Protein Alignment Tep2 and c5

DIOPT Version :10

• Sequence 1: NP_523506.1
• Gene: Tep2 / 34044
• FlyBaseID: FBgn0041182
• Length: 1420
• Species: Drosophila melanogaster
• Sequence 2: NP_001190988.1
• Gene: c5 / 100485433
• XenbaseID: XB-GENE-486371
• Length: 1688
• Species: Xenopus tropicalis
• Alignment Length: 1588
• Identity: 364/1588 - (22%)
• Similarity: 659/1588 - (41%)
• Gaps: 272/1588 - (17%)

  Fly    23 YSVVGPGTLRSNSKYNVVVSVHKADGPSQIKV-SLNGPSYNETKQIELPPMSTQN-----VEFEV 81
            |.|.||...|..:...|||.....:|...|:: :|:.|....|...:...::.||     |:..:
 Frog    25 YLVTGPREWRIGALETVVVQAFGQEGDLAIRINALSYPDKKTTYATQHLVLNDQNNYQGLVKLMI 89

  Fly    82 PKLATGNYNLSAEGVSGVVFK-NSTKLNYADKKP------SVFVQTDKATYKPADLVQFRILFLD 139
            .......|: |::.:..:..: .|...|..::.|      .:|:||||..|.|...|:.|:..:|
 Frog    90 QPKDFPTYS-SSDPMQFIYLQAQSNAFNKEEQVPVSYRNGFLFIQTDKPFYTPDQSVKIRVYSMD 153

  Fly   140 ENTRPAKIEKPISVIIIDGAQNRIKQLSDVKLTKGVFSGELQLSEQPVLGTWKISVSVDGD--NR 202
            |..:|.:  :.:.:...|..:.::..:.:..||..:.....::...|..|.|.|..:...|  ..
 Frog   154 EELKPGR--RKVVLTFKDPEEVKVDSIEEDDLTGIISFPAFKIPANPKFGMWTIEAAYGKDFTTS 216

  Fly   203 ETKSFEVDKYVLPKFEVIVDTPKAVVIADKVIK--ATIRAKYTYGKPVKGKATVSMERSYGYFGD 265
            .|..|||.:||||||.|.::..|..:..||..:  .|:||.| |.|.:...|.|.:.  ||...|
 Frog   217 GTAKFEVKEYVLPKFFVSIEPEKNFICYDKFTEFTITVRASY-YFKKLVDNAKVYIR--YGLIQD 278

  Fly   266 LNANGNKQ--EKTIDV----DGKGHVEFDIIHWAQR--------------GQYLPPIKLFAVVTE 310
                |.:.  .|:||:    :|:...:|:    :|:              |.||    ...|..|
 Frog   279 ----GERTMLPKSIDLQSMFNGESIFQFN----SQKAVEELGYSSLEEISGSYL----YITVSVE 331

  Fly   311 ELTGNKQNATATVVLHQQRYSIEPYE-----RPEHFEANKSFIYQVVVKNVDGSPVTN-----SA 365
            |.||..:.:....|    ::.:.||.     .|.:.:....:..:|.:::....||.|     |.
 Frog   332 ESTGRTEESENVDV----KFVLSPYTFKLVGTPLYVKPTLPYYIKVQLRDTMDKPVGNIPLVLSG 392

  Fly   366 KNVKIGFDKSYSYFHEPSPKTRINFEAPVNENGIATFNVRLP-DSDSRYYRIFASFDGS--ENTI 427
            ..||   :...|   ||....|:...:. ..:|...|.:.:| |..|..::| .:.|||  |:..
 Frog   393 DMVK---EDGTS---EPLTGGRLRMSSD-KRDGTGVFVLNIPSDISSLDFKI-TTDDGSLPEDNQ 449

  Fly   428 GSISKFEPTPMSREPLKIQVNTKKPR----LGEQVSFDVVS----IEDLPYFVYTIVARGNVILS 484
            .:::....:..|.....:.:|..:.:    :|..::..:|.    |..|.::.|.::::|.::..
 Frog   450 ATVNHVAVSYQSLTKSYLYINWAREKEVLHVGSFLTIHLVPNSPYIAKLRHYSYLLISKGKILNF 514

