DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep2 and LOC100489060

DIOPT Version :9

Sequence 1:	NP_523506.1	Gene:	Tep2 / 34044	FlyBaseID:	FBgn0041182	Length:	1420	Species:	Drosophila melanogaster
Sequence 2:	XP_002938549.2	Gene:	LOC100489060 / 100489060	-ID:	-	Length:	1482	Species:	Xenopus tropicalis

Alignment Length:	1543	Identity:	451/1543 - (29%)
Similarity:	718/1543 - (46%)	Gaps:	232/1543 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 QYALLVNATGIYSVVGPGTLRSNSKYNVVVSVHKADGPSQIKVSLNGPSYNET---KQIELPPMS 73
            ||.|||          |..|...|:....:.:...:....:.::|..|:.|.|   ||:
Frog    26 QYLLLV----------PTVLHGASEEKFCLLLSHLNETVTMTLTLYLPTQNHTLLEKQV------ 74

  Fly    74 TQN-----VEFEVPKL---ATGNYNLSAEGVSGVVFKNSTKLNYADKKPSVFVQTDKATYKPADL 130
            |:.     |.|..|||   |.....|..:| ..:.||:..|:.....:..||:||||..|||...
Frog    75 TEKEEDGCVTFMTPKLEVAAVAILTLDVQG-DALHFKSQRKILIKPLQNPVFIQTDKPIYKPGQK 138

  Fly   131 VQFRILFLDENTRPAKIEKPISVIIIDGAQNRIKQLSDVKLTKGVFSGELQLSEQPVLGTWKISV 195
            |||||..||||..|.. ||..:|.|.|...|||.|..:|:|.||:.....|||.:|.||.:|::|
Frog   139 VQFRIASLDENFHPVS-EKFPAVYITDPQGNRISQWLNVELKKGLTQESFQLSSEPTLGIYKLTV 202

  Fly   196 SVDGDNRETKSFEVDKYVLPKFEVIVDTPKAVVIADKVIKATIRAKYTYGKPVKGKATVSMERSY 260
            ..:.....|.||.|::|||||:||.|..|..|.|.||.||.|:..:|||||||.|:..|.:.|.
Frog   203 GREKSAPVTHSFSVEEYVLPKYEVQVKLPPVVGIMDKGIKVTVCGRYTYGKPVLGRIKVRVCRK- 266

  Fly   261 GYFGDLNANGNKQEKTIDVDGKGHVEFDIIHWA-----------------QRGQYLPPIKLFAVV 308
              |.| ..|..|.|:    ||   |..:|.|.|                 :|..|...|:..|.:
Frog   267 --FSD-RYNLCKGEE----DG---VCEEINHRAGPNGCFSEVVSTRMFQMRRSGYEDKIRASATI 321

  Fly   309 TEELTGNKQNATATVVLHQQRYSIEPYERPEHFEANKSFIYQVVVKNVDGSPVTNSAKNVKIGFD 373
            .|:.||.:..|..:..:.:....:.......|:........|:.:::..|:|:.|....:.:|:.
Frog   322 IEDGTGVELTAAVSSEIKKTLAKVSFRHLDSHYRKGLPLFGQLFLEDASGNPMANETVVIFVGYG 386

  Fly   374 KSYSYFHEPSPKTRINFEAPVNENGIATF-----NV---------RLPDSDSRY-YR-IFASFDG 422
            .:::|              ...::|.|.|     ||         |..:.:|.| || :..|:.|
Frog   387 TNFTY--------------TTGQDGTAEFLIDTSNVQKSSLQIRARYKEGESCYQYRWVSVSYQG 437

  Fly   423 SENTIGSISKFEPTPMSREPLKIQVNTKKPRLGEQ----VSFDVVSIEDL-----PYFVYTIVAR 478
            .|.   |:.:|  ...::..||||...|.....:|    |.| ::|.|.:     ..|.|.::::
Frog   438 DER---SVKEF--YSRAKSYLKIQPIYKILECQKQEKVIVHF-ILSAEGVGETTNAVFHYLVMSK 496

