Protein Alignment Tep2 and a2m2c

DIOPT Version :10

• Sequence 1: NP_523506.1
• Gene: Tep2 / 34044
• FlyBaseID: FBgn0041182
• Length: 1420
• Species: Drosophila melanogaster
• Sequence 2: NP_001410202.1
• Gene: a2m2c / 100006993
• ZFINID: ZDB-GENE-030131-1342
• Length: 1417
• Species: Danio rerio
• Alignment Length: 1560
• Identity: 408/1560 - (26%)
• Similarity: 672/1560 - (43%)
• Gaps: 321/1560 - (20%)

  Fly     6 LTGIILQYALLVNATG-----IYSVVGPGTLRSNSKYNVVVS--------------VH------- 44
            |.|..|.:.|.:...|     |:.|..|..:.|.|...:..|              ||
Zfish     9 LKGFFLIFILFLCVNGNKTRPIFMVTFPAVIESGSDAKLCASLLKPNKTLFMNIYLVHSNQSTLL 73

  Fly    45 --------------------KADGPSQIKVSLNGPSYNETKQIELPPMSTQNVEFEVPKLATGNY 89
                                :|:...:|||.|.|.|:|.|::.:
Zfish    74 LQEKAEQEFHRCFNFQAPLAEAESVQKIKVELQGESFNMTEERK--------------------- 117

  Fly    90 NLSAEGVSGVVFKNSTKLNYADKKPSVFVQTDKATYKPADLVQFRILFLDENTRPAKIEKPISVI 154
                     |:||:        ..|..|:|.||..|.....|.||::.:|::.||  :::..|.:
Zfish   118 ---------VMFKS--------YHPLTFIQMDKPFYIAGQTVNFRVVTMDKSFRP--LDQQYSAV 163

  Fly   155 IIDGAQ-NRIKQLSDVKLTKGVFSGELQLSEQPVLGTWKISVSVDGDNRETKSFEVDKYVLPKFE 218
            :::.:| |||.|.::|..|:.:......|:.:...||:|:...: |:...:..|:|.|||||||.
Zfish   164 VLEDSQDNRIGQWTNVSSTRWILQRSYDLNPEAREGTYKVKAFI-GERMISHDFDVKKYVLPKFG 227

  Fly   219 VIVDTPKAVVIADKVIKATIRAKYTYGKPVKGKATVSMERSYGYFGDLNANGNKQEKTIDVDG-- 281
            |.|.:|..|.|.|:.:...:..||||||||.||::|.:.|                ||:|...
Zfish   228 VFVISPNPVSIDDEFMVIEVCGKYTYGKPVLGKSSVKVCR----------------KTLDTHSPL 276

  Fly   282 -------------KGH-VEFDIIHWAQRGQYLPPIKLFAVVTEELTGNKQNATATVVLHQQRYSI 332
                         ..| :...:..:....|.|..:.:.|.:|||.|......:.|:.|..:...:
Zfish   277 CVKESTEISKTGCANHTLALSVFFYPTHHQLLNDLHIEATITEEETEITMTQSNTISLTYEIGKV 341

  Fly   333 EPYERPEHFEANKSFIYQVVVKNVDGSPVTNSAKNVKIGFDKSYSYFHEPSPKTRINFEAPVNEN 397
            ...:.|:.:|.......:|.:....|:.|  ..|::.|  .::||:    .||..:|.  ..:.|
Zfish   342 TFTDLPKTYEYGSVIEGKVKLARFRGTAV--PGKHIYI--LENYSW----PPKVLLNL--TTDSN 396

  Fly   398 GIATFN---VRLPDSD-----SRY--YRIFAS----FDGSENTIGSISKFEPTPMS--------- 439
            |:|.|:   :|...||     |.|  ||.:..    |:..|.|:    :|.|.|.:
Zfish   397 GLANFSLNTLRFVKSDINLMASAYPGYRSYFQKSPYFNTDEKTV----QFFPKPAASYTPTFSEL 457

