DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep2 and c3a.4

DIOPT Version :9

Sequence 1:	NP_523506.1	Gene:	Tep2 / 34044	FlyBaseID:	FBgn0041182	Length:	1420	Species:	Drosophila melanogaster
Sequence 2:	XP_002660623.3	Gene:	c3a.4 / 100331428	ZFINID:	ZDB-GENE-140822-3	Length:	1642	Species:	Danio rerio

Alignment Length:	1610	Identity:	391/1610 - (24%)
Similarity:	669/1610 - (41%)	Gaps:	311/1610 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IFLTGIILQYALLVNATGIYSVVGPGTLRSNSKYNVVVSVHKADGPS-QIKVSLN---------- 57
            :.:..:||...||.....:|.:..|..|:..|...|.|......|.| .:::|:.
Zfish     6 VCVAAVILSLPLLSFCQPLYILSAPNKLKLGSAERVFVEAQDYAGASLNVRISVRRFKDDQREVA 70

  Fly    58 --------GPSYNETKQIELPPMSTQNVEFEVPKLATGNYNLSAEGVSGVVFKNSTKLNYADKKP 114
                    |.::.|..:||:|..|     |...|.|.....|.|:..:.::.|   ::....:..
Zfish    71 STSVTLTAGKNFQELVEIEVPSNS-----FTFDKSAQQYAVLQAQFPNKLLQK---QILVTFQSG 127

  Fly   115 SVFVQTDKATYKPADLVQFRILFLDEN-TRPAKIEKPISVIIIDGAQNRIKQLSDVKLTKGVFSG 178
            .:.:||||..|.|...|.:|:..|... |||.:....:.::..||.....|   .|....||.||
Zfish   128 HIVLQTDKTIYTPDSTVHYRVFSLSPGMTRPFQSGVRVEILTPDGISLESK---SVFPDGGVVSG 189

  Fly   179 ELQLSEQPVLGTWKISVSVDGDNRE--TKSFEVDKYVLPKFEVIVDTPKA-VVIADKVIKATIRA 240
            ...:::....|.||:........::  |..|||.:||||.|||.:...|| ..:.|..:...|.|
Zfish   190 TFGITDPASPGLWKLVAWHKNSPQKNFTSEFEVKEYVLPSFEVSLSPHKAFFYVNDDSLLVDIHA 254

  Fly   241 KYTYGKPVKGKATVSMERSYGYF----GDLNANGNKQEKTIDVDGKGHVEFDIIHWAQRGQYLPP 301
            ||.:|:.|.|...|    .:|..    |.::..|:.|...| .||.|..:   :...|..|..|.
Zfish   255 KYLFGETVNGHGFV----VFGVVTEDKGKISIPGSLQRVQI-WDGSGTAQ---LTKRQILQTFPE 311

  Fly   302 IKLFAVVTEELTGNK---------QNATATVVLHQQRYSI--EPY-----ERPEHFEANKSFIYQ 350
            |:       :|.|..         ::.:..|..|::...|  .||     ..|:.|:....|...
Zfish   312 IR-------QLVGKSLYISVSLLTESGSEMVEAHKKGIHIVTSPYTIYFKRTPQFFKPGMPFDVS 369

  Fly   351 VVVKNVDGSPVTNSAKNVKIGFDKSYSYFHEPSP-----KTRINFEAPVNEN---GIATFNVRLP 407
            |.|.|.|.:|    |||||:          |.:|     :|:.|..|.|..|   |.:|..:...
Zfish   370 VYVTNPDETP----AKNVKV----------EVNPGGVSGQTKANGIAKVTINTPGGSSTLEITAR 420

  Fly   408 DSDSRYYRIFASFDGSENTIGSISKFEPTPMSREPLKIQVNTKKPRLGEQVSFDV-------VSI 465
            .||.:    ..|...:|..: :...:.|...||..|.|.::..:.|:|:.:..::       |..
Zfish   421 TSDPQ----LTSRQQAEKKM-TAHAYVPKGGSRNYLHIGIDAAELRIGDSMKVNLNLGQSPGVRD 480

