DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tep2 and LOC108179231

DIOPT Version :9

Sequence 1:	NP_523506.1	Gene:	Tep2 / 34044	FlyBaseID:	FBgn0041182	Length:	1420	Species:	Drosophila melanogaster
Sequence 2:	XP_021322236.1	Gene:	LOC108179231 / 108179231	-ID:	-	Length:	1104	Species:	Danio rerio

Alignment Length:	1198	Identity:	346/1198 - (28%)
Similarity:	562/1198 - (46%)	Gaps:	230/1198 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   338 PEHFEANKSFIYQVVVKNVDGSPVTNSAKNVKIGFDKSYSYFHEPSPKTRI------NFEAPV-- 394
            |..:|..|       ||.:| .|.|....:|..|..|.:.:...|.|...:      |:.:.:
Zfish     8 PLTYEIGK-------VKVID-LPNTYEHGSVIEGKIKLFDFKDAPIPNKEVYLLEGENWSSKLLL 64

  Fly   395 ----NENGIATFNVR---------------LPDSDSRYYRIFASFDGSENTIGSISKFEPTPMSR 440
                :.:|:|:|::.               .||:..|.|:. ..|...:.|:.......|...:.
Zfish    65 NLTTDSDGLASFSLNTSSLSKKDISLIANVYPDTRFRQYKT-PYFSRDKKTVKLFQTATPYSPTF 128

  Fly   441 EPLKIQVNTKKP-RLGEQVSFDVVSIEDLPYFVY-TIVARGNVILSDY----VDVPDGQKTYTVK 499
            ..|.|: |.::| :.|.::: ..|:|..|.:.|| :::::|.::...|    |...:|..:.|:.
Zfish   129 SKLIIE-NIEQPIKCGTEIT-ATVNINLLHWSVYNSVLSKGVIVHHGYEKVEVKSSNGVASGTMS 191

  Fly   500 FTPTF--SMVPKATIYVYYVV-NNDLQFEEKTIDFEKEFSNSIDVS-APTNAKPSEEVKLRIKTD 560
            |..:.  .:.|...|..|.|: :.::....|::|.||.|.|.:.:. :|..|.|.|:..|::...
Zfish   192 FELSVGADVAPVVRILAYCVLPSENIIAASKSLDIEKCFGNKVSLQFSPAKAVPGEKNTLQLSAQ 256

  Fly   561 ADSFVGLLGVDQSVLLLKSGNDLSQDDIFNSLNIYQTSTPWMNGYGRYPGQTSGLVTLTNANYPY 625
            ..|..||..||||||:|:||..|..|.||:.|       |:...|                 |||
Zfish   257 PGSLCGLSAVDQSVLILESGKRLDADKIFSLL-------PFQYVY-----------------YPY 297

  Fly   626 NTGPLVMSYVFEGSRHPWITRPR--------YR----VGIRGDSG------DRISFLSQSLNDRN 672
            :.         |..:.....|||        |.    ||::..|.      :.:||  :.|....
Zfish   298 SA---------EDEQPCLPVRPRRSVLTDNVYNSLKSVGLKMASNLAVRVPECLSF--RGLTYHR 351

  Fly   673 LKEILLKQTPQR----------------TTIRKEFPETWFFE-----NVGEEEFTLTKKIPDTIT 716
            .::|::..|..|                .|||..|||||.::     :.|..|..:|  :|||||
Zfish   352 FRDIVMYHTSGRVGLGSSIESSTFDNSAVTIRTIFPETWIWDLAEVGDSGSTEVPVT--VPDTIT 414

  Fly   717 SWVVTGFSLNPTSGIALTKNPSKIRVFQPFFVSTNLPYSVKRGEVIAIPVVIFNYLDKTLDADV- 780
            :|....|.|:.| |:.|.. |:::.||||||:..:||||:.|||:..:...:||||.|.:...|
Zfish   415 TWETEAFCLSST-GLGLAP-PAQLTVFQPFFLELSLPYSIIRGEIFELKATVFNYLSKCIMVKVS 477

  Fly   781 --------VMDNSDQEYEFTEATNEVLEKAIDEVRRVKRVTIPANSGKSVSFMIRPKNVGFTTLK 837
                    :..:||.:|.                     ..:.||..::..:::.|..:|...:.
Zfish   478 PAPSSDYTLKASSDDQYS---------------------SCLCANGRQTFKWILTPSVLGVVNVT 521

  Fly   838 ITATSALAG----------------DAIHQKLKVEPEGVTLFENRAVFINLKDQPEMSQSLDADI 886
            ::|.:..:.                |.:.:.|.|:.||:...|..:..:..|.. .:|:::|..:
Zfish   522 VSAEAEASQTVCDNEIVSVPERGRIDIVTRSLLVQAEGIEKTETNSWLLCPKGD-SLSENVDLTV 585