  Fly   440 -----REPLK----IQVNTKKPRLGEQVSFDVVSIEDLPYFVYTIVARGNVILSDY--VDVPDGQ 493
                 .:|||    |....|...:.|.|......|      ||.:::||.:|...|  |:|....
Zfish   458 IIENIEQPLKCGTEITATVKYYFVKETVKIFNADI------VYMVLSRGVIIHHGYEKVEVKSSN 516

  Fly   494 K----TYTVKFTPTFSMVPKATIYVYYVV-NNDLQFEEKTIDFEKEFSNSIDVS-APTNAKPSEE 552
            .    |.:.|.:....:.|...|..|.|: :.::....:....||...|.:.:. :|..|.|.|:
Zfish   517 AVASGTMSFKLSVGADVAPLVQILAYCVLPSENIAIHSENFHVEKCLKNKVSLQFSPAKAVPGEK 581

  Fly   553 VKLRIKTDADSFVGLLGVDQSVLLLKSGNDLSQDDIFNSLNIYQTSTPWMNGYGRYPGQTSGLVT 617
            ..|::.....|..||..||||||:|:||..|..|.|||.|       |...|.| ||.      :
Zfish   582 NTLQLSAQPGSLCGLSAVDQSVLMLESGKRLDADKIFNLL-------PVKYGSG-YPS------S 632

  Fly   618 LTNANYPYNTGPLVMSYVFEGSRHPWITRPRYRVGIRGDSGDRISFLSQSLNDRNLKEILLK--- 679
            |.:....:....:.:..:|:.|:         |:|::  ....::..|.:......|:.:.:
Zfish   633 LPDEKECFYMMAVPIENIFKSSK---------RIGLK--MATNLAVRSGTSTCEMYKKFMFRDIG 686

  Fly   680 ----QTPQRT----TIRKEFPETWFFENV-----GEEEFTLTKKIPDTITSWVVTGFSLNPTSGI 731
                ..|..|    .:|..||:||.::.:     |..|..:|  :|||||||....|.|:.| |:
Zfish   687 LAEDSVPHWTLFEENVRSVFPKTWLWQLIEISDSGSAEVPVT--VPDTITSWETEAFCLSST-GL 748

  Fly   732 ALTKNPSKIRVFQPFFVSTNLPYSVKRGEVIAIPVVIFNYLDKTLDADV---------VMDNSDQ 787
            .|.. |:::.||||||:..:||||:.|||:..:...:||||.|.:...|         :..:||.
Zfish   749 GLAP-PAQLTVFQPFFLELSLPYSIIRGEMFELKATVFNYLSKCIMVKVSPAPSSDYTLKASSDD 812

  Fly   788 EYEFTEATNEVLEKAIDEVRRVKRVTIPANSGKSVSFMIRPKNVGFTTLKITATSALAG------ 846
            :|.                     ..:.||..|:..:::.|..:|...:.:.|.:..:.
Zfish   813 QYS---------------------SCLCANGRKTFKWILTPSVIGVVNVTVRAEAEASQTVCDNE 856

  Fly   847 ----------DAIHQKLKVEPEGVTLFENRAVFINLKDQPEMSQSLDADIPNEVVPQSEFIEFSV 901
                      |.:.:.|.|:.||:...:..:..:..|.. .:.:.:|..:|.:::..|.....||
Zfish   857 IVSVPERGRIDTVTRSLLVQAEGIKKAKTNSWLLCPKGD-SLLEEIDLTLPKDMIEGSVTSSVSV 920

  Fly   902 VGDLLGPTLQNLDNLVRMPYGCGEQNMVNFVPNILVLKYLEVTGRKLPSVESKARKFLEIGYQRE 966
            :||::|.:|:.|...:...|..|.||:....|:|.:|:|||.|.:...::..||..||:.||||:
Zfish   921 IGDIVGRSLKKLHRTLWRIYRSGNQNIAILSPSIYILQYLENTKQLTSAIREKASSFLKSGYQRQ 985

