Protein Alignment Tep2 and a2m3g

DIOPT Version :10

• Sequence 1: NP_523506.1
• Gene: Tep2 / 34044
• FlyBaseID: FBgn0041182
• Length: 1420
• Species: Drosophila melanogaster
• Sequence 2: NP_001108028.1
• Gene: a2m3g / 100136837
• ZFINID: ZDB-GENE-080205-1
• Length: 1453
• Species: Danio rerio
• Alignment Length: 1535
• Identity: 409/1535 - (26%)
• Similarity: 664/1535 - (43%)
• Gaps: 290/1535 - (18%)

  Fly    22 IYSVVGPGTLRSNSKYNVVVSVHKADGPSQIKVSLNGPSYNETKQIELPPMSTQN-----VEFEV 81
            ::.|..|..:.|.|...:..|:.|..|...|.::|......||   :|...:||.     ..|:.
Zfish    48 LFMVTFPSLIESGSGAKLCASLLKPQGSLTITITLVDDKNTET---QLARQTTQRKLHRCFNFQA 109

  Fly    82 PKLATGNYNLSAEGVSGVVFK--NSTKLNYADKKPSVFVQTDKATYKPADLVQFRILFLDENTRP 144
            |.:...:.......|.|..||  ...|:.:....|..|:||||..|.|...|.||::.:.:...|
Zfish   110 PLVNGDSVQTVRVVVQGQSFKMTEERKVMFRSYLPLTFIQTDKPLYNPGQTVNFRVVTMSDKLVP 174

  Fly   145 AKIEKPISVIIIDGAQN-RIKQLSDVKLTKGVFSGELQLSEQPVLGTWKISVSVDGDNRETKSFE 208
              :::..::::::..:| ||.|.::|.....:......|..:..:||:.:...: |:...::||:
Zfish   175 --LDQMYNLVVLEDFRNIRINQWTNVSSVNWILELSHVLIPEAQVGTYTLRAYI-GNRIISQSFD 236

  Fly   209 VDKYVLPKFEVIVDTPKAVVIADKVIKATIRAKYTYGKPVKGKATVSMERS-YGYFGDLNANG-- 270
            |.:||||||:|.|:.|:...:||..:|.....|||:|:||.|:..|.:.|. ..|..|.....
Zfish   237 VKQYVLPKFDVTVNAPQTYSVADVGLKVEACGKYTFGQPVPGQVLVQVCRQPLTYVQDPKVTSIC 301

  Fly   271 -NKQEKTIDVDGKGHVEFDIIHWAQRG---------QYLPPIKLFAVVTEELTGNKQNATATVVL 325
             ||..||   :..|.....:...:..|         .::..:.|    |||.||...:.:.||.:
Zfish   302 LNKSTKT---NNTGCASLTLSTSSYFGTSFESNLQNSFVVNVNL----TEEGTGVVMSKSTTVSI 359

  Fly   326 HQQRYSIEPYERPEHFEANKSFIYQVVVKNVDGSPVTNSAKNVKIGFDKSYSYFHEPS--PKTRI 388
            ..:...:...:.|:.:....:...::.|.:.:|:|:.|.|           .|..:.|  | .::
Zfish   360 TFEVGKVTFVDLPKFYNYGSTVNGKISVSDFNGNPIYNKA-----------VYLLDSSIWP-NKL 412

  Fly   389 NFEAPVNENGIATFNV---RLPDSD---------SRYYRIFASFDGSENTIGSISKFEP-TP--- 437
            .|....|..|.|.|::   ..|.:|         ..|:...:.:..:::.:..:|:.:| ||
Zfish   413 LFNLTTNNYGFAKFSLDTTSFPQADLNLVASATPQSYFSSNSPYFTTDSQVVQLSQTDPDTPTFS 477

  Fly   438 -----MSREPLK----IQVNTKKPRLGE--QVSFDVVSIEDLPYFVYTIVARGNVILSDYVDVPD 491
                 ...:|||    ..|..|...:||  ..|.|:         :|.:::||.::|..:..|..
Zfish   478 DLSIVKLEQPLKCGTTYSVTVKYLFVGETGDYSADI---------IYMVMSRGVIVLHGFKTVQA 533

  Fly   492 GQKTYTVKFTPTF------SMVPKATIYVYYVV-NNDLQFEEKTIDFEKEFSNSIDVS-APTNAK 548
            .......|...||      .|.|...|.||.|: :..:.....:.|.||.|||.:.:. :|:.|.
Zfish   534 RAFNTLTKGMVTFDLSILAKMAPMVQILVYSVLPSQTVVTGSASFDTEKCFSNQVSLQFSPSTAV 598

  Fly   549 PSEEVKLRIKTDADSFVGLLGVDQSVLLLKSGNDLSQDDIFNSLNIYQTSTPWMNGYGRYPGQTS 613
            |.|...|.:...|.|..||..:|||||:::||..||.:.:||.|.:...|
Zfish   599 PGEGSILTVSAQAGSLCGLSAIDQSVLIMQSGGRLSAEAVFNMLPLQSLS--------------- 648

  Fly   614 GLVTLTNANYPYNTGPLVMSYVFEGSRHPWITRPR--------YR----VGIRGDSGDRISFLSQ 666
                    :|||..         |..::....|||        |.    ||::         ::.
Zfish   649 --------DYPYGA---------EDQQNCLNVRPRRAVPTDQAYNTFKSVGMK---------IAT 687

  Fly   667 SLNDR-----NLKEIL---------------LKQTPQR------------TTIRKEFPETWFFE- 698
            :|..|     ..|::|               .::.|..            .|||..|||||.::
Zfish   688 NLPVREPECLKFKDLLYYRNFWGVRDAVFAMAEKAPVSLAMAGTGGSSVDMTIRTYFPETWIWQL 752

