DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep2 and cpamd8

DIOPT Version :9

Sequence 1:	NP_523506.1	Gene:	Tep2 / 34044	FlyBaseID:	FBgn0041182	Length:	1420	Species:	Drosophila melanogaster
Sequence 2:	XP_003201105.2	Gene:	cpamd8 / 100151400	ZFINID:	ZDB-GENE-050208-428	Length:	1860	Species:	Danio rerio

Alignment Length:	1765	Identity:	449/1765 - (25%)
Similarity:	735/1765 - (41%)	Gaps:	437/1765 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFRIFLTGIILQYALLVNATGIYS-------VVGPGTLRSNSKYNVVVSVHK--ADGPSQIKVSL 56
            ::.:|:.|::         :|::|       :..|...|:..:..|.|::..  .|...|:::|:
Zfish    13 LWTVFMCGVM---------SGVHSQERQGYLIAAPSVFRAGVEEAVSVTLFNMVEDTRVQLQLSV 68

  Fly    57 NGP----SYNETKQIELPPMSTQNVEFEVPKLATGNYNLSAEG-----VSGVVFKNSTKLNYADK 112
            .|.    |:...:       ....::.:||....|..:|...|     ..|.:|:|.|.:....|
Zfish    69 KGEIVAHSHGTVR-------DKGTIKIKVPSDLRGQAHLKVWGNCQLNEGGYIFQNHTTVTIDSK 126

  Fly   113 KPSVFVQTDKATYKPADLVQFRILFLDENTRPAKIEKPISVIIIDGAQNRIKQLSDVK-LTKGVF 176
            ..:||:||||..|||...|...:..:..:.:|.. || :...|:|...:.|....|:| :..|:.
Zfish   127 GTTVFIQTDKPVYKPQQKVLINVYAVTPDLKPTS-EK-LEAYIVDPRGSHIVHWKDLKSICCGIV 189

  Fly   177 SGELQLSEQPVLGTWKISVSVDGDNRETKSFEVDKYVLPKFEVIVDTPKAVVIADKVIKATIRAK 241
            :....||:|||.|.|.:.|.:.| :...|||||.|||:|:||:|:..|..:...:...:.|::|:
Zfish   190 NMSFPLSDQPVFGEWLVFVEMQG-HTYNKSFEVQKYVMPRFELIIVPPPYIRDLNSCEQVTVKAR 253

  Fly   242 YTYGKPVKGKATVSME-RSYGYFGDLNANGNKQEKTIDVDGKGHVEF-----DIIHWAQRGQYLP 300
            ||:||||.||.||:|. ...||:  .:..|:...|::::  ||...|     |::.......:..
Zfish   254 YTFGKPVSGKLTVNMTVNGVGYY--RHEVGHPVVKSMEI--KGSASFSLCVKDMMPIEVTDHFRG 314

  Fly   301 PIKLFAVVTEELTGNKQNATATVVLHQQRYSIEPYERP--EHFEANKSFIYQVVVKNVDGSPVTN 363
            .:.::..|.....|.:.....:..:|:|...|: |.:.  :.|:....:...:.|...||||...
Zfish   315 AVNMWVTVNSVDGGQQTMFDDSTPVHKQLIDIK-YSKDTRKQFKPGLPYKGMIEVTYPDGSPAEG 378

  Fly   364 SAKNVKIGFDKSYSYFHEPSPKTRINFEAPVNENGIATFNVRLPDSDSRYYRI---FASFDGS-- 423
            ....||.          |.:||..:.....|::||.|||.:....:.::|..:   ..:.||.
Zfish   379 VHVRVKA----------ELTPKDNVYTSELVSKNGKATFEIPSIPTAAQYVWLESKVTAIDGKPA 433

  Fly   424 -----ENTIGSISKFEPTPMSREPLKIQVNTKKP----RLGEQVSFDVVSIEDLPYFV-YTIVAR 478
                 .|.:...|.:.|:       |..:....|    .:|::....:.|.....:.: |.|.:|
Zfish   434 GDQYLPNYLSITSWYSPS-------KCHIQLLSPSAPLMIGQEAEIFLKSTCPCNFTLHYEIASR 491

  Fly   479 GNVILSDYVDVPDGQK------------TYT----------------------------VKFTPT 503
            ||::.|       ||:            |.|                            :.|..|
Zfish   492 GNIVQS-------GQRHANSTTHREKRATITFDTNIHTTAKPQQDSDSSQAEMDSCVSVLHFNVT 549