  Fly   967 LTYKHDDGSYSAFGKSDASGSTWLTAYVMRSFHQAGTYTDIDPKVITAGLDFLVSKQKESGEFPE 1031
            |.|:|.:|:||.||  :..|:.||||:|::||.:|..|..|||::|.:...:|:..|...|.|.:
Zfish   986 LKYRHRNGAYSTFG--NGKGNAWLTAFVLKSFVKAQKYIYIDPQIIKSAKKWLIGTQDPEGCFIQ 1048

  Fly  1032 VGKLFDN----ANQNPLALTSFVLLAFFE-----NHELIPKYQSAIKKAVRYVAEEADKTDDQYS 1087
            .|:||:|    ...:.:.:|:::..:..|     ...:|.|..|.::..::.|       .:.|:
Zfish  1049 HGRLFNNRLKGGVSDHVTMTAYITASLLELETSVTDPVIIKGLSCLRSVIKDV-------KNTYT 1106

  Fly  1088 LAIAAVALQLAKHPQS-EKVIAKLESVARKENDRMWWSKATESTGEDGRVFHWKPRSNDVEITSY 1151
            .|:.|....||:...: :::..|||.:|..:...:.||::..:...|         |.||||:||
Zfish  1107 TALLAYTFSLARDTNTRQQLFNKLEDLAISDGPLVHWSQSASADDSD---------SLDVEISSY 1162

  Fly  1152 VLLALLEKDPAEK-----ALPIIKWLISQRNSNGGFSSTQDTVIGLQALTKFAYKTGSGSGTMDI 1211
            ||||:|..|....     |..|:.||:.|:|:.||||||||||:.||||:.:|.|..|..|:..:
Zfish  1163 VLLAVLTADSLTTADLGFANRIVSWLVKQQNAYGGFSSTQDTVVALQALSLYATKVFSSDGSSTV 1227

  Fly  1212 EFSSAGESKNTIKVNPENSLVLQTHDLPKSTRKVDFTAKGTGSAMVQLSYRYN-LAEKEKKP--- 1272
            ...|||:| :...||.:|.||.|...|.....|.....||:....||::..|| |..||.|.
Zfish  1228 TVQSAGDS-HYFNVNQDNKLVYQEKQLANVPGKYKIEVKGSACVSVQMAQFYNILTPKEVKTLSI 1291

  Fly  1273 SFKVTPTVKDTPNQLLIVDVCAEYVPLEDADKDKDSNMAVMEIALPSGFVGDSTSL-GKIQA--V 1334
            ..|:....|.|....|:::....|    |...: .:||.::::.|.|||..|.|:: |....  |
Zfish  1292 DVKIEGDCKKTFGNKLLLEFTVNY----DGPHE-TTNMLIVDVKLLSGFTADDTTMFGSSSGFYV 1351

  Fly  1335 DRVKRVETKNSDSTVVVYFDSLTPGDVRCLPLEASKAHAVAKQKPASVSLYDYYDT-ERKATEYY 1398
            ..|::|:.|  |..|:||...:.........::..:...|...|||.:.:||||.| ::..||||
Zfish  1352 PLVEQVDYK--DDHVIVYLKEVPKHFPVNYQIQMKQVLHVMNLKPAVIKVYDYYQTSDQSETEYY 1414

  Fly  1399  1398
            Zfish  1415  1414

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep2	NP_523506.1	YfaS	<72..1395	CDD:441940	382/1443 (26%)
		A2M_2	909..1198	CDD:239227	102/303 (34%)
a2m2c	NP_001410202.1	MG2	128..218	CDD:426464	25/92 (27%)
		MG3	220..299	CDD:465509	29/94 (31%)
		MG4	341..>411	CDD:465507	17/79 (22%)
		A2M_BRD	457..606	CDD:462235	39/154 (25%)
		A2M	709..797	CDD:459711	36/91 (40%)
		SVA	<754..849	CDD:398804	28/115 (24%)
		A2M_2	940..1214	CDD:239227	100/291 (34%)
		A2M_recep	1320..1413	CDD:462226	27/95 (28%)