWLISQRNSNGGFSSTQDTVI 1190
            .|||..          :|.|:|.||.||.::    .|:||   ..||..|.:.:|.|.||||||:
Mouse  1242 APRSPTEPVPQAPALWIETTAYALLHLLLREGKGKMADKA---ASWLTHQGSFHGAFRSTQDTVV 1303

  Fly  1191 GLQALTKFAYKTGSGS---GTMDIEFSSAGESKNTIKVNPENSLVLQTHDLPKSTRKVDFTAKGT 1252
            .|.||:  ||...|.:   ..:::..||.|  :|.:|.   :.|.|..|.:.....::.|:...|
Mouse  1304 TLDALS--AYWIASHTTEEKALNVTLSSMG--RNGLKT---HGLHLNNHQVKGLEEELKFSLGST 1361

  Fly  1253 GSAMVQLSYRYNLAEKEKKPSFKVTPT-----VKDTPNQLLIVDV----CAEY------------ 1296
            .|..|         |...|.:.|:..|     :|:|..|.|.::|    ..||
Mouse  1362 ISVKV---------EGNSKGTLKILRTYNVLDMKNTTCQDLQIEVKVTGAVEYAWDANEDYEDYY 1417

  Fly  1297 ---------VPLE-----------------DADKDKD--------------------SNMAVMEI 1315
                     |||:                 :|.|..:                    |.||:.:|
Mouse  1418 DMPAADDPSVPLQPVTPLQLFEGRRSRRRREAPKVVEEQESRVQYTVCIWRNGKLGLSGMAIADI 1482

  Fly  1316 ALPSGFVGDSTSLGKIQAV-DR-VKRVETKNSDSTVVVYFDSLTPGDVRCLPLEASKAHAVAKQK 1378
            .|.|||......|.|:.:: || |...||....  |::||||: |....|:...||:...|...:
Mouse  1483 TLLSGFHALRADLEKLTSLSDRYVSHFETDGPH--VLLYFDSV-PTTRECVGFGASQEVVVGLVQ 1544

  Fly  1379 PASVSLYDYYDTERKATEYY------QVKSSLC--DICEGADCGEG 1416
            |:|..|||||..:.|.:.:|      |:.::||  |:|:   |.||
Mouse  1545 PSSAVLYDYYSPDHKCSVFYAAPTKSQLLATLCSGDVCQ---CAEG 1587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep2	NP_523506.1	YfaS	<72..1395	CDD:441940	378/1585 (24%)
		A2M_2	909..1198	CDD:239227	94/336 (28%)
C4b	XP_006523594.1	YfaS	<136..1327	CDD:441940	308/1272 (24%)
		A2M	779..867	CDD:459711	29/98 (30%)
		TED_complement	978..1311	CDD:462227	94/341 (28%)
		A2M_recep	1475..1564	CDD:462226	33/91 (36%)
		NTR_like	1582..1736	CDD:470599	4/9 (44%)