DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tep2 and LOC101730404

DIOPT Version :9

Sequence 1:	NP_523506.1	Gene:	Tep2 / 34044	FlyBaseID:	FBgn0041182	Length:	1420	Species:	Drosophila melanogaster
Sequence 2:	XP_031761602.1	Gene:	LOC101730404 / 101730404	-ID:	-	Length:	737	Species:	Xenopus tropicalis

Alignment Length:	822	Identity:	199/822 - (24%)
Similarity:	328/822 - (39%)	Gaps:	211/822 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   292 WAQRGQYL----------------PPIKL--FAVVTEELTGNKQ---NATATVVLHQQRYSIEPY 335
            |..:| ||                |.:|:  .|.:|||.||:|:   :....:||.    ::|..
Frog     3 WGVKG-YLQTTREIDLRPFNVSSNPRVKIMVLASLTEEKTGHKELGFHFLQFIVLE----NVEFV 62

  Fly   336 ERPEHFEANKSFIYQVVVKNVDGSPVTNSAKNVKIGFDKSYSYFHEPSPKTRINFEAPVNENGIA 400
            ....:::....|...:.|.|:...|:.|....:.:..|           :...|.....:|||:|
Frog    63 NLDTYYQKGIPFTGMMKVFNLKKDPMRNEKVYLVVNVD-----------EVDTNITLVTDENGMA 116

  Fly   401 TFNVRLPD--------------SDSRYYR----IFASFDGSENTIGSISKFEPTPMS-REPLKIQ 446
            .|::...|              ..:.|:|    :|..:..|.:.:...:..|....| ::.:.::
Frog   117 RFSLDTSDWNDMVSLTGRISFEEGAGYFRALQWLFPFYSESNSFLKVQTVAEDLLCSTKQSVSVE 181

  Fly   447 VNTKKPRLGEQVSFDVVSIEDLPYFVYTIVARGNVILS-----DYVDVPDG---QKTYTVKFTPT 503
            ....|..|..:        .|...|.|.::::|.:|.:     |..::|.|   |.::.|.|..|
Frog   182 YTIDKNELDPE--------SDHLSFFYILMSKGTIITAKEHKVDVKNLPSGPILQGSFNVTFLVT 238

  Fly   504 FSMVPKATIYVYYV------------VNNDLQFEEKTIDFEKEFSNSIDVSAPTNAKPSEEVKLR 556
            .::||.||:.||.:            .|..:.|:.|.   :.||..:       |..|...|.|.
Frog   239 MNLVPVATLLVYAIFPDGEVAADRVRYNVPICFDNKV---QLEFREN-------NVHPGGNVNLD 293

  Fly   557 IKTDADSFVGLLGVDQSVLL------LKSGNDLSQDDIFNSLNIYQTSTPW-MNGYGRYPGQTSG 614
            :|.||.|...:..||:.:||      .|.|:|:        |..|....|: :..:..||
Frog   294 VKADAGSLCSVRSVDKGLLLHQEHKTNKMGSDI--------LRFYGRGFPYTIEDFEPYP----- 345

  Fly   615 LVTLTNANYPYNTGPLVMSYVFEGSRHPWI--------------------TR---------PRY- 649
              .|.:...|.|.....:      .|.||.                    ||         |.|
Frog   346 --CLEDVPVPPNRAKRSL------KRAPWYQSEADVYSLFKSSSLKVFTNTRIRKPVTCELPEYT 402

  Fly   650 -RVGIRGDSGDRISFLSQSLNDRNLKEILLKQTPQRTTIRKEFPETWFFENV-----GEEEFTLT 708
             |..|:...|         ..||.|.........:...:||.|||||.::.|     |::...||
Frog   403 RRFSIKDGVG---------AADRKLDSPGTAPASKEHPVRKFFPETWLYDLVSVGPQGKKSLNLT 458

  Fly   709 KKIPDTITSWVVTGFSLNPTSGIALTKNPSKIRVFQPFFVSTNLPYSVKRGEVIAIPVVIFNYLD 773
              .|.:||.||...|.:. .||.. ..:..|::.|||:|:...|||||.:.|...:..:::|||:
Frog   459 --APHSITEWVTDAFCVG-NSGFG-EVHDIKMKTFQPYFIDLLLPYSVVQKEHFTLTALVYNYLN 519

  Fly   774 KTLDADVVMDNSDQEYEFTEATNEVLEKAIDEVRRVKRVTIPANSGKSVSFMIRPKNVGFTTLKI 838
            ..:..:|.:....   ||.|...::          .|...|......|.::.|....:|....|:
Frog   520 HCVLVEVALTIPP---EFGEPRTDI----------EKSACICGQETASFTWNITASKLGTIPFKV 571

  Fly   839 TA----------------TSALAGDAIHQKLKVEPEGVTLFENRAVFI-----NLKDQPEMSQSL 882
            |:                .:....||:.:.:.|:|.||.:|:.....:     :::|:..:.
Frog   572 TSRALHVEGDCSDVVLDPETKFKHDAVQKTILVKPSGVEVFKTHTSLLCPTGDSVRDEVSLV--- 633

  Fly   883 DADIPNEVVPQSEFIEFSVVGDLLGPTLQNLDNLVRMPYGCGEQNMVNFVPNILVLKYLEVTGRK 947
               :|:.||..|.....:|:||:||.|:.||.:|:::|||||||||..|.||:.||:||:.....
Frog   634 ---LPDNVVEGSGHAHITVLGDVLGNTISNLGDLLQLPYGCGEQNMAQFAPNVYVLEYLQSAKAL 695

  Fly   948 LPSVESKARKFLEIGYQRELTYKHDDGSYSAFGKSDASGSTW 989
            .|.::.|...:|..||||:|.:|||:|:||||||.|..|:||
Frog   696 TPEIKDKVLNYLTTGYQRQLMFKHDNGAYSAFGKKDEEGNTW 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep2	NP_523506.1	A2M_N	115..209	CDD:280081
		A2M_N_2	445..576	CDD:285005	35/150 (23%)
		A2M	694..782	CDD:278630	29/92 (32%)
		A2M_2	909..1198	CDD:239227	42/81 (52%)
		A2M_comp	961..1199	CDD:284982	19/29 (66%)
		A2M_recep	1308..1398	CDD:284981
LOC101730404	XP_031761602.1	MG4	61..>134	CDD:407661	13/83 (16%)
		A2M_N_2	161..313	CDD:400170	37/169 (22%)
		A2M	439..528	CDD:395153	29/92 (32%)
		SVA	<490..571	CDD:398804	21/93 (23%)
		ISOPREN_C2_like	657..>737	CDD:415487	40/79 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010