Protein Alignment Tep2 and C3

DIOPT Version :10

• Sequence 1: NP_523506.1
• Gene: Tep2 / 34044
• FlyBaseID: FBgn0041182
• Length: 1420
• Species: Drosophila melanogaster
• Sequence 2: NP_033908.2
• Gene: C3 / 12266
• MGIID: 88227
• Length: 1663
• Species: Mus musculus
• Alignment Length: 1645
• Identity: 404/1645 - (24%)
• Similarity: 667/1645 - (40%)
• Gaps: 394/1645 - (23%)

  Fly    19 ATGI--YSVVGPGTLRSNSKYNVVVSVHKADGPSQIKVS----------------LNGPS-YNET 64
            |.||  ||::.|..||..|:..:|:..|.|.|...:.|:                |.|.| :..:
Mouse    22 ALGIPMYSIITPNVLRLESEETIVLEAHDAQGDIPVTVTVQDFLKRQVLTSEKTVLTGASGHLRS 86

  Fly    65 KQIELPPMSTQNVEFEVPKLATGNYNLSAEGVSGVVFKNSTKLNYADKKPSVFVQTDKATYKPAD 129
            ..|::|.....|.:.|..|..|...|.....|...|.. |.:..|      :|:||||..|.|..
Mouse    87 VSIKIPASKEFNSDKEGHKYVTVVANFGETVVEKAVMV-SFQSGY------LFIQTDKTIYTPGS 144

  Fly   130 LVQFRILFLDENTRPAKIEKPISVIIIDGAQNRIKQLSDVKLTKGVFSGELQLS----EQPVLGT 190
            .|.:||..:|.|..|  :.|  :|:|:....:.|....|: |:.....|.|.||    |...:|.
Mouse   145 TVLYRIFTVDNNLLP--VGK--TVVILIETPDGIPVKRDI-LSSNNQHGILPLSWNIPELVNMGQ 204

  Fly   191 WKISVSVDGDNRE--TKSFEVDKYVLPKFEVIVDTPKAVVIAD--KVIKATIRAKYTYGKPVKGK 251
            |||....:...::  :..|||.:||||.|||.|:..:.....|  ..::.:|.||:.|||.|.|.
Mouse   205 WKIRAFYEHAPKQIFSAEFEVKEYVLPSFEVRVEPTETFYYIDDPNGLEVSIIAKFLYGKNVDGT 269

  Fly   252 ATVSMERSYGYFGDLNANGNKQ-------EKTIDVDGKGHVEFDIIHWAQRGQYLPPIKLFAVVT 309
            |.|       .||  ..:|:|:       .:.:..||.|.                     ||:|
Mouse   270 AFV-------IFG--VQDGDKKISLAHSLTRVVIEDGVGD---------------------AVLT 304

  Fly   310 -------------EELTGNKQNATATVVLHQQRYSIE-----------PYE-----RPEHFEANK 345
                         :.|.|.....:.||:||.....:|           ||:     .|:.|:...
Mouse   305 RKVLMEGVRPSNADALVGKSLYVSVTVILHSGSDMVEAERSGIPIVTSPYQIHFTKTPKFFKPAM 369

  Fly   346 SFIYQVVVKNVDGSPVTNSAKNVKIGFDKSYSYFHEPSPKTRINFEAPVNENGIATFNVRLPDSD 410
            .|...|.|.|.||||    |..|.:....|             |.:|...::|:|..::.
Mouse   370 PFDLMVFVTNPDGSP----ASKVLVVTQGS-------------NAKALTQDDGVAKLSIN----- 412

  Fly   411 SRYYRIFASFDGSENTIGSISKFEPTPMSREPLKIQVNTKKPRLGEQ------------------ 457
                                     ||.||:||.|.|.|||..|.|.
Mouse   413 -------------------------TPNSRQPLTITVRTKKDTLPESRQATKTMEAHPYSTMHNS 452

  Fly   458 ---VSFDVVSIEDLP---------------------YFVYTIVARGNVILSDYVDVPDGQKTYTV 498
               :...|..:|..|                     |:.|.::.:|.::.:.......||....:
Mouse   453 NNYLHLSVSRMELKPGDNLNVNFHLRTDPGHEAKIRYYTYLVMNKGKLLKAGRQVREPGQDLVVL 517