  Fly   485 DYVDVPDGQKTYTVKFTPTFSMVPKATIYVYYVVNND-----------LQFEEKTIDFEKEFSNS 538
            ..|...:|..:.::....|..|||...:.|||:|..|           |...|..::.:     :
 Frog   515 GTVQRVEGSDSQSLTLPITSDMVPSVRLLVYYIVTGDATAELVADSIWLDVVESCVNHQ-----T 574

  Fly   539 IDVSA-PTNAKPSEEVKLRIKTDADSFVGLLGVDQSVLLLKSGNDLSQDDIFNSLNIYQTSTPWM 602
            :::|. .|..||.::..|::...:.|.|.|..||.::..:........:.:|..:.....
 Frog   575 VELSTRETTLKPGQKFNLKVSGPSKSLVALSAVDTAIYDVGKRFQRPLETVFRKIEESDL----- 634

  Fly   603 NGYGRYPGQT-------SGLVTLTNAN------YPYNTGPL------------------------ 630
             |.|...||.       :||..|||||      |......:
 Frog   635 -GCGAGAGQNNADVFRLAGLTFLTNANIQASQKYALKCNEVLRPKRSFNFKEEINKKARVYKDRN 698

  Fly   631 --------VMSYVFEGSRHPWITRPRYRVGIR-GDSGDRISFLSQSLNDR-------------NL 673
                    |..::.|......|:|...|.|.. .|:.....|.::||.::             .:
 Frog   699 IRKCCYDGVKCFLEENDCTAGISRVSKRYGKSCTDTFQDCCFFAKSLKEKMDAEIQDVGMGRMYI 763

  Fly   674 KEILLKQTPQRTTIRKEFPETWFFENV-----GEEEFTLTKKIPDTITSWVVTGFSLNPTSGIAL 733
            :.:|....||   ||..|||:|.:|..     ||:  ||:..:||::|:|.:.|.|:: ..|:.:
 Frog   764 RTVLNIDEPQ---IRSYFPESWLWEEYLLDDRGEK--TLSVTLPDSLTTWEIQGVSMS-DKGLCV 822

  Fly   734 TKNPSKIRVFQPFFVSTNLPYSVKRGEVIAIPVVIFNYLDKTLDADVVMDNSDQEYEFTE-ATNE 797
            . :..|:..::.:|:...|||||.|||.|.|.||:|||.:..:...|:|....:..:|:| :|.:
 Frog   823 A-DRFKVTAYKDYFLDVQLPYSVVRGEQIQIKVVVFNYRNNNVKGCVLMSAEKEICKFSETSTRK 886

  Fly   798 VLEKAIDEVRRVKRVTIPANSGKSVSFMIRPKNVGFTTLKITATSALAGDAIHQKLKVEPEGVTL 862
            .|::....       |:.|:|....:|.|.|..||...|..|.:::.:.|.:.:.|:|.|||:..
 Frog   887 GLKECFSH-------TLSASSLTPFTFTILPLEVGLHPLTFTLSASGSSDIVKKTLRVVPEGIKK 944

  Fly   863 FENRAVFIN---LKDQPEMSQSLDADIPNEVVPQSEFIE-FSVVGDLLGPTL------QNLDNLV 917
            ..|....::   ::......|.:...|...:||:|:... .|:.|::||..:      :.|..|:
 Frog   945 ERNAGFTLDPQGIRGVARRRQDISYKIHANIVPKSKVSRILSISGNILGEVINTVVKSEGLQYLI 1009

  Fly   918 RMPYGCGEQNMVNFVPNILVLKYLEVT------GRKLPSVESKARKFLEIGYQRELTYKHDDGSY 976
            .:|....|..::..||...|..|||.:      |..:.:.:.:.::.:..|....|:::..|.||
 Frog  1010 SLPKASAETELMRVVPIFYVYHYLETSKRWDLLGTNILAAQIEMQRKMREGVNSILSFRGSDYSY 1074