  Fly   504 FSMVPKATIYVYYV------VNNDLQFEEKTIDFEKEFSNSIDVSAPTN-AKPSEEVKLRIKTDA 561
            ..|.|.:.:.||||      |.:.||     :..:..|.|.|.||..|| :.|...:.|::|.::
Zfish   550 PPMAPLSRLLVYYVRENGEGVTDSLQ-----LPVQSRFENEISVSLSTNESMPGSPISLKVKAES 609

  Fly   562 DSFVGLLGVDQSVLLLKSGNDLSQDDIFNSLNIYQTS----TPWMNGYGRYPGQTS--------- 613
            .|.|.:..||:|:.|||.|..|:.:.:|..|..:..|    .|...|:..:||.:|
Zfish   610 GSCVCVASVDKSMYLLKPGFQLTPEKVFKDLAEFDVSDAFGVPKDEGHFWWPGLSSRRRRSSVFP 674

  Fly   614 ----------------GLVTLT---NANYPYNTGPLVMSYV--FEGSRHPWITRPRYRVGIRGDS 657
                            |||.:|   :.|:..:.|......|  |:......:.....|.|.|.::
Zfish   675 WHWDITKDARFAFTETGLVVMTDMVSLNHRQSGGMYTDEAVPAFQPHTSTLVAAMHSRSGTRAEN 739

  Fly   658 GDRISFLSQSLNDRNLKEILLKQTPQRTTIRKEFPETWFFE--NV----GEEEFTLTKKIPDTIT 716
                                     :|.|.   |||||.:.  ||    ||.|..|  .|||:||
Zfish   740 -------------------------RRRTF---FPETWIWHCFNVSSLNGEAELHL--DIPDSIT 774

  Fly   717 SWVVTGFSLNPTSGIALTKNPSKIRVFQPFFVSTNLPYSVKRGEVIAIPVVIFNYLDK------- 774
            :||.....|:...|:.|.:. :::|.|:|||:...||||:.|||...:|:.::|||..
Zfish   775 TWVTEAIGLSAEKGLGLART-AELRTFKPFFIDFTLPYSIVRGEQTKVPLTVYNYLPTCSEVHVK 838

  Fly   775 -----------------------------------TLDADVVMDN--------------SD--QE 788
                                               .|.:::|..|              ||  |.
Zfish   839 VSVPKGIKFVGHPGKHHLTRKKCVAPGEATPTFIVLLFSELVSANITARAVAYSEPSCCSDGLQS 903

  Fly   789 YEFTEATNEVLEKA---IDEVRRV---------------------KRVTIPANSGKSVSFMIRPK 829
            .:.::|..|..:::   :|.|||.                     :|:.|...:.....::.:|.
Zfish   904 SKASKAGEEQEDRSPVGMDYVRRSVLVEPEGLPREYTYSVFFCPNERIHISTPNKYEYQYVKKPA 968

  Fly   830 NVGFTTLKI----TATSALAGDAIHQKLKVE---------------------------PEGVTLF 863
            .|....:.|    .|..||:..|......||                           |..::..
Zfish   969 KVTHVQVAIKSHNDAHIALSPSAHDSTEMVEIVLGGRQNSRSWISRGKMGEPVVSTPTPGILSWD 1033

  Fly   864 ENRAVFINLKD---------QPEMSQSL--------------------------------DAD-- 885
            |.|:.:|:.:.         :|....::                                |||
Zfish  1034 EFRSFWISWRGGGVQVGHGLEPSSETTILQLAGPLTSQVRHIGFSTGWGSIGEFRIWRKEDADEN 1098

  Fly   886 --------IPNEVVPQSEFIEFSVVGDLLGPTLQNLDNLVRMPYGCGEQNMVNFVPNILVLKYLE 942
                    :|:.|||.||....:::||::||||.|||.|:|:|:|||||||::|.||:.|||||:
Zfish  1099 HNEAFTLGVPHNVVPGSERATAAMIGDVMGPTLNNLDKLLRLPFGCGEQNMIHFAPNVFVLKYLQ 1163

  Fly   943 VTGRKLPSVESKARKFLEIGYQRELTYKHDDGSYSAFGKSDASGSTWLTAYVMRSFHQAGTYTDI 1007
            .|.:....||::|..:|..||||:||||..||||||||:.|:|||.||||:|::||.|:..:..|
Zfish  1164 KTHQLSLEVEAEATDYLLQGYQRQLTYKRQDGSYSAFGERDSSGSMWLTAFVLKSFAQSRGFIFI 1228