  Fly   499 KFTPTFSMVPKATIYVYYVV-----NNDLQFEEKTIDFEKEFSNSIDVSA---PTNAKPSEEVKL 555
            ....|...:|...:..||.:     ..::..:...:|.:.....::.|..   ..:..|.::..|
Mouse   518 SLPITPEFIPSFRLVAYYTLIGASGQREVVADSVWVDVKDSCIGTLVVKGDPRDNHLAPGQQTTL 582

  Fly   556 RIKTDADSFVGLLGVDQSVLLLKSGNDLSQDDIFNSLNIYQTS-TPWMNGYGR-YPG-------- 610
            ||:.:..:.|||:.||:.|.:|...|.|:|..|::.:...... ||   |.|: |.|
Mouse   583 RIEGNQGARVGLVAVDKGVFVLNKKNKLTQSKIWDVVEKADIGCTP---GSGKNYAGVFMDAGLA 644

  Fly   611 -QTS-GLVTLTNANYPYNTGPLVM----------------SYVFEGSRH-----------PWITR 646
             :|| ||.|...|:... |.|...                .|..:|.|.           .:..:
Mouse   645 FKTSQGLQTEQRADLEC-TKPAARRRRSVQLMERRMDKAGQYTDKGLRKCCEDGMRDIPMRYSCQ 708

  Fly   647 PRYRVGIRGDS--------------------GDRISFLSQSLNDRNLKEILLKQTPQRTTI-RKE 690
            .|.|:..:|::                    .|.:..|::|    .|:|.::   |:...| |..
Mouse   709 RRARLITQGENCIKAFIDCCNHITKLREQHRRDHVLGLARS----ELEEDII---PEEDIISRSH 766

  Fly   691 FPETWFF--ENVGE-EEFTLTKKI-----PDTITSWVVTGFSLNPTSGIALTKNPSKIRVFQPFF 747
            ||::|.:  |.:.| |:..::.|:     .|:||:|.:...||:...||.:. :|.:|||.|.||
Mouse   767 FPQSWLWTIEELKEPEKNGISTKVMNIFLKDSITTWEILAVSLSDKKGICVA-DPYEIRVMQDFF 830

  Fly   748 VSTNLPYSVKRGEVIAIPVVIFNYLDKTLDADVVMDNSDQEYEFTEATNEVLEK------AIDEV 806
            :...|||||.|.|.:.|..|:|||               :|.|..:...|:|..      |..:.
Mouse   831 IDLRLPYSVVRNEQVEIRAVLFNY---------------REQEELKVRVELLHNPAFCSMATAKN 880

  Fly   807 RRVKRVTIPANSGKSVSFMIRPKNVGFTTLKITAT--SALAGDAIHQKLKVEPEGVTLFENRAVF 869
            |..:.:.||..|..:|.::|.|..:|...:::.|.  :....|.:.:.|||.|||:.:  |:.|.
Mouse   881 RYFQTIKIPPKSSVAVPYVIVPLKIGQQEVEVKAAVFNHFISDGVKKTLKVVPEGMRI--NKTVA 943

  Fly   870 INLKDQPEMSQS--LDADIP----NEVVPQSE-----FIEFSVVGDLLGPTL--QNLDNLVRMPY 921
            |:..|..::.|.  ...|:|    ::.||.::     .::.|.|..:....:  :.|.:|:..|.
Mouse   944 IHTLDPEKLGQGGVQKVDVPAADLSDQVPDTDSETRIILQGSPVVQMAEDAVDGERLKHLIVTPA 1008

  Fly   922 GCGEQNMVNFVPNILVLKYLEVTGRKLPSVESKARKFLEI---GYQRELTYKHDDGSYSAFGKSD 983
            |||||||:...|.::.:.||:.|.:.......|.::.||:   ||.::|.:|....:|:||  ::
Mouse  1009 GCGEQNMIGMTPTVIAVHYLDQTEQWEKFGIEKRQEALELIKKGYTQQLAFKQPSSAYAAF--NN 1071