  Fly   977 SAFGKSDASGSTWLTAYVMRSFHQAGTYTDIDPKVITAGLDFLVSK-QKESGEFPE--------- 1031
            |.:  .:...|.||||:.::.|.:...|..::...:...:.:|:.: |...|.|.:
 Frog  1075 SIW--KEGKPSAWLTAFALKIFGEIEKYVYVNKMSVCNSISWLIDQCQLRDGSFIDRSGYQPGKL 1137

  Fly  1032 VGKLFDNANQNPLALTSFVLLAFFENHELIP--KYQSAIKKAVRYVAEEADKTDDQYSLAIAAVA 1094
            .|.:...:.:..|.||:||.:...::..:.|  :..:|:::|..|::....|....::||||..|
 Frog  1138 QGTIPSESEERSLYLTAFVFIGIQKSFHMCPLEEVNAAMRRAEEYLSNNIRKAKSTFTLAIAGYA 1202

  Fly  1095 L-----QLAK----HPQSEKVIAKLES----VARKENDRMWWSKATESTGEDGRVFHWKPRSNDV 1146
            |     .||.    ....|:....:||    :.|...|.:.....|....|..|:         |
 Frog  1203 LASWDGTLASVRYVKGALEREAYVIESGDLPIVRYWKDSLKKVNPTAPGAESARM---------V 1258

  Fly  1147 EITSYVLLALLEKDPAEKALPIIKWLISQRNSNGGFSSTQDTVIGLQALTKFAY--KTGSGSGTM 1209
            |.|:|.||..|:....:...|:::||..|:...|||.|||||.|.|:|||:.:.  |..:.:..:
 Frog  1259 ETTAYALLMYLKLAQKDYYNPVVRWLKEQQRYGGGFYSTQDTAIALEALTEVSIVDKKLTLNMAV 1323

  Fly  1210 DIEFSSAGESKNTIKVNPENSLVLQTHDLPKSTRKVDFTAKGTGSAMVQLSYRYNL----AEK-- 1268
            .:.:..:|:.||....  |.|...:..::|.....:..|....|.|.|.:...||:    .||
 Frog  1324 QVSYKKSGDFKNYRLT--ETSSFTRPEEVPLPEDLIVSTPTANGIATVHVQTVYNIISPPQEKCQ 1386

  Fly  1269 -----EKKPSFKVTPTVKDTPNQLLI-VDVCAEYVPLEDADKDKD---SNMAVMEIALPSGFVGD 1324
                 .||.::|...::.|:.....| ::.||.|...:|     |   |..|||||.:.:|.|.|
 Frog  1387 FHLKIGKKLNWKPRQSIFDSDKSGAIPIEACARYKAPDD-----DPYISGSAVMEITMVTGLVVD 1446

  Fly  1325 STSLGKI-QAVDR-VKRVETKNSDSTVVVYFDSLTPGDVRCLPLEASKAHAVAKQKPASVSLYDY 1387
            .:.|.:: |.||: |...:.:  |..|.::||.:...:..|:.|.|.:...|:...|....:|::
 Frog  1447 ESELEELAQRVDQFVTAYDIE--DGKVNLHFDGIPSDEYICVTLLAWEQFKVSMLSPGVFRVYEF 1509

  Fly  1388 YDTERKATEYYQVKSS--LCDICEGADC 1413
            :..:.:.|..:...:|  |.::|.|..|
 Frog  1510 HAPDEECTTLFNPLASQDLVNVCTGNQC 1537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep2	NP_523506.1	YfaS	<72..1395	CDD:441940	345/1516 (23%)
		A2M_2	909..1198	CDD:239227	79/325 (24%)
c5	NP_001190988.1	MG1	22..124	CDD:465508	21/99 (21%)
		YfaS	<128..1375	CDD:441940	299/1313 (23%)
		complement_C3_C4_C5	1001..1309	CDD:239226	78/318 (25%)
		A2M_recep	1430..1521	CDD:462226	25/92 (27%)
		NTR_like	1532..1688	CDD:470599	3/6 (50%)