Protein Alignment Tep2 and cd109

DIOPT Version :10

• Sequence 1: NP_523506.1
• Gene: Tep2 / 34044
• FlyBaseID: FBgn0041182
• Length: 1420
• Species: Drosophila melanogaster
• Sequence 2: XP_031758448.1
• Gene: cd109 / 100486953
• XenbaseID: XB-GENE-954886
• Length: 1433
• Species: Xenopus tropicalis
• Alignment Length: 1529
• Identity: 424/1529 - (27%)
• Similarity: 703/1529 - (45%)
• Gaps: 245/1529 - (16%)

  Fly     4 IFLTG-IILQYALLVNATGIYSVVGPGTLRSNSKYNVVVSVHKADGPSQIKVSLNGPSYNETKQI 67
            :.|.| ||..:.|...::..|:..||              :.....|..|:     |..|.|..|
 Frog     2 LLLEGLIIFPHILCFISSSAYAAAGP--------------IFLITSPMDIR-----PGVNLTLGI 47

  Fly    68 EL----PPMSTQNVEFE----------------------VPKL----ATGNYNLSAEGVS--GVV 100
            |:    ||:.....:.:                      :|:|    ..|.|.|:.:|.|  .::
 Frog    48 EMLQESPPLVKVVAQLQKDEHTLLEGESFFKRGGFGTLVLPQLPLNSVNGKYELNVKGYSEENLI 112

  Fly   101 FKNSTKLNYADKKPSVFVQTDKATYKPADLVQFRILFLDENTRPAKIEKPISVIIIDGAQNRIKQ 165
            |.|.|.|.:..|..|||::|:...|||...|:.|||....:.:|.|  ..:.:.|:|...|.|:|
 Frog   113 FFNKTSLEFKSKGFSVFIETNSVFYKPGQEVKIRILAFSFHMKPYK--STVDIYILDPQGNLIEQ 175

  Fly   166 LSDVKLTKGVFSGELQLSEQPVLGTWKISVSVDGDNRETKSFEVDKYVLPKFEVIVDTPKAVVIA 230
            ..:.::..||.|..|.||:.|.||.|.|.|.:. .....::|.|.:.|||:|||:::|.....|.
 Frog   176 WLEEEMELGVVSQSLYLSDNPPLGDWTIKVKLH-QQLHYQTFTVMEQVLPRFEVLLNTTLYHSIK 239

  Fly   231 DKVIKATIRAKYTYGKPVKGKATVSMERSYGYFGDLNANGNKQEKTIDVDGKGHVEF------DI 289
            :..::.|:.||||||.|||||.:|.:..:..|....|..     |...::|.....|      ::
 Frog   240 NPHLEGTVTAKYTYGMPVKGKLSVMLSHNSIYKKKTNIT-----KDFVINGCARFSFSNVELKEL 299

  Fly   290 IHWAQRG--QYLPPIKLFAVVTEELTGNKQNATATVVLHQQRYSIEPYERPEHFEANKSFIYQVV 352
            :..|..|  :...|:.:...|.|.|||..||.|.:|.:..:.|:||..:.|...:...:|..::.
 Frog   300 MKNADYGSNKVTGPVDIDVNVKESLTGITQNVTTSVFVIDKEYNIEFLDHPTVLKPMLNFTIRLQ 364

  Fly   353 VKNVDGSPVTNSAKNVKIGFDKSYSYFHEPSPKTRINF-------EAPVNE-------------- 396
            :...||..:|...::.::....:.:        .|.||       .|..||
 Frog   365 IVRYDGRKLTAEERDNEVAVTVTQT--------RRFNFRDNSVELNATENESEDNVEMIQLTRYT 421

  Fly   397 ---NGIATFNVRLPDSDSRYYRIFASFDGSENTIGSISKFEPTPMSREPLKIQVNTKKPRLGEQV 458
               |||....:.|. :|..:..|.|.|..::|.:.....|.    |.....||:  ||
 Frog   422 VPKNGIICIEIPLL-ADIMHLYIKAEFLDAKNNLFINDLFS----SLNGTYIQI--KK------- 472

