Protein Alignment Tep2 and a2ml1

DIOPT Version :9

• Sequence 1: NP_523506.1
• Gene: Tep2 / 34044
• FlyBaseID: FBgn0041182
• Length: 1420
• Species: Drosophila melanogaster
• Sequence 2: XP_031760638.1
• Gene: a2ml1 / 100127688
• XenbaseID: XB-GENE-5943821
• Length: 1486
• Species: Xenopus tropicalis
• Alignment Length: 1583
• Identity: 458/1583 - (28%)
• Similarity: 689/1583 - (43%)
• Gaps: 316/1583 - (19%)

  Fly     9 IILQYALLVNATGIYSVVGPGTLRSNSKYNVVVSVHKADGPSQIKVSLNGPSYNET------KQI 67
            ::|..:..:.|...|:||.|..:|.:|.....|.:..|:|.|:|:|:||....|.|      :|.
 Frog    12 VLLHLSGTLEAKLHYAVVFPSEMRCHSSEQACVHLSGAEGDSRIQVTLNMAERNSTVIERNLRQK 76

  Fly    68 ELPPMSTQNVEFEVPKLATGNYNLSAEGV----SGVVFKNSTKLNYADKKPSVFVQTDKATYKPA 128
            .|    ...|.|:||..:.||..::...:    :|....||:|:....::.|.|:|||||.|||.
 Frog    77 SL----FSCVTFQVPPPSEGNEEVATMEILIESAGETITNSSKVLVKRRRTSTFIQTDKAVYKPG 137

  Fly   129 DLVQFRILFLDENTRPAKIEKPISVI-IIDGAQNRIKQLSDVKLTKGVFSGELQLSEQPVLGTWK 192
            ..|:||::.|.||.:|.  |..|||| :.|..:|||.|..||.||:|:....|.||.:|.||.:.
 Frog   138 QTVRFRVVSLKENLQPG--ENQISVIQLQDPNKNRIAQWLDVTLTQGIAELSLPLSPEPSLGEYS 200

  Fly   193 ISVSVDGDNRETKSFEVDKYVLPKFEVIVDTPKAVVIADKVIKATIRAKYTYGKPVKG--KATVS 255
            |.|   ||.  ...|.|::||||||||....||.|....:..:.....:|||||||:|  ||||.
 Frog   201 IHV---GDT--VHYFSVEEYVLPKFEVSFQFPKVVFFTSEQFQLKTCGRYTYGKPVQGTYKATVC 260

  Fly   256 MERSYGYFGDLNANGNKQEKTIDVDGKGHVEFDIIHWAQRGQYLPPIKLFAVVTEELTGNKQNAT 320
            .:....::|.   |.::.:..:|..||    .|     |.|            ...||...:|..
 Frog   261 RKVIRYWWGH---NDDRSDLCVDFSGK----LD-----QSG------------CSTLTATSENFN 301

  Fly   321 ATVVLHQQRYS-----IEPYERPEHFEANKSFIYQVVVK----NVD-----GSPVTNSAKNVKIG 371
            .|...|:....     .|.....|:..:.|:.|..||..    :.|     |.|.:.:.|.|...
 Frog   302 LTYNTHEMGLEGTSTITEGGTGVEYSGSGKTIISSVVTSCSFLDADSNYKPGIPYSGTVKVVDAN 366

  Fly   372 FDKSYSYFHEPSP---------KTRINFEAPVNENGIATFNVR----------LPDSDSRYYRIF 417
            .|        |.|         ...:|.....:|||:|:|.:.          |..|.:.....|
 Frog   367 DD--------PIPNQIVYLTSHSNEVNKTLVSDENGLASFQLENTAEWKGQLSLRASTTTQDAGF 423

  Fly   418 ASFDGSENTIGSISKFEPTPMSREPLK--IQVNTKKPRLGEQVSFDVVSIEDLPYFV-------- 472
            ....|...|...:|..........|.|  :::::::..|..:...||    .:.|.:
 Frog   424 DFLQGRLITPNDVSASLMLKPFHSPSKSFLKLHSQQGALPCEGQRDV----RVEYIIPNSALGIE 484