  Fly  1008 DPKVITAGLDFLVSKQKESGEFPEVGKLFDNANQ----NPLALTSFVLLAFFENHELIPKYQSAI 1068
            ||:.:.|...:|:|.||:.|.||.:|::.:...|    ..::||::|::|..|......:...|:
Zfish  1229 DPEELRAAKSWLISNQKDEGSFPAMGRILNKDLQGGIHGKISLTAYVVVALMETGITTEEENVAV 1293

  Fly  1069 KKAVRYVAEEADKTDDQYSLAIAAVALQLAKHPQSEKVIAKLESVARKENDRMWWSKATESTGED 1133
            .||..::.......||.|:.|::|.||.|.:.|.:...:.:|..:|..::....|| .|..|..|
Zfish  1294 AKAKAFLESNTYSADDPYTTALSAYALTLLRSPYAPLALRRLNHMAITQDGFTHWS-LTGRTETD 1357

  Fly  1134 GRVF-------HWKPRSNDVEITSYVLLALLEKDPAEKALPIIKWLISQRNSNGGFSSTQDTVIG 1191
            ...|       .....|.:||:|:|.||..........|||::|||..|||:.|||||||||.:.
Zfish  1358 EDTFMGFSDGLSQSVVSAEVEMTAYGLLTYTLLGDVASALPVVKWLSQQRNALGGFSSTQDTCVA 1422

  Fly  1192 LQALTKFAYKTGSGSGTMDIEFSSAG-ESKNTIKVNPENSLVLQTHDLPKSTRKVDFTAKGTGSA 1255
            ||||:::|..:..|...:.|..:|.. :.:.|.::..:|..:||...:|.....:..:|||.|..
Zfish  1423 LQALSEYAILSYVGGVNLTISLASTNLDFQETFELQWDNKKILQKAVIPSIPTGLFVSAKGEGCC 1487

  Fly  1256 MVQLSYRYNLAEKEKKPSFKVTPTVKD--------------TPNQLLIVDVCAEY-----VPLED 1301
            ::|:...||:.:...||:|::...:|:              :|......|..:|.     .|::|
Zfish  1488 LMQIDVSYNVPDPVAKPAFQLKVDLKEPRQEQHILPSSRHISPRTRSRADNRSELTRKRRAPVDD 1552

  Fly  1302 AD----KDK-----------------DSNMAVMEIALPSGFVGDSTSLGKIQAVDRV--KRVETK 1343
            .|    :|.                 .|||||:|:.|.|||..|..||.::....||  ||.|.
Zfish  1553 EDPAGHQDHLDYRVTLEVCTRWLHVGSSNMAVLEVPLLSGFRADIESLERLLLDKRVGLKRYEV- 1616

  Fly  1344 NSDSTVVVYFDSLTPGDVRCLPLEASKAHAVAKQKPASVSLYDYYDTERKATEYYQVKSS---LC 1405
             ....|:.|||.:....:.|:...|.:.:.|.|..|..|.:||||:...:||.:|.|..|   ..
Zfish  1617 -DGRKVLFYFDEIPSQCMTCVAFNAVREYIVGKTAPVPVKVYDYYEPAFEATRFYNVSESSPLAR 1680

  Fly  1406 DICEGADCGE 1415
            ::|:|..|.|
Zfish  1681 ELCDGTTCNE 1690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep2	NP_523506.1	A2M_N	115..209	CDD:280081	31/94 (33%)
		A2M_N_2	445..576	CDD:285005	39/182 (21%)
		A2M	694..782	CDD:278630	35/135 (26%)
		A2M_2	909..1198	CDD:239227	123/299 (41%)
		A2M_comp	961..1199	CDD:284982	95/248 (38%)
		A2M_recep	1308..1398	CDD:284981	34/91 (37%)
cpamd8	XP_003201105.2	A2M_N	130..221	CDD:280081	31/93 (33%)
		A2M_N_2	460..624	CDD:285005	39/175 (22%)
		A2M	748..839	CDD:278630	34/93 (37%)
		Methyltransf_FA	985..1086	CDD:289052	10/100 (10%)
		A2M_2	1130..1429	CDD:239227	123/299 (41%)
		A2M_comp	1182..1431	CDD:284982	95/249 (38%)
		A2M_recep	1580..1670	CDD:284981	34/91 (37%)
		KAZAL	1724..1768	CDD:197624
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	1	1.000	-	-		FOG0002157
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820