  Fly   466 EDLPYFVYTIVARGNVILSDYVDVPDGQKTYTVKFTPTFSMVPKATIYVYY-VVNNDLQFEEKTI 529
            :|   |.|.|::||.::.::... ..||...::....|..|||......|| |.::::..:...:
Zfish   481 QD---FTYMILSRGQIVQANRFK-RRGQTLVSLSLPVTKDMVPSFRFVAYYHVGSSEVVSDSVWV 541

  Fly   530 DFEKEFSNS--IDVSAPTNA-KPSEEVKLRIKTDADSFVGLLGVDQSVLLLKSGNDLSQDDIFNS 591
            |.:.....|  ::|..|... :|.||.:|||..|..:.|||:.||:.|.:|.:.:.::|..|::.
Zfish   542 DVKDTCMGSLKVEVHDPVEVYEPGEEFELRITGDPGAKVGLVAVDKGVYVLNNKHRITQSKIWDV 606

  Fly   592 LNIYQTSTPWMNGYGRYPGQTSG-----LVTLTNANYPYNTGPLVMSYVFEGSRHPWITRPRYR- 650
            :..:.|            |.|:|     :...::|...:.:.....:.|...|..|..:|.|.|
Zfish   607 VESHDT------------GCTAGSGKNSMQVFSDAGLLFESSSAGGTSVRTNSECPSSSRRRKRR 659

  Fly   651 ---VGIRGDSGDRISFLSQS-----------------------LNDRNLKEILLKQTPQRTTIRK 689
               |.:.....|:.|.|::.                       |:.:..::..|....:.|:.|:
Zfish   660 ETLVNLHKTLLDKYSGLARECCVDGLKALDVLDFSCEYRSSFILDGKECRDAFLDCCNRLTSHRE 724

  Fly   690 E---------------------------FPETWFFENV------GEEE---FTLTKK---IPDTI 715
            |                           |||:|.:|.|      |..:   .||.|.   :.|:|
Zfish   725 EPAEEEIFLGRSEDEEFVNSDDIVSRTLFPESWLWEEVMLPKCLGNRQCQTTTLPKDGLWLKDSI 789

  Fly   716 TSWVVTGFSLNPTSGIALTKNPSKIRVFQPFFVSTNLPYSVKRGEVIAIPVVIFNYLDKTLDADV 780
            |:|.:|..||:.|.||.:. :..::.|.:.||:...:|||..|.|.|.|..:|.|...|.:...|
Zfish   790 TTWEITAISLSNTHGICVA-DVHEMIVAKNFFIDLKIPYSAVRNEQIEIKAIIHNLYSKAVKVRV 853

  Fly   781 VMDNSDQEYEFTEATNEVLEKAIDEVRRVKRVTIPANSGKSVSFMIRPKNVGFTTLKI-TATSAL 844
            .:          :.|.::...|.::.|....||:.:.|..||.|:|.|..:|...::: .|.|..
Zfish   854 EL----------KETKDICSPASNKGRYAVTVTVASKSSYSVPFVIVPLALGRHAIEVKAAASGR 908

  Fly   845 AGDAIHQKLKVEPEGV-TLFENRAVFINLKDQPEMSQSLDADI-----PNEVVPQSEFIEFSVVG 903
            ..|.:.:.|.|..||| |.......|...|...|..|.:.:.|     ||  .|.|.:::  .:|
Zfish   909 GNDGVKKDLLVVSEGVLTKISENLQFNPFKKGDEDVQVIRSHILKDQAPN--TPSSTYVQ--AIG 969

  Fly   904 DLLGPTLQN------LDNLVRMPYGCGEQNMVNFVPNILVLKYLEVTGR---KLPSVESKARKFL 959
            |.:..|::.      :.:|:..|.|||||||:.....::...||:.|.:   ....:...|.:::
Zfish   970 DTITITIEKAISGAAMGSLIIQPGGCGEQNMMGLTMPVIATHYLDKTNQWHTVRAGLRQTATEYI 1034

  Fly   960 EIGYQRELTYKHDDGSYSAFGKSDASGSTWLTAYVMRSFHQAGTYTDIDPKVITAGLDFLV-SKQ 1023
            ..||.:||.|:..|||::|:  .:...||||||||.:.|..|.....||..||.:.|.:|: ::|
Zfish  1035 RKGYNQELAYRKSDGSFAAW--INRPSSTWLTAYVAKVFAMASDIIHIDQNVICSALRWLIMNRQ 1097