  Fly   473 -------YTIVARGNVILSDYVDVP---DG------QKTYTVKFTPTFSMVP--KATIYVYYVVN 519
                   |.:.::|:|..|..|:||   :|      :...::|.|.:..:.|  :|..:: .:.|
 Frog   485 VKHMELHYLVASKGSVKDSGSVEVPITSEGGGSSELRGEVSIKLTLSADVSPTLRALAFI-SLPN 548

  Fly   520 NDLQFEEKTIDFEKEFSNSIDVS-APTNAKPSEEVKLRIKTDADSFVGLLGVDQSVLLLKSGNDL 583
            .:|..:..|...::.|.|.:.|. :|....|..:|.|:::..|.|..||..|||||:|:|...:|
 Frog   549 GELVADSATFKLQRCFKNKVSVGFSPDEVLPGADVSLQVQAAAGSLCGLRVVDQSVVLMKPDKEL 613

  Fly   584 SQDDIFNSLNIYQTSTPWMNGYGRYPGQTSGLVTLTNANYPYNTGPLVMSYVFEGSRHPWITRPR 648
            :.|.|.|....     |...||       ...|..::.:.|:               :||..||.
 Frog   614 TADQIHNLFPF-----PDFGGY-------DARVQDSDDHCPF---------------YPWFHRPM 651

  Fly   649 YRVGI--------RGDSGDRISFLSQSLNDRNLK----------------EILLKQT-------- 681
            ::..|        ..|..|..|.    ..|..||                |..|:..
 Frog   652 WKRSIVLPPWHMPHEDEVDVYSL----FKDMRLKIVTSAEIKKPLRCREPEFALQYNVLAHPRIA 712

  Fly   682 ----------------------PQRTTIRKEFPETWFF--ENVGEE-EFTLTKKIPDTITSWVVT 721
                                  |....||..|||||.:  |.|||. ...:....|||||.|...
 Frog   713 DAGDGLVRAMPKAVGVGNELTEPAAEIIRAYFPETWIWQLEPVGESGRAEVHGSAPDTITEWNAG 777

  Fly   722 GFSLNPTSGIALTKNPSKIRVFQPFFVSTNLPYSVKRGEVIAIPVVIFNYLDKTLDADVVMDNS- 785
            .|.:.| ||..::. |:.:|.||||||...|||||.|||...:...:||||.:.:.....:..|
 Frog   778 AFCMGP-SGFGISP-PTSLRAFQPFFVELTLPYSVVRGESFTLKASVFNYLKQCIKVQTTLQPSL 840

  Fly   786 --------DQEYEFTEATNEVLEKAIDEVRRVKRVTIPANSGKSVSFMIRPKNVGFTTLKITATS 842
                    |.:|.                     ..|.|:..|:..:.::..|:|...:.: .|.
 Frog   841 ELEQEPCADCQYS---------------------SCICADESKTFYWNLKASNLGEVNITV-RTE 883

  Fly   843 AL-----------------AGDAIHQKLKVEPEGVTLFENRAVFINLKDQPEMSQSLD--ADIPN 888
            ||                 ..|.:.:.|.|:|.||.:.::.:..|...:..:.|::.|  .::|.
 Frog   884 ALNTQDMCNNEIPIVPKQGHSDTVIKPLLVQPGGVLIEKSHSSLICSPEGEDHSKTEDISLNVPE 948

  Fly   889 EVVPQSEFIEFSVVGDLLGPTLQNLDNLVRMPYGCGEQNMVNFVPNILVLKYLEVTGRKLPSVES 953
            .::..||....:.:|||:|..:||||.|:.|||||||||||.|.|||.:|:|||.|.:..|.:::
 Frog   949 NILEGSERAYVTALGDLMGTAMQNLDRLLAMPYGCGEQNMVLFAPNIFILQYLENTHQLSPEIQT 1013

  Fly   954 KARKFLEIGYQRELTYKHDDGSYSAFGKSDASGSTWLTAYVMRSFHQAGTYTDIDPKVITAGLDF 1018
            ||:.|||.||||:||||.:||||||||..|..|:|||||:|::||.:|..|..||...:.....:
 Frog  1014 KAKGFLESGYQRQLTYKRNDGSYSAFGSRDPEGNTWLTAFVVKSFSKARPYIFIDGDHLNHSFSW 1078