  Fly   887 PNEVVPQSEFIEFSVVGDLLGPTLQNLDNLVRMPYGCGEQNMVNFVPNILVLKYLEVTGRKLPSV 951
            |.:|:..|.....||:||:||..||||..|:|||||||||||....|||.:|:|||.|.:...::
Zfish   586 PKDVIEGSAKSSVSVIGDILGRALQNLHGLLRMPYGCGEQNMAVLSPNIYILQYLENTKQLTSAI 650

  Fly   952 ESKARKFLEIGYQRELTYKHDDGSYSAFGKSDASGSTWLTAYVMRSFHQAGTYTDIDPKVITAGL 1016
            ..||..||:.||||:|.|||.||:||.||..|  |:|||||:|:|||.:|..||.|||::|.:..
Zfish   651 REKASSFLKSGYQRQLNYKHFDGAYSTFGYGD--GNTWLTAFVLRSFGKAQKYTFIDPQIIQSAK 713

  Fly  1017 DFLVSKQKESGEFPEVGKLFDNANQ----NPLALTSFVLLAFFENHELIPKYQSAIKK---AVRY 1074
            |:|:|::...|.|.:.|:||:|..:    :.:.:|:::..:..|..  .|.....:.|   .:|.
Zfish   714 DWLISRRDSDGCFIQQGRLFNNRMKGGVTDNVTMTAYITASLLELE--TPVTDPVVTKGLSCLRS 776

  Fly  1075 VAEEADKTDDQYSLAIAAVALQLAKHPQS-EKVIAKLESVARKENDRMWWSKATESTGEDGRVFH 1138
            |.|:...|   |:.|:.|....||:...: :::.:|||.:|..:...:.||::  ::.:|.
Zfish   777 VIEDVKNT---YTTALLAYTFSLARDTNTRQQLFSKLEDLAISDGPLVHWSQS--ASADDS---- 832

  Fly  1139 WKPRSNDVEITSYVLLALLEKDPAEK-----ALPIIKWLISQRNSNGGFSSTQDTVIGLQALTKF 1198
               .|.||||:||||||:|..|....     |..|:.||:.|:|:.||||||||||:.||||:.:
Zfish   833 ---ASLDVEISSYVLLAVLTADSLTTADLGFANRIVSWLVKQQNAYGGFSSTQDTVVALQALSLY 894

  Fly  1199 AYKTGSGSGTMDIEFSSAGESKNTIKVNPENSLVLQTHDLPKSTRKVDFTAKGTGSAMVQLSYRY 1263
            |.|..|..|:..:...|||:|.: ..||.:|.|:.|...|.....|.....||:....||::..|
Zfish   895 ATKVFSSDGSSTVTVQSAGDSHH-FDVNQDNKLLYQEKQLANVPGKYSIEVKGSACVSVQMAQFY 958

  Fly  1264 NLAEKEKKPSFKVTPTV----KDTPNQLLIVDVCAEYVPLEDADKDKDSNMAVMEIALPSGFVGD 1324
            |:....:..:..:...|    |.|..|.|:::|...|    |..::: :||.:::|.|.|||..|
Zfish   959 NIPTPTEAKTLSIDAEVEGDCKKTFGQNLMLNVTVTY----DGPQNR-TNMVIVDIKLLSGFTAD 1018

  Fly  1325 STSLGKIQ-----AVD-----RVKRVETKNSDSTVVVYFDSLTPGDVRCLPLEASKAHAVAKQKP 1379
             ||:.|.|     ::|     .|:|:::|  |..|:||.:.:...|...|.:..::...|...||
Zfish  1019 -TSMLKTQRQSFDSLDFFGHAPVERIDSK--DDHVLVYLEEVLKEDPVNLQIGLNQIIQVKNLKP 1080

  Fly  1380 ASVSLYDYYDT-ERKATEYYQVKSSLCD 1406
            |.:.:||||.| ::...||    ||.|:
Zfish  1081 AVIKVYDYYQTSDQSEMEY----SSHCE 1104

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep2	NP_523506.1	A2M_N	115..209	CDD:280081
		A2M_N_2	445..576	CDD:285005	38/140 (27%)
		A2M	694..782	CDD:278630	36/101 (36%)
		A2M_2	909..1198	CDD:239227	122/301 (41%)
		A2M_comp	961..1199	CDD:284982	94/250 (38%)
		A2M_recep	1308..1398	CDD:284981	32/100 (32%)
LOC108179231	XP_021322236.1	A2M_N_2	131..273	CDD:311575	40/143 (28%)
		A2M	389..477	CDD:306673	35/91 (38%)
		A2M_2	608..894	CDD:239227	122/301 (41%)
		A2M_recep	1002..1099	CDD:311553	31/99 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584146
Domainoid	1	1.000	217	1.000	Domainoid score	I2610
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	517	1.000	Inparanoid score	I1243
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6406
orthoMCL	1	0.900	-	-		OOG6_100452
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X292
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.800