  Fly   459 SFDVVSIEDLPYFV-YTIVARGNVILSD--YVDVPDGQ-------KTYTVKFTPTFSMVPKATIY 513
                 :.:||...: ||:...|:..|.|  |:.|..||       ....:...|..:..|:..:.
 Frog   473 -----ADQDLKVGIPYTLSVDGSFPLKDISYLVVSKGQIVAGGKGNPKNITLNPENTWTPEVCLI 532

  Fly   514 VYYVVNNDLQFEEKT-IDFEKEFSNSIDVS-APTNAKPSEEVKLRIK-TDADSFVGLLGVDQSVL 575
            ||:|.|:.....:.| :..:..|.|.:.:| ..|.|:|::.|.|.:. .:.:|.|.|..:|:.|.
 Frog   533 VYHVANDGTVTNDVTAVSVQPIFENKVYISWNTTQARPADMVSLNVNVAEPNSLVVLSVIDKRVK 597

  Fly   576 LLKSGNDLSQDDIFNSLNIYQTSTPWMNGYGRYPGQTSGLVTLTNANYPYNTGPLVMSYVFEGSR 640
            ||....::|..::...|..|.||                       :..:.|.|   |.|||
 Frog   598 LLGDRQEISTANVLKELKSYSTS-----------------------HIQHYTNP---SEVFE--- 633

  Fly   641 HPWITRPRYRVGIRGDSG----DRISFLSQSLNDRNLKEILLKQ--TPQRTTIRKEFPETWFFEN 699
                   ...:|:..|:.    |....|.:|..|..::..|...  :|:   ||..|||||.:::
 Frog   634 -------MCNIGVMTDANIEVHDHFDILFESGFDIPVQGALPVNFGSPR---IRSLFPETWIWKH 688

  Fly   700 V---GEEEFTLTKKIPDTITSWVVTGFSLNPTSGIALTKNPSKIRVFQPFFVSTNLPYSVKRGEV 761
            :   .....||..|:||.||:|:.:.:.::...|..:...|.::..|||||:|.|||..|.|||.
 Frog   689 LKTGSTTHMTLDLKVPDVITTWITSAYVISENFGFGMLAPPEQLEAFQPFFLSLNLPSYVIRGEQ 753

  Fly   762 IAIPVVIFNYLDKTLDADVVMDNSDQ---EYEFTEATNEVLEKAIDEVRRVKRVTIPANSGKSVS 823
            ..:.|::||||.|..:..|.::.||.   :..|..|:..           .:.|::|:..||.|.
 Frog   754 FVLEVIVFNYLQKETEVSVTLEKSDAFEIQLAFVNASES-----------QQSVSVPSQEGKIVF 807

  Fly   824 FMIRPKNVGFTTLKITATSALAGDAIHQKLKVEPEGVTLFENRAVFINLK-DQPE-MSQSLDADI 886
            |.|:|.::|...:.:.|.||||.||:.|||:|:.|||....::.:.::|. ::|: :||:|:...
 Frog   808 FPIKPIHLGEIPITVKAISALASDAVTQKLQVKAEGVQQSHSQTLLLDLMGNKPKSISQTLNFTF 872

  Fly   887 PNEVVPQSEFIEFSVVGDLLGPTLQNLDNLVRMPYGCGEQNMVNFVPNILVLKYLEVTGRKLPSV 951
            |.:||..||....:||||.||.:::::.:|::||||||||||:.|.|||.:::||..|.:....|
 Frog   873 PPDVVSGSEKAFITVVGDHLGLSIRSIKSLIQMPYGCGEQNMIRFAPNIFIMEYLSRTKQLNEDV 937