  Fly  1019 LVSKQKESGEFPEVGKLFDNANQ----NPLALTSFVLLAFFE-----NHELIPKYQSAIKKAVRY 1074
            |..|::.||.|..|||||:||.:    :.::|:::|.:|..|     ...::....|.::||.|
 Frog  1079 LKDKRQRSGCFRSVGKLFNNAMKGGVDDEISLSAYVTIALMEAGLSKEDPMVSDALSCLRKAAR- 1142

  Fly  1075 VAEEADKTDDQYSLAIAAVALQLA---KHPQSEKVIAKLESVARKENDRMWWSKATESTGEDGRV 1136
                  |....|:.|:.|....|:   ||  .||::||||..|.:::.::.|.:...|...|...
 Frog  1143 ------KVSSAYTQALLAYTFTLSDDTKH--REKLLAKLEEKAVRKDGQLHWERKPASKASDLPY 1199

  Fly  1137 FHWKPRSNDVEITSYVLLALL---EKDPAEKALPIIKWLISQRNSNGGFSSTQDTVIGLQALTKF 1198
            ::..| |.:||:|||.|||||   .|| ..||..|:.||..|:|..||||||||||:.||||.::
 Frog  1200 WYRAP-SAEVELTSYALLALLSGPNKD-LGKASEIVNWLSKQQNPYGGFSSTQDTVVALQALAEY 1262

  Fly  1199 AYKTGSGSGTMDIEFSSAGESKNTIKVNPENSLVLQTHDLPKSTRKVDFTAKGTGSAMVQLSYRY 1263
            |..|.|..|.:.:..:|.........|:..|.|:||...||....:...:|.|:|...||...||
 Frog  1263 AEATFSDKGDVTVTVTSKTGFHQQFHVDQTNRLLLQKASLPDIPGEYSLSATGSGCVYVQTVLRY 1327

  Fly  1264 NLAEKEKKPSFKVTPTVKDTPNQL-------LIVDVCAEYVPLEDADKDKDSNMAVMEIALPSGF 1321
            |:.......:|.|  .|:..|.|.       :.:|:..:|.    ..::| ||||::|:.:.|||
 Frog  1328 NIPPPRSDATFSV--RVETQPQQCPQEPMKQMGIDIYIQYT----GSREK-SNMALVEVKMLSGF 1385

  Fly  1322 VGDSTSLGKIQAVDRVKR-----VETKNSDSTVVVYFDSLTPGDVRCLPLEASKAHAVAKQKPAS 1381
            ..|..|      :|:|.|     :.::.....|..|...|....|. ......:...|...:||.
 Frog  1386 TPDKKS------IDQVIRWNNFIMWSETQTDKVTFYLSELGRHPVN-FSFMVEQEVLVKNLRPAI 1443

  Fly  1382 VSLYDYYD-TERKATEYYQVKSS 1403
            |.:||||: .|...|||....||
 Frog  1444 VKVYDYYEPVEHAVTEYNSPCSS 1466

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep2	NP_523506.1	A2M_N	115..209	CDD:280081	43/94 (46%)
		A2M_N_2	445..576	CDD:285005	35/157 (22%)
		A2M	694..782	CDD:278630	36/90 (40%)
		A2M_2	909..1198	CDD:239227	133/303 (44%)
		A2M_comp	961..1199	CDD:284982	102/252 (40%)
		A2M_recep	1308..1398	CDD:284981	28/95 (29%)
a2ml1	XP_031760638.1	A2M_N	124..222	CDD:396416	50/104 (48%)
		MG3	214..303	CDD:407663	34/112 (30%)
		MG4	342..420	CDD:407661	16/85 (19%)
		A2M_N_2	453..607	CDD:400170	35/158 (22%)
		A2M	747..836	CDD:395153	36/90 (40%)
		SVA	<798..893	CDD:398804	28/116 (24%)
		A2M_2	969..1262	CDD:239227	133/303 (44%)
		A2M_recep	1372..1460	CDD:400149	27/94 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	243	1.000	Domainoid score	I2167
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9328
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X292
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.010