  Fly   479 GNVI--LSDYVDVPDGQK---TYTVKFTPTFSMVPKATIYVYYVV-NNDLQFEEKTIDFEKEFSN 537
            |.:.  ....:::...|.   |:..:.|....:.|.|...||.:: :.::..:..::..||.|.|
Frog   497 GGIAGHGRHEIEISPNQNASGTFWFRLTAGTDIAPSANFLVYLILESGEVIADSISLKVEKCFGN 561

  Fly   538 SIDVS-APTNAKPSEEVKLRIKTDADSFVGLLGVDQSVLLLKSGNDLSQDDIFNSLNIYQTSTPW 601
            .:::| :|:.|.|.....|.:.|...|...|..||:|||:||...:||...|:|.|.:..
Frog   562 KVELSFSPSEALPGAPADLHLLTAPSSLCALRAVDESVLILKPEAELSAQTIYNLLPLQD----- 621

  Fly   602 MNGY---GRY-------------PGQTSGLVTL-TNANYPYNTGPLVMSY---VFEGS--RHPWI 644
            ::||   |.:             |...:|:..: ||..:..:|..::.:.   ||..:  |.|.:
Frog   622 LSGYIHDGNFLEELWDDPCIKMEPLFINGIYYMPTNPEWDTDTYTILKNLGLKVFTNARIRPPLV 686

  Fly   645 TRPR--YR-----------------VGIRGDSGDRISFLSQSLN-DRNLKEILLKQTPQRTTIRK 689
            ..||  |.                 :|::...|.:.......|: .||:.    ...|...|:||
Frog   687 CGPRSFYEHYGTGGPFAVPMSLSAGMGVQAGMGVQAGMSGAGLHIGRNIP----VAEPVIETVRK 747

  Fly   690 EFPETWFFENV-----GEEEFTLTKKIPDTITSWVVTGFSLNPTSGIALTKNPSKIRVFQPFFVS 749
            .|||||.::.|     |:.:..:|  :|||||:|....|..:..:|..|::..|.: .|||||:.
Frog   748 YFPETWLWQLVETDADGKADLAVT--VPDTITTWKAGMFCTSQGAGFGLSETISLV-AFQPFFLE 809

  Fly   750 TNLPYSVKRGEVIAIPVVIFNYLDKTLDADVVMDNSDQEYEFTEATNEVLEKAIDEVRRVKRVTI 814
            ..||||..|||:..:...:||||.:|:...:::::|:|   |.....:|.|..         ..:
Frog   810 LTLPYSAIRGEIFTLKATVFNYLSQTIRVGILLEDSNQ---FLAKPTKVQEDG---------YCV 862

  Fly   815 PANSGKSVSFMIRPKNVGFTTLKITA-------------TSALAG--DAIHQKLKVEPEGVTLFE 864
            .||...::|:.:..|::|.....::|             .|...|  |.|.:.:.||||||...|
Frog   863 TANGQVTLSWEVTLKSLGEVNFTMSAETLNGEGLCENEIVSPAQGRKDTITKHIIVEPEGVKKEE 927

  Fly   865 NRAVFINLKDQPEMSQSLDADIPNEVVPQSEFIEFSVVGDLLGPTLQNLDNLVRMPYGCGEQNMV 929
            ..:..|..|.. |:::::...:|.:||..|....||.|||:||..:|||.|||:|||||||||||
Frog   928 THSTMICGKGS-EITENIPLKLPEKVVEGSARAYFSAVGDILGTAMQNLGNLVQMPYGCGEQNMV 991

  Fly   930 NFVPNILVLKYLEVTGRKLPSVESKARKFLEIGYQRELTYKHDDGSYSAFGKSDASGSTWLTAYV 994
            .|.|.|.:.:||..|.:..|.::||...::..|||::|:|||.||||||||:....|:|||||:.
Frog   992 LFTPIIYISEYLNKTNQLTPEMKSKTLSYMSTGYQKQLSYKHPDGSYSAFGQRYGEGNTWLTAFT 1056