  Fly  1024 KESGEFPE-----VGKLFDN--ANQNPLALTSFVLLAFFENHE----LIPKYQSAIKKAVRYVAE 1077
            ..:|.|.|     .|::..|  .:.:..::|:||.:|..|...    .:....|:|.||:.|:..
Zfish  1098 LPNGVFRENAPVIHGEMTGNVQGSNSEASMTAFVTIALQEGRSRCNGQVSSLDSSIYKAIAYLKS 1162

  Fly  1078 EADKTDDQYSLAIAAVALQLAKHPQSEKVIAKLESVARKENDRMWWSKATESTGEDGRVFHWK-P 1141
            :.....:.|::|:|:.||                :.|...|.::..|||:....      ||. |
Zfish  1163 QLQGLINPYAVAMASYAL----------------ANANSLNKQVLMSKASADKS------HWPVP 1205

  Fly  1142 RSND--VEITSYVLLALLEKDPAEKALPIIKWLISQRNSNGGFSSTQDTVIGLQALTKFAYKTGS 1204
            .|:.  :|.:||.||||::....:...||:.||.:||..|||:.:||.|::..||:.::... ..
Zfish  1206 GSSSFTLEASSYALLALVKLHDYQNTAPIVNWLNNQRQYNGGYGTTQATIMVFQAVAEYRIH-AK 1269

  Fly  1205 GSGTMDIEFSSAGE---------SKNTIKVNPENSLVLQTHDLPKSTRKVDFTAKGTGSAMVQLS 1260
            ....:|:|.|...|         |||       |..:.||..:| |.:.:..:|||.|.|.|.:.
Zfish  1270 NIKQLDLELSIRVEGVRPTVFTFSKN-------NDHLSQTAKIP-SNKGITISAKGFGEASVTVV 1326

  Fly  1261 YRYNLAEKEKK---PSFKVTPTV-KDTPNQLLIVDVCAEY---VPLEDADKDKDSNMAVMEIALP 1318
            ..|....||..   .:|::..|. ||  |::........|   :.......|:|:.|::::::|.
Zfish  1327 TEYYAKPKESSSTCKNFELELTFEKD--NEVRYQGATESYKLTINTRYLSADRDATMSILDVSLL 1389

  Fly  1319 SGFVGDSTSL-----GKIQAVDRVKRVETKNSDSTVVVYFDSL--TPGDVRCLPLEASKAHAVAK 1376
            :|||.|...|     |:.:.:.:.:..:..:...::::|.|.:  |..|     ..|.:.|.:..
Zfish  1390 TGFVVDENDLKALSTGRDKLIQKFEMNKQLSERGSLIIYLDKISHTRKD-----RVAFRLHRIMN 1449

  Fly  1377 ---QKPASVSLYDYYDTERKATEYY---QVKSSLCDICEGADCGEGCKKD 1420
               .:||.|::|:||..|.:..::|   :.:..|..||:...|  .|.:|
Zfish  1450 GGFLQPAGVTVYEYYSIENRCVKFYHPTRKEGGLQKICKNDVC--QCAED 1497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep2	NP_523506.1	A2M_N	115..209	CDD:280081	25/96 (26%)
		A2M_N_2	445..576	CDD:285005	36/141 (26%)
		A2M	694..782	CDD:278630	31/99 (31%)
		A2M_2	909..1198	CDD:239227	90/312 (29%)
		A2M_comp	961..1199	CDD:284982	76/252 (30%)
		A2M_recep	1308..1398	CDD:284981	21/99 (21%)
c3a.4	XP_002660623.3	A2M_N	131..222	CDD:280081	25/93 (27%)
		A2M_N_2	453..591	CDD:285005	36/141 (26%)
		ANATO	668..734	CDD:237984	8/65 (12%)
		A2M	756..855	CDD:278630	31/99 (31%)
		complement_C3_C4_C5	981..1264	CDD:239226	89/306 (29%)
		A2M_comp	1036..1264	CDD:284982	76/251 (30%)
		A2M_recep	1379..1474	CDD:284981	21/99 (21%)
		NTR_like	1494..1641	CDD:295338	2/4 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584198
Domainoid	1	1.000	48	1.000	Domainoid score	I11904
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	7	6.800