  Fly   952 ESKARKFLEIGYQRELTYKHDDGSYSAFGKSDASGSTWLTAYVMRSFHQAGTYTDIDPKVITAGL 1016
            ..|...|::.||||:|.|:.:|||:||||..|..|||||:|:|::.|.:|..:..:||.|:...|
 Frog   938 AHKLISFIKNGYQRQLVYQREDGSFSAFGNKDPFGSTWLSAFVLQCFLKARPFILVDPVVLHNTL 1002

  Fly  1017 DFLVSKQKESGEFPEVGKL----FDNANQNPLALTSFVLLAFFENHELIPKYQSAIKKAVRYVAE 1077
            .:|:..|:::|||.|.|.:    ....:.:.:.||::::.|..|...|  |..|.:..|..|:..
 Frog  1003 TWLLKHQRKNGEFWEPGTVIYSQIQGGHHSAITLTAYIMAALIEYPGL--KNSSQVAAATDYLES 1065

  Fly  1078 EADK-TDDQYSLAIAAVALQLAKHPQSEKVIAKLESVARKENDRMWWSKATESTGEDGRVFHWKP 1141
            :.|: ..|.|:|::...||.|....::.:.:..|...|.:|....:|..:..|...        |
 Frog  1066 QMDEIISDNYTLSLVTYALSLVGRSKATEGLDLLNMRAEQEGQLRFWRSSISSCQH--------P 1122

  Fly  1142 RSNDVEITSYVLLALLEKDPAEKALPIIKWLISQRNSNGGFSSTQDTVIGLQALTKFA--YKTGS 1204
            .|.|:.|::|.||:.:.::...:.:.::|||..||:..|||||||||:|.|||::.||  |....
 Frog  1123 CSTDIVISAYALLSYVVQNRIAEGMAVMKWLSQQRSHLGGFSSTQDTIIALQAMSSFASVYTINK 1187

  Fly  1205 GSGTMDIEFSSAGESKNTIKVNPENSLVLQTHDLPKSTRKVDFT--AKGTGSAMVQLSYRYNLAE 1267
            ....:.:: |....|..|.:::..|.::|||..|... ::::.|  |:|||.|::|....|||..
 Frog  1188 QILAITVD-SHPLNSTATFQIDSNNRILLQTKQLAVQ-QQMNLTVHAEGTGFAILQFHTIYNLKN 1250

  Fly  1268 K--------EKKPSFKVTPTVKDTPNQLLIV--DVCAEYVPLEDADKDKDSNMAVMEIALPSGFV 1322
            .        ..:.:|.:..||.|..:.|.:|  ::|...:|   .|....:.|.:|::.|.|||
 Frog  1251 SVPGRYKSISSQDAFDLGITVLDNKDNLNVVSLNICTRSIP---RDGSTQTGMVLMQVDLLSGF- 1311

  Fly  1323 GDSTSLGKIQAVDRVKRVETKNSDSTVVVYFDSLTPGDVRCLPLEASKAHAVAKQKPASVSLYDY 1387
              |.....|.....:|:|:  .::..:.:|.|||...:| |:.:.|::...|...:.|.|.:.||
 Frog  1312 --SLVPEGIPMKYPIKKVD--YNEGKINIYLDSLNQTEV-CINIPATRDFKVGYTQEAFVYVIDY 1371

  Fly  1388 YDTERKATEYY------QVKSSLCDICEGADCGE 1415
            ||..::|...|      ||  |.|..|.. ||.:
 Frog  1372 YDPGQRAIRSYNSEVMQQV--SPCSFCND-DCNQ 1402

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep2	NP_523506.1	YfaS	<72..1395	CDD:441940	398/1428 (28%)
		A2M_2	909..1198	CDD:239227	101/293 (34%)
cd109	XP_031758448.1	YfaS	<137..1236	CDD:441940	342/1195 (29%)
		A2M_2	895..1179	CDD:239227	101/293 (34%)
		A2M_recep	1296..1383	CDD:462226	25/92 (27%)