  Fly   995 MRSFHQAGTYTDIDPKVITAGLDFLVSKQKESGEFPEVGKLFDNANQ----NPLALTSFVLLAFF 1055
            |:||.:|..:..|:.|:||..|.:|..:||.:|.|..|||||:||.:    :.:.|.:::.:|..
Frog  1057 MKSFARARAHIYIEEKLITGALLWLSIRQKPNGCFHSVGKLFNNAMKGGVDDEVTLAAYITIALL 1121

  Fly  1056 ENHELIPKYQSAIKKAVRYVAEEADKTDDQYSLAIAAVALQLA-KHPQSEKVIAKLESVARKEND 1119
            |..  :|.....::.|:..:.......:..|:.|:.|.|..|| :.....:::..|:..|.|::.
Frog  1122 EYP--LPVTHPTVRNALFCLESALGGKNGIYTKALMAYAFTLAGRMDIRRQLLQSLDEQAIKKDG 1184

  Fly  1120 RMWWSKA--TESTGEDGRVFHWKPRSNDVEITSYVLLALLEK-----DPAEKALPIIKWLISQRN 1177
            .:...:.  ::.:|.|...:...| |.:||:.||:|||||.|     :....|..::.|:|.|:|
Frog  1185 TVHLHRPEFSDDSGVDRFPYRRAP-SAEVEMNSYMLLALLSKHNVSDEDLTLATQVVSWMIKQQN 1248

  Fly  1178 SNGGFSSTQDTVIGLQALTKFAYKTGSGSGTMDIEFSSAGESKNTIKVNPENSLVLQTHDLPKST 1242
            .|||||||||||:.||||:.:...|.|......:..|..........|...|.|:||...|.:..
Frog  1249 PNGGFSSTQDTVVALQALSLYGSLTLSHDAMRTVSLSLDKTPVAEFHVEDSNRLLLQRIALKEVP 1313

  Fly  1243 RKVDFTAKGTGSAMVQLSYRYNLAEKEKKPSFKVTPTV-------KDTPNQLLIVDVCAEYVPLE 1300
            .....|..|:|...:|.:.|||:...::...|.::.|.       |......::.:|  .||
Frog  1314 GDYLATVSGSGCLYLQTTLRYNVPIPKEDAPFTISVTTDPETCDRKSLKTFTIVANV--SYV--- 1373

  Fly  1301 DADKDKDSNMAVMEIALPSGFVGDSTSLGKIQAVDR-VKRVETKNSDSTVVVYFDSLTPGDVRCL 1364
              .|..:|||||:|:.||||::....|:.|:.|.:| ::|.|...::  |:|||:||.. |::..
Frog  1374 --GKRLNSNMAVVEVKLPSGYIPIKPSVKKMTASNRLIQRAEAHANE--VIVYFESLFK-DIQSF 1433

  Fly  1365 PLEASKAHAVAKQKPASVSLYDYYDTERKATEYYQVKSSLCDICEGAD 1412
            .....:...:...:||:|.:||||:|:..|...|...   |...:||:
Frog  1434 RFSVEQEIPIGNLQPATVVVYDYYETDDLAITKYDAP---CSAKDGAN 1478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep2	NP_523506.1	A2M_N	115..209	CDD:280081	43/93 (46%)
		A2M_N_2	445..576	CDD:285005	34/146 (23%)
		A2M	694..782	CDD:278630	32/92 (35%)
		A2M_2	909..1198	CDD:239227	116/300 (39%)
		A2M_comp	961..1199	CDD:284982	90/249 (36%)
		A2M_recep	1308..1398	CDD:284981	32/90 (36%)
LOC100489060	XP_002938549.2	YfaS	<124..>1065	CDD:225248	301/997 (30%)
		A2M_N	124..216	CDD:280081	43/92 (47%)
		A2M_N_2	455..600	CDD:285005	33/145 (23%)
		A2M	752..838	CDD:278630	32/88 (36%)
		A2M_2	971..1269	CDD:239227	116/300 (39%)
		A2M_comp	1023..1270	CDD:284982	90/249 (36%)
		A2M_recep	1379..1467	CDD:284981	32/90 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010