  Fly   984 ASGSTWLTAYVMRSFHQAGTYTDIDPKVITAGLDFLV-SKQKESGEFPEVGKL--------FDNA 1039
            ...||||||||::.|..|.....||..|:...:.:|: .|||..|.|.|.|.:        |.||
Mouse  1072 RPPSTWLTAYVVKVFSLAANLIAIDSHVLCGAVKWLILEKQKPDGVFQEDGPVIHQEMIGGFRNA 1136

  Fly  1040 NQNPLALTSFVLLAFFENHEL----IPKYQSAIKKAVRYVAEEADKTDDQYSLAIAAVALQLAKH 1100
            .:..::||:|||:|..|..::    :.....:|.||..|:..........|::|||..||.| .:
Mouse  1137 KEADVSLTAFVLIALQEARDICEGQVNSLPGSINKAGEYIEASYMNLQRPYTVAIAGYALAL-MN 1200

  Fly  1101 PQSEKVIAKLESVARKENDRMWWSKATESTGEDGRVFHWKPRSNDVEITSYVLLALLEKDPAEKA 1165
            ...|..:.|..:.|:   ||..|.:      .|.:::       :||.|||.|||||.....:..
Mouse  1201 KLEEPYLGKFLNTAK---DRNRWEE------PDQQLY-------NVEATSYALLALLLLKDFDSV 1249

  Fly  1166 LPIIKWLISQRNSNGGFSSTQDTVIGLQALTKFAYKTGSGSG---TMDIEFS-SAGESKNTIKVN 1226
            .|:::||..||...||:.|||.|.:..|||.:  |:|.....   .||:.|. .:..|..|.::.
Mouse  1250 PPVVRWLNEQRYYGGGYGSTQATFMVFQALAQ--YQTDVPDHKDLNMDVSFHLPSRSSATTFRLL 1312

  Fly  1227 PENSLVLQTHDLPKSTRKVDFTAKGTGSAMVQLSYRYNLAEKEK--------KPSFKVTPTVKDT 1283
            .||..:|::.: .|.......||||.|...:.:...|:...|.|        :.|.:..|.....
Mouse  1313 WENGNLLRSEE-TKQNEAFSLTAKGKGRGTLSVVAVYHAKLKSKVTCKKFDLRVSIRPAPETAKK 1376

  Fly  1284 PNQ---LLIVDVCAEYVPLEDADKDKDSNMAVMEIALPSGFVGDSTSLGKI-QAVDR-VKRVETK 1343
            |.:   .:.:::|.:|:      .|.|:.|::::|::.:||..|:..|..: ..||| :.:.|..
Mouse  1377 PEEAKNTMFLEICTKYL------GDVDATMSILDISMMTGFAPDTKDLELLASGVDRYISKYEMN 1435

  Fly  1344 ---NSDSTVVVYFDSLTPGDVRCLPLEASKAHAVAKQKPASVSLYDYYDTERKATEYYQ------ 1399
               ::.:|:::|.:.::..:..||..:..:...|...:|.||.:|.||:.|...|.:|.
Mouse  1436 KAFSNKNTLIIYLEKISHTEEDCLTFKVHQYFNVGLIQPGSVKVYSYYNLEESCTRFYHPEKDDG 1500

  Fly  1400 VKSSLC--DICEGADCGEGC 1417
            :.|.||  ::|..|:  |.|
Mouse  1501 MLSKLCHSEMCRCAE--ENC 1518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep2	NP_523506.1	YfaS	<72..1395	CDD:441940	376/1541 (24%)
		A2M_2	909..1198	CDD:239227	97/306 (32%)
C3	NP_033908.2	MG1	26..125	CDD:465508	23/99 (23%)
		MG2	130..225	CDD:426464	30/105 (29%)
		MG3	227..308	CDD:465509	29/110 (26%)
		MG4	356..446	CDD:465507	30/136 (22%)
		A2M_BRD	456..604	CDD:462235	24/147 (16%)
		ANATO	678..747	CDD:237984	7/68 (10%)
		A2M	770..866	CDD:459711	34/111 (31%)
		complement_C3_C4_C5	996..1282	CDD:239226	97/306 (32%)
		A2M_recep	1397..1494	CDD:462226	24/96 (25%)
		NTR_complement_C3	1513..1661	CDD:239638	3/8 (38%)
		Interaction with CFP/properdin. /evidence=ECO:0000250|UniProtKB:P01024	1634..1659