  Fly   699 ----NVGEEEFTLTKKIPDTITSWVVTGFSLNPTSGIALTKNPSKIRVFQPFFVSTNLPYSVKRG 759
                :.|.....||  :|||||:|....|.|: ::|..|.. |:.:..|||||:...||||:.||
Zfish   753 SLVGDSGSTSVPLT--VPDTITTWDTEAFCLS-SNGFGLAP-PALLTSFQPFFLELTLPYSIIRG 813

  Fly   760 EVIAIPVVIFNYLDKTLDADVVMDNSDQEYEFTEATNEVLEKAIDEVRRVKRVTIPANSGKSVSF 824
            |...:...:||||.:.:...|..         |.::|..|....|    :...|:..|..|::.:
Zfish   814 EAFELVATVFNYLLQCIKIQVTP---------TPSSNYTLTPIND----LSSSTLSTNWRKTIKW 865

  Fly   825 MIRPKNVGFTTLKITATSA----LAG------------DAIHQKLKVEPEGVTLFENRAVFINLK 873
            .:....:|...:.|:|.::    |.|            |.:.:.|:|..|||.....|:..:..|
Zfish   866 ALTASVIGTVNVTISAEASPSQELCGDQDVTVPSRGRIDIVTRSLRVLAEGVERTFTRSWLLCPK 930

  Fly   874 DQPEMSQSLDADIPNEVVPQSEFIEFSVVGDLLGPTLQNLDNLVRMPYGCGEQNMVNFVPNILVL 938
            .. .:|:|:...:|..|:..|.....||:||::|..|.||.||::||.|||||||:...||:.:|
Zfish   931 GS-VLSESVKITLPTNVIQGSASCSVSVIGDIMGRALNNLANLLQMPSGCGEQNMIILAPNVYIL 994

  Fly   939 KYLEVTGRKLPSVESKARKFLEIGYQRELTYKHDDGSYSAFGKSDASGSTWLTAYVMRSFHQAGT 1003
            :||.||.:..|:::..|..:|..|||.||.|:|.|||:|.|| .||| :|||||:|||:|..|.:
Zfish   995 RYLTVTAQLTPAIQDTATSYLLTGYQGELNYRHSDGSFSTFG-YDAS-NTWLTAFVMRTFGLARS 1057

  Fly  1004 YTDIDPKVITAGLDFLVSKQKESGEFPEVGKLFDNANQ----NPLALTSFVLLAFFENHELIPKY 1064
            :|.|||.|:....|:|:..|...|.|.:.|.|:.|..:    :.:.:|.:::.:..|..  :|..
Zfish  1058 FTYIDPNVLKGAKDWLIGTQGSDGCFVQQGTLYHNDMKGGVGDNVTMTGYIVASLLEIG--VPAT 1120

  Fly  1065 QSAIKKAVRYVAEEADKTDDQYSLAIAAVALQLAKHPQSE-KVIAKLESVARKENDRMWWSKATE 1128
            ...|.||:.::........:.|..|:.|....||....:. ::::.|.:.|..|...:.||:.|
Zfish  1121 DPVITKALSFLRPLVGYLGNTYVTALLAYTFSLAGETSTRAQLLSSLRNTAISEGTTLHWSQTT- 1184

  Fly  1129 STGEDGRVFHWKPRSND---VEITSYVLLALLEKDPAEK-----ALPIIKWLISQRNSNGGFSST 1185
                          |.|   |||::|||||:|...|...     |..|:.|:::|:|..||||||
Zfish  1185 --------------SGDTLAVEISAYVLLAVLTVQPVTTANLGYANRIVSWIVAQQNPYGGFSST 1235

  Fly  1186 QDTVIGLQALTKFAYK--TGSGSGTMDIEFS-SAGESKNTIKVNPENSLVLQTHDLPKSTRKVDF 1247
            ||||:.||||..:|.:  |..||.|:.|:.| .||:..| ..|.|.|.|:.|.:.|.........
Zfish  1236 QDTVVALQALALYAAQAFTPGGSSTVTIQSSVPAGDIFN-FAVTPNNRLLYQRNSLNNFPGTYSV 1299

  Fly  1248 TAKGTGSAMVQLSYRYNLAEKEKKPSFKVTPTVKDTPNQLLIV-----DVCAEYVPL------ED 1301
            .|:|:..|.||::..||:            ||.......|.:|     |..|..|.|      :.
Zfish  1300 VARGSACASVQVACFYNI------------PTPVTVARTLSVVAKVTGDCQAATVNLMLTFTVKY 1352

  Fly  1302 ADKDKDSNMAVMEIALPSGFVGDSTSLGK-------IQAVDRVKRVETKNSDSTVVVYFDSLTPG 1359
            ..:...:||.:::|.:.|||..|::.||.       :|.||       .|.|. |:||...:..|
Zfish  1353 NGRKPTTNMVLVDIKVLSGFTADTSLLGSPPNFAPLVQRVD-------SNGDH-VLVYLQEVPKG 1409

  Fly  1360 DVRCLPLEASKAHAVAKQKPASVSLYDYYDTERKATEYYQ 1399
            ......::.::..||...|||.:::||||....|....|:
Zfish  1410 IPVTFSIQLTQTVAVQNLKPAVINIYDYYQRNDKFETTYK 1449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep2	NP_523506.1	YfaS	<72..1395	CDD:441940	396/1479 (27%)
		A2M_2	909..1198	CDD:239227	111/301 (37%)
a2m3g	NP_001108028.1	YfaS	<147..1239	CDD:441940	321/1200 (27%)
		A2M_2	965..1240	CDD:239227	106/293 (36%)
		A2M_recep	1357..1448	CDD:462226	28/98 (29%)